SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_L_FUAL710_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0b HEMOGLOBIN

(Phacoides
pectinatus) 		PF00042
(Globin) 		5 PHE A  92
PHE A  29
LEU A  32
VAL A 112
VAL A  39
 HEM  A 144 (-4.4A)
CYN  A 145 (-4.4A)
None
None
HEM  A 144 ( 3.6A)
 1.20A 1q23L-1b0bA:
undetectable		 1q23L-1b0bA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 THR A 335
PHE A 332
LEU A 438
VAL A 355
PHE A 620
 None
 1.37A 1q23L-1br2A:
0.0		 1q23L-1br2A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		5 THR A  11
TYR A 309
LEU A 240
VAL A 231
PHE A 227
 None
 1.37A 1q23L-1bxcA:
0.0		 1q23L-1bxcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 SER A 388
PHE A 392
LEU A 284
VAL A 286
VAL A 210
 None
 1.29A 1q23L-1c4kA:
3.3		 1q23L-1c4kA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		5 PHE A 173
LEU A 124
VAL A 187
PHE A 107
VAL A 119
 None
 1.38A 1q23L-1ci9A:
0.1		 1q23L-1ci9A:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		6 THR A  94
PHE A 103
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.56A 1q23L-1ciaA:
32.1		 1q23L-1ciaA:
44.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		5 THR A  56
LEU A  17
VAL A  47
PHE A  37
VAL A  30
 None
 1.40A 1q23L-1hdfA:
undetectable		 1q23L-1hdfA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		5 PHE A 133
LEU A 127
VAL A 180
PHE A 111
VAL A  83
 None
 1.37A 1q23L-1jneA:
0.0		 1q23L-1jneA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr1 HEVAMINE A

(Hevea
brasiliensis) 		PF00704
(Glyco_hydro_18) 		5 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.24A 1q23L-1kr1A:
0.0		 1q23L-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8j ENDOTHELIAL PROTEIN
C RECEPTOR

(Homo sapiens) 		PF16497
(MHC_I_3) 		5 PHE A  19
SER A  17
TYR A  27
PHE A 114
VAL A 116
 None
None
None
PTY  A 200 ( 4.8A)
None
 1.33A 1q23L-1l8jA:
0.0		 1q23L-1l8jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A 172
PHE A  62
LEU A 300
VAL A  22
VAL A   8
 None
 1.22A 1q23L-1ml4A:
undetectable		 1q23L-1ml4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nq6 XYS1

(Streptomyces
halstedii) 		PF00331
(Glyco_hydro_10) 		5 PHE A 217
LEU A 284
VAL A 298
PHE A  15
VAL A 267
 None
 1.32A 1q23L-1nq6A:
undetectable		 1q23L-1nq6A:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		11 THR A  93
PHE A 102
SER A 104
TYR A 133
PHE A 134
SER A 146
PHE A 156
LEU A 158
VAL A 160
PHE A 166
VAL A 170
 None
 0.51A 1q23L-1pd5A:
35.3		 1q23L-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		5 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.08A 1q23L-1pk6A:
undetectable		 1q23L-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.41A 1q23L-1ptjA:
undetectable		 1q23L-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxl SEX-LETHAL PROTEIN
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		5 SER A  84
LEU A  87
VAL A  60
PHE A  34
VAL A  78
 None
 1.36A 1q23L-1sxlA:
undetectable		 1q23L-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		5 PHE A  28
SER A  30
PHE A1143
LEU A1139
VAL A1159
 None
 1.36A 1q23L-1w1wA:
undetectable		 1q23L-1w1wA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y25 PROBABLE THIOL
PEROXIDASE

(Mycobacterium
tuberculosis) 		PF08534
(Redoxin) 		5 THR A  30
SER A 105
LEU A 128
VAL A 117
VAL A  81
 None
 1.18A 1q23L-1y25A:
undetectable		 1q23L-1y25A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.33A 1q23L-2ag8A:
undetectable		 1q23L-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byk CHRAC-14
CHRAC-16

