SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_G_FUAG708_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1akp | APOKEDARCIDIN (actinomyceteATCC 53650) |
PF00960(Neocarzinostat) | 3 | VAL A 99ALA A 34HIS A 53 | None | 0.75A | 1q23H-1akpA:undetectable | 1q23H-1akpA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cli | PROTEIN(PHOSPHORIBOSYL-AMINOIMIDAZOLESYNTHETASE) (Escherichiacoli) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | VAL A 88ALA A 89HIS A 190 | None | 0.51A | 1q23H-1cliA:0.0 | 1q23H-1cliA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ey2 | HOMOGENTISATE1,2-DIOXYGENASE (Homo sapiens) |
PF04209(HgmA) | 3 | VAL A 266ALA A 267HIS A 269 | None | 0.71A | 1q23H-1ey2A:0.0 | 1q23H-1ey2A:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f1e | HISTONE FOLD PROTEIN (Methanopyruskandleri) |
PF00808(CBFD_NFYB_HMF) | 3 | VAL A 105ALA A 104HIS A 62 | None CL A1001 ( 4.9A)None | 0.56A | 1q23H-1f1eA:undetectable | 1q23H-1f1eA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | VAL B 75ALA B 120HIS B 48 | None | 0.75A | 1q23H-1ffvB:0.0 | 1q23H-1ffvB:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gy8 | UDP-GALACTOSE4-EPIMERASE (Trypanosomabrucei) |
PF01370(Epimerase) | 3 | VAL A 271ALA A 203HIS A 221 | NoneNAD A1382 (-3.5A)UDP A1383 (-4.2A) | 0.75A | 1q23H-1gy8A:0.0 | 1q23H-1gy8A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2t | 80 KDA NUCLEAR CAPBINDING PROTEIN (Homo sapiens) |
PF02854(MIF4G)PF09088(MIF4G_like)PF09090(MIF4G_like_2) | 3 | VAL C 506ALA C 505HIS C 553 | None | 0.71A | 1q23H-1h2tC:0.0 | 1q23H-1h2tC:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iqc | DI-HEME PEROXIDASE (Nitrosomonaseuropaea) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 3 | VAL A 113ALA A 110HIS A 107 | None | 0.76A | 1q23H-1iqcA:0.0 | 1q23H-1iqcA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kc8 | RIBOSOMAL PROTEINL21E (Haloarculamarismortui) |
PF01157(Ribosomal_L21e) | 3 | VAL R 30ALA R 29HIS R 90 | None | 0.56A | 1q23H-1kc8R:undetectable | 1q23H-1kc8R:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lt8 | BETAINE-HOMOCYSTEINEMETHYLTRANSFERASE (Homo sapiens) |
PF02574(S-methyl_trans) | 3 | VAL A 50ALA A 49HIS A 60 | None | 0.71A | 1q23H-1lt8A:0.0 | 1q23H-1lt8A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxn | HYPOTHETICAL PROTEINMTH1187 (Methanothermobacterthermautotrophicus) |
PF01910(Thiamine_BP) | 3 | VAL A 26ALA A 25HIS A 61 | None | 0.76A | 1q23H-1lxnA:undetectable | 1q23H-1lxnA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nij | HYPOTHETICAL PROTEINYJIA (Escherichiacoli) |
PF02492(cobW)PF07683(CobW_C) | 3 | VAL A 133ALA A 132HIS A 170 | None | 0.48A | 1q23H-1nijA:undetectable | 1q23H-1nijA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nuq | FKSG76 (Homo sapiens) |
PF01467(CTP_transf_like) | 3 | VAL A 65ALA A 66HIS A 230 | None | 0.62A | 1q23H-1nuqA:undetectable | 1q23H-1nuqA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nvm | ACETALDEHYDEDEHYDROGENASE(ACYLATING) (Pseudomonas sp.CF600) |
PF01118(Semialdhyde_dh)PF09290(AcetDehyd-dimer) | 3 | VAL B 147ALA B 148HIS B 151 | None | 0.73A | 1q23H-1nvmB:undetectable | 1q23H-1nvmB:19.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pd5 | CHLORAMPHENICOLACETYLTRANSFERASE (Escherichiacoli) |
