SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_G_FUAG708_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akp APOKEDARCIDIN

(actinomycete
ATCC 53650)
PF00960
(Neocarzinostat)
3 VAL A  99
ALA A  34
HIS A  53
None
0.75A 1q23H-1akpA:
undetectable
1q23H-1akpA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)


(Escherichia
coli)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 VAL A  88
ALA A  89
HIS A 190
None
0.51A 1q23H-1cliA:
0.0
1q23H-1cliA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE


(Homo sapiens)
PF04209
(HgmA)
3 VAL A 266
ALA A 267
HIS A 269
None
0.71A 1q23H-1ey2A:
0.0
1q23H-1ey2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri)
PF00808
(CBFD_NFYB_HMF)
3 VAL A 105
ALA A 104
HIS A  62
None
CL  A1001 ( 4.9A)
None
0.56A 1q23H-1f1eA:
undetectable
1q23H-1f1eA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 VAL B  75
ALA B 120
HIS B  48
None
0.75A 1q23H-1ffvB:
0.0
1q23H-1ffvB:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE


(Trypanosoma
brucei)
PF01370
(Epimerase)
3 VAL A 271
ALA A 203
HIS A 221
None
NAD  A1382 (-3.5A)
UDP  A1383 (-4.2A)
0.75A 1q23H-1gy8A:
0.0
1q23H-1gy8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN


(Homo sapiens)
PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2)
3 VAL C 506
ALA C 505
HIS C 553
None
0.71A 1q23H-1h2tC:
0.0
1q23H-1h2tC:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqc DI-HEME PEROXIDASE

(Nitrosomonas
europaea)
PF00034
(Cytochrom_C)
PF03150
(CCP_MauG)
3 VAL A 113
ALA A 110
HIS A 107
None
0.76A 1q23H-1iqcA:
0.0
1q23H-1iqcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L21E


(Haloarcula
marismortui)
PF01157
(Ribosomal_L21e)
3 VAL R  30
ALA R  29
HIS R  90
None
0.56A 1q23H-1kc8R:
undetectable
1q23H-1kc8R:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE


(Homo sapiens)
PF02574
(S-methyl_trans)
3 VAL A  50
ALA A  49
HIS A  60
None
0.71A 1q23H-1lt8A:
0.0
1q23H-1lt8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxn HYPOTHETICAL PROTEIN
MTH1187


(Methanothermobacter
thermautotrophicus)
PF01910
(Thiamine_BP)
3 VAL A  26
ALA A  25
HIS A  61
None
0.76A 1q23H-1lxnA:
undetectable
1q23H-1lxnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA


(Escherichia
coli)
PF02492
(cobW)
PF07683
(CobW_C)
3 VAL A 133
ALA A 132
HIS A 170
None
0.48A 1q23H-1nijA:
undetectable
1q23H-1nijA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens)
PF01467
(CTP_transf_like)
3 VAL A  65
ALA A  66
HIS A 230
None
0.62A 1q23H-1nuqA:
undetectable
1q23H-1nuqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)


(Pseudomonas sp.
CF600)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer)
3 VAL B 147
ALA B 148
HIS B 151
None
0.73A 1q23H-1nvmB:
undetectable
1q23H-1nvmB:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE


(Escherichia
coli)
PF00302
(CAT)
3 VAL A  28
ALA A  29
HIS A 193
None
0.31A 1q23H-1pd5A:
36.5
1q23H-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA


(Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
3 VAL A 108
ALA A 107
HIS A 156
None
0.51A 1q23H-1pn3A:
undetectable
1q23H-1pn3A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
3 VAL A 370
ALA A 371
HIS A 366
None
0.65A 1q23H-1q8iA:
undetectable
1q23H-1q8iA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C


(Homo sapiens)
PF00899
(ThiF)
PF08825
(E2_bind)
3 VAL B 302
ALA B 301
HIS A 491
None
0.70A 1q23H-1r4nB:
undetectable
1q23H-1r4nB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9u PUTATIVE COMPONENT
OF ANAEROBIC
DEHYDROGENASES


(Salmonella
enterica)
PF02613
(Nitrate_red_del)
3 VAL A  34
ALA A  31
HIS A  28
None
0.70A 1q23H-1s9uA:
undetectable
1q23H-1s9uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t57 CONSERVED PROTEIN
MTH1675


