SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q97_B_ADNB486_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		4 VAL A 271
ALA A 267
LEU A 382
PHE A 268
 None
 1.26A 1q97B-1bxcA:
0.0		 1q97B-1bxcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 VAL A 282
ALA A 278
LEU A 255
PHE A 279
 None
 1.17A 1q97B-1c3rA:
undetectable		 1q97B-1c3rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 VAL A 667
ALA A 677
LEU A 645
PHE A 681
 None
 1.12A 1q97B-1c4kA:
0.0		 1q97B-1c4kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		4 VAL A 116
ALA A 120
LEU A 133
PHE A  22
 None
 1.25A 1q97B-1cwuA:
undetectable		 1q97B-1cwuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9m MOLYBDENUM-BINDING-P
ROTEIN

(Azotobacter
vinelandii) 		PF03459
(TOBE) 		4 VAL A  59
ALA A  57
LEU A  29
PHE A   9
 None
 1.26A 1q97B-1h9mA:
1.5		 1q97B-1h9mA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9m MOLYBDENUM-BINDING-P
ROTEIN

(Azotobacter
vinelandii) 		PF03459
(TOBE) 		4 VAL A 136
ALA A  57
LEU A  29
PHE A   9
 None
 0.84A 1q97B-1h9mA:
1.5		 1q97B-1h9mA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqo URE2 PROTEIN

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 VAL A 159
ALA A 167
LEU A 144
PHE A 117
 None
 1.07A 1q97B-1hqoA:
undetectable		 1q97B-1hqoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		no annotation 4 VAL B 106
ALA B 108
LEU B  60
PHE B  97
 None
 1.03A 1q97B-1jmzB:
0.2		 1q97B-1jmzB:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od3 PUTATIVE XYLANASE

([Clostridium]
stercorarium) 		PF03422
(CBM_6) 		4 VAL A  77
ALA A  79
LEU A 133
PHE A 144
 None
 1.09A 1q97B-1od3A:
undetectable		 1q97B-1od3A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 VAL A  48
ALA A  33
LEU A  17
PHE A   9
 None
 0.64A 1q97B-1pl0A:
undetectable		 1q97B-1pl0A:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A 172
ALA A 185
LEU A 226
PHE A 246
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.4A)
None
 0.42A 1q97B-1q8yA:
55.8		 1q97B-1q8yA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 VAL A  70
ALA A  66
LEU A  78
PHE A  63
 None
 1.20A 1q97B-1ru4A:
undetectable		 1q97B-1ru4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s40 CELL DIVISION
CONTROL PROTEIN 13

(Saccharomyces
cerevisiae) 		PF02765
(POT1) 		4 VAL A 139
ALA A  82
LEU A  34
PHE A  47
 None
 1.07A 1q97B-1s40A:
undetectable		 1q97B-1s40A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyn ENDO-1,4-BETA-XYLANA
SE I

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		4 VAL A  26
ALA A 172
LEU A  63
PHE A  54
 None
 1.26A 1q97B-1xynA:
undetectable		 1q97B-1xynA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y75 PHOSPHOLIPASE A2
ISOFORM 5

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 VAL A  13
ALA A 102
LEU A  41
PHE A 101
 None
 1.24A 1q97B-1y75A:
undetectable		 1q97B-1y75A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus) 		no annotation 4 VAL A  87
ALA A 144
LEU A 152
PHE A 141
 None
 1.05A 1q97B-1yc6A:
undetectable		 1q97B-1yc6A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z77 TRANSCRIPTIONAL
REGULATOR (TETR
FAMILY)