PF00302(CAT) | 3 | VAL A 28ALA A 29HIS A 193 | None | 0.31A | 1q23H-1pd5A:36.5 | 1q23H-1pd5A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pn3 | GLYCOSYLTRANSFERASEGTFA (Amycolatopsisorientalis) |
PF03033(Glyco_transf_28) | 3 | VAL A 108ALA A 107HIS A 156 | None | 0.51A | 1q23H-1pn3A:undetectable | 1q23H-1pn3A:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8i | DNA POLYMERASE II (Escherichiacoli) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 3 | VAL A 370ALA A 371HIS A 366 | None | 0.65A | 1q23H-1q8iA:undetectable | 1q23H-1q8iA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r4n | AMYLOID BETAPRECURSORPROTEIN-BINDINGPROTEIN 1UBIQUITIN-ACTIVATINGENZYME E1C (Homo sapiens) |
PF00899(ThiF)PF08825(E2_bind) | 3 | VAL B 302ALA B 301HIS A 491 | None | 0.70A | 1q23H-1r4nB:undetectable | 1q23H-1r4nB:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9u | PUTATIVE COMPONENTOF ANAEROBICDEHYDROGENASES (Salmonellaenterica) |
PF02613(Nitrate_red_del) | 3 | VAL A 34ALA A 31HIS A 28 | None | 0.70A | 1q23H-1s9uA:undetectable | 1q23H-1s9uA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t57 | CONSERVED PROTEINMTH1675 (Methanothermobacterthermautotrophicus) |
PF02887(PK_C) | 3 | VAL A 37ALA A 38HIS A 61 | NoneFMN A 200 (-3.7A)FMN A 200 (-4.2A) | 0.60A | 1q23H-1t57A:undetectable | 1q23H-1t57A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u0k | GENE PRODUCT PA4716 (Pseudomonasaeruginosa) |
PF02567(PhzC-PhzF) | 3 | VAL A 105ALA A 106HIS A 95 | None | 0.66A | 1q23H-1u0kA:undetectable | 1q23H-1u0kA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ub7 | 3-OXOACYL-[ACYL-CARRIER PROTEIN]SYNTHASE (Thermusthermophilus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 3 | VAL A 219ALA A 218HIS A 246 | NoneNoneCSO A 110 ( 3.9A) | 0.60A | 1q23H-1ub7A:undetectable | 1q23H-1ub7A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xl8 | PEROXISOMALCARNITINEO-OCTANOYLTRANSFERASE (Mus musculus) |
PF00755(Carn_acyltransf) | 3 | VAL A 88ALA A 89HIS A 327 | NoneNone152 A 613 (-4.3A) | 0.70A | 1q23H-1xl8A:10.0 | 1q23H-1xl8A:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9a | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Entamoebahistolytica) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | VAL A 253ALA A 250HIS A 247 | NoneNoneOHS A 245 ( 3.7A) | 0.74A | 1q23H-1y9aA:undetectable | 1q23H-1y9aA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2anp | LEUCYLAMINOPEPTIDASE (Vibrioproteolyticus) |
PF04389(Peptidase_M28) | 3 | VAL A 78ALA A 147HIS A 97 | NoneNone ZN A 502 (-3.3A) | 0.73A | 1q23H-2anpA:undetectable | 1q23H-2anpA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btu | PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE (Bacillusanthracis) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | VAL A 85ALA A 86HIS A 187 | None | 0.50A | 1q23H-2btuA:undetectable | 1q23H-2btuA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c20 | UDP-GLUCOSE4-EPIMERASE (Bacillusanthracis) |
PF01370(Epimerase) | 3 | VAL A 18ALA A 17HIS A 234 | None | 0.55A | 1q23H-2c20A:undetectable | 1q23H-2c20A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dyc | GALECTIN-4 (Mus musculus) |
PF00337(Gal-bind_lectin) | 3 | VAL A 60ALA A 61HIS A 126 | None | 0.68A | 1q23H-2dycA:undetectable | 1q23H-2dycA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1e | PROTEIN APAG (Xanthomonascitri) |