(Methanothermobacter
thermautotrophicus)
PF02887
(PK_C)
3 VAL A  37
ALA A  38
HIS A  61
None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.2A)
0.60A 1q23H-1t57A:
undetectable
1q23H-1t57A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa)
PF02567
(PhzC-PhzF)
3 VAL A 105
ALA A 106
HIS A  95
None
0.66A 1q23H-1u0kA:
undetectable
1q23H-1u0kA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE


(Thermus
thermophilus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
3 VAL A 219
ALA A 218
HIS A 246
None
None
CSO  A 110 ( 3.9A)
0.60A 1q23H-1ub7A:
undetectable
1q23H-1ub7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E


(Mus musculus)
PF00755
(Carn_acyltransf)
3 VAL A  88
ALA A  89
HIS A 327
None
None
152  A 613 (-4.3A)
0.70A 1q23H-1xl8A:
10.0
1q23H-1xl8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Entamoeba
histolytica)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 VAL A 253
ALA A 250
HIS A 247
None
None
OHS  A 245 ( 3.7A)
0.74A 1q23H-1y9aA:
undetectable
1q23H-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE


(Vibrio
proteolyticus)
PF04389
(Peptidase_M28)
3 VAL A  78
ALA A 147
HIS A  97
None
None
ZN  A 502 (-3.3A)
0.73A 1q23H-2anpA:
undetectable
1q23H-2anpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE


(Bacillus
anthracis)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 VAL A  85
ALA A  86
HIS A 187
None
0.50A 1q23H-2btuA:
undetectable
1q23H-2btuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE


(Bacillus
anthracis)
PF01370
(Epimerase)
3 VAL A  18
ALA A  17
HIS A 234
None
0.55A 1q23H-2c20A:
undetectable
1q23H-2c20A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyc GALECTIN-4

(Mus musculus)
PF00337
(Gal-bind_lectin)
3 VAL A  60
ALA A  61
HIS A 126
None
0.68A 1q23H-2dycA:
undetectable
1q23H-2dycA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1e PROTEIN APAG

(Xanthomonas
citri)
PF04379
(DUF525)
3 VAL A  48
ALA A  49
HIS A  51
None
0.73A 1q23H-2f1eA:
undetectable
1q23H-2f1eA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1e PROTEIN APAG

(Xanthomonas
citri)
PF04379
(DUF525)
3 VAL A  48
ALA A  49
HIS A 100
None
0.67A 1q23H-2f1eA:
undetectable
1q23H-2f1eA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)


(Arabidopsis
thaliana)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
3 VAL A  60
ALA A 122
HIS A 105
None
0.67A 1q23H-2fgeA:
undetectable
1q23H-2fgeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE


(Escherichia
coli)
PF00557
(Peptidase_M24)
3 VAL A  16
ALA A  17
HIS A 106
None
0.70A 1q23H-2gtxA:
undetectable
1q23H-2gtxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis)
PF01979
(Amidohydro_1)
3 VAL A  85
ALA A  86
HIS A 338
None
None
CL  A 605 (-4.2A)
0.71A 1q23H-2gwnA:
undetectable
1q23H-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isb FUMARASE

(Archaeoglobus
fulgidus)
PF05683
(Fumerase_C)
3 VAL A 155
ALA A  34
HIS A  63
None
0.75A 1q23H-2isbA:
undetectable
1q23H-2isbA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isj BLUB

(Sinorhizobium
meliloti)
PF00881
(Nitroreductase)
3 VAL A 149
ALA A 148
HIS A  55
None
0.54A 1q23H-2isjA:
undetectable
1q23H-2isjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7


(Mycobacterium
tuberculosis)
PF00582
(Usp)
3 VAL A 101
ALA A 100
HIS A  42
None
ATP  A1296 (-3.6A)
ATP  A1296 (-4.4A)
0.44A 1q23H-2jaxA:
undetectable
1q23H-2jaxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Homo sapiens)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 VAL A 517
ALA A 518
HIS A 620
None
0.53A 1q23H-2v9yA:
undetectable
1q23H-2v9yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL


(Homo sapiens)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
3 VAL A 488
ALA A 487
HIS A 518
None
0.69A 1q23H-2wd9A:
undetectable
1q23H-2wd9A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME


(Candidatus
Cloacimonas
acidaminovorans)
PF05853
(BKACE)
3 VAL A 172
ALA A 205
HIS A 211
None
0.69A 1q23H-2y7dA:
undetectable
1q23H-2y7dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE


(Thermus
thermophilus)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
3 VAL A  36
ALA A   7
HIS A  82
None
None
DAL  A 401 (-4.5A)
0.73A 1q23H-2yzmA:
undetectable
1q23H-2yzmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Geobacillus
kaustophilus)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 VAL A  85
ALA A  86
HIS A 187
None
0.52A 1q23H-2z01A:
undetectable
1q23H-2z01A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayd GALECTIN-3

(Homo sapiens)
PF00337
(Gal-bind_lectin)
3 VAL A 155
ALA A 156
HIS A 223
None
0.69A 1q23H-3aydA:
undetectable
1q23H-3aydA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE


(Xanthomonas
campestris)
PF13561
(adh_short_C2)
3 VAL A  58
ALA A  55
HIS A  52
None
0.72A 1q23H-3e03A:
undetectable
1q23H-3e03A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY


(Methanopyrus
kandleri)
PF00493
(MCM)
3 VAL A 146
ALA A 147
HIS A 136
None
0.66A 1q23H-3f8tA:
undetectable
1q23H-3f8tA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkj PUTATIVE
PHOSPHOSUGAR
ISOMERASES


(Salmonella
enterica)
PF01380
(SIS)
3 VAL A  87
ALA A  88
HIS A  62
None
0.76A 1q23H-3fkjA:
undetectable
1q23H-3fkjA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Entamoeba
histolytica;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 VAL A 253
ALA A 250
HIS A 247
None
0.75A 1q23H-3fpcA:
undetectable
1q23H-3fpcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 VAL A  76
ALA A  77
HIS A  79
None
0.58A 1q23H-3g8dA:
undetectable
1q23H-3g8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdi PERIOD CIRCADIAN
PROTEIN HOMOLOG 2


(Mus musculus)
PF08447
(PAS_3)
3 VAL A 349
ALA A 348
HIS A 430
None
0.63A 1q23H-3gdiA:
undetectable
1q23H-3gdiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN


(Drosophila
melanogaster)
PF00989
(PAS)
PF14598
(PAS_11)
3 VAL A 409
ALA A 408
HIS A 493
None
0.74A 1q23H-3gecA:
undetectable
1q23H-3gecA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE


(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C)
3 VAL A 108
ALA A 107
HIS A 156
None
0.40A 1q23H-3h4iA:
undetectable
1q23H-3h4iA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8y MAJOR CARBOXYSOME
SHELL PROTEIN 1C


(Halothiobacillus
neapolitanus)
PF00936
(BMC)
3 VAL A  76
ALA A  77
HIS A  79
None
0.65A 1q23H-3h8yA:
undetectable
1q23H-3h8yA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiu UNCHARACTERIZED
PROTEIN


(Xanthomonas
campestris)
PF05974
(DUF892)
3 VAL A 156
ALA A 153
HIS A 150
None
EDO  A 170 ( 4.9A)
None
0.76A 1q23H-3hiuA:
undetectable
1q23H-3hiuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
3 VAL A 735
ALA A 399
HIS A1358
None
0.64A 1q23H-3hmjA:
1.3
1q23H-3hmjA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE


(Nitrosospira
multiformis)
PF00365
(PFK)
3 VAL A 322
ALA A 321
HIS A 138
None
0.76A 1q23H-3hnoA:
undetectable
1q23H-3hnoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8t GALECTIN-4

(Mus musculus)
PF00337
(Gal-bind_lectin)
3 VAL A  72
ALA A  73
HIS A 138
None
None
GOL  A 166 ( 4.7A)
0.70A 1q23H-3i8tA:
undetectable
1q23H-3i8tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Staphylococcus
aureus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
3 VAL A 211
ALA A 210
HIS A 238
None
0.75A 1q23H-3il7A:
undetectable
1q23H-3il7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II


(Escherichia
coli)
PF00294
(PfkB)
3 VAL A 148
ALA A 147
HIS A 120
None
0.56A 1q23H-3iq0A:
undetectable
1q23H-3iq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN


(Mycobacterium
tuberculosis)
PF01960
(ArgJ)
3 VAL A  42
ALA A  24
HIS A 151
None
0.70A 1q23H-3it4A:
undetectable
1q23H-3it4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki6 CHOLIX TOXIN

