SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q6I_A_FK5A301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 13pk | 3-PHOSPHOGLYCERATEKINASE (Trypanosomabrucei) |
PF00162(PGK) | 5 | LEU A 227VAL A 282ILE A 283TYR A 325ILE A 317 | None | 1.43A | 1q6iA-13pkA:undetectable | 1q6iA-13pkA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eom | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F3 (Elizabethkingiameningoseptica) |
PF00704(Glyco_hydro_18) | 5 | ASP A 34VAL A 284ILE A 271TYR A 274ILE A 29 | None | 1.38A | 1q6iA-1eomA:undetectable | 1q6iA-1eomA:20.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fd9 | PROTEIN (MACROPHAGEINFECTIVITYPOTENTIATOR PROTEIN) (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 8 | TYR A 131ASP A 142VAL A 158ILE A 159TRP A 162TYR A 185ILE A 194PHE A 202 | None | 0.55A | 1q6iA-1fd9A:23.5 | 1q6iA-1fd9A:37.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fkk | FK506 BINDINGPROTEIN (Bos taurus) |
PF00254(FKBP_C) | 8 | TYR A 26ASP A 37VAL A 55ILE A 56TRP A 59TYR A 82ILE A 91PHE A 99 | None | 0.54A | 1q6iA-1fkkA:16.3 | 1q6iA-1fkkA:32.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i4s | RIBONUCLEASE III (Aquifexaeolicus) |
PF14622(Ribonucleas_3_3) | 5 | ASP A 138VAL A 47ILE A 51ILE A 143PHE A 79 | None | 1.22A | 1q6iA-1i4sA:undetectable | 1q6iA-1i4sA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ix5 | FKBP (Methanothermococcusthermolithotrophicus) |
PF00254(FKBP_C) | 5 | TYR A 15ASP A 26LEU A 48TYR A 84PHE A 145 | None | 0.83A | 1q6iA-1ix5A:9.0 | 1q6iA-1ix5A:22.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1jvw | MACROPHAGEINFECTIVITYPOTENTIATOR (Trypanosomacruzi) |
PF00254(FKBP_C) | 8 | TYR A 92ASP A 103VAL A 119ILE A 120TRP A 123TYR A 146ILE A 155PHE A 163 | None | 0.63A | 1q6iA-1jvwA:20.6 | 1q6iA-1jvwA:31.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kt1 | FK506-BINDINGPROTEIN FKBP51 (Saimiriboliviensis) |
PF00254(FKBP_C)PF00515(TPR_1)PF13181(TPR_8) | 6 | TYR A 57VAL A 86ILE A 87TRP A 90TYR A 113PHE A 130 | None | 0.87A | 1q6iA-1kt1A:14.6 | 1q6iA-1kt1A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m6u | NDT80 PROTEIN (Saccharomycescerevisiae) |
PF05224(NDT80_PhoG) | 5 | LEU A 313VAL A 150TYR A 241ILE A 246PHE A 130 | None | 1.22A | 1q6iA-1m6uA:undetectable | 1q6iA-1m6uA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n1a | FKBP52 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 57ASP A 68VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | None | 0.65A | 1q6iA-1n1aA:15.9 | 1q6iA-1n1aA:29.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pbk | FKBP25 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 135ASP A 146LEU A 162VAL A 171ILE A 172TRP A 175TYR A 198ILE A 208PHE A 216 | RAP A 225 (-3.9A)RAP A 225 (-3.0A)RAP A 225 (-4.8A)RAP A 225 (-3.5A)RAP A 225 (-3.9A)RAP A 225 (-3.4A)RAP A 225 (-4.6A)RAP A 225 ( 4.9A)None | 0.60A | 1q6iA-1pbkA:15.7 | 1q6iA-1pbkA:25.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q6h | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKPA (Escherichiacoli) |
PF00254(FKBP_C)PF01346(FKBP_N) | 9 | TYR A 146ASP A 157LEU A 166VAL A 173ILE A 174TRP A 177TYR A 200ILE A 208PHE A 216 | None | 0.39A | 1q6iA-1q6hA:27.4 | 1q6iA-1q6hA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdl | PROTEIN(ANTHRANILATESYNTHASE(TRPG-SUBUNIT)) (Sulfolobussolfataricus) |
