SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_H_FUAH709_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 SER A 266
LEU A  73
VAL A  96
VAL A  49
ALA A 274
 None
 1.04A 1q23H-1bjwA:
1.1
1q23I-1bjwA:
1.5		 1q23H-1bjwA:
21.17
1q23I-1bjwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 PHE A 115
PHE A 270
VAL A 277
ALA A 232
HIS A 109
 None
C2O  A 500 ( 4.8A)
None
None
C2O  A 500 ( 3.3A)
 1.24A 1q23H-1bt2A:
0.0
1q23I-1bt2A:
0.0		 1q23H-1bt2A:
19.57
1q23I-1bt2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 TYR A 131
PHE A 310
LEU A 298
PHE A 240
VAL A 313
 None
 1.10A 1q23H-1cvrA:
0.3
1q23I-1cvrA:
0.0		 1q23H-1cvrA:
19.55
1q23I-1cvrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 THR A 218
LEU A 223
PHE A 260
VAL A 192
ALA A 212
 None
 1.24A 1q23H-1g0vA:
0.0
1q23I-1g0vA:
undetectable		 1q23H-1g0vA:
20.71
1q23I-1g0vA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1heh ENDO-1,4-BETA-XYLANA
SE D

(Cellulomonas
fimi) 		no annotation 5 LEU C 590
PHE C 624
VAL C 588
VAL C 565
ALA C 564
 None
 1.12A 1q23H-1hehC:
undetectable
1q23I-1hehC:
undetectable		 1q23H-1hehC:
15.09
1q23I-1hehC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		5 LEU A  89
VAL A 165
PHE A 161
VAL A 102
HIS A  62
 None
 1.16A 1q23H-1iduA:
0.0
1q23I-1iduA:
0.0		 1q23H-1iduA:
15.61
1q23I-1iduA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		5 SER A 262
PHE A  58
LEU A  55
VAL A 221
HIS A 211
 None
None
None
None
ZN  A 501 ( 3.4A)
 1.19A 1q23H-1krmA:
undetectable
1q23I-1krmA:
0.0		 1q23H-1krmA:
18.82
1q23I-1krmA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 LEU A 402
VAL A 443
PHE A 295
VAL A 427
VAL A 303
 None
 1.24A 1q23H-1kwgA:
0.0
1q23I-1kwgA:
0.0		 1q23H-1kwgA:
15.04
1q23I-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		5 SER A  19
LEU A  22
VAL A  69
PHE A  63
ALA A  71
 None
 1.21A 1q23H-1musA:
0.0
1q23I-1musA:
0.9		 1q23H-1musA:
16.87
1q23I-1musA:
16.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		9 THR A  93
TYR A 133
PHE A 144
SER A 146
PHE A 156
LEU A 158
VAL A 160
PHE A 166
VAL A 170
 None
 0.47A 1q23H-1pd5A:
36.5
1q23I-1pd5A:
35.9		 1q23H-1pd5A:
100.00
1q23I-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		5 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.09A 1q23H-1pk6A:
undetectable
1q23I-1pk6A:
undetectable		 1q23H-1pk6A:
18.54
1q23I-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxl SEX-LETHAL PROTEIN
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		5 LEU A  87
VAL A  78
PHE A  34
VAL A  60
ALA A  74
 None
 1.19A 1q23H-1sxlA:
undetectable
1q23I-1sxlA:
undetectable		 1q23H-1sxlA:
17.94
1q23I-1sxlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 THR A 171
SER A 201
LEU A 224
VAL A 199
ALA A 187
 None
 1.23A 1q23H-1u08A:
undetectable
1q23I-1u08A:
undetectable		 1q23H-1u08A:
20.78
1q23I-1u08A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PHE A 213
LEU A 206
VAL A 195
PHE A 182
VAL A 210
 None
 1.22A 1q23H-1yzyA:
undetectable
1q23I-1yzyA:
undetectable		 1q23H-1yzyA:
20.24
1q23I-1yzyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.07A 1q23H-1zybA:
undetectable
1q23I-1zybA:
undetectable		 1q23H-1zybA:
23.32
1q23I-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		6 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
VAL A  84
 None
 1.39A 1q23H-2ag8A:
undetectable
1q23I-2ag8A:
undetectable		 1q23H-2ag8A:
18.98
1q23I-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 PHE B 114
SER B 113
LEU B  89
VAL B  46
VAL B  72
 None
 1.15A 1q23H-2amcB:
3.3
1q23I-2amcB:
3.4		 1q23H-2amcB:
13.12
1q23I-2amcB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1) 		5 PHE A 286
LEU A 303
PHE A 281
VAL A 310
ALA A 271
 None
 1.09A 1q23H-2bfwA:
undetectable
1q23I-2bfwA:
undetectable		 1q23H-2bfwA:
19.21
1q23I-2bfwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00121
(TIM) 		5 LEU A  58
VAL A  39
PHE A 242
VAL A  29
ALA A   6
 None
 1.17A 1q23H-2btmA:
undetectable
1q23I-2btmA:
undetectable		 1q23H-2btmA:
20.23
1q23I-2btmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eix NADH-CYTOCHROME B5
REDUCTASE

