SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_J_FUAJ711

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		5 THR A 385
PHE A 364
LEU A 345
VAL A 319
VAL A 360
 None
 1.34A 1q23J-1bf5A:
0.0		 1q23J-1bf5A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cee GTP-BINDING RHO-LIKE
PROTEIN
WISKOTT-ALDRICH
SYNDROME PROTEIN
WASP

(Homo sapiens) 		PF00071
(Ras)
PF00786
(PBD) 		5 THR A  17
TYR A  40
PHE A  56
VAL B  31
PHE B  42
 MG  A 180 ( 3.4A)
None
None
None
None
 1.03A 1q23J-1ceeA:
undetectable		 1q23J-1ceeA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.62A 1q23J-1ciaA:
32.3		 1q23J-1ciaA:
44.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 340
PHE A 339
SER A 168
LEU A 187
VAL A 139
 None
 1.23A 1q23J-1gngA:
0.0		 1q23J-1gngA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		5 THR A  56
LEU A  17
VAL A  47
PHE A  37
VAL A  30
 None
 1.35A 1q23J-1hdfA:
0.0		 1q23J-1hdfA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A 172
PHE A  62
LEU A 300
VAL A  22
VAL A   8
 None
 1.17A 1q23J-1ml4A:
0.5		 1q23J-1ml4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR E 162
SER E 176
TYR E 178
PHE E 118
VAL F 154
 None
 1.45A 1q23J-1nfdE:
0.0		 1q23J-1nfdE:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		11 THR A  93
SER A 104
TYR A 133
PHE A 134
PHE A 138
SER A 146
PHE A 156
LEU A 158
VAL A 160
PHE A 166
VAL A 170
 None
 0.41A 1q23J-1pd5A:
35.2		 1q23J-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.36A 1q23J-1ptjA:
undetectable		 1q23J-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu0 LAMININ ALPHA2 CHAIN

(Mus musculus) 		PF02210
(Laminin_G_2) 		5 PHE A2940
PHE A3080
LEU A3089
VAL A2960
VAL A3060
 None
 1.14A 1q23J-1qu0A:
undetectable		 1q23J-1qu0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT

(Homo sapiens) 		PF08785
(Ku_PK_bind) 		5 PHE A  84
PHE A 146
VAL A 108
PHE A 116
VAL A 120
 None
 1.23A 1q23J-1rw2A:
undetectable		 1q23J-1rw2A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydg TRP REPRESSOR
BINDING PROTEIN WRBA

(Deinococcus
radiodurans) 		PF03358
(FMN_red) 		5 SER A  83
SER A 117
LEU A   7
VAL A  36
VAL A 188
 None
 1.32A 1q23J-1ydgA:
undetectable		 1q23J-1ydgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4k 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 PHE A 116
LEU A 126
VAL A 125
PHE A  71
VAL A  84
 None
 1.41A 1q23J-2a4kA:
undetectable		 1q23J-2a4kA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.31A 1q23J-2ag8A:
undetectable		 1q23J-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		5 PHE A 341
PHE A 460
LEU A 461
VAL A 453
VAL A 484
 None
SIA  A1692 ( 4.9A)
None
None
None
 1.35A 1q23J-2bf6A:
undetectable		 1q23J-2bf6A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		5 PHE A 487
LEU A 578
VAL A 572
PHE A 334
VAL A 286
 None
 1.41A 1q23J-2f5vA:
undetectable		 1q23J-2f5vA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7g DNA TOPOISOMERASE 1

(Variola virus) 		PF01028
(Topoisom_I)
PF09266
(VirDNA-topo-I_N) 		5 THR X 190
PHE X 200
PHE X 120
PHE X 127
VAL X 176
 None
 1.34A 1q23J-2h7gX:
undetectable		 1q23J-2h7gX:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		5 PHE A 164
SER A 100
PHE A 147
LEU A 133
VAL A 127
 None
 1.22A 1q23J-2in3A:
undetectable		 1q23J-2in3A:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jww PARVALBUMIN ALPHA

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 SER A  71
PHE A  29
LEU A  35
VAL A  43
PHE A 102
 None
 1.39A 1q23J-2jwwA:
undetectable		 1q23J-2jwwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		5 THR A 294
PHE A 326
SER A 249
LEU A 208
VAL A 357
 None
 1.27A 1q23J-2ntbA:
undetectable		 1q23J-2ntbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0y TRANSCRIPTIONAL
REGULATOR