(Thermotoga
maritima) 		PF00440
(TetR_N) 		4 VAL A 145
ALA A 150
LEU A 194
PHE A 153
 None
 1.20A 1q97B-1z77A:
undetectable		 1q97B-1z77A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		4 VAL C 289
ALA C 313
LEU C 373
PHE C 379
 None
 0.83A 1q97B-1zq1C:
0.5		 1q97B-1zq1C:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  98
ALA A 111
LEU A 143
PHE A 159
 None
 0.36A 1q97B-2ac5A:
20.8		 1q97B-2ac5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 VAL A 373
ALA A 303
LEU A 526
PHE A 328
 None
 0.70A 1q97B-2ahwA:
undetectable		 1q97B-2ahwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		4 VAL A  78
ALA A  59
LEU A 364
PHE A 342
 None
 0.89A 1q97B-2depA:
undetectable		 1q97B-2depA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		4 VAL A  52
ALA A 129
LEU A  85
PHE A 130
 None
 0.95A 1q97B-2hkeA:
undetectable		 1q97B-2hkeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  63
ALA A  76
LEU A 108
PHE A 124
 None
 0.45A 1q97B-2hw6A:
21.4		 1q97B-2hw6A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n5b THIOREDOXIN-1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 VAL A  21
ALA A  14
LEU A  55
PHE A  11
 None
 1.10A 1q97B-2n5bA:
undetectable		 1q97B-2n5bA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPONENT 6

(Homo sapiens) 		PF01138
(RNase_PH) 		4 VAL F  62
ALA F 148
LEU F 126
PHE F 100
 None
 1.02A 1q97B-2nn6F:
undetectable		 1q97B-2nn6F:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 VAL A 449
ALA A 475
LEU A 399
PHE A 419
 None
 0.84A 1q97B-2o1xA:
undetectable		 1q97B-2o1xA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 VAL A 218
ALA A 222
LEU A 226
PHE A 199
 None
 1.19A 1q97B-2o6qA:
undetectable		 1q97B-2o6qA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 295
ALA A 300
LEU A 306
PHE A 301
 None
 1.12A 1q97B-2p6rA:
undetectable		 1q97B-2p6rA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		4 VAL A 318
ALA A 256
LEU A 275
PHE A 267
 None
 0.77A 1q97B-2p82A:
undetectable		 1q97B-2p82A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 319
ALA A 310
LEU A 343
PHE A 311
 None
 0.94A 1q97B-2p88A:
undetectable		 1q97B-2p88A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poa 14 KDA FATTY
ACID-BINDING PROTEIN

(Schistosoma
mansoni) 		PF00061
(Lipocalin) 		4 VAL A 118
ALA A 125
LEU A  10
PHE A  16
 None
 1.23A 1q97B-2poaA:
undetectable		 1q97B-2poaA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qul D-TAGATOSE
3-EPIMERASE

(Pseudomonas
cichorii) 		PF01261
(AP_endonuc_2) 		4 VAL A 128
ALA A 131
LEU A 151
PHE A 110
 None
 1.08A 1q97B-2qulA:
undetectable		 1q97B-2qulA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 VAL A 190
ALA A 195
LEU A 166
PHE A 198
 None
 1.16A 1q97B-2w3pA:
undetectable		 1q97B-2w3pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		4 VAL A 279
ALA A 377
LEU A 414
PHE A 378
 None
 1.18A 1q97B-2w5fA:
undetectable		 1q97B-2w5fA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		4 VAL A 421
ALA A 423
LEU A 373
PHE A 479
 None
 1.08A 1q97B-2x24A:
undetectable		 1q97B-2x24A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF13302
(Acetyltransf_3) 		4 VAL A  74
ALA A  25
LEU A  54
PHE A  26
 None
 1.13A 1q97B-2z11A:
undetectable		 1q97B-2z11A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 VAL A 152
ALA A 283
LEU A 195
PHE A 287
 None
 0.89A 1q97B-3ayxA:
undetectable		 1q97B-3ayxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 VAL A 165
ALA A 147
LEU A 432
PHE A 153
 None
 1.18A 1q97B-3b40A:
undetectable		 1q97B-3b40A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 VAL A 152
ALA A 368
LEU A 353
PHE A 367
 None
 1.20A 1q97B-3cp2A:
undetectable		 1q97B-3cp2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 VAL A 349
ALA A 341
LEU A 311
PHE A 338
 None
 1.22A 1q97B-3d1jA:
0.4		 1q97B-3d1jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		4 VAL A  84
ALA A 161
LEU A 197
PHE A 162
 None
 1.11A 1q97B-3emqA:
undetectable		 1q97B-3emqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 VAL A 152
ALA A 368
LEU A 353
PHE A 367
 None
 1.15A 1q97B-3g05A:
undetectable		 1q97B-3g05A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf2 SHORT CHAIN
OXIDOREDUCTASE
Q9HYA2