(Drosophila
melanogaster) 		PF00808
(CBFD_NFYB_HMF) 		5 PHE B  81
SER B  80
PHE A  91
LEU A  89
VAL A  82
 None
 1.14A 1q23L-2bykB:
undetectable		 1q23L-2bykB:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		5 SER A 470
TYR A 469
PHE A   5
PHE A  21
VAL A  28
 None
 1.30A 1q23L-2f6dA:
undetectable		 1q23L-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 5 THR A  74
PHE A  85
LEU A  90
VAL A  35
PHE A  63
 None
 1.22A 1q23L-2f9rA:
undetectable		 1q23L-2f9rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		5 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.42A 1q23L-2fg5A:
undetectable		 1q23L-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		5 PHE A  62
PHE A   2
SER A  91
PHE A  96
LEU A 111
 None
None
None
OLA  A 130 ( 4.2A)
None
 1.29A 1q23L-2ftbA:
undetectable		 1q23L-2ftbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs5 CONSERVED
HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF02622
(DUF179) 		5 THR A  94
LEU A  38
VAL A  50
PHE A 135
VAL A 165
 None
 1.15A 1q23L-2gs5A:
undetectable		 1q23L-2gs5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 407
PHE A 374
SER A 409
VAL A 360
VAL A 290
 None
 1.43A 1q23L-2htvA:
undetectable		 1q23L-2htvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 PHE A 233
TYR A 219
PHE A 112
VAL A 161
PHE A 170
 None
 1.41A 1q23L-2nq5A:
undetectable		 1q23L-2nq5A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 PHE A 293
SER A 234
PHE A 423
LEU A 427
VAL A 431
 None
 1.08A 1q23L-2nztA:
undetectable		 1q23L-2nztA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA

(Legionella
pneumophila) 		PF04378
(RsmJ) 		5 PHE A 104
LEU A 259
VAL A 255
PHE A  79
VAL A  68
 None
 1.30A 1q23L-2oo3A:
undetectable		 1q23L-2oo3A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwj MITOCHONDRIAL
PEROXIREDOXIN

(Pisum sativum) 		PF08534
(Redoxin) 		5 PHE A 116
SER A 119
SER A  17
LEU A 150
VAL A 152
 None
 1.43A 1q23L-2pwjA:
undetectable		 1q23L-2pwjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		5 THR A  39
PHE A  38
PHE A  58
VAL A 180
PHE A 152
 None
 1.41A 1q23L-2qagA:
undetectable		 1q23L-2qagA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsi PUTATIVE HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HUPG

(Rhodopseudomonas
palustris) 		PF07449
(HyaE) 		5 PHE A  38
LEU A  36
VAL A  34
PHE A  26
VAL A  18
 None
 1.37A 1q23L-2qsiA:
undetectable		 1q23L-2qsiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		5 SER A   6
LEU A  84
VAL A  39
PHE A  53
VAL A  27
 None
 1.32A 1q23L-2qsvA:
undetectable		 1q23L-2qsvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A 331
PHE A 334
SER A 333
PHE A 358
VAL A 377
 None
 1.26A 1q23L-2rjtA:
undetectable		 1q23L-2rjtA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd7 CORE HISTONE
MACRO-H2A.2

(Homo sapiens) 		PF01661
(Macro) 		5 PHE A 183
SER A 202
PHE A 354
LEU A 268
VAL A 273
 None
 1.33A 1q23L-2xd7A:
undetectable		 1q23L-2xd7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.35A 1q23L-2yevB:
undetectable		 1q23L-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 SER A 218
LEU A 225
VAL A 228
PHE A 112
VAL A 165
 None
 1.39A 1q23L-3a2qA:
undetectable		 1q23L-3a2qA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		5 SER A  48
PHE A   2
VAL A  36
PHE A  28
VAL A  44
 DLZ  A 191 (-3.5A)
None
None
None
None
 1.43A 1q23L-3a3gA:
undetectable		 1q23L-3a3gA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 THR A3042
SER A3041
SER A3044
LEU A3277
VAL A3323
 None
 1.43A 1q23L-3cmvA:
undetectable		 1q23L-3cmvA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5o SERUM AMYLOID
P-COMPONENT

