SIMILAR PATTERNS OF AMINO ACIDS FOR 1QFI_B_DVAB8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		3 THR A 217
THR A 192
PRO A 194
 None
 0.70A 1qfiB-1cj2A:
undetectable		 1qfiB-1cj2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 THR A 111
THR A 109
PRO A 107
 None
 0.72A 1qfiB-1cptA:
undetectable		 1qfiB-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 THR A  61
THR A  59
PRO A  57
 None
 0.77A 1qfiB-1ethA:
undetectable		 1qfiB-1ethA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq7 PROCLAVAMINATE
AMIDINO HYDROLASE

(Streptomyces
clavuligerus) 		PF00491
(Arginase) 		3 THR A 149
THR A 162
PRO A 151
 None
 0.81A 1qfiB-1gq7A:
undetectable		 1qfiB-1gq7A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		3 THR A 113
THR A 115
PRO A 109
 None
 0.79A 1qfiB-1gz4A:
undetectable		 1qfiB-1gz4A:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  62
THR H  64
PRO H  60
 None
 0.77A 1qfiB-1h3pH:
undetectable		 1qfiB-1h3pH:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 THR A 554
THR A 555
PRO A 553
 None
 0.87A 1qfiB-1h7wA:
undetectable		 1qfiB-1h7wA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		3 THR A 199
THR A 166
PRO A 201
 None
 0.83A 1qfiB-1he3A:
undetectable		 1qfiB-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		3 THR A  99
THR A  97
PRO A  95
 None
 0.81A 1qfiB-1jioA:
undetectable		 1qfiB-1jioA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		3 THR A 165
THR A 163
PRO A 167
 None
 0.86A 1qfiB-1mqtA:
undetectable		 1qfiB-1mqtA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		3 THR A 415
THR A 417
PRO A 414
 None
 0.86A 1qfiB-1nq7A:
undetectable		 1qfiB-1nq7A:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 309
THR A 307
PRO A 305
 None
 0.80A 1qfiB-1pjbA:
undetectable		 1qfiB-1pjbA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		3 THR A 688
THR A 687
PRO A 614
 None
 0.84A 1qfiB-1qafA:
undetectable		 1qfiB-1qafA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqh PAPILLOMAVIRUS
TRANSCRIPTION FACTOR
E2

(Alphapapillomavirus
7) 		PF00508
(PPV_E2_N) 		3 THR A 107
THR A 104
PRO A 106
 None
 0.86A 1qfiB-1qqhA:
undetectable		 1qfiB-1qqhA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		3 THR A 243
THR A 245
PRO A 241
 None
 0.81A 1qfiB-1qyiA:
undetectable		 1qfiB-1qyiA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujt KIAA1568 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		3 THR A 112
THR A 111
PRO A  29
 None
 0.86A 1qfiB-1ujtA:
undetectable		 1qfiB-1ujtA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d07 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		3 THR A 121
THR A 196
PRO A 198
 None
 0.85A 1qfiB-2d07A:
undetectable		 1qfiB-2d07A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzj SYNAPTIC
GLYCOPROTEIN SC2

(Homo sapiens) 		no annotation 3 THR A  46
THR A  44
PRO A  48
 None
 0.77A 1qfiB-2dzjA:
undetectable		 1qfiB-2dzjA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 308
THR A 306
PRO A 304
 None
 0.83A 1qfiB-2eezA:
undetectable		 1qfiB-2eezA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum) 		PF13247
(Fer4_11) 		3 THR B 155
THR B 266
PRO B 157
 None
SF4  B1357 ( 4.6A)
SF4  B1357 ( 4.8A)
 0.86A 1qfiB-2ivfB:
undetectable		 1qfiB-2ivfB:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2

(Alphapapillomavirus
9) 		PF00508
(PPV_E2_N) 		3 THR A 107
THR A 104
PRO A 106
 None
 0.71A 1qfiB-2nnuA:
undetectable		 1qfiB-2nnuA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 THR A 548
THR A 546
PRO A 544
 None
 0.85A 1qfiB-2nq5A:
undetectable		 1qfiB-2nq5A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		3 THR A 317
THR A 315
PRO A 319
 THR  A 317 ( 0.8A)
THR  A 315 ( 0.8A)
PRO  A 319 ( 1.1A)
 0.86A 1qfiB-2ogsA:
undetectable		 1qfiB-2ogsA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 THR A 188
THR A 184
PRO A 186
 None
 0.86A 1qfiB-2okxA:
undetectable		 1qfiB-2okxA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00483
(NTP_transferase) 		3 THR A  32
THR A  30
PRO A  34
 None
 0.74A 1qfiB-2pa4A:
undetectable		 1qfiB-2pa4A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 THR B  55
THR B  56
PRO B  54
 None
 0.82A 1qfiB-2pffB:
undetectable		 1qfiB-2pffB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv6 GTP CYCLOHYDROLASE
III

