SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_I_FUAI707

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  88
ALA A  89
HIS A 190
 None
 0.61A 1q23G-1cliA:
0.0		 1q23G-1cliA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 VAL A 215
ALA A 216
HIS A 204
 CAA  A 600 (-4.9A)
None
None
 0.68A 1q23G-1ee0A:
0.1		 1q23G-1ee0A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		3 VAL A 266
ALA A 267
HIS A 269
 None
 0.69A 1q23G-1ey2A:
0.0		 1q23G-1ey2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri) 		PF00808
(CBFD_NFYB_HMF) 		3 VAL A 105
ALA A 104
HIS A  62
 None
CL  A1001 ( 4.9A)
None
 0.66A 1q23G-1f1eA:
undetectable		 1q23G-1f1eA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		3 VAL A 466
ALA A 467
HIS A 421
 None
None
HEM  A1001 (-3.4A)
 0.77A 1q23G-1fftA:
undetectable		 1q23G-1fftA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		3 VAL A 271
ALA A 203
HIS A 221
 None
NAD  A1382 (-3.5A)
UDP  A1383 (-4.2A)
 0.72A 1q23G-1gy8A:
0.0		 1q23G-1gy8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L21E

(Haloarcula
marismortui) 		PF01157
(Ribosomal_L21e) 		3 VAL R  30
ALA R  29
HIS R  90
 None
 0.40A 1q23G-1kc8R:
undetectable		 1q23G-1kc8R:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		3 VAL A1064
ALA A1065
HIS A1163
 None
 0.74A 1q23G-1lurA:
undetectable		 1q23G-1lurA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 VAL A 113
ALA A 114
HIS A 117
 None
 0.72A 1q23G-1n8pA:
0.9		 1q23G-1n8pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		3 VAL A 133
ALA A 132
HIS A 170
 None
 0.50A 1q23G-1nijA:
2.0		 1q23G-1nijA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 VAL A  65
ALA A  66
HIS A 230
 None
 0.67A 1q23G-1nuqA:
0.1		 1q23G-1nuqA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		3 VAL A  28
ALA A  29
HIS A 193
 None
 0.40A 1q23G-1pd5A:
36.3		 1q23G-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		3 VAL A 108
ALA A 107
HIS A 156
 None
 0.53A 1q23G-1pn3A:
undetectable		 1q23G-1pn3A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 VAL A 370
ALA A 371
HIS A 366
 None
 0.71A 1q23G-1q8iA:
undetectable		 1q23G-1q8iA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		3 VAL B 302
ALA B 301
HIS A 491
 None
 0.60A 1q23G-1r4nB:
undetectable		 1q23G-1r4nB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t57 CONSERVED PROTEIN
MTH1675

(Methanothermobacter
thermautotrophicus) 		PF02887
(PK_C) 		3 VAL A  37
ALA A  38
HIS A  61
 None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.2A)
 0.65A 1q23G-1t57A:
undetectable		 1q23G-1t57A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		3 VAL A 105
ALA A 106
HIS A  95
 None
 0.69A 1q23G-1u0kA:
undetectable		 1q23G-1u0kA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 VAL A 219
ALA A 218
HIS A 246
 None
None
CSO  A 110 ( 3.9A)
 0.62A 1q23G-1ub7A:
undetectable		 1q23G-1ub7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 VAL A  88
ALA A  89
HIS A 327
 None
None
152  A 613 (-4.3A)
 0.59A 1q23G-1xl8A:
9.8		 1q23G-1xl8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		3 VAL A 236
ALA A 237
HIS A 239
 None
 0.71A 1q23G-1xnyA:
undetectable		 1q23G-1xnyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE

(Bacillus
anthracis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  85
ALA A  86
HIS A 187
 None
 0.57A 1q23G-2btuA:
undetectable		 1q23G-2btuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		3 VAL A  18
ALA A  17
HIS A 234
 None
 0.69A 1q23G-2c20A:
undetectable		 1q23G-2c20A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1e PROTEIN APAG

(Xanthomonas
citri) 		PF04379
(DUF525) 		3 VAL A  48
ALA A  49
HIS A 100
 None
 0.67A 1q23G-2f1eA:
undetectable		 1q23G-2f1eA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		3 VAL A  85
ALA A  86
HIS A 338
 None
None
CL  A 605 (-4.2A)
 0.60A 1q23G-2gwnA:
undetectable		 1q23G-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isj BLUB