(Physarum
polycephalum) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A  44
VAL A  78
PHE A 113
VAL A 140
VAL A 104
 None
 1.20A 1q23H-2eixA:
undetectable
1q23I-2eixA:
undetectable		 1q23H-2eixA:
20.75
1q23I-2eixA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eng ENDOGLUCANASE V

(Humicola
insolens) 		PF02015
(Glyco_hydro_45) 		5 PHE A  72
LEU A  70
VAL A  64
PHE A  68
VAL A 105
 None
 1.23A 1q23H-2engA:
undetectable
1q23I-2engA:
undetectable		 1q23H-2engA:
20.50
1q23I-2engA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		5 PHE A  56
LEU A  10
VAL A  82
VAL A 112
ALA A  80
 None
 1.24A 1q23H-2fg5A:
undetectable
1q23I-2fg5A:
undetectable		 1q23H-2fg5A:
17.33
1q23I-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwx ZUOTIN

(Saccharomyces
cerevisiae) 		PF16717
(RAC_head) 		5 PHE A 368
LEU A 411
VAL A 381
VAL A 394
ALA A 397
 None
 1.21A 1q23H-2lwxA:
undetectable
1q23I-2lwxA:
undetectable		 1q23H-2lwxA:
21.03
1q23I-2lwxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8q PREDICTED PROTEIN

(Chlamydomonas
reinhardtii) 		PF01722
(BolA) 		5 SER A 103
PHE A  77
LEU A  79
VAL A  81
ALA A  42
 None
 1.24A 1q23H-2n8qA:
undetectable
1q23I-2n8qA:
undetectable		 1q23H-2n8qA:
20.83
1q23I-2n8qA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqt HYPOTHETICAL PROTEIN
SPY0176

(Streptococcus
pyogenes) 		PF00359
(PTS_EIIA_2) 		5 PHE A  91
LEU A  85
VAL A  89
VAL A  30
ALA A  29
 None
 1.15A 1q23H-2oqtA:
undetectable
1q23I-2oqtA:
undetectable		 1q23H-2oqtA:
18.50
1q23I-2oqtA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkh HISTIDINE
UTILIZATION
REPRESSOR

(Pseudomonas
syringae group
genomosp. 3) 		PF07702
(UTRA) 		5 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.93A 1q23H-2pkhA:
undetectable
1q23I-2pkhA:
undetectable		 1q23H-2pkhA:
18.26
1q23I-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		6 PHE A 393
LEU A 385
VAL A 330
PHE A 382
VAL A 390
ALA A 263
 None
 1.36A 1q23H-2q8nA:
undetectable
1q23I-2q8nA:
undetectable		 1q23H-2q8nA:
16.02
1q23I-2q8nA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsu P-HYDROXYCINNAMOYL
COA HYDRATASE/LYASE

(Pseudomonas
fluorescens) 		PF00378
(ECH_1) 		5 THR C 201
LEU C 125
PHE C 139
VAL C 113
ALA C 183
 None
 1.14A 1q23H-2vsuC:
undetectable
1q23I-2vsuC:
undetectable		 1q23H-2vsuC:
19.13
1q23I-2vsuC:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcu PROTEIN FUCU HOMOLOG