PF00117(GATase) | 5 | TYR B 123ASP B 150LEU B 122VAL B 83ILE B 159 | None | 1.38A | 1q6iA-1qdlB:undetectable | 1q6iA-1qdlB:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r9h | FK506 BINDINGPROTEIN FAMILY (Caenorhabditiselegans) |
PF00254(FKBP_C) | 8 | TYR A 40ASP A 51VAL A 69ILE A 70TRP A 73TYR A 96ILE A 105PHE A 113 | None | 0.57A | 1q6iA-1r9hA:17.1 | 1q6iA-1r9hA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2z | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Saccharomycescerevisiae) |
PF08123(DOT1) | 5 | TYR A 445LEU A 444ILE A 319TYR A 315ILE A 272 | None | 1.14A | 1q6iA-1u2zA:undetectable | 1q6iA-1u2zA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u79 | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE3 (Arabidopsisthaliana) |
PF00254(FKBP_C) | 8 | TYR A 37ASP A 48LEU A 57VAL A 66ILE A 67TYR A 99ILE A 113PHE A 121 | None | 0.60A | 1q6iA-1u79A:16.9 | 1q6iA-1u79A:29.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u79 | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE3 (Arabidopsisthaliana) |
PF00254(FKBP_C) | 8 | TYR A 37ASP A 48VAL A 66ILE A 67TRP A 70TYR A 99ILE A 113PHE A 121 | None | 0.47A | 1q6iA-1u79A:16.9 | 1q6iA-1u79A:29.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xat | XENOBIOTICACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00132(Hexapep) | 5 | LEU A 47VAL A 58ILE A 59ILE A 119PHE A 40 | None | 1.43A | 1q6iA-1xatA:undetectable | 1q6iA-1xatA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yat | FK506 BINDINGPROTEIN (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 8 | TYR A 26ASP A 37VAL A 55ILE A 56TRP A 59TYR A 82ILE A 91PHE A 99 | FK5 A 108 ( 4.0A)FK5 A 108 ( 3.3A)FK5 A 108 ( 3.4A)FK5 A 108 ( 3.7A)FK5 A 108 ( 3.6A)FK5 A 108 ( 4.7A)NoneNone | 0.41A | 1q6iA-1yatA:18.3 | 1q6iA-1yatA:25.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bs9 | BETA-XYLOSIDASE (Geobacillusstearothermophilus) |
PF01229(Glyco_hydro_39) | 5 | TYR A 145LEU A 90ILE A 98ILE A 63PHE A 141 | None | 1.40A | 1q6iA-2bs9A:undetectable | 1q6iA-2bs9A:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ekd | HYPOTHETICAL PROTEINPH0250 (Pyrococcushorikoshii) |
PF03192(DUF257) | 5 | LEU A 57VAL A 34ILE A 33ILE A 184PHE A 152 | None | 1.05A | 1q6iA-2ekdA:undetectable | 1q6iA-2ekdA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gw1 | MITOCHONDRIALPRECURSOR PROTEINSIMPORT RECEPTOR (Saccharomycescerevisiae) |
PF00515(TPR_1)PF13181(TPR_8)PF13432(TPR_16) | 5 | TYR A 291LEU A 287ILE A 338TYR A 368ILE A 367 | None | 1.43A | 1q6iA-2gw1A:undetectable | 1q6iA-2gw1A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i8l | HYDROGENASE 3MATURATION PROTEASE (Escherichiacoli) |
PF01750(HycI) | 5 | ASP A 3LEU A 139VAL A 61ILE A 60ILE A 105 | None | 1.33A | 1q6iA-2i8lA:undetectable | 1q6iA-2i8lA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ius | DNA TRANSLOCASE FTSK (Escherichiacoli) |
PF01580(FtsK_SpoIIIE) | 5 | TYR A1010LEU A 846ILE A1005TYR A1032ILE A1035 | None | 1.19A | 1q6iA-2iusA:undetectable | 1q6iA-2iusA:20.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2lpv | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Aedes aegypti) |
PF00254(FKBP_C) | 5 | TYR A 27ILE A 57TRP A 60ILE A 92PHE A 100 | None | 1.29A | 1q6iA-2lpvA:13.9 | 1q6iA-2lpvA:32.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2lpv | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Aedes aegypti) |