(Vibrio cholerae)
PF09009
(Exotox-A_cataly)
3 VAL A 465
ALA A 466
HIS A 460
None
None
G9L  A   1 (-3.9A)
0.70A 1q23H-3ki6A:
undetectable
1q23H-3ki6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa)
no annotation 3 VAL X 490
ALA X 526
HIS X 546
None
0.74A 1q23H-3kvnX:
undetectable
1q23H-3kvnX:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
3 VAL A 101
ALA A 100
HIS A 130
None
None
GOL  A6502 ( 3.8A)
0.67A 1q23H-3l01A:
undetectable
1q23H-3l01A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III


(Rhodopseudomonas
palustris)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
3 VAL A 181
ALA A 207
HIS A 340
None
0.44A 1q23H-3ledA:
undetectable
1q23H-3ledA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvy CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY


(Streptococcus
mutans)
PF02627
(CMD)
3 VAL A 182
ALA A  83
HIS A  85
None
None
BME  A 191 (-3.7A)
0.69A 1q23H-3lvyA:
undetectable
1q23H-3lvyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncv DNA MISMATCH REPAIR
PROTEIN MUTL


(Neisseria
gonorrhoeae)
PF08676
(MutL_C)
3 VAL A 499
ALA A 496
HIS A 493
None
0.72A 1q23H-3ncvA:
undetectable
1q23H-3ncvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens)
PF00514
(Arm)
3 VAL A 450
ALA A 449
HIS A 408
None
0.71A 1q23H-3nmzA:
undetectable
1q23H-3nmzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE


(Mycolicibacterium
smegmatis)
PF00561
(Abhydrolase_1)
3 VAL A 274
ALA A 249
HIS A 280
None
None
EDO  A 312 (-4.7A)
0.70A 1q23H-3nwoA:
undetectable
1q23H-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC


(Bacillus
anthracis)
PF00425
(Chorismate_bind)
3 VAL A 305
ALA A 304
HIS A 242
None
0.66A 1q23H-3os6A:
undetectable
1q23H-3os6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Vibrio cholerae)
PF00586
(AIRS)
PF02769
(AIRS_C)
3 VAL A  89
ALA A  90
HIS A 191
None
0.53A 1q23H-3p4eA:
undetectable
1q23H-3p4eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp7 PYRUVATE KINASE

(Leishmania
mexicana)
PF00224
(PK)
PF02887
(PK_C)
3 VAL A 461
ALA A 458
HIS A 455
None
0.75A 1q23H-3pp7A:
undetectable
1q23H-3pp7A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum)
PF07859
(Abhydrolase_3)
3 VAL A 192
ALA A 163
HIS A  88
None
0.72A 1q23H-3qh4A:
undetectable
1q23H-3qh4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7g PROTEIN SPIRE
HOMOLOG 1


(Homo sapiens)
PF16474
(KIND)
3 VAL A  61
ALA A  60
HIS A 216
None
0.73A 1q23H-3r7gA:
undetectable
1q23H-3r7gA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rty PERIOD CIRCADIAN
PROTEIN


(Drosophila
melanogaster)
PF00989
(PAS)
PF14598
(PAS_11)
3 VAL A 409
ALA A 408
HIS A 493
DTT  A 900 (-4.9A)
None
None
0.59A 1q23H-3rtyA:
undetectable
1q23H-3rtyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL


(Trypanosoma
brucei)
PF01786
(AOX)
3 VAL A 125
ALA A 126
HIS A 165
None
OH  A 503 ( 3.7A)
FE  A 501 (-3.3A)
0.76A 1q23H-3vvaA:
undetectable
1q23H-3vvaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE


(Bifidobacterium
longum)
PF07944
(Glyco_hydro_127)
3 VAL A  54
ALA A  55
HIS A  69
None
0.71A 1q23H-3wrfA:
undetectable
1q23H-3wrfA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
3 VAL A 352
ALA A 353
HIS A 358
None
FAD  A3005 (-3.6A)
FAD  A3005 (-3.8A)
0.74A 1q23H-3zyvA:
undetectable
1q23H-3zyvA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6


(Chaetomium
thermophilum)
PF01341
(Glyco_hydro_6)
3 VAL A 327
ALA A 326
HIS A 288
None
0.75A 1q23H-4a05A:
undetectable
1q23H-4a05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens)
PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
3 VAL A 609
ALA A 608
HIS A 226
None
0.73A 1q23H-4a5wA:
undetectable
1q23H-4a5wA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq2 HOMOGENTISATE
1,2-DIOXYGENASE