(Rhodococcus sp.) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 SER A 172
PHE A 178
LEU A 182
VAL A 186
VAL A 168
 None
 1.35A 1q23J-2o0yA:
undetectable		 1q23J-2o0yA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 THR A 133
PHE A 323
LEU A 409
VAL A 444
VAL A  72
 None
 1.11A 1q23J-2oodA:
undetectable		 1q23J-2oodA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		5 SER A   6
LEU A  84
VAL A  39
PHE A  53
VAL A  27
 None
 1.37A 1q23J-2qsvA:
undetectable		 1q23J-2qsvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		5 PHE A 430
PHE A 565
LEU A 566
VAL A 558
VAL A 589
 None
 1.29A 1q23J-2w20A:
undetectable		 1q23J-2w20A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 TYR A 447
SER A 356
PHE A 543
LEU A 473
VAL A 479
 ZKD  A1569 (-4.0A)
None
None
None
None
 1.41A 1q23J-2xgoA:
undetectable		 1q23J-2xgoA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1

(Treponema
denticola) 		PF03781
(FGE-sulfatase) 		5 PHE A 174
SER A 149
LEU A 325
VAL A 102
PHE A 323
 None
 1.31A 1q23J-2y3cA:
undetectable		 1q23J-2y3cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.36A 1q23J-2yevB:
undetectable		 1q23J-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apu ALPHA-1-ACID
GLYCOPROTEIN 2

(Homo sapiens) 		PF00061
(Lipocalin) 		5 SER A 114
TYR A  37
PHE A  51
LEU A  79
VAL A  88
 None
 1.14A 1q23J-3apuA:
undetectable		 1q23J-3apuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs4 UNCHARACTERIZED
PROTEIN PH0321

(Pyrococcus
horikoshii) 		no annotation 5 THR A 165
SER A 166
PHE A  54
VAL A 153
PHE A  92
 None
 1.43A 1q23J-3bs4A:
undetectable		 1q23J-3bs4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 THR A3042
SER A3041
SER A3044
LEU A3277
VAL A3323
 None
 1.41A 1q23J-3cmvA:
undetectable		 1q23J-3cmvA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqo FBP32

(Morone
saxatilis) 		PF00754
(F5_F8_type_C) 		5 THR A  64
SER A  65
LEU A  57
VAL A  55
VAL A   6
 None
 1.43A 1q23J-3cqoA:
undetectable		 1q23J-3cqoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 5 SER A  21
PHE A  48
PHE A  25
SER A 132
VAL A 370
 None
 1.38A 1q23J-3cv3A:
undetectable		 1q23J-3cv3A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgf RESPONSE REGULATOR

(Thermotoga
maritima) 		PF00072
(Response_reg) 		5 PHE C  20
LEU C  49
VAL C 116
PHE C 112
VAL C  51
 None
 1.40A 1q23J-3dgfC:
undetectable		 1q23J-3dgfC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 THR A 118
TYR A  75
PHE A  79
LEU A 108
VAL A 107
 None
 1.38A 1q23J-3e53A:
undetectable		 1q23J-3e53A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.20A 1q23J-3e77A:
1.7		 1q23J-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		5 SER A  16
SER A 312
LEU A  46
VAL A 105
VAL A 308
 None
None
None
None
FAD  A 600 (-3.6A)
 1.14A 1q23J-3i3lA:
undetectable		 1q23J-3i3lA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.30A 1q23J-3i6sA:
undetectable		 1q23J-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 THR A 991
SER A1204
LEU A1174
VAL A1178
VAL A1202
 None
 1.42A 1q23J-3jb9A:
undetectable		 1q23J-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 THR A1112
PHE A1212
PHE A1097
LEU A 985
VAL A 988
 None
 1.35A 1q23J-3jb9A:
undetectable		 1q23J-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km3 DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Anaplasma
phagocytophilum) 		no annotation 5 PHE A  22
LEU A 122
VAL A 102
PHE A 153
VAL A 130
 None
 1.41A 1q23J-3km3A:
undetectable		 1q23J-3km3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		5 THR A 132
SER A 135
LEU A  83
PHE A  66
VAL A   9
 None
 1.38A 1q23J-3lp5A:
undetectable		 1q23J-3lp5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		5 PHE A 180
LEU A 277
VAL A 374
PHE A 358
VAL A 321
 None
 1.24A 1q23J-3ndaA:
undetectable		 1q23J-3ndaA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njn PEPTIDASE

(Shewanella
oneidensis) 		PF08985
(DP-EP) 		5 PHE A  99
LEU A  58
VAL A  15
PHE A  24
VAL A 112
 None
 1.37A 1q23J-3njnA:
undetectable		 1q23J-3njnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
 ATP  A 763 (-4.5A)
None
None
None
None
 1.11A 1q23J-3o8lA:
undetectable		 1q23J-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1i EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		5 THR A  45
PHE A  96
LEU A 132
PHE A 181
VAL A 107
 None
 1.20A 1q23J-3p1iA:
undetectable		 1q23J-3p1iA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		5 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.44A 1q23J-3pl5A:
undetectable		 1q23J-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN

(Leishmania
infantum) 		PF00857
(Isochorismatase) 		5 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.25A 1q23J-3r2jA:
undetectable		 1q23J-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 SER A 228
TYR A 247
LEU A 178
VAL A 179
PHE A  83
 None
 1.24A 1q23J-3r4vA:
undetectable		 1q23J-3r4vA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 PHE A 119
LEU A 142
VAL A 140
PHE A  99
VAL A  33
 None
 1.43A 1q23J-3wv6A:
undetectable		 1q23J-3wv6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.14A 1q23J-4cczA:
undetectable		 1q23J-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cit VANADIUM-DEPENDENT
HALOPEROXIDASE

(Zobellia
galactanivorans) 		PF01569
(PAP2) 		5 THR A 295
SER A 297
PHE A 299
PHE A 399
VAL A 374
 None
 1.44A 1q23J-4citA:
undetectable		 1q23J-4citA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 THR A  82
LEU A 201
VAL A 188
PHE A 163
VAL A 237
 None
 1.44A 1q23J-4ecnA:
undetectable		 1q23J-4ecnA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		5 THR A 403
LEU A 444
VAL A 426
PHE A 422
VAL A 410
 None
 1.37A 1q23J-4eppA:
undetectable		 1q23J-4eppA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00404
(Dockerin_1)
PF00963
(Cohesin) 		5 THR A  34
SER A  33
PHE C  43
VAL C  33
VAL C 138
 None
 1.29A 1q23J-4fl4A:
undetectable		 1q23J-4fl4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fu0 D-ALANINE--D-ALANINE
LIGASE 7

(Enterococcus
faecalis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 SER A 296
LEU A 290
VAL A 147
PHE A 310
VAL A 313
 None
 1.20A 1q23J-4fu0A:
undetectable		 1q23J-4fu0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		5 SER A 282
LEU A 174
VAL A 173
PHE A 265
VAL A 269
 None
 1.32A 1q23J-4hwgA:
undetectable		 1q23J-4hwgA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 PHE A 920
LEU A 840
VAL A 836
PHE A 766
VAL A 845
 None
 1.45A 1q23J-4knhA:
undetectable		 1q23J-4knhA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 PHE A  43
LEU A  23
VAL A  25
PHE A 586
VAL A 502
 None
 1.16A 1q23J-4lnvA:
undetectable		 1q23J-4lnvA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		5 PHE A 273
PHE A 272
PHE A  90
LEU A  87
VAL A  31
 None
 1.40A 1q23J-4lxiA:
undetectable		 1q23J-4lxiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		5 SER A  49
LEU A 309
VAL A  97
PHE A 326
VAL A 330
 None
 1.28A 1q23J-4mfiA:
undetectable		 1q23J-4mfiA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6

(Trypanosoma
brucei) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.15A 1q23J-4nlbA:
undetectable		 1q23J-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 SER A 127
LEU A  81
VAL A 116
PHE A 111
VAL A  77
 None
 1.26A 1q23J-4od7A:
undetectable		 1q23J-4od7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 SER A 214
LEU A 158
VAL A 237
PHE A 240
VAL A 153
 None
 1.34A 1q23J-4wb7A:
undetectable		 1q23J-4wb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2

(Arabidopsis
thaliana) 		no annotation 5 PHE A 365
PHE A 295
LEU A 347
VAL A 353
VAL A 345
 None
 1.43A 1q23J-4wt5A:
undetectable		 1q23J-4wt5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 SER A 194
PHE A  56
LEU A  52
VAL A  16
VAL A  50
 PO4  A 303 ( 4.2A)
None
None
None
PO4  A 303 (-4.7A)
 1.43A 1q23J-4x2rA:
undetectable		 1q23J-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 SER A   5
PHE A 165
VAL A  20
PHE A  38
VAL A  29
 None
 1.37A 1q23J-4y9wA:
undetectable		 1q23J-4y9wA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye2 CAPPING ENZYME
PROTEIN

(Rotavirus A) 		PF05213
(Corona_NS2A) 		5 TYR A 756
PHE A 705
LEU A 719
PHE A 794
VAL A 770
 None
 1.38A 1q23J-4ye2A:
undetectable		 1q23J-4ye2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 PHE A  13
PHE A  16
LEU A 224
VAL A 227
VAL A 231
 None
 1.43A 1q23J-4zk3A:
undetectable		 1q23J-4zk3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		5 PHE A  90
PHE A 105
LEU A 239
PHE A 226
VAL A 230
 None
 1.13A 1q23J-5a2aA:
undetectable		 1q23J-5a2aA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		5 THR O 598
PHE A 949
LEU A1770
PHE A1844
VAL A1774
 None
 1.38A 1q23J-5a31O:
undetectable		 1q23J-5a31O:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Stackebrandtia
nassauensis) 		PF03734
(YkuD) 		5 PHE A 229
PHE A 207
LEU A 197
VAL A 274
VAL A 188
 None
 1.25A 1q23J-5bmqA:
undetectable		 1q23J-5bmqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)

(synthetic
construct) 		PF00079
(Serpin) 		5 SER A  31
PHE A 354
PHE A 162
SER A  37
LEU A  73
 None
 1.18A 1q23J-5ce0A:
undetectable		 1q23J-5ce0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE

(Bacillus
subtilis) 		PF09819
(ABC_cobalt) 		5 SER A 168
LEU A 116
VAL A 115
PHE A 103
VAL A  54
 None
 1.30A 1q23J-5edlA:
undetectable		 1q23J-5edlA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Corynebacterium
glutamicum) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 PHE A 107
LEU A  64
VAL A  89
PHE A  81
VAL A  60
 None
 1.31A 1q23J-5eesA:
undetectable		 1q23J-5eesA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eur UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		no annotation 5 THR A  43
SER A  42
LEU A   8
VAL A  21
PHE A  31
 None
 1.07A 1q23J-5eurA:
undetectable		 1q23J-5eurA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 THR A 133
TYR A  90
PHE A  94
LEU A 123
VAL A 122
 None
 1.41A 1q23J-5ey8A:
undetectable		 1q23J-5ey8A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flj QUERCETINASE QUED

(Streptomyces
sp. FLA) 		PF07883
(Cupin_2) 		5 TYR A 117
PHE A  78
PHE A 165
PHE A 137
VAL A 174
 QUE  A 301 (-4.8A)
QUE  A 301 (-3.9A)
None
QUE  A 301 ( 4.9A)
None
 1.29A 1q23J-5fljA:
undetectable		 1q23J-5fljA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 PHE B 920
LEU B 840
VAL B 836
PHE B 766
VAL B 845
 None
 1.43A 1q23J-5hb4B:
undetectable		 1q23J-5hb4B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.27A 1q23J-5hdiA:
undetectable		 1q23J-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm2 3C PROTEINASE

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 SER A 182
SER A  83
VAL A  36
PHE A 103
VAL A 194
 None
 1.44A 1q23J-5hm2A:
undetectable		 1q23J-5hm2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 PHE A2940
PHE A3080
LEU A3089
VAL A2960
VAL A3060
 None
 1.13A 1q23J-5ik8A:
undetectable		 1q23J-5ik8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 SER A 312
SER A 314
VAL A 383
PHE A 320
VAL A 318
 None
 1.28A 1q23J-5ikzA:
undetectable		 1q23J-5ikzA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		5 PHE A 283
PHE A 324
LEU A 238
VAL A 242
PHE A 264
 None
 1.20A 1q23J-5jtvA:
undetectable		 1q23J-5jtvA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.28A 1q23J-5k3hA:
undetectable		 1q23J-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 SER A 606
LEU A 590
VAL A 587
PHE A 649
VAL A 594
 None
 1.17A 1q23J-5l56A:
undetectable		 1q23J-5l56A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 THR A 527
LEU A 516
VAL A 501
PHE A 488
VAL A 482
 None
 1.26A 1q23J-5m11A:
undetectable		 1q23J-5m11A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 PHE B 374
SER B 184
LEU B 187
VAL B 146
VAL B 153
 None
 1.40A 1q23J-5mrwB:
undetectable		 1q23J-5mrwB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 SER A 866
TYR A 905
SER A 856
PHE A 799
VAL A 858
 None
 1.43A 1q23J-5n4lA:
undetectable		 1q23J-5n4lA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 5 THR A 286
PHE A 211
LEU A 244
VAL A 276
PHE A  88
 None
 1.44A 1q23J-5o9wA:
undetectable		 1q23J-5o9wA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 SER A  79
LEU A 104
VAL A  51
PHE A  36
VAL A 100
 None
 1.16A 1q23J-5ti1A:
undetectable		 1q23J-5ti1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Mycobacterium
tuberculosis) 		no annotation 5 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.30A 1q23J-5tjzA:
undetectable		 1q23J-5tjzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi4 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN

(Mus musculus) 		PF13895
(Ig_2)
PF13927
(Ig_3) 		5 TYR C 166
PHE C 223
PHE C 127
LEU C 129
VAL C 131
 None
 1.40A 1q23J-5vi4C:
undetectable		 1q23J-5vi4C:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 THR A  46
PHE A 162
LEU A 185
PHE A 133
VAL A 108
 CL  A 302 (-3.4A)
None
None
None
None
 1.43A 1q23J-5wl7A:
undetectable		 1q23J-5wl7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.38A 1q23J-6a91A:
undetectable		 1q23J-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amz 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 SER A 115
PHE A  90
LEU A 123
VAL A 140
VAL A 128
 None
 1.41A 1q23J-6amzA:
undetectable		 1q23J-6amzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.34A 1q23J-6cajC:
undetectable		 1q23J-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 5 THR A 539
SER A 537
TYR A 578
SER A 541
PHE A 279
 None
 1.39A 1q23J-6coyA:
undetectable		 1q23J-6coyA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eh1 STRUCTURAL PROTEIN
VP3