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 VAL A  74
ALA A 128
LEU A  91
PHE A 129
 None
 0.98A 1q97B-3lf2A:
undetectable		 1q97B-3lf2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		4 VAL A 158
ALA A 302
LEU A 638
PHE A 614
 None
 1.25A 1q97B-3lvvA:
0.0		 1q97B-3lvvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		4 VAL A  38
ALA A  20
LEU A 313
PHE A 290
 None
 0.94A 1q97B-3msgA:
undetectable		 1q97B-3msgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvf FOMA PROTEIN

(Streptomyces
wedmorensis) 		PF00696
(AA_kinase) 		4 VAL A  29
ALA A  33
LEU A  49
PHE A  36
 None
 1.13A 1q97B-3qvfA:
undetectable		 1q97B-3qvfA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		4 VAL A1387
ALA A1318
LEU A1367
PHE A1321
 None
 1.26A 1q97B-3swhA:
undetectable		 1q97B-3swhA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ury EXOTOXIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 VAL A 215
ALA A 213
LEU A 245
PHE A 233
 None
 1.26A 1q97B-3uryA:
undetectable		 1q97B-3uryA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcs ERYTHROAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		4 VAL A 112
ALA A 110
LEU A  53
PHE A 230
 None
 1.26A 1q97B-3wcsA:
undetectable		 1q97B-3wcsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 VAL A 189
ALA A 193
LEU A 197
PHE A 162
 None
 1.22A 1q97B-3wpeA:
undetectable		 1q97B-3wpeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dh2 DOCKERIN TYPE 1

(Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1) 		4 VAL B  43
ALA B  37
LEU B  23
PHE B  35
 None
 1.21A 1q97B-4dh2B:
undetectable		 1q97B-4dh2B:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 VAL A 374
ALA A 406
LEU A 252
PHE A 407
 None
 0.99A 1q97B-4ehiA:
undetectable		 1q97B-4ehiA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6o METACASPASE-1

(Saccharomyces
cerevisiae) 		PF00656
(Peptidase_C14) 		4 VAL A 388
ALA A 384
LEU A 359
PHE A 385
 None
 1.04A 1q97B-4f6oA:
undetectable		 1q97B-4f6oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ius GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF00583
(Acetyltransf_1) 		4 VAL A  22
ALA A  66
LEU A  74
PHE A  67
 None
 1.21A 1q97B-4iusA:
undetectable		 1q97B-4iusA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A3508
ALA A3556
LEU A3598
PHE A3586
 None
 1.18A 1q97B-4kc5A:
undetectable		 1q97B-4kc5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ku4 RAS-3 FROM
CRYPHONECTRIA
PARASITICA

(Cryphonectria
parasitica) 		PF00071
(Ras) 		4 VAL A 140
ALA A 182
LEU A  31
PHE A 183
 None
 1.26A 1q97B-4ku4A:
undetectable		 1q97B-4ku4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of0 PROTEIN SYG-1,
ISOFORM B

(Caenorhabditis
elegans) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 VAL A 201
ALA A 203
LEU A 244
PHE A 233
 None
 1.21A 1q97B-4of0A:
undetectable		 1q97B-4of0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 VAL B 363
ALA B 250
LEU B 398
PHE B 254
 None
 1.12A 1q97B-4p37B:
undetectable		 1q97B-4p37B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 VAL A 649
ALA A 605
LEU A 670
PHE A 606
 None
MOF  A 801 ( 4.8A)
None
None
 1.19A 1q97B-4p6wA:
undetectable		 1q97B-4p6wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 VAL A 218
ALA A 222
LEU A 226
PHE A 199
 None
 1.22A 1q97B-4p8sA:
undetectable		 1q97B-4p8sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		4 VAL A 151
ALA A 155
LEU A 159
PHE A 132
 None
 1.19A 1q97B-4po4A:
undetectable		 1q97B-4po4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		4 VAL A 214
ALA A 212
LEU A 130
PHE A  92
 None
 1.15A 1q97B-4pxlA:
undetectable		 1q97B-4pxlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1j POLYKETIDE
BIOSYNTHESIS
ENOYL-COA ISOMERASE
PKSI