PF04379(DUF525) | 3 | VAL A 48ALA A 49HIS A 51 | None | 0.73A | 1q23H-2f1eA:undetectable | 1q23H-2f1eA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1e | PROTEIN APAG (Xanthomonascitri) |
PF04379(DUF525) | 3 | VAL A 48ALA A 49HIS A 100 | None | 0.67A | 1q23H-2f1eA:undetectable | 1q23H-2f1eA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 3 | VAL A 60ALA A 122HIS A 105 | None | 0.67A | 1q23H-2fgeA:undetectable | 1q23H-2fgeA:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gtx | METHIONINEAMINOPEPTIDASE (Escherichiacoli) |
PF00557(Peptidase_M24) | 3 | VAL A 16ALA A 17HIS A 106 | None | 0.70A | 1q23H-2gtxA:undetectable | 1q23H-2gtxA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gwn | DIHYDROOROTASE (Porphyromonasgingivalis) |
PF01979(Amidohydro_1) | 3 | VAL A 85ALA A 86HIS A 338 | NoneNone CL A 605 (-4.2A) | 0.71A | 1q23H-2gwnA:undetectable | 1q23H-2gwnA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isb | FUMARASE (Archaeoglobusfulgidus) |
PF05683(Fumerase_C) | 3 | VAL A 155ALA A 34HIS A 63 | None | 0.75A | 1q23H-2isbA:undetectable | 1q23H-2isbA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isj | BLUB (Sinorhizobiummeliloti) |
PF00881(Nitroreductase) | 3 | VAL A 149ALA A 148HIS A 55 | None | 0.54A | 1q23H-2isjA:undetectable | 1q23H-2isjA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jax | HYPOTHETICAL PROTEINTB31.7 (Mycobacteriumtuberculosis) |
PF00582(Usp) | 3 | VAL A 101ALA A 100HIS A 42 | NoneATP A1296 (-3.6A)ATP A1296 (-4.4A) | 0.44A | 1q23H-2jaxA:undetectable | 1q23H-2jaxA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9y | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Homo sapiens) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | VAL A 517ALA A 518HIS A 620 | None | 0.53A | 1q23H-2v9yA:undetectable | 1q23H-2v9yA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wd9 | ACYL-COENZYME ASYNTHETASE ACSM2A,MITOCHONDRIAL (Homo sapiens) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | VAL A 488ALA A 487HIS A 518 | None | 0.69A | 1q23H-2wd9A:undetectable | 1q23H-2wd9A:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7d | 3-KETO-5-AMINOHEXANOATE CLEAVAGE ENZYME (CandidatusCloacimonasacidaminovorans) |
PF05853(BKACE) | 3 | VAL A 172ALA A 205HIS A 211 | None | 0.69A | 1q23H-2y7dA:undetectable | 1q23H-2y7dA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzm | D-ALANINE--D-ALANINELIGASE (Thermusthermophilus) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 3 | VAL A 36ALA A 7HIS A 82 | NoneNoneDAL A 401 (-4.5A) | 0.73A | 1q23H-2yzmA:undetectable | 1q23H-2yzmA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z01 | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Geobacilluskaustophilus) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | VAL A 85ALA A 86HIS A 187 | None | 0.52A | 1q23H-2z01A:undetectable | 1q23H-2z01A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayd | GALECTIN-3 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 3 | VAL A 155ALA A 156HIS A 223 | None | 0.69A | 1q23H-3aydA:undetectable | 1q23H-3aydA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e03 | SHORT CHAINDEHYDROGENASE (Xanthomonascampestris) |