(Mus musculus) 		PF05025
(RbsD_FucU) 		5 LEU A  30
VAL A 130
VAL A  62
VAL A  46
ALA A 128
 None
 1.02A 1q23H-2wcuA:
undetectable
1q23I-2wcuA:
undetectable		 1q23H-2wcuA:
20.26
1q23I-2wcuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 SER A 510
PHE A 406
VAL A 512
VAL A 529
ALA A 537
 None
 1.15A 1q23H-3aiiA:
undetectable
1q23I-3aiiA:
undetectable		 1q23H-3aiiA:
16.57
1q23I-3aiiA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5c RAS-LIKE PROTEIN 12

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A 132
VAL A 175
PHE A 176
VAL A 180
ALA A 179
 None
 1.22A 1q23H-3c5cA:
undetectable
1q23I-3c5cA:
undetectable		 1q23H-3c5cA:
21.19
1q23I-3c5cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570

(Thermotoga
maritima) 		PF09936
(Methyltrn_RNA_4) 		5 THR X  24
LEU X 140
VAL X   7
VAL X 172
VAL X  85
 None
SAM  X5452 (-4.5A)
None
SAM  X5452 (-3.7A)
None
 1.21A 1q23H-3dcmX:
undetectable
1q23I-3dcmX:
undetectable		 1q23H-3dcmX:
23.25
1q23I-3dcmX:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.22A 1q23H-3dl1A:
undetectable
1q23I-3dl1A:
undetectable		 1q23H-3dl1A:
21.03
1q23I-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0k UPF0200 PROTEIN
SSO1041

(Sulfolobus
solfataricus) 		PF13238
(AAA_18) 		6 LEU A 106
VAL A  77
PHE A  90
VAL A  10
VAL A  72
ALA A  73
 None
 1.44A 1q23H-3h0kA:
undetectable
1q23I-3h0kA:
undetectable		 1q23H-3h0kA:
18.64
1q23I-3h0kA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 5 SER B 216
LEU B 162
VAL B 170
VAL B 220
ALA B 143
 None
 1.25A 1q23H-3h4jB:
undetectable
1q23I-3h4jB:
undetectable		 1q23H-3h4jB:
18.86
1q23I-3h4jB:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A 299
SER A  55
LEU A 331
VAL A  35
HIS A 305
 None
 1.23A 1q23H-3i6tA:
undetectable
1q23I-3i6tA:
undetectable		 1q23H-3i6tA:
19.37
1q23I-3i6tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 PHE A 192
VAL A   9
PHE A  51
VAL A  20
ALA A   7
 None
 1.06A 1q23H-3i8bA:
undetectable
1q23I-3i8bA:
undetectable		 1q23H-3i8bA:
19.19
1q23I-3i8bA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ios DISULFIDE BOND
FORMING PROTEIN
(DSBF)

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 LEU A 170
VAL A 174
PHE A 103
VAL A  91
VAL A 152
 None
 1.20A 1q23H-3iosA:
undetectable
1q23I-3iosA:
undetectable		 1q23H-3iosA:
21.92
1q23I-3iosA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktn CARBOHYDRATE KINASE,
PFKB FAMILY

(Enterococcus
faecalis) 		PF00294
(PfkB) 		5 PHE A 236
LEU A 189
PHE A 166
VAL A 195
VAL A 203
 None
 1.10A 1q23H-3ktnA:
undetectable
1q23I-3ktnA:
undetectable		 1q23H-3ktnA:
20.22
1q23I-3ktnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 PHE A 286
LEU A 303
PHE A 281
VAL A 310
ALA A 271
 None
 1.19A 1q23H-3l01A:
undetectable
1q23I-3l01A:
undetectable		 1q23H-3l01A:
18.25
1q23I-3l01A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 0.96A 1q23H-3mc2A:
undetectable
1q23I-3mc2A:
undetectable		 1q23H-3mc2A:
14.91
1q23I-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meq ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Brucella suis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 164
SER A 264
VAL A 198
VAL A 215
ALA A 196
 None
 1.16A 1q23H-3meqA:
undetectable
1q23I-3meqA:
undetectable		 1q23H-3meqA:
20.11
1q23I-3meqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxq SENSOR PROTEIN

(Vibrio cholerae) 		PF08448
(PAS_4) 		5 SER A  37
LEU A  87
PHE A  55
VAL A  39
VAL A  22
 None
 1.22A 1q23H-3mxqA:
undetectable
1q23I-3mxqA:
undetectable		 1q23H-3mxqA:
20.18
1q23I-3mxqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4p TERMINASE SUBUNIT
UL89 PROTEIN