(Sinorhizobium
meliloti) 		PF00881
(Nitroreductase) 		3 VAL A 149
ALA A 148
HIS A  55
 None
 0.49A 1q23G-2isjA:
undetectable		 1q23G-2isjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		3 VAL A 101
ALA A 100
HIS A  42
 None
ATP  A1296 (-3.6A)
ATP  A1296 (-4.4A)
 0.50A 1q23G-2jaxA:
undetectable		 1q23G-2jaxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 VAL A  20
ALA A  19
HIS A  69
 None
None
PO4  A 503 (-4.1A)
 0.67A 1q23G-2plaA:
undetectable		 1q23G-2plaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A 517
ALA A 518
HIS A 620
 None
 0.54A 1q23G-2v9yA:
undetectable		 1q23G-2v9yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 VAL A 488
ALA A 487
HIS A 518
 None
 0.77A 1q23G-2wd9A:
undetectable		 1q23G-2wd9A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 VAL A 273
ALA A 199
HIS A 201
 None
 0.77A 1q23G-2x3kA:
undetectable		 1q23G-2x3kA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		3 VAL A 172
ALA A 205
HIS A 211
 None
 0.75A 1q23G-2y7dA:
undetectable		 1q23G-2y7dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  85
ALA A  86
HIS A 187
 None
 0.60A 1q23G-2z01A:
undetectable		 1q23G-2z01A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		3 VAL A 146
ALA A 147
HIS A 136
 None
 0.74A 1q23G-3f8tA:
undetectable		 1q23G-3f8tA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES

(Salmonella
enterica) 		PF01380
(SIS) 		3 VAL A  87
ALA A  88
HIS A  62
 None
 0.75A 1q23G-3fkjA:
undetectable		 1q23G-3fkjA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 VAL A  76
ALA A  77
HIS A  79
 None
 0.63A 1q23G-3g8dA:
undetectable		 1q23G-3g8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		3 VAL A 215
ALA A 214
HIS A 168
 None
 0.73A 1q23G-3g8rA:
undetectable		 1q23G-3g8rA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdi PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus musculus) 		PF08447
(PAS_3) 		3 VAL A 349
ALA A 348
HIS A 430
 None
 0.57A 1q23G-3gdiA:
undetectable		 1q23G-3gdiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		3 VAL A 409
ALA A 408
HIS A 493
 None
 0.74A 1q23G-3gecA:
undetectable		 1q23G-3gecA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		3 VAL A 108
ALA A 107
HIS A 156
 None
 0.42A 1q23G-3h4iA:
undetectable		 1q23G-3h4iA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		3 VAL A 735
ALA A 399
HIS A1358
 None
 0.53A 1q23G-3hmjA:
undetectable		 1q23G-3hmjA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihu TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Cupriavidus
pinatubonensis) 		PF00392
(GntR)
PF07729
(FCD) 		3 VAL A  92
ALA A  93
HIS A 207
 None
 0.73A 1q23G-3ihuA:
undetectable		 1q23G-3ihuA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 VAL A 211
ALA A 210
HIS A 238
 None
 0.70A 1q23G-3il7A:
undetectable		 1q23G-3il7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		3 VAL A 148
ALA A 147
HIS A 120
 None
 0.62A 1q23G-3iq0A:
undetectable		 1q23G-3iq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki6 CHOLIX TOXIN

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly) 		3 VAL A 465
ALA A 466
HIS A 460
 None
None
G9L  A   1 (-3.9A)
 0.64A 1q23G-3ki6A:
undetectable		 1q23G-3ki6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 VAL A 181
ALA A 207
HIS A 340
 None
 0.42A 1q23G-3ledA:
undetectable		 1q23G-3ledA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncv DNA MISMATCH REPAIR
PROTEIN MUTL