(Homo sapiens) 		PF00354
(Pentaxin) 		5 THR A  81
SER A  82
SER A  72
PHE A  37
VAL A  63
 None
 1.41A 1q23L-3d5oA:
undetectable		 1q23L-3d5oA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.17A 1q23L-3e77A:
undetectable		 1q23L-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0o 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 SER A  56
PHE A  60
LEU A  67
VAL A  97
VAL A  87
 None
 1.43A 1q23L-3g0oA:
undetectable		 1q23L-3g0oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hib PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF02889
(Sec63) 		5 PHE A1934
LEU A1930
VAL A1926
PHE A1889
VAL A1954
 None
 1.27A 1q23L-3hibA:
undetectable		 1q23L-3hibA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M) 		5 PHE B 717
PHE B 792
LEU B 814
VAL B 858
PHE B 860
 None
 1.33A 1q23L-3hs0B:
undetectable		 1q23L-3hs0B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.34A 1q23L-3i6sA:
undetectable		 1q23L-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 0.98A 1q23L-3mc2A:
undetectable		 1q23L-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		5 PHE A 276
PHE A  66
LEU A  28
VAL A  35
VAL A  24
 None
 1.21A 1q23L-3n0vA:
undetectable		 1q23L-3n0vA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 PHE A 272
LEU A 310
VAL A 312
PHE A 317
VAL A 325
 None
 1.25A 1q23L-3o82A:
undetectable		 1q23L-3o82A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
 ATP  A 763 (-4.5A)
None
None
None
None
 1.13A 1q23L-3o8lA:
undetectable		 1q23L-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		5 PHE A  56
PHE A 267
LEU A 263
VAL A 259
PHE A 253
 None
 1.41A 1q23L-3p9uA:
undetectable		 1q23L-3p9uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		5 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.41A 1q23L-3pl5A:
undetectable		 1q23L-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 THR A 229
PHE A 224
SER A 231
LEU A  68
VAL A  71
 None
 1.44A 1q23L-3qghA:
2.2		 1q23L-3qghA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN

(Leishmania
infantum) 		PF00857
(Isochorismatase) 		5 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.24A 1q23L-3r2jA:
undetectable		 1q23L-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 SER A 228
TYR A 247
LEU A 178
VAL A 179
PHE A  83
 None
 1.22A 1q23L-3r4vA:
undetectable		 1q23L-3r4vA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd6 MLL3558 PROTEIN

(Mesorhizobium
loti) 		PF08327
(AHSA1) 		5 THR A  11
LEU A 107
VAL A  23
PHE A  27
VAL A 105
 None
 1.36A 1q23L-3rd6A:
3.0		 1q23L-3rd6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		5 THR A 491
SER A 489
TYR A 502
PHE A 487
VAL A 385
 None
 1.35A 1q23L-3vsmA:
undetectable		 1q23L-3vsmA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zph CHALCONE ISOMERASE

(Eubacterium
ramulus) 		no annotation 5 PHE A 221
PHE A 183
LEU A 182
PHE A 249
VAL A 186
 None
 1.18A 1q23L-3zphA:
undetectable		 1q23L-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.36A 1q23L-4cczA:
undetectable		 1q23L-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		5 THR A 574
PHE A 393
LEU A 392
VAL A 314
VAL A 284
 None
 1.37A 1q23L-4fo0A:
undetectable		 1q23L-4fo0A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9s INHIBITOR OF G-TYPE
LYSOZYME