PF00254(FKBP_C) | 5 | TYR A 27VAL A 56ILE A 57TRP A 60ILE A 92 | None | 1.02A | 1q6iA-2lpvA:13.9 | 1q6iA-2lpvA:32.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2mph | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP3 (Homo sapiens) |
PF00254(FKBP_C) | 5 | LEU A 162VAL A 171ILE A 172TRP A 175PHE A 216 | None | 1.31A | 1q6iA-2mphA:13.7 | 1q6iA-2mphA:35.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2mph | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP3 (Homo sapiens) |
PF00254(FKBP_C) | 5 | TYR A 135LEU A 162VAL A 171ILE A 172TRP A 175 | None | 1.00A | 1q6iA-2mphA:13.7 | 1q6iA-2mphA:35.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pbc | FK506-BINDINGPROTEIN 2 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 56ASP A 67VAL A 85ILE A 86TRP A 89TYR A 112ILE A 121PHE A 129 | PEG A 201 (-4.4A)NonePEG A 201 (-3.6A)PEG A 201 (-3.8A)PEG A 201 (-3.7A)NoneNoneNone | 0.69A | 1q6iA-2pbcA:13.3 | 1q6iA-2pbcA:25.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2vcd | OUTER MEMBRANEPROTEIN MIP (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 5 | ASP A 66VAL A 82ILE A 83TRP A 86PHE A 126 | RAP A 138 (-2.7A)RAP A 138 (-3.2A)RAP A 138 (-3.6A)RAP A 138 (-2.3A)RAP A 138 ( 4.7A) | 0.90A | 1q6iA-2vcdA:19.7 | 1q6iA-2vcdA:37.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2vcd | OUTER MEMBRANEPROTEIN MIP (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 6 | TYR A 55ASP A 66VAL A 82ILE A 83TRP A 86TYR A 109 | RAP A 138 (-2.6A)RAP A 138 (-2.7A)RAP A 138 (-3.2A)RAP A 138 (-3.6A)RAP A 138 (-2.3A)RAP A 138 (-3.8A) | 0.91A | 1q6iA-2vcdA:19.7 | 1q6iA-2vcdA:37.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn1 | 70 KDAPEPTIDYLPROLYLISOMERASE (Plasmodiumfalciparum) |
PF00254(FKBP_C) | 8 | TYR A 44ASP A 56VAL A 74ILE A 75TRP A 78TYR A 101ILE A 110PHE A 118 | FK5 A 501 (-4.1A)FK5 A 501 (-3.4A)FK5 A 501 (-3.5A)FK5 A 501 (-4.3A)FK5 A 501 (-3.3A)FK5 A 501 (-4.7A)NoneFK5 A 501 (-4.8A) | 0.49A | 1q6iA-2vn1A:16.7 | 1q6iA-2vn1A:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w2k | D-MANDELATEDEHYDROGENASE (Rhodotorulagraminis) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ASP B 239LEU B 214VAL B 224ILE B 252PHE B 243 | None | 1.28A | 1q6iA-2w2kB:undetectable | 1q6iA-2w2kB:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y78 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 8 | TYR A 33ASP A 44VAL A 62ILE A 63TRP A 66TYR A 89ILE A 98PHE A 106 | None | 0.61A | 1q6iA-2y78A:18.6 | 1q6iA-2y78A:27.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfn | ALPHA-GALACTOSIDASE-SUCROSE KINASE AGASK ([Ruminococcus]gnavus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 5 | TYR A 36LEU A 183VAL A 295ILE A 296TYR A 311 | None | 1.49A | 1q6iA-2yfnA:undetectable | 1q6iA-2yfnA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7x | FK506-BINDINGPROTEIN 6 (Homo sapiens) |
PF00254(FKBP_C) | 5 | TYR A 61ASP A 73TYR A 118ILE A 127PHE A 135 | None | 0.89A | 1q6iA-3b7xA:15.7 | 1q6iA-3b7xA:25.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bgy | POLYNUCLEOTIDE5'-TRIPHOSPHATASE (Acanthamoebapolyphagamimivirus) |
no annotation | 5 | TYR A 112LEU A 116ILE A 170TYR A 172ILE A 199 | None | 1.30A | 1q6iA-3bgyA:undetectable | 1q6iA-3bgyA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ebv | CHINITASE A (Streptomycescoelicolor) |