(Human
betaherpesvirus
5) 		PF02499
(DNA_pack_C) 		5 THR A 445
LEU A 458
VAL A 460
VAL A 519
VAL A 656
 None
 0.99A 1q23H-3n4pA:
undetectable
1q23I-3n4pA:
undetectable		 1q23H-3n4pA:
21.36
1q23I-3n4pA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqi PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		no annotation 5 SER A 133
VAL A  36
PHE A 212
VAL A 135
ALA A  34
 None
None
PEG  A 329 (-4.8A)
None
None
 1.17A 1q23H-3nqiA:
undetectable
1q23I-3nqiA:
undetectable		 1q23H-3nqiA:
18.15
1q23I-3nqiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
 ATP  A 763 (-4.5A)
None
None
None
None
 1.13A 1q23H-3o8lA:
undetectable
1q23I-3o8lA:
undetectable		 1q23H-3o8lA:
15.81
1q23I-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		5 THR A 313
PHE A 273
LEU A 269
VAL A 335
ALA A 338
 None
 1.23A 1q23H-3pj0A:
1.9
1q23I-3pj0A:
1.6		 1q23H-3pj0A:
21.88
1q23I-3pj0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN

(Leishmania
infantum) 		PF00857
(Isochorismatase) 		5 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.25A 1q23H-3r2jA:
undetectable
1q23I-3r2jA:
undetectable		 1q23H-3r2jA:
20.00
1q23I-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 PHE A1122
SER A1118
VAL A 659
PHE A 691
VAL A 727
 None
 1.16A 1q23H-3s5kA:
undetectable
1q23I-3s5kA:
undetectable		 1q23H-3s5kA:
9.21
1q23I-3s5kA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 THR A 525
PHE A 520
LEU A 413
VAL A 449
VAL A 517
 None
 1.24A 1q23H-3ua4A:
undetectable
1q23I-3ua4A:
undetectable		 1q23H-3ua4A:
14.77
1q23I-3ua4A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		5 SER A   6
LEU A  18
VAL A  85
VAL A 107
ALA A  83
 None
 1.13A 1q23H-3v48A:
undetectable
1q23I-3v48A:
undetectable		 1q23H-3v48A:
19.08
1q23I-3v48A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 LEU A 341
VAL A 373
PHE A 304
VAL A 293
HIS A 279
 None
 1.21A 1q23H-3v7nA:
undetectable
1q23I-3v7nA:
undetectable		 1q23H-3v7nA:
18.48
1q23I-3v7nA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphingomonas
wittichii) 		PF00903
(Glyoxalase) 		5 LEU A 148
PHE A  11
VAL A 207
ALA A  64
HIS A 115
 None
 1.22A 1q23H-3vb0A:
undetectable
1q23I-3vb0A:
undetectable		 1q23H-3vb0A:
21.78
1q23I-3vb0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 PHE A 245
LEU A 188
VAL A 193
VAL A 220
ALA A 271
 None
None
None
B12  A 800 (-4.8A)
None
 1.09A 1q23H-3whpA:
undetectable
1q23I-3whpA:
undetectable		 1q23H-3whpA:
20.27
1q23I-3whpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 PHE A 222
LEU A 236
PHE A 295
VAL A 245
ALA A 288
 None
 1.24A 1q23H-3wv6A:
undetectable
1q23I-3wv6A:
undetectable		 1q23H-3wv6A:
20.20
1q23I-3wv6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		5 LEU A 399
VAL A 365
PHE A 422
VAL A 424
VAL A 388
 None
 1.23A 1q23H-3x0uA:
undetectable
1q23I-3x0uA:
undetectable		 1q23H-3x0uA:
20.67
1q23I-3x0uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		5 LEU A 189
VAL A 148
PHE A 153
VAL A 194
VAL A 102
 None
 1.23A 1q23H-4cn8A:
undetectable
1q23I-4cn8A:
undetectable		 1q23H-4cn8A:
19.55
1q23I-4cn8A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 PHE A 372
LEU A 425
VAL A 424
PHE A  35
VAL A  43
 None
 1.14A 1q23H-4ex4A:
undetectable
1q23I-4ex4A:
undetectable		 1q23H-4ex4A:
14.27
1q23I-4ex4A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fei HEAT SHOCK
PROTEIN-RELATED
PROTEIN