(Neisseria
gonorrhoeae) 		PF08676
(MutL_C) 		3 VAL A 499
ALA A 496
HIS A 493
 None
 0.76A 1q23G-3ncvA:
undetectable		 1q23G-3ncvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		3 VAL A 450
ALA A 449
HIS A 408
 None
 0.63A 1q23G-3nmzA:
undetectable		 1q23G-3nmzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		3 VAL A 274
ALA A 249
HIS A 280
 None
None
EDO  A 312 (-4.7A)
 0.75A 1q23G-3nwoA:
undetectable		 1q23G-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		3 VAL A 305
ALA A 304
HIS A 242
 None
 0.76A 1q23G-3os6A:
undetectable		 1q23G-3os6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 VAL A 279
ALA A 278
HIS A 299
 None
 0.76A 1q23G-3oytA:
undetectable		 1q23G-3oytA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  89
ALA A  90
HIS A 191
 None
 0.59A 1q23G-3p4eA:
undetectable		 1q23G-3p4eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rty PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		3 VAL A 409
ALA A 408
HIS A 493
 DTT  A 900 (-4.9A)
None
None
 0.51A 1q23G-3rtyA:
undetectable		 1q23G-3rtyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		3 VAL A 310
ALA A  18
HIS A  45
 None
 0.75A 1q23G-3tg9A:
undetectable		 1q23G-3tg9A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 VAL A 149
ALA A 150
HIS A 376
 None
 0.66A 1q23G-3uszA:
undetectable		 1q23G-3uszA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF01786
(AOX) 		3 VAL A 125
ALA A 126
HIS A 165
 None
OH  A 503 ( 3.7A)
FE  A 501 (-3.3A)
 0.68A 1q23G-3vvaA:
undetectable		 1q23G-3vvaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		3 VAL A  54
ALA A  55
HIS A  69
 None
 0.59A 1q23G-3wrfA:
undetectable		 1q23G-3wrfA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 VAL A 352
ALA A 353
HIS A 358
 None
FAD  A3005 (-3.6A)
FAD  A3005 (-3.8A)
 0.76A 1q23G-3zyvA:
undetectable		 1q23G-3zyvA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6

(Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		3 VAL A 327
ALA A 326
HIS A 288
 None
 0.74A 1q23G-4a05A:
undetectable		 1q23G-4a05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 VAL A 609
ALA A 608
HIS A 226
 None
 0.66A 1q23G-4a5wA:
undetectable		 1q23G-4a5wA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq2 HOMOGENTISATE
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF04209
(HgmA) 		3 VAL A 262
ALA A 263
HIS A 265
 None
 0.66A 1q23G-4aq2A:
undetectable		 1q23G-4aq2A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 VAL B2136
ALA B2137
HIS B2122
 None
None
CUO  B9006 (-3.2A)
 0.70A 1q23G-4bedB:
undetectable		 1q23G-4bedB:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		3 VAL A 173
ALA A 172
HIS A  95
 None
 0.72A 1q23G-4c3sA:
0.9		 1q23G-4c3sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj3 PERIOD CIRCADIAN
PROTEIN HOMOLOG 3

(Mus musculus) 		PF08447
(PAS_3) 		3 VAL A 288
ALA A 287
HIS A 370
 None
 0.63A 1q23G-4dj3A:
undetectable		 1q23G-4dj3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo3 BACTERIOFERRITIN
COMIGRATORY
PROTEIN/NADH
DEHYDROGENASE

(Thermotoga
maritima) 		PF00578
(AhpC-TSA)
PF00881
(Nitroreductase) 		3 VAL A 245
ALA A 244
HIS A 175
 None
 0.68A 1q23G-4eo3A:
undetectable		 1q23G-4eo3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqy ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 VAL A 247
ALA A 246
HIS A 165
 None
 0.76A 1q23G-4eqyA:
undetectable		 1q23G-4eqyA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE

(Leishmania
major) 		PF00248
(Aldo_ket_red) 		3 VAL A  37
ALA A  36
HIS A 243
 None
 0.71A 1q23G-4f40A:
undetectable		 1q23G-4f40A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 VAL A  79
ALA A  80
HIS A  71
 ATP  A 401 (-4.7A)
None
None
 0.74A 1q23G-4fg8A:
undetectable		 1q23G-4fg8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 VAL A 102
ALA A 103
HIS A 105
 None
 0.74A 1q23G-4fomA:
undetectable		 1q23G-4fomA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqz GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 VAL A  62
ALA A  63
HIS A 128
 None
 0.77A 1q23G-4fqzA:
undetectable		 1q23G-4fqzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		3 VAL A 257
ALA A 256
HIS A 360
 None
 0.50A 1q23G-4isyA:
undetectable		 1q23G-4isyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 VAL A 543
ALA A 542
HIS A 497
 None
 0.68A 1q23G-4jhzA:
undetectable		 1q23G-4jhzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knt MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07732
(Cu-oxidase_3) 		3 VAL A 289
ALA A 273
HIS A 227
 None
 0.76A 1q23G-4kntA:
undetectable		 1q23G-4kntA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		3 VAL B 206
ALA B 203
HIS B 240
 None
 0.73A 1q23G-4kvgB:
undetectable		 1q23G-4kvgB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		3 VAL A  67
ALA A  48
HIS A  43
 None
 0.55A 1q23G-4kvoA:
undetectable		 1q23G-4kvoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0k DRAIII