PF00704(Glyco_hydro_18) | 5 | TYR A 59LEU A 51VAL A 35ILE A 33TRP A 11 | None | 1.42A | 1q6iA-3ebvA:undetectable | 1q6iA-3ebvA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ilr | HEPARIN LYASE I (Bacteroidesthetaiotaomicron) |
PF14099(Polysacc_lyase) | 5 | LEU A 229VAL A 335ILE A 334ILE A 293PHE A 238 | None | 0.73A | 1q6iA-3ilrA:undetectable | 1q6iA-3ilrA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9d | OUTER CAPSID PROTEINVP2 (Bluetonguevirus) |
PF00898(Orbi_VP2) | 5 | ASP A 679VAL A 712ILE A 701TYR A 745ILE A 674 | None | 1.44A | 1q6iA-3j9dA:undetectable | 1q6iA-3j9dA:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3no6 | TRANSCRIPTIONALACTIVATOR TENA (Staphylococcusepidermidis) |
PF03070(TENA_THI-4) | 5 | TYR A 40ASP A 44LEU A 89ILE A 144PHE A 212 | NoneIMD A 300 (-3.3A)NoneNoneNone | 1.33A | 1q6iA-3no6A:undetectable | 1q6iA-3no6A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyw | PUTATIVEOXIDOREDUCTASE (Bacteroidesthetaiotaomicron) |
PF00106(adh_short) | 5 | TYR A 30LEU A 220VAL A 90ILE A 10ILE A 49 | None | 1.40A | 1q6iA-3nywA:undetectable | 1q6iA-3nywA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o5d | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 57ASP A 68VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | None | 0.82A | 1q6iA-3o5dA:14.5 | 1q6iA-3o5dA:25.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o5e | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 57ASP A 68VAL A 86ILE A 87TRP A 90ILE A 122PHE A 130 | None | 0.90A | 1q6iA-3o5eA:17.0 | 1q6iA-3o5eA:30.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o5e | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 57ASP A 68VAL A 86ILE A 87TYR A 113ILE A 122PHE A 130 | None | 0.73A | 1q6iA-3o5eA:17.0 | 1q6iA-3o5eA:30.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pa7 | 70 KDAPEPTIDYLPROLYLISOMERASE, PUTATIVE (Plasmodiumvivax) |
PF00254(FKBP_C) | 8 | TYR A 43ASP A 55VAL A 73ILE A 74TRP A 77TYR A 100ILE A 109PHE A 117 | None | 0.60A | 1q6iA-3pa7A:16.7 | 1q6iA-3pa7A:26.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhg | PUTATIVEPHOPHOTRIESTERASE (Proteusmirabilis) |
PF02126(PTE) | 5 | TYR A 63LEU A 297ILE A 101TYR A 126ILE A 127 | UNL A 373 ( 3.6A)NoneUNL A 374 ( 3.7A)UNL A 372 (-4.3A)None | 1.37A | 1q6iA-3rhgA:undetectable | 1q6iA-3rhgA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tix | CHROMODOMAIN-CONTAININGPROTEIN 1 (Schizosaccharomycespombe) |
no annotation | 5 | LEU B 941VAL B 813ILE B 845TYR B 892ILE B 897 | None | 1.42A | 1q6iA-3tixB:undetectable | 1q6iA-3tixB:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty7 | PUTATIVE ALDEHYDEDEHYDROGENASESAV2122 (Staphylococcusaureus) |
PF00171(Aldedh) | 5 | ASP A 256LEU A 393VAL A 411ILE A 412ILE A 260 | None | 1.24A | 1q6iA-3ty7A:undetectable | 1q6iA-3ty7A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | TYR A 569VAL A 210ILE A 224TYR A 226ILE A 200 | None | 1.26A | 1q6iA-3um6A:undetectable | 1q6iA-3um6A:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwc | NUCLEOTIDE-SUGARAMINOTRANSFERASE (Coxiellaburnetii) |
PF01041(DegT_DnrJ_EryC1) | 5 | TYR A 285ASP A 259LEU A 287VAL A 361ILE A 358 | None | 1.15A | 1q6iA-3uwcA:undetectable | 1q6iA-3uwcA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uy4 | PANTOTHENATESYNTHETASE (Campylobacterjejuni) |