(Sacbrood virus) 		no annotation 5 PHE C  90
LEU C 118
VAL C 236
PHE C  80
VAL C 214
 None
 1.09A 1q23J-6eh1C:
undetectable		 1q23J-6eh1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzv PROCOLLAGEN
C-ENDOPEPTIDASE
ENHANCER 1

(Homo sapiens) 		no annotation 5 SER D 192
SER D 160
LEU D  95
VAL D  72
PHE D  86
 None
 1.30A 1q23J-6fzvD:
undetectable		 1q23J-6fzvD:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.33A 1q23J-6gl3A:
undetectable		 1q23J-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ALA A 293
VAL A 236
ALA A 287
HIS A 209
 None
 1.19A 1q23K-1dgjA:
0.0		 1q23K-1dgjA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ALA A 620
VAL A 619
ALA A 878
HIS A 876
 None
 1.21A 1q23K-1dgjA:
0.0		 1q23K-1dgjA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 314
VAL B 312
ALA B 313
HIS B 260
 None
 1.16A 1q23K-1e6vB:
0.9		 1q23K-1e6vB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		4 ALA A 134
VAL A 144
ALA A 183
HIS A 141
 None
 0.90A 1q23K-1eyeA:
0.0		 1q23K-1eyeA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri) 		PF00808
(CBFD_NFYB_HMF) 		4 ALA A 100
VAL A 105
ALA A 104
HIS A  62
 None
None
CL  A1001 ( 4.9A)
None
 1.07A 1q23K-1f1eA:
undetectable		 1q23K-1f1eA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ALA A 554
VAL A 558
ALA A 555
HIS A 552
 None
 1.06A 1q23K-1i8qA:
undetectable		 1q23K-1i8qA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrh AUXIN-BINDING
PROTEIN 1

(Zea mays) 		PF02041
(Auxin_BP) 		4 ALA A 142
VAL A 144
ALA A 143
HIS A 140
 None
 0.99A 1q23K-1lrhA:
0.0		 1q23K-1lrhA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrv LEUCINE-RICH REPEAT
VARIANT

(Azotobacter
vinelandii) 		PF01816
(LRV)
PF05484
(LRV_FeS) 		4 ALA A 191
VAL A 210
ALA A 213
HIS A 217
 None
 1.13A 1q23K-1lrvA:
0.0		 1q23K-1lrvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ALA A 402
VAL A 405
ALA A 406
HIS A 484
 None
 0.94A 1q23K-1mroA:
0.9		 1q23K-1mroA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		4 ALA A 163
VAL A 133
ALA A 132
HIS A 170
 None
 0.78A 1q23K-1nijA:
2.0		 1q23K-1nijA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 ALA A  99
VAL A 287
ALA A  89
HIS A 116
 None
 1.21A 1q23K-1nt4A:
0.0		 1q23K-1nt4A:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 ALA A  24
VAL A  28
ALA A  29
HIS A 193
 None
 0.33A 1q23K-1pd5A:
35.4		 1q23K-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		4 ALA A 221
VAL A 218
ALA A 217
HIS A 137
 None
 1.14A 1q23K-1t0bA:
undetectable		 1q23K-1t0bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 ALA C 805
VAL C 803
ALA C 804
HIS C 848
 None
 1.20A 1q23K-1u6gC:
undetectable		 1q23K-1u6gC:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ALA A  46
VAL A  49
ALA A  51
HIS A  52
 None
 1.02A 1q23K-1ulsA:
undetectable		 1q23K-1ulsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 ALA A 100
VAL A  81
ALA A  80
HIS A 200
 None
None
None
FE  A1293 (-3.2A)
 1.10A 1q23K-1uzrA:
undetectable		 1q23K-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ALA A 402
VAL A 405
ALA A 406
HIS A 422
 None
 1.24A 1q23K-1vcnA:
undetectable		 1q23K-1vcnA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 ALA A 230
VAL A 226
ALA A 225
HIS A 180
 None
 1.17A 1q23K-1vliA:
undetectable		 1q23K-1vliA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 360
VAL A 363
ALA A 364
HIS A 103
 None
 1.20A 1q23K-1ysjA:
undetectable		 1q23K-1ysjA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ALA A 266
VAL A 263
ALA A 264
HIS A 344
 None
 1.16A 1q23K-1z47A:
undetectable		 1q23K-1z47A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 ALA A 226
VAL A 223
ALA A 189
HIS A 187
 None
 1.21A 1q23K-2d1cA:
undetectable		 1q23K-2d1cA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
HG  A1001 (-3.1A)
 1.03A 1q23K-2di4A:
undetectable		 1q23K-2di4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 ALA A  69
VAL C 658
ALA C 657
HIS C 646
 FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.6A)
None
 1.06A 1q23K-2e1mA:
undetectable		 1q23K-2e1mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		4 ALA A 101
VAL A  98
ALA A  91
HIS A  94
 None
 1.14A 1q23K-2fe1A:
undetectable		 1q23K-2fe1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0b FEEM

