SIMILAR PATTERNS OF AMINO ACIDS FOR 1QFT_A_HSMA177_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1n60	CARBON MONOXIDE DEHYDROGENASE LARGE CHAIN (Oligotropha carboxidovorans)	PF01315 (Ald_Xan_dh_C) PF02738 (Ald_Xan_dh_C2)	5	TYR B 94 ASP B 163 TYR B 376 ASP B 101 VAL B 102	None	1.48A	1qftA-1n60B: 0.0	1qftA-1n60B: 12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2v25	MAJOR CELL-BINDING FACTOR (Campylobacter jejuni)	PF00497 (SBP_bac_3)	5	TYR A 156 GLU A 39 TYR A 198 ASP A 174 VAL A 173	ASP A1234 (-4.5A) None None ASP A1234 (-2.8A) None	1.47A	1qftA-2v25A: 0.0	1qftA-2v25A: 22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3g7x	FEMALE-SPECIFIC HISTAMINE-BINDING PROTEIN 2 (Rhipicephalus appendiculatus)	PF02098 (His_binding)	10	TYR A 36 ASP A 39 VAL A 41 TRP A 42 GLU A 82 TYR A 100 PHE A 108 ASP A 110 VAL A 124 GLU A 135	None HSM A 174 (-2.8A) HSM A 174 ( 4.3A) HSM A 174 (-3.7A) HSM A 174 (-2.8A) HSM A 174 (-3.6A) HSM A 174 (-4.0A) HSM A 174 (-3.2A) HSM A 174 (-4.4A) HSM A 174 (-3.4A)	0.18A	1qftA-3g7xA: 35.0	1qftA-3g7xA: 99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4igl	YENC2 (Yersinia entomophaga)	no annotation	5	ASP B 461 VAL B 460 TYR B 674 ASP B 85 VAL B 84	None	1.26A	1qftA-4iglB: 0.0	1qftA-4iglB: 14.65

[["1QFT_A_HSMA177_1","1n60","Oligotropha carboxidovorans","CARBON MONOXIDE DEHYDROGENASE LARGE CHAIN","PF01315(Ald_Xan_dh_C);PF02738(Ald_Xan_dh_C2)",5,"TYR B  94;ASP B 163;TYR B 376;ASP B 101;VAL B 102","None","1.48A","1qftA-1n60B:0.0","1qftA-1n60B:12.65"],["1QFT_A_HSMA177_1","2v25","Campylobacter jejuni","MAJOR CELL-BINDING FACTOR","PF00497(SBP_bac_3)",5,"TYR A 156;GLU A  39;TYR A 198;ASP A 174;VAL A 173","ASP A1234 (-4.5A);None;None;ASP A1234 (-2.8A);None","1.47A","1qftA-2v25A:0.0","1qftA-2v25A:22.26"],["1QFT_A_HSMA177_1","3g7x","Rhipicephalus appendiculatus","FEMALE-SPECIFIC HISTAMINE-BINDING PROTEIN 2","PF02098(His_binding)",10,"TYR A  36;ASP A  39;VAL A  41;TRP A  42;GLU A  82;TYR A 100;PHE A 108;ASP A 110;VAL A 124;GLU A 135","None;HSM A 174 (-2.8A);HSM A 174 ( 4.3A);HSM A 174 (-3.7A);HSM A 174 (-2.8A);HSM A 174 (-3.6A);HSM A 174 (-4.0A);HSM A 174 (-3.2A);HSM A 174 (-4.4A);HSM A 174 (-3.4A)","0.18A","1qftA-3g7xA:35.0","1qftA-3g7xA:99.42"],["1QFT_A_HSMA177_1","4igl","Yersinia entomophaga","YENC2","no annotation",5,"ASP B 461;VAL B 460;TYR B 674;ASP B  85;VAL B  84","None","1.26A","1qftA-4iglB:0.0","1qftA-4iglB:14.65"]]