(Deinococcus
radiophilus) 		no annotation 3 VAL A 151
ALA A 152
HIS A 130
 None
 0.75A 1q23G-4l0kA:
undetectable		 1q23G-4l0kA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		3 VAL A 196
ALA A 197
HIS A 232
 None
 0.61A 1q23G-4lejA:
undetectable		 1q23G-4lejA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 VAL A 674
ALA A 675
HIS A 734
 None
 0.74A 1q23G-4wjlA:
undetectable		 1q23G-4wjlA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		3 VAL A 450
ALA A 449
HIS A 408
 None
 0.67A 1q23G-4yk6A:
undetectable		 1q23G-4yk6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		3 VAL A 253
ALA A 252
HIS A 204
 None
 0.55A 1q23G-5a5tA:
undetectable		 1q23G-5a5tA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		3 VAL A  91
ALA A  90
HIS A  97
 None
 0.64A 1q23G-5dpdA:
undetectable		 1q23G-5dpdA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm9 MAMO PROTEASE DOMAIN

(Magnetospirillum
magneticum) 		PF13365
(Trypsin_2) 		3 VAL A  42
ALA A  41
HIS A 119
 None
 0.53A 1q23G-5hm9A:
undetectable		 1q23G-5hm9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxz BARBITURASE

(Rhodococcus
erythropolis) 		PF09663
(Amido_AtzD_TrzD) 		3 VAL A 296
ALA A 363
HIS A 157
 None
 0.55A 1q23G-5hxzA:
undetectable		 1q23G-5hxzA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it6 GALECTIN-RELATED
PROTEIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		3 VAL A  47
ALA A  48
HIS A 113
 None
 0.69A 1q23G-5it6A:
undetectable		 1q23G-5it6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9o HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 VAL F  56
ALA F  57
HIS F  60
 None
 0.57A 1q23G-5k9oF:
undetectable		 1q23G-5k9oF:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE

(Enterobacter
cloacae) 		PF00724
(Oxidored_FMN) 		3 VAL A 167
ALA A 166
HIS A  75
 None
 0.62A 1q23G-5lgxA:
undetectable		 1q23G-5lgxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Chaetomium
thermophilum) 		PF01912
(eIF-6) 		3 VAL A 182
ALA A 183
HIS A 162
 None
 0.62A 1q23G-5m3qA:
undetectable		 1q23G-5m3qA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n77 MAGNESIUM TRANSPORT
PROTEIN CORA

(Escherichia
coli) 		PF01544
(CorA) 		3 VAL A  92
ALA A  93
HIS A  73
 None
 0.69A 1q23G-5n77A:
undetectable		 1q23G-5n77A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfb GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 VAL A 155
ALA A 156
HIS A 223
 None
 0.76A 1q23G-5nfbA:
undetectable		 1q23G-5nfbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 3 VAL A 869
ALA A 870
HIS A 872
 None
 0.70A 1q23G-5vhaA:
undetectable		 1q23G-5vhaA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  86
ALA A  87
HIS A 188
 None
 0.51A 1q23G-5vk4A:
undetectable		 1q23G-5vk4A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyq UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		3 VAL A  18
ALA A  15
HIS A  12
 None
 0.73A 1q23G-5vyqA:
undetectable		 1q23G-5vyqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT

(Oryctolagus
cuniculus) 		no annotation 3 VAL B 291
ALA B 290
HIS B 268
 None
 0.66A 1q23G-5w7aB:
undetectable		 1q23G-5w7aB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb6 UNCHARACTERIZED
PROTEIN YCJY

(Escherichia
coli) 		no annotation 3 VAL A 142
ALA A 118
HIS A  41
 None
 0.68A 1q23G-5xb6A:
undetectable		 1q23G-5xb6A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb PSAL

(Cyanidioschyzon
merolae) 		no annotation 3 VAL L 126
ALA L 125
HIS L  54
 None
None
BCR  L 205 (-3.9A)
 0.57A 1q23G-5zgbL:
undetectable		 1q23G-5zgbL:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aon DIHYDROLIPOYL
DEHYDROGENASE

(Bordetella
pertussis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 VAL A 340
ALA A 339
HIS A 350
 None
 0.57A 1q23G-6aonA:
undetectable		 1q23G-6aonA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar7 UNCHARACTERIZED
PROTEIN