(Methanocaldococcus
jannaschii) 		PF05165
(GCH_III) 		3 THR A  18
THR A  16
PRO A  14
 None
 0.87A 1qfiB-2qv6A:
undetectable		 1qfiB-2qv6A:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus B) 		PF00073
(Rhv) 		3 THR 2 147
THR 2 145
PRO 2 149
 None
 0.81A 1qfiB-2rs52:
undetectable		 1qfiB-2rs52:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		3 THR A  64
THR A  66
PRO A  63
 None
 0.82A 1qfiB-2v7zA:
undetectable		 1qfiB-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 THR A 228
THR A 230
PRO A 186
 None
 0.73A 1qfiB-2v9qA:
undetectable		 1qfiB-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkt CTP SYNTHASE 2

(Homo sapiens) 		PF00117
(GATase) 		3 THR A 348
THR A 346
PRO A 351
 None
 0.86A 1qfiB-2vktA:
undetectable		 1qfiB-2vktA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		3 THR A  36
THR A  37
PRO A  35
 None
 0.84A 1qfiB-2z5lA:
undetectable		 1qfiB-2z5lA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.80A 1qfiB-2z5xA:
undetectable		 1qfiB-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		3 THR A 320
THR A 318
PRO A 322
 None
 0.82A 1qfiB-2zm2A:
undetectable		 1qfiB-2zm2A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 THR A 115
THR A 113
PRO A 117
 None
 0.74A 1qfiB-3ai7A:
undetectable		 1qfiB-3ai7A:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		3 THR A 546
THR A 547
PRO A 545
 CYN  A 605 (-3.7A)
None
CYN  A 605 ( 3.6A)
 0.85A 1qfiB-3ayxA:
undetectable		 1qfiB-3ayxA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1e BETAC-S LYASE

(Streptococcus
anginosus) 		PF00155
(Aminotran_1_2) 		3 THR A  25
THR A  23
PRO A  27
 None
 0.85A 1qfiB-3b1eA:
undetectable		 1qfiB-3b1eA:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		3 THR A 238
THR A 236
PRO A 240
 None
 0.67A 1qfiB-3cskA:
undetectable		 1qfiB-3cskA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		3 THR A  94
THR A  96
PRO A  93
 None
 0.86A 1qfiB-3d6jA:
undetectable		 1qfiB-3d6jA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		3 THR A 314
THR A 201
PRO A 203
 None
 0.87A 1qfiB-3g05A:
undetectable		 1qfiB-3g05A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		3 THR A 147
THR A 166
PRO A 165
 None
 0.77A 1qfiB-3h1qA:
undetectable		 1qfiB-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 THR A 636
THR A 638
PRO A 635
 None
 0.79A 1qfiB-3ikmA:
undetectable		 1qfiB-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		3 THR A  22
THR A  20
PRO A  24
 None
 0.80A 1qfiB-3jujA:
undetectable		 1qfiB-3jujA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		3 THR A 127
THR A 129
PRO A 125
 None
 0.74A 1qfiB-3nz4A:
undetectable		 1qfiB-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc9 UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Entamoeba
histolytica) 		PF01704
(UDPGP) 		3 THR A  12
THR A  10
PRO A  14
 None
 0.78A 1qfiB-3oc9A:
undetectable		 1qfiB-3oc9A:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 THR A  69
THR A  70
PRO A 425
 None
 0.84A 1qfiB-3oksA:
undetectable		 1qfiB-3oksA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens) 		PF13927
(Ig_3) 		3 THR A 410
THR A 367
PRO A 366
 None
 0.84A 1qfiB-3p40A:
undetectable		 1qfiB-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		3 THR A 268
THR A 270
PRO A 266
 None
 0.71A 1qfiB-3q1yA:
undetectable		 1qfiB-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 THR A  76
THR A  77
PRO A 426
 None
 0.86A 1qfiB-3q8nA:
undetectable		 1qfiB-3q8nA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT

(Mycobacterium
marinum) 		PF00202
(Aminotran_3) 		3 THR A  68
THR A  69
PRO A 424
 None
 0.84A 1qfiB-3r4tA:
undetectable		 1qfiB-3r4tA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.86A 1qfiB-3rgwL:
undetectable		 1qfiB-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)