PF13561(adh_short_C2) | 3 | VAL A 58ALA A 55HIS A 52 | None | 0.72A | 1q23H-3e03A:undetectable | 1q23H-3e03A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8t | PREDICTED ATPASEINVOLVED INREPLICATION CONTROL,CDC46/MCM FAMILY (Methanopyruskandleri) |
PF00493(MCM) | 3 | VAL A 146ALA A 147HIS A 136 | None | 0.66A | 1q23H-3f8tA:undetectable | 1q23H-3f8tA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkj | PUTATIVEPHOSPHOSUGARISOMERASES (Salmonellaenterica) |
PF01380(SIS) | 3 | VAL A 87ALA A 88HIS A 62 | None | 0.76A | 1q23H-3fkjA:undetectable | 1q23H-3fkjA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpc | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Entamoebahistolytica;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | VAL A 253ALA A 250HIS A 247 | None | 0.75A | 1q23H-3fpcA:undetectable | 1q23H-3fpcA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8d | BIOTIN CARBOXYLASE (Escherichiacoli) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | VAL A 76ALA A 77HIS A 79 | None | 0.58A | 1q23H-3g8dA:undetectable | 1q23H-3g8dA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdi | PERIOD CIRCADIANPROTEIN HOMOLOG 2 (Mus musculus) |
PF08447(PAS_3) | 3 | VAL A 349ALA A 348HIS A 430 | None | 0.63A | 1q23H-3gdiA:undetectable | 1q23H-3gdiA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gec | PERIOD CIRCADIANPROTEIN (Drosophilamelanogaster) |
PF00989(PAS)PF14598(PAS_11) | 3 | VAL A 409ALA A 408HIS A 493 | None | 0.74A | 1q23H-3gecA:undetectable | 1q23H-3gecA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4i | GLYCOSYLTRANSFERASEGTFA,GLYCOSYLTRANSFERASE (Actinoplanesteichomyceticus;Amycolatopsisorientalis) |
PF03033(Glyco_transf_28)PF04101(Glyco_tran_28_C) | 3 | VAL A 108ALA A 107HIS A 156 | None | 0.40A | 1q23H-3h4iA:undetectable | 1q23H-3h4iA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h8y | MAJOR CARBOXYSOMESHELL PROTEIN 1C (Halothiobacillusneapolitanus) |
PF00936(BMC) | 3 | VAL A 76ALA A 77HIS A 79 | None | 0.65A | 1q23H-3h8yA:undetectable | 1q23H-3h8yA:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hiu | UNCHARACTERIZEDPROTEIN (Xanthomonascampestris) |
PF05974(DUF892) | 3 | VAL A 156ALA A 153HIS A 150 | NoneEDO A 170 ( 4.9A)None | 0.76A | 1q23H-3hiuA:undetectable | 1q23H-3hiuA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 3 | VAL A 735ALA A 399HIS A1358 | None | 0.64A | 1q23H-3hmjA:1.3 | 1q23H-3hmjA:7.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hno | PYROPHOSPHATE-DEPENDENTPHOSPHOFRUCTOKINASE (Nitrosospiramultiformis) |
PF00365(PFK) | 3 | VAL A 322ALA A 321HIS A 138 | None | 0.76A | 1q23H-3hnoA:undetectable | 1q23H-3hnoA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8t | GALECTIN-4 (Mus musculus) |
PF00337(Gal-bind_lectin) | 3 | VAL A 72ALA A 73HIS A 138 | NoneNoneGOL A 166 ( 4.7A) | 0.70A | 1q23H-3i8tA:undetectable | 1q23H-3i8tA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il7 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Staphylococcusaureus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 3 | VAL A 211ALA A 210HIS A 238 | None | 0.75A | 1q23H-3il7A:undetectable | 1q23H-3il7A:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iq0 | PUTATIVE RIBOKINASEII (Escherichiacoli) |