(Escherichia
coli) 		PF04151
(PPC) 		5 SER B  90
PHE B  54
LEU B 109
VAL B 111
VAL B  64
 None
 1.32A 1q23L-4g9sB:
undetectable		 1q23L-4g9sB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 TYR A   6
PHE A  11
PHE A 109
LEU A  71
VAL A 191
 None
 1.40A 1q23L-4go4A:
undetectable		 1q23L-4go4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		5 SER A 282
LEU A 174
VAL A 173
PHE A 265
VAL A 269
 None
 1.37A 1q23L-4hwgA:
undetectable		 1q23L-4hwgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		5 PHE B 379
LEU B 324
VAL B 319
PHE B 315
VAL B 327
 None
 1.41A 1q23L-4i6jB:
undetectable		 1q23L-4i6jB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.37A 1q23L-4itxA:
2.5		 1q23L-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jm0 PROTEIN UL141

(Human
betaherpesvirus
5) 		PF16758
(UL141) 		5 THR A  50
PHE A 157
LEU A 145
VAL A  77
VAL A  69
 None
 1.38A 1q23L-4jm0A:
undetectable		 1q23L-4jm0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 PHE A  43
LEU A  23
VAL A  25
PHE A 586
VAL A 502
 None
 1.14A 1q23L-4lnvA:
undetectable		 1q23L-4lnvA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		5 PHE A 818
PHE A 868
LEU A 710
VAL A 736
VAL A 872
 None
 1.33A 1q23L-4n9nA:
undetectable		 1q23L-4n9nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6

(Trypanosoma
brucei) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.18A 1q23L-4nlbA:
undetectable		 1q23L-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 SER A 127
LEU A  81
VAL A 116
PHE A 111
VAL A  77
 None
 1.31A 1q23L-4od7A:
undetectable		 1q23L-4od7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		5 THR A 253
PHE A 316
LEU A 318
VAL A 320
PHE A 348
 None
 1.20A 1q23L-4q8kA:
undetectable		 1q23L-4q8kA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		5 THR A  86
PHE A 149
LEU A 151
VAL A 153
PHE A 181
 None
 1.22A 1q23L-4q8lA:
undetectable		 1q23L-4q8lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhs FLAGELLAR REGULATORY
PROTEIN C

(Vibrio cholerae) 		PF00158
(Sigma54_activat) 		5 PHE A 284
LEU A 247
VAL A 246
PHE A 219
VAL A 267
 None
 1.13A 1q23L-4qhsA:
undetectable		 1q23L-4qhsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3d ENDOTHELIAL PROTEIN
C RECEPTOR

(Homo sapiens) 		PF16497
(MHC_I_3) 		5 PHE B  19
SER B  17
TYR B  27
PHE B 114
VAL B 116
 None
None
None
PTY  B 200 ( 4.9A)
PTY  B 200 (-4.9A)
 1.29A 1q23L-4v3dB:
undetectable		 1q23L-4v3dB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 SER A 214
LEU A 158
VAL A 237
PHE A 240
VAL A 153
 None
 1.44A 1q23L-4wb7A:
undetectable		 1q23L-4wb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		5 THR A 265
SER A 268
LEU A  33
VAL A 250
VAL A 272
 None
 1.43A 1q23L-4wcjA:
undetectable		 1q23L-4wcjA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 SER A 194
PHE A  56
LEU A  52
VAL A  16
VAL A  50
 PO4  A 303 ( 4.2A)
None
None
None
PO4  A 303 (-4.7A)
 1.41A 1q23L-4x2rA:
undetectable		 1q23L-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		5 PHE A 276
SER A 274
LEU A 338
VAL A 331
VAL A 319
 None
ACT  A 409 ( 4.5A)
None
None
None
 1.25A 1q23L-4xdtA:
undetectable		 1q23L-4xdtA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwj PHOSPHOCARRIER
PROTEIN HPR