(uncultured
bacterium) 		no annotation 4 ALA A 109
VAL A 108
ALA A 107
HIS A 102
 None
 1.13A 1q23K-2g0bA:
undetectable		 1q23K-2g0bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 ALA A 303
VAL A 307
ALA A 304
HIS A 301
 None
 0.99A 1q23K-2g4oA:
undetectable		 1q23K-2g4oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		4 ALA A  83
VAL A  85
ALA A  86
HIS A 338
 None
None
None
CL  A 605 (-4.2A)
 0.86A 1q23K-2gwnA:
undetectable		 1q23K-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mts HEPATITIS C VIRUS P7
PROTEIN

(Hepacivirus C) 		no annotation 4 ALA A  10
VAL A  13
ALA A  14
HIS A  17
 None
 0.83A 1q23K-2mtsA:
undetectable		 1q23K-2mtsA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr4 CONSERVED
HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF04289
(DUF447) 		4 ALA A 191
VAL A 162
ALA A 161
HIS A 186
 None
 1.21A 1q23K-2nr4A:
undetectable		 1q23K-2nr4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		4 ALA A 955
VAL A1094
ALA A1091
HIS A1088
 None
 1.18A 1q23K-2psoA:
undetectable		 1q23K-2psoA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ALA A 520
VAL A 547
ALA A 521
HIS A 875
 None
 1.13A 1q23K-2qo3A:
1.7		 1q23K-2qo3A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r01 NITROREDUCTASE
FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF00881
(Nitroreductase) 		4 ALA A  94
VAL A  33
ALA A  32
HIS A  30
 None
 1.19A 1q23K-2r01A:
undetectable		 1q23K-2r01A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rrk CTP
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 ALA A  88
VAL A  72
ALA A  73
HIS A  75
 None
 1.17A 1q23K-2rrkA:
undetectable		 1q23K-2rrkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ALA A 292
VAL A 296
ALA A 293
HIS A 290
 None
 1.23A 1q23K-2vr2A:
undetectable		 1q23K-2vr2A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA B 109
VAL B  61
ALA B 103
HIS B  34
 None
 1.25A 1q23K-2w55B:
undetectable		 1q23K-2w55B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 ALA A 148
VAL A  36
ALA A 131
HIS A 152
 None
 1.19A 1q23K-2xfbA:
undetectable		 1q23K-2xfbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc7 BETA-LACTAMASE ACT-1

(Klebsiella
pneumoniae) 		PF00144
(Beta-lactamase) 		4 ALA A 231
VAL A 337
ALA A  31
HIS A  39
 None
 1.23A 1q23K-2zc7A:
undetectable		 1q23K-2zc7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.12A 1q23K-3a0hB:
undetectable		 1q23K-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asf MAGNETOSOME PROTEIN
MAMA

(Magnetospirillum
gryphiswaldense) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		4 ALA A  89
VAL A  66
ALA A  65
HIS A  85
 None
 1.25A 1q23K-3asfA:
undetectable		 1q23K-3asfA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 ALPHAA-GLOBIN
BETA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		4 ALA B 116
VAL A 111
ALA A 110
HIS A 122
 None
 1.19A 1q23K-3at6B:
undetectable		 1q23K-3at6B:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ALA A 222
VAL A 220
ALA A 221
HIS A  62
 None
 1.25A 1q23K-3be7A:
undetectable		 1q23K-3be7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		4 ALA A 159
VAL A 207
ALA A 213
HIS A 215
 None
 1.18A 1q23K-3bptA:
undetectable		 1q23K-3bptA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A 103
VAL A 107
ALA A 104
HIS A 101
 None
 1.21A 1q23K-3ce6A:
undetectable		 1q23K-3ce6A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 ALA A 707
VAL A 711
ALA A 708
HIS A 705
 None
 0.93A 1q23K-3cqcA:
undetectable		 1q23K-3cqcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqg NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 ALA A 707
VAL A 711
ALA A 708
HIS A 705
 None
 1.01A 1q23K-3cqgA:
undetectable		 1q23K-3cqgA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Bacillus
halodurans) 		PF13580
(SIS_2) 		4 ALA A  71
VAL A  46
ALA A  56
HIS A  53
 None
None
None
MG  A 243 (-3.5A)
 1.22A 1q23K-3cvjA:
undetectable		 1q23K-3cvjA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		4 ALA A  54
VAL A  58
ALA A  55
HIS A  52
 None
 0.98A 1q23K-3e03A:
undetectable		 1q23K-3e03A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ALA A 280
VAL A 300
ALA A 283
HIS A 271
 None
 1.23A 1q23K-3eoqA:
undetectable		 1q23K-3eoqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0i ARSENATE REDUCTASE