PF00294(PfkB) | 3 | VAL A 148ALA A 147HIS A 120 | None | 0.56A | 1q23H-3iq0A:undetectable | 1q23H-3iq0A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3it4 | ARGININEBIOSYNTHESISBIFUNCTIONAL PROTEINARGJ ALPHA CHAIN (Mycobacteriumtuberculosis) |
PF01960(ArgJ) | 3 | VAL A 42ALA A 24HIS A 151 | None | 0.70A | 1q23H-3it4A:undetectable | 1q23H-3it4A:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ki6 | CHOLIX TOXIN (Vibrio cholerae) |
PF09009(Exotox-A_cataly) | 3 | VAL A 465ALA A 466HIS A 460 | NoneNoneG9L A 1 (-3.9A) | 0.70A | 1q23H-3ki6A:undetectable | 1q23H-3ki6A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kvn | ESTERASE ESTA (Pseudomonasaeruginosa) |
no annotation | 3 | VAL X 490ALA X 526HIS X 546 | None | 0.74A | 1q23H-3kvnX:undetectable | 1q23H-3kvnX:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l01 | GLGA GLYCOGENSYNTHASE (Pyrococcusabyssi) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 3 | VAL A 101ALA A 100HIS A 130 | NoneNoneGOL A6502 ( 3.8A) | 0.67A | 1q23H-3l01A:undetectable | 1q23H-3l01A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3led | 3-OXOACYL-ACYLCARRIER PROTEINSYNTHASE III (Rhodopseudomonaspalustris) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 3 | VAL A 181ALA A 207HIS A 340 | None | 0.44A | 1q23H-3ledA:undetectable | 1q23H-3ledA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lvy | CARBOXYMUCONOLACTONEDECARBOXYLASE FAMILY (Streptococcusmutans) |
PF02627(CMD) | 3 | VAL A 182ALA A 83HIS A 85 | NoneNoneBME A 191 (-3.7A) | 0.69A | 1q23H-3lvyA:undetectable | 1q23H-3lvyA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ncv | DNA MISMATCH REPAIRPROTEIN MUTL (Neisseriagonorrhoeae) |
PF08676(MutL_C) | 3 | VAL A 499ALA A 496HIS A 493 | None | 0.72A | 1q23H-3ncvA:undetectable | 1q23H-3ncvA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nmz | APC VARIANT PROTEIN (Homo sapiens) |
PF00514(Arm) | 3 | VAL A 450ALA A 449HIS A 408 | None | 0.71A | 1q23H-3nmzA:undetectable | 1q23H-3nmzA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwo | PROLINEIMINOPEPTIDASE (Mycolicibacteriumsmegmatis) |
PF00561(Abhydrolase_1) | 3 | VAL A 274ALA A 249HIS A 280 | NoneNoneEDO A 312 (-4.7A) | 0.70A | 1q23H-3nwoA:undetectable | 1q23H-3nwoA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os6 | ISOCHORISMATESYNTHASE DHBC (Bacillusanthracis) |
PF00425(Chorismate_bind) | 3 | VAL A 305ALA A 304HIS A 242 | None | 0.66A | 1q23H-3os6A:undetectable | 1q23H-3os6A:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4e | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Vibrio cholerae) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | VAL A 89ALA A 90HIS A 191 | None | 0.53A | 1q23H-3p4eA:undetectable | 1q23H-3p4eA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pp7 | PYRUVATE KINASE (Leishmaniamexicana) |
PF00224(PK)PF02887(PK_C) | 3 | VAL A 461ALA A 458HIS A 455 | None | 0.75A | 1q23H-3pp7A:undetectable | 1q23H-3pp7A:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qh4 | ESTERASE LIPW (Mycobacteriummarinum) |
PF07859(Abhydrolase_3) | 3 | VAL A 192ALA A 163HIS A 88 | None | 0.72A | 1q23H-3qh4A:undetectable | 1q23H-3qh4A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r7g | PROTEIN SPIREHOMOLOG 1 (Homo sapiens) |
PF16474(KIND) | 3 | VAL A 61ALA A 60HIS A 216 | None | 0.73A | 1q23H-3r7gA:undetectable | 1q23H-3r7gA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rty | PERIOD CIRCADIANPROTEIN (Drosophilamelanogaster) |