PF02569(Pantoate_ligase) | 5 | ASP A 274LEU A 181VAL A 267ILE A 236ILE A 241 | None | 1.42A | 1q6iA-3uy4A:undetectable | 1q6iA-3uy4A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wb1 | UNCHARACTERIZEDPROTEIN MJ0488 (Methanocaldococcusjannaschii) |
PF11576(DUF3236) | 5 | ASP A 118LEU A 91VAL A 42ILE A 41ILE A 35 | None | 1.31A | 1q6iA-3wb1A:undetectable | 1q6iA-3wb1A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf8 | FPR4 (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 8 | TYR A 313ASP A 324VAL A 341ILE A 342TRP A 345TYR A 368ILE A 376PHE A 384 | None | 0.76A | 1q6iA-4bf8A:15.5 | 1q6iA-4bf8A:26.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz7 | HISTONE DEACETYLASE8 (Schistosomamansoni) |
PF00850(Hist_deacetyl) | 5 | LEU A 349VAL A 28ILE A 32TRP A 136ILE A 358 | None | 1.46A | 1q6iA-4bz7A:undetectable | 1q6iA-4bz7A:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dip | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP14 (Homo sapiens) |
PF00254(FKBP_C) | 5 | TYR A 52TRP A 88TYR A 111ILE A 119PHE A 127 | None | 0.74A | 1q6iA-4dipA:14.5 | 1q6iA-4dipA:25.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dz3 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 8 | TYR A 33ASP A 44VAL A 62ILE A 63TRP A 66TYR A 89ILE A 98PHE A 106 | FK5 A 201 ( 3.9A)FK5 A 201 (-3.5A)FK5 A 201 ( 3.6A)FK5 A 201 (-3.8A)FK5 A 201 (-3.4A)FK5 A 201 (-4.7A)NoneFK5 A 201 (-4.8A) | 0.37A | 1q6iA-4dz3A:18.5 | 1q6iA-4dz3A:30.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hbk | ALDO-KETO REDUCTASEFAMILY 1, MEMBER B4(ALDOSE REDUCTASE) (Schistosomajaponicum) |
PF00248(Aldo_ket_red) | 5 | LEU A 210VAL A 254ILE A 15TYR A 39ILE A 37 | None | 1.06A | 1q6iA-4hbkA:undetectable | 1q6iA-4hbkA:19.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqc | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1B (Homo sapiens) |
PF00254(FKBP_C) | 6 | TYR A 26ASP A 37ILE A 56TYR A 82ILE A 91PHE A 99 | None | 0.71A | 1q6iA-4iqcA:15.9 | 1q6iA-4iqcA:32.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqc | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1B (Homo sapiens) |
PF00254(FKBP_C) | 6 | TYR A 26VAL A 55ILE A 56TYR A 82ILE A 91PHE A 99 | None | 0.85A | 1q6iA-4iqcA:15.9 | 1q6iA-4iqcA:32.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iyk | UNCHARACTERIZEDPROTEIN (Bacteroidesuniformis) |
PF12866(DUF3823) | 5 | VAL A 111ILE A 30TYR A 76ILE A 53PHE A 103 | None | 1.47A | 1q6iA-4iykA:undetectable | 1q6iA-4iykA:26.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4law | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP4 (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 57ASP A 68VAL A 86ILE A 87TRP A 90ILE A 122PHE A 130 | NoneNoneDMS A 304 (-3.5A)DMS A 304 (-3.8A)DMS A 304 ( 4.0A)NoneDMS A 304 (-4.3A) | 0.70A | 1q6iA-4lawA:16.7 | 1q6iA-4lawA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4law | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP4 (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 57VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | NoneDMS A 304 (-3.5A)DMS A 304 (-3.8A)DMS A 304 ( 4.0A)NoneNoneDMS A 304 (-4.3A) | 0.63A | 1q6iA-4lawA:16.7 | 1q6iA-4lawA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxf | TREHALOSE SYNTHASE (Mycobacteriumtuberculosis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | TYR A 211LEU A 209VAL A 223ILE A 224PHE A 260 | None | 1.39A | 1q6iA-4lxfA:undetectable | 1q6iA-4lxfA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4msp | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP14 (Homo sapiens) |