(Deinococcus
radiodurans) 		PF00011
(HSP20) 		5 PHE A 114
LEU A  86
VAL A  88
VAL A 134
ALA A  78
 None
 1.25A 1q23H-4feiA:
undetectable
1q23I-4feiA:
undetectable		 1q23H-4feiA:
18.92
1q23I-4feiA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 TYR A 150
LEU A 232
VAL A 142
VAL A 228
HIS A 243
 EDO  A 302 ( 4.2A)
None
None
None
EDO  A 304 ( 3.9A)
 1.18A 1q23H-4j2hA:
undetectable
1q23I-4j2hA:
undetectable		 1q23H-4j2hA:
23.36
1q23I-4j2hA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knt MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07732
(Cu-oxidase_3) 		5 LEU A 226
PHE A 184
VAL A 289
ALA A 273
HIS A 227
 None
 1.21A 1q23H-4kntA:
undetectable
1q23I-4kntA:
undetectable		 1q23H-4kntA:
21.50
1q23I-4kntA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 PHE A  43
LEU A  23
VAL A  25
PHE A 586
VAL A 502
 None
 1.17A 1q23H-4lnvA:
undetectable
1q23I-4lnvA:
undetectable		 1q23H-4lnvA:
9.23
1q23I-4lnvA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 SER A 275
LEU A 189
VAL A 211
VAL A 216
ALA A 215
 SCY  A 112 ( 3.3A)
COA  A 401 (-4.2A)
COA  A 401 (-3.9A)
None
None
 1.20A 1q23H-4nhdA:
undetectable
1q23I-4nhdA:
undetectable		 1q23H-4nhdA:
21.97
1q23I-4nhdA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 SER A 127
LEU A  81
VAL A 116
PHE A 111
VAL A  77
 None
 1.23A 1q23H-4od7A:
undetectable
1q23I-4od7A:
undetectable		 1q23H-4od7A:
24.44
1q23I-4od7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 SER A 127
LEU A  81
VAL A 116
VAL A  77
ALA A 118
 None
 1.02A 1q23H-4od7A:
undetectable
1q23I-4od7A:
undetectable		 1q23H-4od7A:
24.44
1q23I-4od7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 SER B 134
LEU B 141
PHE B 167
VAL B 190
ALA B 203
 None
 1.20A 1q23H-4ourB:
undetectable
1q23I-4ourB:
undetectable		 1q23H-4ourB:
16.88
1q23I-4ourB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		5 PHE A 285
LEU A 281
VAL A 279
VAL A  20
ALA A 319
 None
 1.20A 1q23H-4p0fA:
undetectable
1q23I-4p0fA:
undetectable		 1q23H-4p0fA:
18.39
1q23I-4p0fA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 LEU A 709
PHE A 664
VAL A 694
VAL A 730
ALA A 653
 None
 1.16A 1q23H-4q73A:
undetectable
1q23I-4q73A:
undetectable		 1q23H-4q73A:
11.97
1q23I-4q73A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 5 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.19A 1q23H-4qt8B:
undetectable
1q23I-4qt8B:
undetectable		 1q23H-4qt8B:
13.64
1q23I-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 PHE A1069
LEU A1086
PHE A1064
VAL A1093
ALA A1054
 None
 1.05A 1q23H-4s0vA:
undetectable
1q23I-4s0vA:
undetectable		 1q23H-4s0vA:
15.41
1q23I-4s0vA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING

(Xanthobacter
autotrophicus) 		PF02826
(2-Hacid_dh_C) 		5 VAL A  51
PHE A  67
VAL A  44
VAL A  73
ALA A  54
 None
 1.10A 1q23H-4xa8A:
undetectable
1q23I-4xa8A:
undetectable		 1q23H-4xa8A:
21.04
1q23I-4xa8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe3 CYTOCHROME P-450