PF00989(PAS)PF14598(PAS_11) | 3 | VAL A 409ALA A 408HIS A 493 | DTT A 900 (-4.9A)NoneNone | 0.59A | 1q23H-3rtyA:undetectable | 1q23H-3rtyA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vva | ALTERNATIVE OXIDASE,MITOCHONDRIAL (Trypanosomabrucei) |
PF01786(AOX) | 3 | VAL A 125ALA A 126HIS A 165 | None OH A 503 ( 3.7A) FE A 501 (-3.3A) | 0.76A | 1q23H-3vvaA:undetectable | 1q23H-3vvaA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrf | NON-REDUCING ENDBETA-L-ARABINOFURANOSIDASE (Bifidobacteriumlongum) |
PF07944(Glyco_hydro_127) | 3 | VAL A 54ALA A 55HIS A 69 | None | 0.71A | 1q23H-3wrfA:undetectable | 1q23H-3wrfA:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 3 | VAL A 352ALA A 353HIS A 358 | NoneFAD A3005 (-3.6A)FAD A3005 (-3.8A) | 0.74A | 1q23H-3zyvA:undetectable | 1q23H-3zyvA:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a05 | CELLOBIOHYDROLASEFAMILY 6 (Chaetomiumthermophilum) |
PF01341(Glyco_hydro_6) | 3 | VAL A 327ALA A 326HIS A 288 | None | 0.75A | 1q23H-4a05A:undetectable | 1q23H-4a05A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5w | COMPLEMENT C5 (Homo sapiens) |
PF00207(A2M)PF01759(NTR)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2) | 3 | VAL A 609ALA A 608HIS A 226 | None | 0.73A | 1q23H-4a5wA:undetectable | 1q23H-4a5wA:8.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aq2 | HOMOGENTISATE1,2-DIOXYGENASE (Pseudomonasputida) |
PF04209(HgmA) | 3 | VAL A 262ALA A 263HIS A 265 | None | 0.71A | 1q23H-4aq2A:undetectable | 1q23H-4aq2A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4axs | CARBAMATE KINASE (Mycoplasmapenetrans) |
PF00696(AA_kinase) | 3 | VAL A 227ALA A 7HIS A 45 | None | 0.74A | 1q23H-4axsA:undetectable | 1q23H-4axsA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 3 | VAL B2136ALA B2137HIS B2122 | NoneNoneCUO B9006 (-3.2A) | 0.58A | 1q23H-4bedB:undetectable | 1q23H-4bedB:8.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 3 | VAL B2254ALA B2253HIS B2148 | None | 0.76A | 1q23H-4bedB:undetectable | 1q23H-4bedB:8.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bmb | GALECTIN-8 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 3 | VAL A 62ALA A 63HIS A 128 | None | 0.70A | 1q23H-4bmbA:undetectable | 1q23H-4bmbA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3s | ALDEHYDEDEHYDROGENASE (Lachnoclostridiumphytofermentans) |
PF00171(Aldedh) | 3 | VAL A 173ALA A 172HIS A 95 | None | 0.65A | 1q23H-4c3sA:undetectable | 1q23H-4c3sA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dj3 | PERIOD CIRCADIANPROTEIN HOMOLOG 3 (Mus musculus) |
PF08447(PAS_3) | 3 | VAL A 288ALA A 287HIS A 370 | None | 0.66A | 1q23H-4dj3A:undetectable | 1q23H-4dj3A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eo3 | BACTERIOFERRITINCOMIGRATORYPROTEIN/NADHDEHYDROGENASE (Thermotogamaritima) |
PF00578(AhpC-TSA)PF00881(Nitroreductase) | 3 | VAL A 245ALA A 244HIS A 175 | None | 0.65A | 1q23H-4eo3A:undetectable | 1q23H-4eo3A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewp | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Micrococcusluteus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 3 | VAL A 148ALA A 174HIS A 317 | None | 0.67A | 1q23H-4ewpA:undetectable | 1q23H-4ewpA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f40 | PROSTAGLANDINF2-ALPHASYNTHASE/D-ARABINOSEDEHYDROGENASE (Leishmaniamajor) |