PF00254(FKBP_C)PF13499(EF-hand_7) | 5 | TYR A 33TRP A 69TYR A 92ILE A 100PHE A 108 | None | 0.63A | 1q6iA-4mspA:15.3 | 1q6iA-4mspA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ni2 | GUANYLATE CYCLASESOLUBLE SUBUNITALPHA-3 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | TYR A 510LEU A 506VAL A 563ILE A 575PHE A 513 | NoneEDO A 702 ( 4.8A)NoneNoneNone | 1.21A | 1q6iA-4ni2A:undetectable | 1q6iA-4ni2A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ni2 | GUANYLATE CYCLASESOLUBLE SUBUNITBETA-1 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | TYR B 454LEU B 450VAL B 510ILE B 521PHE B 457 | None | 1.25A | 1q6iA-4ni2B:undetectable | 1q6iA-4ni2B:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ni2 | GUANYLATE CYCLASESOLUBLE SUBUNITBETA-1 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | TYR B 454LEU B 450VAL B 517ILE B 521PHE B 457 | NoneNoneEDO B 704 ( 3.6A)NoneNone | 0.96A | 1q6iA-4ni2B:undetectable | 1q6iA-4ni2B:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnr | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP2 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 56ASP A 67VAL A 85ILE A 86TRP A 89TYR A 112ILE A 121PHE A 129 | FK5 A 201 (-4.1A)FK5 A 201 (-3.4A)FK5 A 201 (-3.4A)FK5 A 201 (-3.8A)FK5 A 201 (-3.5A)FK5 A 201 (-4.5A)NoneFK5 A 201 (-4.9A) | 0.37A | 1q6iA-4nnrA:13.5 | 1q6iA-4nnrA:27.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4odm | PEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD (Thermusthermophilus) |
PF00254(FKBP_C) | 5 | TYR A 13ASP A 23ILE A 37TYR A 63PHE A 128 | None | 0.66A | 1q6iA-4odmA:9.9 | 1q6iA-4odmA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4odr | PEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD,PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A CHIMERA (Homo sapiens;Thermusthermophilus) |
PF00254(FKBP_C) | 7 | TYR A 13ASP A 23LEU A 27ILE A 37TYR A 63ILE A 72PHE A 80 | FK5 A 201 ( 3.6A)FK5 A 201 (-3.6A)FK5 A 201 (-4.1A)FK5 A 201 (-3.9A)FK5 A 201 (-4.4A)NoneFK5 A 201 ( 4.8A) | 0.85A | 1q6iA-4odrA:11.2 | 1q6iA-4odrA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oko | RAPID ENCYSTMENTPHENOTYPE PROTEIN 34KDA (Francisellatularensis) |
PF00246(Peptidase_M14) | 5 | TYR A 156ASP A 50LEU A 160ILE A 115ILE A 40 | None | 1.39A | 1q6iA-4okoA:undetectable | 1q6iA-4okoA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0x | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 57ASP A 68VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | None | 0.85A | 1q6iA-4r0xA:17.0 | 1q6iA-4r0xA:27.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txw | HYALURONOGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C) | 5 | TYR A 7VAL A 145ILE A 146TYR A 52ILE A 67 | None | 1.43A | 1q6iA-4txwA:undetectable | 1q6iA-4txwA:24.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydh | FORMIN-LIKE PROTEIN1 (Homo sapiens) |
PF06367(Drf_FH3)PF06371(Drf_GBD) | 5 | TYR A 153ASP A 226LEU A 87ILE A 220PHE A 156 | None | 1.47A | 1q6iA-4ydhA:undetectable | 1q6iA-4ydhA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zv3 | CYTOSOLIC ACYLCOENZYME A THIOESTERHYDROLASE (Mus musculus) |