(Burkholderia
thailandensis) 		PF07007
(LprI) 		3 VAL A 195
ALA A 196
HIS A 106
 None
 0.64A 1q23G-6ar7A:
undetectable		 1q23G-6ar7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 3 VAL A  69
ALA A  50
HIS A  45
 None
 0.63A 1q23G-6c9mA:
undetectable		 1q23G-6c9mA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus) 		no annotation 3 VAL A 218
ALA A 208
HIS A  41
 None
 0.77A 1q23G-6cv0A:
undetectable		 1q23G-6cv0A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 3 VAL A2314
ALA A2313
HIS A 892
 None
 0.75A 1q23G-6ez8A:
undetectable		 1q23G-6ez8A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 3 VAL B 280
ALA B 277
HIS B 274
 None
CLA  B1214 (-3.4A)
CLA  B1215 (-3.4A)
 0.74A 1q23G-6fosB:
undetectable		 1q23G-6fosB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 SER A 388
PHE A 392
LEU A 284
VAL A 286
VAL A 210
 None
 1.18A 1q23I-1c4kA:
3.3		 1q23I-1c4kA:
13.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.68A 1q23I-1ciaA:
32.2		 1q23I-1ciaA:
44.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 TYR A 131
PHE A 310
LEU A 298
PHE A 240
VAL A 313
 None
 1.14A 1q23I-1cvrA:
0.0		 1q23I-1cvrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdf SPHERULIN 3A

(Physarum
polycephalum) 		PF08964
(Crystall_3) 		5 THR A  56
LEU A  17
VAL A  47
PHE A  37
VAL A  30
 None
 1.31A 1q23I-1hdfA:
undetectable		 1q23I-1hdfA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A 172
PHE A  62
LEU A 300
VAL A  22
VAL A   8
 None
 1.17A 1q23I-1ml4A:
0.3		 1q23I-1ml4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE

(Pseudomonas
aeruginosa) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 THR A 136
PHE A 126
PHE A  52
LEU A  50
VAL A  74
 None
 1.33A 1q23I-1ortA:
0.0		 1q23I-1ortA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		11 THR A  93
SER A 104
TYR A 133
PHE A 134
PHE A 144
SER A 146
PHE A 156
LEU A 158
VAL A 160
PHE A 166
VAL A 170
 None
 0.48A 1q23I-1pd5A:
35.9		 1q23I-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		5 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.12A 1q23I-1pk6A:
0.0		 1q23I-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.43A 1q23I-1ptjA:
0.0		 1q23I-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 SER A  61
PHE A  40
LEU A 135
VAL A 313
VAL A 121
 None
 1.37A 1q23I-1rblA:
undetectable		 1q23I-1rblA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PHE A 213
LEU A 206
VAL A 195
PHE A 182
VAL A 210
 None
 1.28A 1q23I-1yzyA:
undetectable		 1q23I-1yzyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 SER A 258
TYR A 260
PHE A 256
PHE A 296
PHE A  48
 BME  A 316 ( 4.7A)
None
BME  A 316 (-4.7A)
None
BME  A 316 (-4.9A)
 1.11A 1q23I-1zswA:
undetectable		 1q23I-1zswA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.08A 1q23I-1zybA:
undetectable		 1q23I-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.37A 1q23I-2ag8A:
undetectable		 1q23I-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjs REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2)
no annotation 		5 THR C  98
PHE A  49
LEU A  60
VAL A  62
VAL A   6
 ZN  C 201 ( 4.7A)
None
None
None
None
 1.27A 1q23I-2cjsC:
undetectable		 1q23I-2cjsC:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		5 THR A 308
SER A 335
PHE A 199
LEU A  89
VAL A  88
 None
 1.39A 1q23I-2d7sA:
undetectable		 1q23I-2d7sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		5 SER A 470
TYR A 469
PHE A   5
PHE A  21
VAL A  28
 None
 1.29A 1q23I-2f6dA:
undetectable		 1q23I-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		5 SER A 470
TYR A 469
PHE A   5
SER A  29
PHE A  21
 None
 1.41A 1q23I-2f6dA:
undetectable		 1q23I-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		5 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.35A 1q23I-2fg5A:
undetectable		 1q23I-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs5 CONSERVED
HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF02622
(DUF179) 		5 THR A  94
LEU A  38
VAL A  50
PHE A 135
VAL A 165
 None
 1.24A 1q23I-2gs5A:
undetectable		 1q23I-2gs5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 407
PHE A 374
SER A 409
VAL A 360
VAL A 290
 None
 1.38A 1q23I-2htvA:
undetectable		 1q23I-2htvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF02671
(PAH) 		5 THR B 463
PHE B 468
LEU B 509
VAL B 505
PHE B 484
 None
 1.43A 1q23I-2ld7B:
undetectable		 1q23I-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 SER A 223
PHE A  89
LEU A 106
VAL A 212
VAL A 114
 None
 1.38A 1q23I-2pi5A:
undetectable		 1q23I-2pi5A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkh HISTIDINE
UTILIZATION
REPRESSOR