(Triticum
aestivum) 		PF00450
(Peptidase_S10) 		3 THR B 344
THR B 346
PRO B 342
 None
 0.68A 1qfiB-3sc2B:
undetectable		 1qfiB-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.84A 1qfiB-3uscL:
undetectable		 1qfiB-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsu TLL2057 PROTEIN

(Thermosynechococcus
elongatus) 		no annotation 3 THR A 103
THR A 105
PRO A 102
 None
 0.82A 1qfiB-3zsuA:
undetectable		 1qfiB-3zsuA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens) 		PF12790
(T6SS-SciN) 		3 THR A 143
THR A 145
PRO A 142
 None
 0.86A 1qfiB-4a1rA:
undetectable		 1qfiB-4a1rA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		3 THR A 421
THR A 423
PRO A 420
 None
 0.82A 1qfiB-4av6A:
undetectable		 1qfiB-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 3 THR A 295
THR A 297
PRO A 299
 None
 0.71A 1qfiB-4btpA:
undetectable		 1qfiB-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		3 THR A 466
THR A 468
PRO A 465
 None
 0.87A 1qfiB-4c02A:
undetectable		 1qfiB-4c02A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdp PUTATIVE
HEME/HEMOGLOBIN
TRANSPORT PROTEIN

(Escherichia
coli) 		PF05171
(HemS) 		3 THR A 190
THR A 293
PRO A 292
 None
HEM  A 402 ( 4.8A)
EDO  A1343 (-3.8A)
 0.86A 1qfiB-4cdpA:
undetectable		 1qfiB-4cdpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 THR A 250
THR A 248
PRO A 252
 None
 0.73A 1qfiB-4dzaA:
undetectable		 1qfiB-4dzaA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		3 THR A 174
THR A 176
PRO A 173
 None
 0.77A 1qfiB-4eogA:
undetectable		 1qfiB-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2

(Danio rerio) 		PF03372
(Exo_endo_phos) 		3 THR A 210
THR A 211
PRO A 209
 None
 0.86A 1qfiB-4f1hA:
undetectable		 1qfiB-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		3 THR A 193
THR A 217
PRO A 192
 None
 0.84A 1qfiB-4fd0A:
undetectable		 1qfiB-4fd0A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		3 THR A  72
THR A  73
PRO A 423
 None
 0.82A 1qfiB-4ffcA:
undetectable		 1qfiB-4ffcA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h16 SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		3 THR A 149
THR A 148
PRO A 145
 None
P6G  A 305 ( 4.5A)
None
 0.83A 1qfiB-4h16A:
undetectable		 1qfiB-4h16A:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjd INTESTINAL-TYPE
ALKALINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00245
(Alk_phosphatase) 		3 THR A  48
THR A  50
PRO A  47
 None
 0.87A 1qfiB-4kjdA:
undetectable		 1qfiB-4kjdA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 310
THR A 308
PRO A 306
 None
 0.72A 1qfiB-4lmpA:
undetectable		 1qfiB-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4r EPHRIN TYPE-A
RECEPTOR 4

(Homo sapiens) 		PF00041
(fn3)
PF01404
(Ephrin_lbd) 		3 THR A 534
THR A 453
PRO A 536
 None
 0.86A 1qfiB-4m4rA:
undetectable		 1qfiB-4m4rA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		3 THR A 200
THR A 202
PRO A 198
 None
 0.80A 1qfiB-4n8gA:
undetectable		 1qfiB-4n8gA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		3 THR A 257
THR A 259
PRO A 255
 None
 0.85A 1qfiB-4ovjA:
undetectable		 1qfiB-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		3 THR A 143
THR A 111
PRO A 113
 None
 0.79A 1qfiB-4pmhA:
undetectable		 1qfiB-4pmhA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 THR A 728
THR A 726
PRO A 730
 None
 0.82A 1qfiB-4r04A:
undetectable		 1qfiB-4r04A:
0.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 THR A 162
THR A 166
PRO A 168
 None
 0.82A 1qfiB-4s3jA:
undetectable		 1qfiB-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Bacillus
subtilis) 		PF11638
(DnaA_N) 		3 THR B  31
THR B  44
PRO B  46
 None
 0.82A 1qfiB-4tpsB:
undetectable		 1qfiB-4tpsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		3 THR A 152
THR A 150
PRO A 154
 None
 0.76A 1qfiB-4uobA:
undetectable		 1qfiB-4uobA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		3 THR A 284
THR A 282
PRO A 287
 None
 0.84A 1qfiB-4uz1A:
undetectable		 1qfiB-4uz1A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)