PF03061(4HBT) | 5 | LEU A 234VAL A 312ILE A 310TYR A 336ILE A 274 | None | 1.10A | 1q6iA-4zv3A:undetectable | 1q6iA-4zv3A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0z | CHOLINETRIMETHYLAMINE LYASE (Klebsiellapneumoniae) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | TYR A 351LEU A 352VAL A 707ILE A 653ILE A 678 | None | 1.18A | 1q6iA-5a0zA:undetectable | 1q6iA-5a0zA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa5 | NIFE-HYDROGENASESMALL SUBUNIT, HOFK (Cupriavidusnecator) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | TYR A 167ASP A 130LEU A 168ILE A 26ILE A 123 | None | 1.39A | 1q6iA-5aa5A:undetectable | 1q6iA-5aa5A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b8i | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Coccidioidesimmitis) |
PF00254(FKBP_C) | 8 | TYR C 36ASP C 56VAL C 73ILE C 74TRP C 77TYR C 100ILE C 109PHE C 117 | FK5 C 201 (-4.1A)FK5 C 201 ( 3.8A)FK5 C 201 (-3.5A)FK5 C 201 (-3.8A)FK5 C 201 (-3.4A)FK5 C 201 (-4.5A)NoneFK5 C 201 (-4.7A) | 0.39A | 1q6iA-5b8iC:15.5 | 1q6iA-5b8iC:24.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c54 | DIHYDRODIPICOLINATESYNTHASE/N-ACETYLNEURAMINATE LYASE (Corynebacteriumglutamicum) |
PF00701(DHDPS) | 5 | LEU A 135VAL A 81ILE A 82ILE A 140PHE A 44 | None | 1.29A | 1q6iA-5c54A:undetectable | 1q6iA-5c54A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h78 | CAMP-DEPENDENTPROTEIN KINASE TYPEII-ALPHA REGULATORYSUBUNIT,DHR14 (Homo sapiens;syntheticconstruct) |
PF02197(RIIa) | 5 | ASP A 140LEU A 183VAL A 148ILE A 147ILE A 105 | None | 1.40A | 1q6iA-5h78A:undetectable | 1q6iA-5h78A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i7p | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A,FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD,PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A (Escherichiacoli;Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 26ASP A 37VAL A 55ILE A 56TRP A 59TYR A 82PHE A 146 | None | 0.58A | 1q6iA-5i7pA:15.0 | 1q6iA-5i7pA:24.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i7q | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A,FKBP-TYPE 16KDA PEPTIDYL-PROLYLCIS-TRANSISOMERASE,PEPTIDYL-PROLYL CIS-TRANSISOMERASE FKBP1A (Escherichiacoli;Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 26ASP A 37VAL A 55ILE A 56TRP A 59TYR A 82PHE A 147 | None | 0.54A | 1q6iA-5i7qA:15.1 | 1q6iA-5i7qA:25.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i98 | FK506-BINDINGPROTEIN 1 (Candidaalbicans) |
PF00254(FKBP_C) | 7 | TYR A 30ASP A 41VAL A 59ILE A 60TRP A 63TYR A 97ILE A 102 | None | 1.45A | 1q6iA-5i98A:16.4 | 1q6iA-5i98A:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i98 | FK506-BINDINGPROTEIN 1 (Candidaalbicans) |
PF00254(FKBP_C) | 8 | TYR A 30ASP A 41VAL A 59ILE A 60TRP A 63TYR A 97ILE A 106PHE A 114 | None | 0.50A | 1q6iA-5i98A:16.4 | 1q6iA-5i98A:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6e | FK506-BINDINGPROTEIN 1A (Aspergillusfumigatus) |
PF00254(FKBP_C) | 8 | TYR A 27ASP A 38VAL A 56ILE A 57TRP A 60TYR A 83ILE A 92PHE A 100 | None | 0.60A | 1q6iA-5j6eA:16.6 | 1q6iA-5j6eA:27.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jcv | LMO2181 PROTEIN (Listeriamonocytogenes) |
PF04203(Sortase) | 5 | ASP A 125VAL A 75ILE A 89TYR A 161ILE A 221 | None | 1.01A | 1q6iA-5jcvA:undetectable | 1q6iA-5jcvA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jnf | LINEAR GRAMICIDINSYNTHASE SUBUNIT A (Brevibacillusparabrevis) |