(Bacillus
subtilis) 		PF00378
(ECH_1) 		4 VAL A   6
ALA A  40
LEU A  89
PHE A  41
 None
 1.18A 1q97B-4q1jA:
undetectable		 1q97B-4q1jA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrl HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16585
(Lipocalin_8) 		4 VAL A  50
ALA A  61
LEU A  88
PHE A  73
 None
 1.06A 1q97B-4qrlA:
undetectable		 1q97B-4qrlA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 VAL A 418
ALA A 408
LEU A 309
PHE A 407
 None
 1.25A 1q97B-4qwwA:
undetectable		 1q97B-4qwwA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis) 		PF00561
(Abhydrolase_1) 		4 VAL A  32
ALA A 107
LEU A 118
PHE A 110
 None
 1.23A 1q97B-4uhhA:
undetectable		 1q97B-4uhhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		4 VAL A 386
ALA A 427
LEU A 443
PHE A 428
 None
 1.17A 1q97B-4wxoA:
undetectable		 1q97B-4wxoA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yb9 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Bos taurus) 		PF00083
(Sugar_tr) 		4 VAL D 414
ALA D 410
LEU D 274
PHE D 403
 None
 1.21A 1q97B-4yb9D:
undetectable		 1q97B-4yb9D:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 VAL A 234
ALA A 131
LEU A 225
PHE A 134
 None
 1.08A 1q97B-4yj1A:
3.0		 1q97B-4yj1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywl CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 VAL A 221
ALA A 215
LEU A 207
PHE A 185
 None
 1.18A 1q97B-4ywlA:
undetectable		 1q97B-4ywlA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD

(Shewanella
oneidensis) 		PF03060
(NMO) 		4 VAL A 220
ALA A 265
LEU A 194
PHE A 233
 None
 1.18A 1q97B-4z9rA:
undetectable		 1q97B-4z9rA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A 205
ALA A 207
LEU A 183
PHE A 227
 None
 0.93A 1q97B-5a05A:
undetectable		 1q97B-5a05A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 VAL A 409
ALA A 414
LEU A 420
PHE A 415
 None
 1.18A 1q97B-5agaA:
undetectable		 1q97B-5agaA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoh CARF

(Serratia sp.
ATCC 39006) 		PF03781
(FGE-sulfatase) 		4 VAL A  90
ALA A  95
LEU A 261
PHE A  98
 None
 1.23A 1q97B-5aohA:
undetectable		 1q97B-5aohA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c04 PUTATIVE
PEROXIREDOXIN MT2298

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 VAL A  35
ALA A  66
LEU A  56
PHE A  88
 None
 1.06A 1q97B-5c04A:
undetectable		 1q97B-5c04A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c04 PUTATIVE
PEROXIREDOXIN MT2298

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 VAL A  35
ALA A  66
LEU A 148
PHE A  59
 None
 1.19A 1q97B-5c04A:
undetectable		 1q97B-5c04A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 105
ALA A 103
LEU A  95
PHE A 112
 None
 1.26A 1q97B-5c5hA:
undetectable		 1q97B-5c5hA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP1

(Enterovirus A) 		PF00073
(Rhv) 		4 VAL A 179
ALA A 188
LEU A 249
PHE A 137
 STE  A 301 (-4.6A)
None
None
None
 1.16A 1q97B-5c8cA:
undetectable		 1q97B-5c8cA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doz JAMJ

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 VAL A 332
ALA A 317
LEU A  19
PHE A 318
 None
 1.07A 1q97B-5dozA:
undetectable		 1q97B-5dozA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dte MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		4 VAL A  79
ALA A 103
LEU A 121
PHE A 104
 None
 0.93A 1q97B-5dteA:
undetectable		 1q97B-5dteA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 VAL A 334
ALA A  22
LEU A 686
PHE A  23
 None
 1.26A 1q97B-5e3cA:
undetectable		 1q97B-5e3cA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		4 VAL A  56
ALA A  59
LEU A  75
PHE A  74
 None
 0.98A 1q97B-5gooA:
undetectable		 1q97B-5gooA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		4 VAL A 122
ALA A 135
LEU A 168
PHE A 161
 None
 1.20A 1q97B-5jp9A:
undetectable		 1q97B-5jp9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1