(Chaetomium) 		PF13472
(Lipase_GDSL_2) 		3 THR A 288
THR A 285
PRO A 287
 None
 0.81A 1qfiB-4xvhA:
undetectable		 1qfiB-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		no annotation 3 THR A 131
THR A 129
PRO A 134
 None
 0.77A 1qfiB-4yk2A:
undetectable		 1qfiB-4yk2A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ac9 VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 THR 1  68
THR 1  70
PRO 1 188
 None
 0.76A 1qfiB-5ac91:
undetectable		 1qfiB-5ac91:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2

(Saccharomyces
cerevisiae) 		PF16843
(Get5_bdg) 		3 THR D  21
THR D  23
PRO D  25
 None
 0.73A 1qfiB-5bw8D:
undetectable		 1qfiB-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqr ELONGATOR COMPLEX
PROTEIN 1

(Homo sapiens) 		PF04762
(IKI3) 		3 THR A 795
THR A 793
PRO A 798
 None
 0.86A 1qfiB-5cqrA:
undetectable		 1qfiB-5cqrA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		3 THR B 388
THR B 282
PRO B 278
 None
 0.85A 1qfiB-5dynB:
undetectable		 1qfiB-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7o DMSO REDUCTASE
FAMILY TYPE II
ENZYME, IRON-SULFUR
SUBUNIT

(Azospira oryzae) 		PF13247
(Fer4_11) 		3 THR B 141
THR B 252
PRO B 143
 None
SF4  B 403 ( 4.9A)
SF4  B 403 ( 4.8A)
 0.84A 1qfiB-5e7oB:
undetectable		 1qfiB-5e7oB:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		3 THR A 393
THR A 390
PRO A 392
 None
 0.83A 1qfiB-5eodA:
undetectable		 1qfiB-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		3 THR A  66
THR A  64
PRO A  62
 None
 0.72A 1qfiB-5hasA:
undetectable		 1qfiB-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB

(Bacillus
subtilis) 		PF01638
(HxlR) 		3 THR A  41
THR A  39
PRO A  43
 None
 0.60A 1qfiB-5hs8A:
undetectable		 1qfiB-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		3 THR A  81
THR A  56
PRO A  83
 None
 0.85A 1qfiB-5ifyA:
undetectable		 1qfiB-5ifyA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		3 THR A 394
THR A 392
PRO A 396
 None
 0.79A 1qfiB-5jwbA:
undetectable		 1qfiB-5jwbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31

(Saccharomyces
cerevisiae) 		PF01125
(G10) 		3 THR L  22
THR L  24
PRO L  21
 None
 0.86A 1qfiB-5lj3L:
undetectable		 1qfiB-5lj3L:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1m MATRIX PROTEIN 1

(Influenza C
virus) 		PF03026
(CM1) 		3 THR A  23
THR A  21
PRO A  19
 None
 0.76A 1qfiB-5m1mA:
undetectable		 1qfiB-5m1mA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 3 THR A 228
THR A 199
PRO A 201
 TAM  A 303 (-3.9A)
None
None
 0.84A 1qfiB-5mqzA:
undetectable		 1qfiB-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4

(Homo sapiens) 		no annotation 3 THR D 386
THR D 388
PRO D 385
 None
 0.85A 1qfiB-5of4D:
undetectable		 1qfiB-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR B 129
THR B 131
PRO B 127
 None
 0.72A 1qfiB-5tteB:
undetectable		 1qfiB-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 THR A 129
THR A 131
PRO A 127
 None
 0.85A 1qfiB-5udhA:
undetectable		 1qfiB-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens) 		PF07686
(V-set) 		3 THR G  10
THR G 104
PRO G   8
 None
 0.80A 1qfiB-5ujzG:
undetectable		 1qfiB-5ujzG:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		3 THR A 505
THR A 502
PRO A 504
 None
 0.82A 1qfiB-5w1uA:
undetectable		 1qfiB-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 THR A 191
THR A 237
PRO A 193
 None
 0.86A 1qfiB-5xdrA:
undetectable		 1qfiB-5xdrA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 3 THR A1074
THR A1076
PRO A1073
 None
 0.81A 1qfiB-6bq1A:
undetectable		 1qfiB-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 THR A1044
THR A1042
PRO A1040
 None
 0.84A 1qfiB-6emkA:
undetectable		 1qfiB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 3 THR A 349
THR A 395
PRO A 351
 None
 0.85A 1qfiB-6fa5A:
undetectable		 1qfiB-6fa5A:
undetectable