PF00248(Aldo_ket_red) | 3 | VAL A 37ALA A 36HIS A 243 | None | 0.75A | 1q23H-4f40A:undetectable | 1q23H-4f40A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f92 | U5 SMALL NUCLEARRIBONUCLEOPROTEIN200 KDA HELICASE (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | VAL B1741ALA B1738HIS B1735 | None | 0.72A | 1q23H-4f92B:undetectable | 1q23H-4f92B:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fg8 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1 (Homo sapiens) |
PF00069(Pkinase) | 3 | VAL A 79ALA A 80HIS A 71 | ATP A 401 (-4.7A)NoneNone | 0.74A | 1q23H-4fg8A:undetectable | 1q23H-4fg8A:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fom | POLIOVIRUSRECEPTOR-RELATEDPROTEIN 3 (Homo sapiens) |
PF07686(V-set)PF08205(C2-set_2) | 3 | VAL A 102ALA A 103HIS A 105 | None | 0.71A | 1q23H-4fomA:undetectable | 1q23H-4fomA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqz | GALECTIN-8 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 3 | VAL A 62ALA A 63HIS A 128 | None | 0.66A | 1q23H-4fqzA:undetectable | 1q23H-4fqzA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4isy | CYSTEINE DESULFURASE (Mycobacteriumtuberculosis) |
PF00266(Aminotran_5) | 3 | VAL A 257ALA A 256HIS A 360 | None | 0.53A | 1q23H-4isyA:undetectable | 1q23H-4isyA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhz | BETA-GLUCURONIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 3 | VAL A 543ALA A 542HIS A 497 | None | 0.63A | 1q23H-4jhzA:undetectable | 1q23H-4jhzA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kvg | AMYLOID BETA A4PRECURSORPROTEIN-BINDINGFAMILY B MEMBER1-INTERACTINGPROTEIN (Mus musculus) |
PF00169(PH)PF00788(RA) | 3 | VAL B 206ALA B 203HIS B 240 | None | 0.76A | 1q23H-4kvgB:undetectable | 1q23H-4kvgB:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kvo | N-TERMINALACETYLTRANSFERASE ACOMPLEX SUBUNIT NAT1 (Schizosaccharomycespombe) |
PF12569(NARP1) | 3 | VAL A 67ALA A 48HIS A 43 | None | 0.72A | 1q23H-4kvoA:undetectable | 1q23H-4kvoA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l0k | DRAIII (Deinococcusradiophilus) |
no annotation | 3 | VAL A 151ALA A 152HIS A 130 | None | 0.73A | 1q23H-4l0kA:undetectable | 1q23H-4l0kA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9o | SEC16,PROTEINTRANSPORT PROTEINSEC13 (Komagataellapastoris;Komagataellaphaffii) |
PF00400(WD40) | 3 | VAL A2103ALA A2104HIS A2106 | None | 0.76A | 1q23H-4l9oA:undetectable | 1q23H-4l9oA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lej | VICILIN (Pinuskoraiensis) |
PF00190(Cupin_1) | 3 | VAL A 196ALA A 197HIS A 232 | None | 0.66A | 1q23H-4lejA:undetectable | 1q23H-4lejA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhb | PUTATIVE ALDO/KETOREDUCTASE (Yersinia pestis) |
PF00248(Aldo_ket_red) | 3 | VAL A 184ALA A 183HIS A 152 | NoneSO4 A 303 (-3.7A)SO4 A 305 (-4.3A) | 0.68A | 1q23H-4mhbA:undetectable | 1q23H-4mhbA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ook | METHIONINEAMINOPEPTIDASE 2 (Mycobacteriumtuberculosis) |
PF00557(Peptidase_M24) | 3 | VAL A 52ALA A 53HIS A 140 | None NA A 305 ( 4.5A)None | 0.71A | 1q23H-4ookA:undetectable | 1q23H-4ookA:19.34 |