(Pseudomonas
syringae group
genomosp. 3) 		PF07702
(UTRA) 		5 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.96A 1q23I-2pkhA:
undetectable		 1q23I-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
 None
 1.42A 1q23I-2vdcA:
undetectable		 1q23I-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 390
SER A 391
LEU A 365
VAL A 512
VAL A 370
 TPP  A 600 (-3.1A)
None
None
None
None
 1.13A 1q23I-2vk4A:
undetectable		 1q23I-2vk4A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.16A 1q23I-2vp1A:
undetectable		 1q23I-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A

(Mycobacterium
tuberculosis) 		PF00977
(His_biosynth) 		5 SER A 200
PHE A  58
LEU A  54
VAL A  18
VAL A  52
 None
 1.44A 1q23I-2y89A:
undetectable		 1q23I-2y89A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 THR B 273
SER B 274
VAL B 121
PHE B 164
VAL B 212
 None
 1.33A 1q23I-2yevB:
undetectable		 1q23I-2yevB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 THR A 322
SER A 321
LEU A 402
VAL A 416
VAL A 319
 None
 1.41A 1q23I-3a0fA:
undetectable		 1q23I-3a0fA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 SER A 230
LEU A 225
VAL A 165
PHE A 112
VAL A 228
 None
 1.44A 1q23I-3a2qA:
undetectable		 1q23I-3a2qA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apu ALPHA-1-ACID
GLYCOPROTEIN 2

(Homo sapiens) 		PF00061
(Lipocalin) 		5 SER A 114
TYR A  37
PHE A  51
LEU A  79
VAL A  88
 None
 1.19A 1q23I-3apuA:
undetectable		 1q23I-3apuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		5 SER A 809
LEU A 803
VAL A 673
PHE A 671
VAL A 815
 None
 1.43A 1q23I-3bdlA:
undetectable		 1q23I-3bdlA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 THR A3042
SER A3041
SER A3044
LEU A3277
VAL A3323
 None
 1.36A 1q23I-3cmvA:
undetectable		 1q23I-3cmvA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.28A 1q23I-3dl1A:
undetectable		 1q23I-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 PHE A 274
PHE A 344
VAL A 329
PHE A 316
VAL A 342
 None
 1.34A 1q23I-3e38A:
undetectable		 1q23I-3e38A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.14A 1q23I-3e77A:
undetectable		 1q23I-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0o 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 SER A  56
PHE A  60
LEU A  67
VAL A  97
VAL A  87
 None
 1.38A 1q23I-3g0oA:
undetectable		 1q23I-3g0oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		5 THR A 249
PHE A 173
PHE A 199
SER A 250
VAL A 236
 None
 1.43A 1q23I-3h7nA:
undetectable		 1q23I-3h7nA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 THR B 447
PHE B 483
SER B 671
VAL B 248
VAL B 600
 None
 1.31A 1q23I-3hhsB:
undetectable		 1q23I-3hhsB:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.32A 1q23I-3i6sA:
undetectable		 1q23I-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 THR A1112
PHE A1212
PHE A1097
LEU A 985
VAL A 988
 None
 1.41A 1q23I-3jb9A:
undetectable		 1q23I-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.01A 1q23I-3mc2A:
undetectable		 1q23I-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhx PUTATIVE FERROUS
IRON TRANSPORT
PROTEIN A

(Stenotrophomonas
maltophilia) 		PF04023
(FeoA) 		5 PHE A  63
LEU A   3
VAL A  73
PHE A  35
VAL A  56
 None
 1.43A 1q23I-3mhxA:
undetectable		 1q23I-3mhxA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		5 PHE A 276
PHE A  66
LEU A  28
VAL A  35
VAL A  24
 None
 1.21A 1q23I-3n0vA:
undetectable		 1q23I-3n0vA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
 ATP  A 763 (-4.5A)
None
None
None
None
 1.16A 1q23I-3o8lA:
undetectable		 1q23I-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.35A 1q23I-3p91A:
undetectable		 1q23I-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		5 THR A  62
PHE A  89
LEU A 171
PHE A 163
VAL A 271
 PLM  A 702 (-3.7A)
PLM  A 702 ( 4.9A)
None
PLM  A 702 (-3.9A)
None
 1.42A 1q23I-3pl5A:
undetectable		 1q23I-3pl5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN

(Leishmania
infantum) 		PF00857
(Isochorismatase) 		5 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.26A 1q23I-3r2jA:
undetectable		 1q23I-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 SER A 228
TYR A 247
LEU A 178
VAL A 179
PHE A  83
 None
 1.23A 1q23I-3r4vA:
undetectable		 1q23I-3r4vA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd6 MLL3558 PROTEIN

(Mesorhizobium
loti) 		PF08327
(AHSA1) 		5 THR A  11
LEU A 107
VAL A  23
PHE A  27
VAL A 105
 None
 1.35A 1q23I-3rd6A:
3.2		 1q23I-3rd6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 SER N  84
PHE N 241
SER N  41
VAL J 153
VAL N  21
 None
 1.37A 1q23I-3rkoN:
undetectable		 1q23I-3rkoN:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
 None
 1.35A 1q23I-3tefA:
undetectable		 1q23I-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zph CHALCONE ISOMERASE

(Eubacterium
ramulus) 		no annotation 5 PHE A 221
PHE A 183
LEU A 182
PHE A 249
VAL A 186
 None
 1.21A 1q23I-3zphA:
undetectable		 1q23I-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		5 PHE A  91
PHE A 162
PHE A 211
VAL A 237
PHE A 139
 PEG  A1260 (-3.8A)
None
None
None
None
 1.32A 1q23I-4bptA:
undetectable		 1q23I-4bptA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.22A 1q23I-4cczA:
undetectable		 1q23I-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		5 PHE A 439
SER A 364
LEU A 451
VAL A 453
VAL A 366
 None
 1.28A 1q23I-4fwwA:
undetectable		 1q23I-4fwwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9s INHIBITOR OF G-TYPE
LYSOZYME

(Escherichia
coli) 		PF04151
(PPC) 		5 SER B  90
PHE B  54
LEU B 109
VAL B 111
VAL B  64
 None
 1.37A 1q23I-4g9sB:
undetectable		 1q23I-4g9sB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 TYR A   6
PHE A  11
PHE A 109
LEU A  71
VAL A 191
 None
 1.38A 1q23I-4go4A:
undetectable		 1q23I-4go4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 397
PHE A 434
PHE A 360
LEU A 421
VAL A 408
 None
 1.39A 1q23I-4i5jA:
undetectable		 1q23I-4i5jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.37A 1q23I-4itxA:
2.5		 1q23I-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jm0 PROTEIN UL141

(Human
betaherpesvirus
5) 		PF16758
(UL141) 		5 THR A  50
PHE A 157
LEU A 145
VAL A  77
VAL A  69
 None
 1.36A 1q23I-4jm0A:
undetectable		 1q23I-4jm0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD

(Mycobacterium
tuberculosis) 		PF02559
(CarD_CdnL_TRCF)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		5 THR A 138
LEU B  37
VAL B  19
PHE B   3
VAL B  58
 None
 1.28A 1q23I-4kbmA:
undetectable		 1q23I-4kbmA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 PHE A  43
LEU A  23
VAL A  25
PHE A 586
VAL A 502
 None
 1.13A 1q23I-4lnvA:
undetectable		 1q23I-4lnvA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.35A 1q23I-4mrmA:
undetectable		 1q23I-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 SER A 127
LEU A  81
VAL A 116
PHE A 111
VAL A  77
 None
 1.28A 1q23I-4od7A:
undetectable		 1q23I-4od7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1

(Homo sapiens) 		PF05014
(Nuc_deoxyrib_tr) 		5 PHE A  25
PHE A  49
LEU A 154
VAL A 150
VAL A  91
 None
 1.36A 1q23I-4p5eA:
undetectable		 1q23I-4p5eA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 5 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.21A 1q23I-4qt8B:
undetectable		 1q23I-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY

(Acinetobacter
baumannii) 		PF05638
(T6SS_HCP) 		5 THR A 115
PHE A 128
VAL A  14
PHE A   8
VAL A 111
 None
 1.30A 1q23I-4w64A:
undetectable		 1q23I-4w64A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 SER A 214
LEU A 158
VAL A 237
PHE A 240
VAL A 153
 None
 1.40A 1q23I-4wb7A:
undetectable		 1q23I-4wb7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 SER A 194
PHE A  56
LEU A  52
VAL A  16
VAL A  50
 PO4  A 303 ( 4.2A)
None
None
None
PO4  A 303 (-4.7A)
 1.37A 1q23I-4x2rA:
undetectable		 1q23I-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 THR A 164
SER A 194
PHE A  56
LEU A  52
VAL A  16
 None
PO4  A 303 ( 4.2A)
None
None
None
 1.43A 1q23I-4x2rA:
undetectable		 1q23I-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 SER A   5
PHE A 165
VAL A  20
PHE A  38
VAL A  29
 None
 1.35A 1q23I-4y9wA:
undetectable		 1q23I-4y9wA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 THR C  72
SER C  71
PHE C 297
SER C 280
LEU C 290
 None
 1.28A 1q23I-4yfaC:
undetectable		 1q23I-4yfaC:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 PHE A1077
PHE A 878
PHE A 976
VAL A1121
VAL A 877
 None
 1.24A 1q23I-5aorA:
undetectable		 1q23I-5aorA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 THR A 274
SER A 273
PHE A 499
SER A 482
LEU A 492
 None
 1.26A 1q23I-5c9iA:
undetectable		 1q23I-5c9iA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK

(Pseudomonas
putida) 		no annotation 5 THR A 166
PHE A 168
PHE A 263
VAL A 259
VAL A  92
 None
 1.33A 1q23I-5d2jA:
undetectable		 1q23I-5d2jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 THR A 124
PHE A 297
PHE A 243
LEU A  46
VAL A 225
 None
 1.24A 1q23I-5df0A:
undetectable		 1q23I-5df0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.25A 1q23I-5gkvA:
undetectable		 1q23I-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.24A 1q23I-5hdiA:
undetectable		 1q23I-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 SER A  58
LEU A  64
VAL A 108
PHE A  24
VAL A  56
 None
 1.14A 1q23I-5hkjA:
undetectable		 1q23I-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 THR A 366
SER A 229
VAL A  97
PHE A 265
VAL A 194
 None
 1.23A 1q23I-5hkjA:
undetectable		 1q23I-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 PHE A 749
PHE A 598
LEU A 640
VAL A 642
VAL A 636
 None
 1.38A 1q23I-5ikpA:
undetectable		 1q23I-5ikpA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		5 SER A 834
LEU A 828
VAL A 698
PHE A 696
VAL A 840
 None
 1.40A 1q23I-5m9oA:
undetectable		 1q23I-5m9oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		5 PHE C 552
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.28A 1q23I-5mioC:
undetectable		 1q23I-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		5 SER C 551
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.34A 1q23I-5mioC:
undetectable		 1q23I-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 PHE A 383
PHE A 455
LEU A 420
VAL A 422
VAL A 407
 None
 1.31A 1q23I-5mqpA:
undetectable		 1q23I-5mqpA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ola TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 THR A 332
LEU A 344
VAL A 191
PHE A 317
VAL A 300
 None
 1.40A 1q23I-5olaA:
undetectable		 1q23I-5olaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.30A 1q23I-5oltA:
undetectable		 1q23I-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		5 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.24A 1q23I-5t2kA:
undetectable		 1q23I-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 SER A  79
LEU A 104
VAL A  51
PHE A  36
VAL A 100
 None
 1.21A 1q23I-5ti1A:
undetectable		 1q23I-5ti1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Mycobacterium
tuberculosis) 		no annotation 5 PHE A 105
LEU A  62
VAL A  87
PHE A  79
VAL A  58
 NAP  A 304 (-4.6A)
None
None
None
None
 1.38A 1q23I-5tjzA:
undetectable		 1q23I-5tjzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umw GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE

(Streptomyces
sp. CB03234) 		no annotation 5 PHE A 120
SER A 124
LEU A  56
VAL A  44
VAL A  10
 None
 1.25A 1q23I-5umwA:
undetectable		 1q23I-5umwA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 5 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.21A 1q23I-5z5kA:
undetectable		 1q23I-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdh TYPE II SECRETION
SYSTEM LIPOPROTEIN

(Escherichia
coli) 		no annotation 5 THR P  88
TYR P  65
PHE P  61
LEU P  23
VAL P  33
 None
 1.34A 1q23I-5zdhP:
undetectable		 1q23I-5zdhP:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 SER A 870
LEU A 962
VAL A 965
PHE A1304
VAL A1308
 None
 1.37A 1q23I-6a91A:
undetectable		 1q23I-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1

(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		no annotation 5 PHE A 195
SER A 121
LEU A 202
VAL A 214
VAL A 197
 None
 1.34A 1q23I-6ap1A:
undetectable		 1q23I-6ap1A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.31A 1q23I-6cajC:
undetectable		 1q23I-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 5 SER A 388
PHE A 333
LEU A 367
VAL A 383
VAL A 363
 None
 1.34A 1q23I-6f72A:
undetectable		 1q23I-6f72A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.32A 1q23I-6gl3A:
undetectable		 1q23I-6gl3A:
undetectable