(Vibrio cholerae) 		PF03960
(ArsC) 		4 ALA A  83
VAL A  40
ALA A  86
HIS A  88
 None
 0.93A 1q23K-3f0iA:
undetectable		 1q23K-3f0iA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		4 ALA A 173
VAL A 168
ALA A 163
HIS A 160
 None
 1.17A 1q23K-3fdjA:
undetectable		 1q23K-3fdjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ALA A   9
VAL A  35
ALA A  10
HIS A  19
 None
 1.17A 1q23K-3fhlA:
undetectable		 1q23K-3fhlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		4 ALA A 219
VAL A 215
ALA A 214
HIS A 168
 None
 1.09A 1q23K-3g8rA:
undetectable		 1q23K-3g8rA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A  96
VAL A 100
ALA A  97
HIS A  94
 None
 1.12A 1q23K-3glqA:
undetectable		 1q23K-3glqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hin PUTATIVE
3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Rhodopseudomonas
palustris) 		PF00378
(ECH_1) 		4 ALA A 201
VAL A 132
ALA A 112
HIS A  65
 None
 1.04A 1q23K-3hinA:
undetectable		 1q23K-3hinA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i07 ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Vibrio cholerae) 		PF02566
(OsmC) 		4 ALA A  73
VAL A  75
ALA A  70
HIS A  68
 None
None
None
GOL  A 302 ( 3.9A)
 1.17A 1q23K-3i07A:
undetectable		 1q23K-3i07A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7m XAA-PRO DIPEPTIDASE

(Lactobacillus
brevis) 		PF01321
(Creatinase_N) 		4 ALA A 101
VAL A 100
ALA A  16
HIS A  14
 None
 1.18A 1q23K-3i7mA:
undetectable		 1q23K-3i7mA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01512
(Complex1_51K)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10531
(SLBB)
PF10588
(NADH-G_4Fe-4S_3)
PF10589
(NADH_4Fe-4S)
PF13510
(Fer2_4) 		4 ALA 1 349
VAL 1 363
ALA 1 364
HIS 3 208
 None
 1.18A 1q23K-3i9v1:
undetectable		 1q23K-3i9v1:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 ALA A 472
VAL A 474
ALA A 473
HIS A 432
 None
 1.18A 1q23K-3js8A:
undetectable		 1q23K-3js8A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ALA E 484
VAL E 488
ALA E 485
HIS E 423
 None
None
None
ZN  E 996 ( 3.3A)
 1.03A 1q23K-3kdsE:
undetectable		 1q23K-3kdsE:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A 103
VAL A 181
ALA A 207
HIS A 340
 None
 0.97A 1q23K-3ledA:
undetectable		 1q23K-3ledA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ALA A 346
VAL A 339
ALA A 338
HIS A 270
 None
 1.10A 1q23K-3lk6A:
undetectable		 1q23K-3lk6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		4 ALA A 186
VAL A 185
ALA A 245
HIS A 244
 None
 1.16A 1q23K-3lstA:
undetectable		 1q23K-3lstA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncv DNA MISMATCH REPAIR
PROTEIN MUTL

(Neisseria
gonorrhoeae) 		PF08676
(MutL_C) 		4 ALA A 495
VAL A 499
ALA A 496
HIS A 493
 None
 0.83A 1q23K-3ncvA:
undetectable		 1q23K-3ncvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		4 ALA A  97
VAL A 285
ALA A  87
HIS A 114
 None
 1.21A 1q23K-3ntlA:
undetectable		 1q23K-3ntlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 ALA A 241
VAL A 213
ALA A 212
HIS A 206
 None
None
None
MN  A 365 (-3.4A)
 1.18A 1q23K-3rmjA:
undetectable		 1q23K-3rmjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzv STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		4 ALA A 306
VAL A 279
ALA A 280
HIS A 335
 None
None
None
ZN  A   1 (-3.3A)
 1.25A 1q23K-3rzvA:
undetectable		 1q23K-3rzvA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 143
VAL A 178
ALA A 179
HIS A 207
 None
 1.22A 1q23K-3t8qA:
undetectable		 1q23K-3t8qA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 ALA A  31
VAL A  28
ALA A  27
HIS A 203
 None
 1.08A 1q23K-3tr1A:
undetectable		 1q23K-3tr1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt9 PLAKOPHILIN-2

(Homo sapiens) 		PF00514
(Arm) 		4 ALA A 374
VAL A 415
ALA A 414
HIS A 379
 None
 1.13A 1q23K-3tt9A:
undetectable		 1q23K-3tt9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		4 ALA A 375
VAL A 176
ALA A 376
HIS A 261
 None
 1.21A 1q23K-3v7iA:
undetectable		 1q23K-3v7iA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu B1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		4 ALA D  96
VAL D 100
ALA D  97
HIS D  94
 None
 1.24A 1q23K-3wcuD:
undetectable		 1q23K-3wcuD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 ALA A 223
VAL A 231
ALA A 234
HIS A 238
 None
 1.21A 1q23K-3zjkA:
undetectable		 1q23K-3zjkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC

(Leishmania
major) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ALA A  59
VAL A  63
ALA A  60
HIS A  57
 None
 1.07A 1q23K-4a26A:
undetectable		 1q23K-4a26A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 ALA A 365
VAL A 344
ALA A 343
HIS A 375
 None
 1.11A 1q23K-4blaA:
undetectable		 1q23K-4blaA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 301
VAL A 305
ALA A 302
HIS A 299
 None
None
None
CAJ  A 503 (-4.1A)
 1.05A 1q23K-4emwA:
undetectable		 1q23K-4emwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kx6 FUMARATE REDUCTASE
SUBUNIT C

(Escherichia
coli) 		PF02300
(Fumarate_red_C) 		4 ALA C  35
VAL C  33
ALA C  32
HIS C  82
 None
 1.21A 1q23K-4kx6C:
undetectable		 1q23K-4kx6C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		4 ALA A 173
VAL A  48
ALA A  47
HIS A  35
 None
 1.01A 1q23K-4o48A:
undetectable		 1q23K-4o48A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		4 ALA A 365
VAL A 344
ALA A 343
HIS A 428
 None
 1.22A 1q23K-4qvhA:
undetectable		 1q23K-4qvhA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		4 ALA A  91
VAL A  95
ALA A  92
HIS A  89
 None
 0.93A 1q23K-4u4eA:
undetectable		 1q23K-4u4eA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 ALA A  80
VAL A  77
ALA A  58
HIS A  53
 None
 1.22A 1q23K-4xpdA:
undetectable		 1q23K-4xpdA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		4 ALA A 280
VAL A 291
ALA A 290
HIS A 244
 None
None
None
ZN  A 402 (-3.3A)
 1.20A 1q23K-4xukA:
undetectable		 1q23K-4xukA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		4 ALA A 178
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.22A 1q23K-4y4nA:
undetectable		 1q23K-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		4 ALA A 227
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.17A 1q23K-4y4nA:
undetectable		 1q23K-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
ZN  A 701 (-3.3A)
 0.98A 1q23K-4z8xA:
undetectable		 1q23K-4z8xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 ALA A  65
VAL A  63
ALA A  62
HIS A  29
 None
 1.25A 1q23K-5abmA:
undetectable		 1q23K-5abmA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 ALA A1009
VAL A1013
ALA A1010
HIS A1007
 None
 1.20A 1q23K-5f3yA:
undetectable		 1q23K-5f3yA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 4 ALA A  77
VAL A  74
ALA A  86
HIS A  88
 None
 1.00A 1q23K-5gufA:
undetectable		 1q23K-5gufA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		4 ALA B 524
VAL A  13
ALA A  14
HIS A  16
 None
 1.12A 1q23K-5hftB:
undetectable		 1q23K-5hftB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 ALA A  59
VAL A 184
ALA A  62
HIS A  61
 None
 1.22A 1q23K-5hx9A:
undetectable		 1q23K-5hx9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 ALA A  55
VAL A  38
ALA A  56
HIS A  62
 None
 1.13A 1q23K-5l80A:
undetectable		 1q23K-5l80A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 ALA B  72
VAL B  80
ALA B  73
HIS B 124
 None
None
None
EDO  B 715 (-3.4A)
 1.24A 1q23K-5lxzB:
undetectable		 1q23K-5lxzB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 4 ALA A 289
VAL A 274
ALA A 290
HIS A 105
 PG4  A 403 ( 4.2A)
None
None
PG4  A 403 (-4.5A)
 1.15A 1q23K-5o25A:
undetectable		 1q23K-5o25A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 ALA 2 563
VAL 2 556
ALA 2 560
HIS 2 561
 None
 1.19A 1q23K-5udb2:
undetectable		 1q23K-5udb2:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A  87
VAL A  91
ALA A  88
HIS A  85
 None
 1.11A 1q23K-5utuA:
undetectable		 1q23K-5utuA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		4 ALA A  67
VAL A  71
ALA A  68
HIS A  65
 None
 1.02A 1q23K-5uvmA:
undetectable		 1q23K-5uvmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1

(Xenopus laevis) 		PF00520
(Ion_trans)
PF03520
(KCNQ_channel) 		4 ALA A 501
VAL A 505
ALA A 502
HIS A 499
 None
 0.97A 1q23K-5vmsA:
undetectable		 1q23K-5vmsA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 ALA A 854
VAL A 858
ALA A 855
HIS A 476
 None
 1.16A 1q23K-5wmmA:
undetectable		 1q23K-5wmmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 ALA A 302
VAL A 306
ALA A 303
HIS A 300
 None
 0.91A 1q23K-5z9sA:
undetectable		 1q23K-5z9sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 ALA A 268
VAL A 272
ALA A 269
HIS A 266
 None
 0.93A 1q23K-6c26A:
undetectable		 1q23K-6c26A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ALA A1035
VAL A1025
ALA A1026
HIS A1028
 None
 1.25A 1q23K-6f9nA:
undetectable		 1q23K-6f9nA:
15.53