(Mus musculus) 		PF01825
(GPS) 		4 VAL A 237
ALA A 235
LEU A 179
PHE A 228
 None
 1.15A 1q97B-5kvmA:
undetectable		 1q97B-5kvmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A 457
ALA A 454
LEU A 434
PHE A 461
 None
 1.16A 1q97B-5mdnA:
undetectable		 1q97B-5mdnA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		4 VAL A 563
ALA A 561
LEU A 575
PHE A 533
 None
 1.04A 1q97B-5mqoA:
undetectable		 1q97B-5mqoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 4 VAL A 328
ALA A 388
LEU A 105
PHE A 392
 VAL  A 328 ( 0.6A)
ALA  A 388 ( 0.0A)
LEU  A 105 ( 0.6A)
PHE  A 392 ( 1.3A)
 1.06A 1q97B-5nksA:
undetectable		 1q97B-5nksA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula) 		no annotation 4 VAL A  34
ALA A  26
LEU A  69
PHE A 105
 None
 1.17A 1q97B-5nzbA:
undetectable		 1q97B-5nzbA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 4 VAL A 645
ALA A 601
LEU A 666
PHE A 602
 None
CPS  A 803 ( 3.9A)
None
None
 1.06A 1q97B-5uc1A:
undetectable		 1q97B-5uc1A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wue UNCHARACTERIZED
PROTEIN

(Sulfolobus
acidocaldarius) 		PF03458
(UPF0126) 		4 VAL A 160
ALA A 156
LEU A 201
PHE A 154
 None
SO4  A 301 (-3.0A)
SO4  A 301 ( 4.9A)
None
 1.12A 1q97B-5wueA:
undetectable		 1q97B-5wueA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xao UNCHARACTERIZED
PROTEIN

(Parastagonospora
nodorum) 		PF01266
(DAO) 		4 VAL A 236
ALA A 234
LEU A 422
PHE A 282
 None
 1.10A 1q97B-5xaoA:
undetectable		 1q97B-5xaoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaz GAMMA-BUTYROLACTONE
RECEPTOR PROTEIN

(Streptomyces
fradiae) 		PF00440
(TetR_N) 		4 VAL A  15
ALA A  19
LEU A 105
PHE A  22
 None
 1.08A 1q97B-5xazA:
undetectable		 1q97B-5xazA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 VAL B 104
ALA B 108
LEU B 112
PHE B  85
 None
 1.26A 1q97B-5xwuB:
undetectable		 1q97B-5xwuB:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		4 VAL A 272
ALA A 268
LEU A 383
PHE A 269
 None
 1.13A 1q97B-5y4jA:
undetectable		 1q97B-5y4jA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 4 VAL A  57
ALA A  60
LEU A  76
PHE A  75
 None
 1.00A 1q97B-5z73A:
undetectable		 1q97B-5z73A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 VAL A 315
ALA A 271
LEU A 131
PHE A 272
 None
 1.26A 1q97B-5zbhA:
1.5		 1q97B-5zbhA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bt4 S-LAYER PROTEIN SAP

(Bacillus
anthracis) 		no annotation 4 VAL A 191
ALA A 196
LEU A 138
PHE A 199
 None
None
None
SO4  A 302 (-4.5A)
 0.96A 1q97B-6bt4A:
undetectable		 1q97B-6bt4A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 4 VAL A 701
ALA A 715
LEU A 751
PHE A 767
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-4.5A)
919  A1101 (-3.8A)
 0.34A 1q97B-6cnhA:
31.4		 1q97B-6cnhA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehi NUCLEASE NUCT

(Helicobacter
pylori) 		no annotation 4 VAL A  28
ALA A 104
LEU A  17
PHE A 112
 None
 1.12A 1q97B-6ehiA:
undetectable		 1q97B-6ehiA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 4 VAL A  98
ALA A 186
LEU A 223
PHE A 187
 None
 1.15A 1q97B-6fhfA:
undetectable		 1q97B-6fhfA:
undetectable