(Streptomyces
antibioticus) 		PF00067
(p450) 		5 LEU A 306
VAL A  64
VAL A  40
VAL A 299
ALA A 300
 None
 1.14A 1q23H-4xe3A:
undetectable
1q23I-4xe3A:
undetectable		 1q23H-4xe3A:
19.01
1q23I-4xe3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		5 THR A  31
LEU A 149
VAL A  99
VAL A  46
ALA A  47
 None
 1.12A 1q23H-4ynzA:
undetectable
1q23I-4ynzA:
undetectable		 1q23H-4ynzA:
18.16
1q23I-4ynzA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		5 SER A 155
LEU A 208
VAL A 227
VAL A 166
ALA A 201
 None
 1.02A 1q23H-4yslA:
undetectable
1q23I-4yslA:
undetectable		 1q23H-4yslA:
18.67
1q23I-4yslA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 PHE A 495
SER A 496
LEU A 396
VAL A 505
ALA A 403
 None
 1.17A 1q23H-4zdkA:
undetectable
1q23I-4zdkA:
undetectable		 1q23H-4zdkA:
15.53
1q23I-4zdkA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 PHE A1069
LEU A1086
PHE A1064
VAL A1093
ALA A1054
 None
 1.13A 1q23H-4zj8A:
undetectable
1q23I-4zj8A:
undetectable		 1q23H-4zj8A:
16.07
1q23I-4zj8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 PHE A 286
LEU A 267
VAL A 307
PHE A 334
ALA A 309
 None
 1.22A 1q23H-5d6nA:
undetectable
1q23I-5d6nA:
undetectable		 1q23H-5d6nA:
15.98
1q23I-5d6nA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhm IMMUNOREACTIVE 32
KDA ANTIGEN

(Porphyromonas
gingivalis) 		no annotation 5 THR C  87
LEU C  68
VAL C 116
VAL C 100
ALA C 118
 None
 0.94A 1q23H-5dhmC:
undetectable
1q23I-5dhmC:
undetectable		 1q23H-5dhmC:
22.30
1q23I-5dhmC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f07 PUTATIVE GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 SER A  37
VAL A  54
VAL A  12
ALA A  11
HIS A  32
 None
GSH  A 301 (-3.8A)
GSH  A 301 (-4.3A)
GSH  A 301 ( 4.4A)
None
 1.24A 1q23H-5f07A:
undetectable
1q23I-5f07A:
undetectable		 1q23H-5f07A:
20.55
1q23I-5f07A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		5 LEU A  61
VAL A  67
PHE A  75
VAL A  59
VAL A  31
 None
 1.25A 1q23H-5fclA:
undetectable
1q23I-5fclA:
undetectable		 1q23H-5fclA:
20.54
1q23I-5fclA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 SER A  58
LEU A  64
VAL A 108
PHE A  24
VAL A  56
 None
 1.11A 1q23H-5hkjA:
undetectable
1q23I-5hkjA:
undetectable		 1q23H-5hkjA:
20.76
1q23I-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		5 TYR C1625
LEU C1675
PHE C1643
VAL C1669
VAL C1629
 None
 1.12A 1q23H-5jpnC:
undetectable
1q23I-5jpnC:
undetectable		 1q23H-5jpnC:
20.27
1q23I-5jpnC:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 TYR A  54
LEU A 362
VAL A 394
VAL A 294
ALA A  43
 None
 1.13A 1q23H-5kp7A:
undetectable
1q23I-5kp7A:
undetectable		 1q23H-5kp7A:
19.29
1q23I-5kp7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1

(Sorangium
cellulosum) 		PF00067
(p450) 		5 THR A 283
PHE A 114
LEU A 330
PHE A  88
VAL A 213
 GOL  A 502 (-4.0A)
None
None
None
None
 1.21A 1q23H-5livA:
undetectable
1q23I-5livA:
undetectable		 1q23H-5livA:
19.12
1q23I-5livA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 THR A 296
LEU A 289
PHE A 100
VAL A 292
ALA A 311
 None
 1.05A 1q23H-5n28A:
undetectable
1q23I-5n28A:
undetectable		 1q23H-5n28A:
16.64
1q23I-5n28A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 PHE B 479
LEU B 483
PHE B 423
VAL B 232
VAL B 554
 None
 1.19A 1q23H-5nd1B:
undetectable
1q23I-5nd1B:
undetectable		 1q23H-5nd1B:
16.67
1q23I-5nd1B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 5 PHE A 529
LEU A  25
PHE A 295
VAL A 526
HIS A   7
 None
 1.15A 1q23H-5odoA:
undetectable
1q23I-5odoA:
undetectable		 1q23H-5odoA:
18.06
1q23I-5odoA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 6 PHE A 419
VAL A 508
PHE A 514
VAL A 502
VAL A 481
HIS A 423
 None
 1.48A 1q23H-5ot1A:
undetectable
1q23I-5ot1A:
undetectable		 1q23H-5ot1A:
17.56
1q23I-5ot1A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td6 FOG-3 PROTEIN