no annotation | 5 | TYR C 20LEU C 24VAL C 149ILE C 148PHE C 141 | None | 1.48A | 1q6iA-5jnfC:undetectable | 1q6iA-5jnfC:17.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ktk | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF08659(KR) | 5 | TYR A 144ASP A 86LEU A 143VAL A 108ILE A 64 | None | 1.39A | 1q6iA-5ktkA:undetectable | 1q6iA-5ktkA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msz | THERMOBIA DOMESTICADOMESTICA AA15 (Thermobiadomestica) |
no annotation | 5 | ASP A 84VAL A 72ILE A 190TYR A 75ILE A 81 | None | 1.29A | 1q6iA-5mszA:undetectable | 1q6iA-5mszA:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5thw | DEACYLASE (Burkholderiamultivorans) |
PF01546(Peptidase_M20) | 5 | TYR A 229ASP A 312LEU A 332VAL A 258PHE A 300 | None | 1.22A | 1q6iA-5thwA:undetectable | 1q6iA-5thwA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8t | UBIQUITIN-LIKEPROTEINSMT3,PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei;Saccharomycescerevisiae) |
no annotation | 8 | TYR A 33ASP A 44VAL A 62ILE A 63TRP A 66TYR A 89ILE A 98PHE A 106 | 8ZV A 201 (-3.8A)8ZV A 201 (-3.9A)8ZV A 201 (-3.6A)8ZV A 201 (-4.0A)8ZV A 201 (-3.3A)8ZV A 201 (-4.6A)8ZV A 201 ( 4.8A)8ZV A 201 (-4.6A) | 0.40A | 1q6iA-5v8tA:18.7 | 1q6iA-5v8tA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf3 | MAJOR CAPSID PROTEIN (Escherichiavirus T4) |
PF07068(Gp23) | 5 | TYR A 424ASP A 110VAL A 307ILE A 310PHE A 375 | None | 1.42A | 1q6iA-5vf3A:undetectable | 1q6iA-5vf3A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wiv | D(4) DOPAMINERECEPTOR, SOLUBLECYTOCHROME B562CHIMERA (Escherichiacoli;Homo sapiens) |
no annotation | 5 | LEU A 81VAL A 74ILE A 73TYR A 448ILE A 447 | NoneOLA A1207 ( 4.5A)NoneNoneNone | 1.28A | 1q6iA-5wivA:undetectable | 1q6iA-5wivA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb0 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF00254(FKBP_C) | 8 | TYR A 147ASP A 158VAL A 171ILE A 172TRP A 175TYR A 198ILE A 207PHE A 215 | TLA A 301 ( 4.4A)TLA A 301 (-3.7A)TLA A 301 (-3.4A)TLA A 301 (-3.4A)TLA A 301 (-3.4A)NoneNoneNone | 0.67A | 1q6iA-5xb0A:20.7 | 1q6iA-5xb0A:28.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xhw | PUTATIVE6-DEOXY-D-MANNOHEPTOSE PATHWAY PROTEIN (Yersiniapseudotuberculosis) |
no annotation | 5 | TYR A 207VAL A 132ILE A 165TYR A 140ILE A 213 | None | 1.43A | 1q6iA-5xhwA:undetectable | 1q6iA-5xhwA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0y | SERINEHYDROXYMETHYLTRANSFERASE (Komagataellaphaffii) |
no annotation | 5 | TYR A 339ASP A 418VAL A 393ILE A 395PHE A 334 | None | 1.33A | 1q6iA-5z0yA:undetectable | 1q6iA-5z0yA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4p | PEPTIDYLPROLYLISOMERASE (Naegleriafowleri) |
no annotation | 8 | TYR A 38ASP A 49VAL A 67ILE A 68TRP A 71TYR A 94ILE A 103PHE A 111 | None | 0.68A | 1q6iA-6b4pA:16.8 | 1q6iA-6b4pA:27.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ez4 | RNA POLYMERASEII-ASSOCIATEDPROTEIN 3 (Homo sapiens) |
no annotation | 5 | VAL A 595ILE A 594TYR A 578ILE A 573PHE A 556 | None | 1.46A | 1q6iA-6ez4A:undetectable | 1q6iA-6ez4A:12.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f0k | ACTHQUINOL:CYTOCHROME COXIDOREDUCTASEMONOHEME CYTOCHROMESUBUNIT (Rhodothermusmarinus) |
no annotation | 5 | TYR H 159LEU E 102ILE E 172TYR E 113ILE E 112 | NoneNoneNoneHEC E 400 ( 4.6A)None | 1.37A | 1q6iA-6f0kH:undetectable | 1q6iA-6f0kH:15.91 |