(Escherichia
coli) 		PF00381
(PTS-HPr) 		5 THR B  59
SER B  37
LEU B  50
VAL B  23
VAL B  35
 None
 1.41A 1q23L-4xwjB:
undetectable		 1q23L-4xwjB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 SER A   5
PHE A 165
VAL A  20
PHE A  38
VAL A  29
 None
 1.35A 1q23L-4y9wA:
undetectable		 1q23L-4y9wA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Corynebacterium
glutamicum) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 PHE A 107
LEU A  64
VAL A  89
PHE A  81
VAL A  60
 None
 1.30A 1q23L-5eesA:
undetectable		 1q23L-5eesA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eur UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		no annotation 5 THR A  43
SER A  42
LEU A   8
VAL A  21
PHE A  31
 None
 1.09A 1q23L-5eurA:
undetectable		 1q23L-5eurA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2

(Aedes aegypti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 PHE A 108
PHE A 120
LEU A  36
VAL A  34
PHE A  46
 GSH  A1221 (-3.8A)
None
GSH  A1221 (-3.7A)
None
None
 1.16A 1q23L-5ft3A:
undetectable		 1q23L-5ft3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 PHE A 169
SER A 191
LEU A 156
VAL A 119
VAL A 186
 None
 1.39A 1q23L-5gt5A:
undetectable		 1q23L-5gt5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 PHE A 193
SER A 191
LEU A 156
VAL A 119
VAL A 186
 None
 1.30A 1q23L-5gt5A:
undetectable		 1q23L-5gt5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.26A 1q23L-5hdiA:
undetectable		 1q23L-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 SER A  58
LEU A  64
VAL A 108
PHE A  24
VAL A  56
 None
 1.10A 1q23L-5hkjA:
undetectable		 1q23L-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 THR A 366
SER A 229
VAL A  97
PHE A 265
VAL A 194
 None
 1.28A 1q23L-5hkjA:
undetectable		 1q23L-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 5 THR A 286
PHE A 211
LEU A 244
VAL A 276
PHE A  88
 None
 1.41A 1q23L-5o9wA:
undetectable		 1q23L-5o9wA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.17A 1q23L-5oltA:
undetectable		 1q23L-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 THR A1167
TYR A1101
PHE A1233
LEU A1202
VAL A1161
 None
 1.22A 1q23L-5t8vA:
undetectable		 1q23L-5t8vA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbf TRANSLATION
ELONGATION FACTOR

(Vibrio cholerae) 		PF11826
(DUF3346) 		5 PHE A 233
PHE A 366
PHE A 293
LEU A 189
VAL A 223
 None
 1.30A 1q23L-5tbfA:
undetectable		 1q23L-5tbfA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 SER A  79
LEU A 104
VAL A  51
PHE A  36
VAL A 100
 None
 1.12A 1q23L-5ti1A:
undetectable		 1q23L-5ti1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Mycobacterium
tuberculosis) 		no annotation 5 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.30A 1q23L-5tjzA:
undetectable		 1q23L-5tjzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 5 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.29A 1q23L-5z5kA:
undetectable		 1q23L-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdh TYPE II SECRETION
SYSTEM LIPOPROTEIN

(Escherichia
coli) 		no annotation 5 THR P  88
TYR P  65
PHE P  61
LEU P  23
VAL P  33
 None
 1.28A 1q23L-5zdhP:
undetectable		 1q23L-5zdhP:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 5 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.43A 1q23L-6brrA:
undetectable		 1q23L-6brrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.31A 1q23L-6cajC:
undetectable		 1q23L-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 5 THR A 807
PHE A 974
PHE A 919
LEU A 923
VAL A 927
 None
 1.30A 1q23L-6d4jA:
undetectable		 1q23L-6d4jA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE

(Thermotoga
maritima) 		no annotation 5 THR B 138
PHE B 207
LEU B 271
VAL B 275
PHE B 288
 None
 1.26A 1q23L-6fpeB:
undetectable		 1q23L-6fpeB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.30A 1q23L-6gl3A:
undetectable		 1q23L-6gl3A:
undetectable