(Caenorhabditis
elegans) 		PF07742
(BTG) 		5 LEU A  84
VAL A  80
PHE A  28
VAL A  12
ALA A  67
 None
 1.06A 1q23H-5td6A:
undetectable
1q23I-5td6A:
undetectable		 1q23H-5td6A:
19.82
1q23I-5td6A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 PHE A1069
LEU A1086
PHE A1064
VAL A1093
ALA A1054
 None
 1.09A 1q23H-5u09A:
undetectable
1q23I-5u09A:
undetectable		 1q23H-5u09A:
17.13
1q23I-5u09A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8l PGT145 ANTIBODY,
LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 THR N  72
SER N  22
LEU N  11
VAL N  13
ALA N  18
 None
 1.21A 1q23H-5v8lN:
undetectable
1q23I-5v8lN:
undetectable		 1q23H-5v8lN:
21.29
1q23I-5v8lN:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Human
betaherpesvirus
5;
Lama glama) 		no annotation 5 PHE A 197
PHE A 116
LEU A 119
PHE A 237
ALA A 280
 None
 1.18A 1q23H-5wb1A:
undetectable
1q23I-5wb1A:
undetectable		 1q23H-5wb1A:
17.59
1q23I-5wb1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 PHE A 729
LEU A 751
VAL A 764
VAL A 718
ALA A 831
 EDO  A1802 (-3.7A)
None
None
None
None
 1.09A 1q23H-5x7sA:
undetectable
1q23I-5x7sA:
undetectable		 1q23H-5x7sA:
8.99
1q23I-5x7sA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc3 PROBABLE RAB-RELATED
GTPASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 THR A 111
SER A  79
LEU A  10
PHE A 161
VAL A 147
 None
 1.22A 1q23H-5xc3A:
undetectable
1q23I-5xc3A:
undetectable		 1q23H-5xc3A:
24.77
1q23I-5xc3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL

(Homo sapiens) 		PF01257
(2Fe-2S_thioredx)
PF04800
(ETC_C1_NDUFA4) 		5 THR L 174
LEU O  83
VAL O  82
VAL O 112
VAL O  67
 None
 1.22A 1q23H-5xtbL:
undetectable
1q23I-5xtbL:
undetectable		 1q23H-5xtbL:
21.11
1q23I-5xtbL:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 5 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.19A 1q23H-5z5kA:
undetectable
1q23I-5z5kA:
undetectable		 1q23H-5z5kA:
15.46
1q23I-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 5 THR A  83
LEU A  47
VAL A  44
VAL A 113
ALA A  40
 None
 1.11A 1q23H-6arrA:
undetectable
1q23I-6arrA:
undetectable		 1q23H-6arrA:
13.76
1q23I-6arrA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0t FASCIN

(Homo sapiens) 		no annotation 5 LEU A 363
VAL A 273
PHE A 376
VAL A 355
VAL A 263
 None
 1.21A 1q23H-6b0tA:
undetectable
1q23I-6b0tA:
undetectable		 1q23H-6b0tA:
14.03
1q23I-6b0tA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA

(Escherichia
coli) 		no annotation 5 SER A  11
PHE A  34
VAL A  30
PHE A   3
ALA A  44
 None
 1.20A 1q23H-6bogA:
undetectable
1q23I-6bogA:
undetectable		 1q23H-6bogA:
15.45
1q23I-6bogA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f85 CYTOCHROME P450
CYP260A1

(Sorangium
cellulosum) 		no annotation 5 PHE A  64
LEU A 280
PHE A  38
VAL A 163
ALA A 303
 None
 1.25A 1q23H-6f85A:
undetectable
1q23I-6f85A:
undetectable		 1q23H-6f85A:
17.35
1q23I-6f85A:
17.35