(Pseudomonas
putida)
PF04209
(HgmA)
3 VAL A 262
ALA A 263
HIS A 265
None
0.71A 1q23H-4aq2A:
undetectable
1q23H-4aq2A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axs CARBAMATE KINASE

(Mycoplasma
penetrans)
PF00696
(AA_kinase)
3 VAL A 227
ALA A   7
HIS A  45
None
0.74A 1q23H-4axsA:
undetectable
1q23H-4axsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
3 VAL B2136
ALA B2137
HIS B2122
None
None
CUO  B9006 (-3.2A)
0.58A 1q23H-4bedB:
undetectable
1q23H-4bedB:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
3 VAL B2254
ALA B2253
HIS B2148
None
0.76A 1q23H-4bedB:
undetectable
1q23H-4bedB:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens)
PF00337
(Gal-bind_lectin)
3 VAL A  62
ALA A  63
HIS A 128
None
0.70A 1q23H-4bmbA:
undetectable
1q23H-4bmbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE


(Lachnoclostridium
phytofermentans)
PF00171
(Aldedh)
3 VAL A 173
ALA A 172
HIS A  95
None
0.65A 1q23H-4c3sA:
undetectable
1q23H-4c3sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj3 PERIOD CIRCADIAN
PROTEIN HOMOLOG 3


(Mus musculus)
PF08447
(PAS_3)
3 VAL A 288
ALA A 287
HIS A 370
None
0.66A 1q23H-4dj3A:
undetectable
1q23H-4dj3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo3 BACTERIOFERRITIN
COMIGRATORY
PROTEIN/NADH
DEHYDROGENASE


(Thermotoga
maritima)
PF00578
(AhpC-TSA)
PF00881
(Nitroreductase)
3 VAL A 245
ALA A 244
HIS A 175
None
0.65A 1q23H-4eo3A:
undetectable
1q23H-4eo3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Micrococcus
luteus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
3 VAL A 148
ALA A 174
HIS A 317
None
0.67A 1q23H-4ewpA:
undetectable
1q23H-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE


(Leishmania
major)
PF00248
(Aldo_ket_red)
3 VAL A  37
ALA A  36
HIS A 243
None
0.75A 1q23H-4f40A:
undetectable
1q23H-4f40A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
3 VAL B1741
ALA B1738
HIS B1735
None
0.72A 1q23H-4f92B:
undetectable
1q23H-4f92B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1


(Homo sapiens)
PF00069
(Pkinase)
3 VAL A  79
ALA A  80
HIS A  71
ATP  A 401 (-4.7A)
None
None
0.74A 1q23H-4fg8A:
undetectable
1q23H-4fg8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3


(Homo sapiens)
PF07686
(V-set)
PF08205
(C2-set_2)
3 VAL A 102
ALA A 103
HIS A 105
None
0.71A 1q23H-4fomA:
undetectable
1q23H-4fomA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqz GALECTIN-8

(Homo sapiens)
PF00337
(Gal-bind_lectin)
3 VAL A  62
ALA A  63
HIS A 128
None
0.66A 1q23H-4fqzA:
undetectable
1q23H-4fqzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
3 VAL A 257
ALA A 256
HIS A 360
None
0.53A 1q23H-4isyA:
undetectable
1q23H-4isyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 VAL A 543
ALA A 542
HIS A 497
None
0.63A 1q23H-4jhzA:
undetectable
1q23H-4jhzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN


(Mus musculus)
PF00169
(PH)
PF00788
(RA)
3 VAL B 206
ALA B 203
HIS B 240
None
0.76A 1q23H-4kvgB:
undetectable
1q23H-4kvgB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1


(Schizosaccharomyces
pombe)
PF12569
(NARP1)
3 VAL A  67
ALA A  48
HIS A  43
None
0.72A 1q23H-4kvoA:
undetectable
1q23H-4kvoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0k DRAIII

(Deinococcus
radiophilus)
no annotation 3 VAL A 151
ALA A 152
HIS A 130
None
0.73A 1q23H-4l0kA:
undetectable
1q23H-4l0kA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13


(Komagataella
pastoris;
Komagataella
phaffii)
PF00400
(WD40)
3 VAL A2103
ALA A2104
HIS A2106
None
0.76A 1q23H-4l9oA:
undetectable
1q23H-4l9oA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis)
PF00190
(Cupin_1)
3 VAL A 196
ALA A 197
HIS A 232
None
0.66A 1q23H-4lejA:
undetectable
1q23H-4lejA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE


(Yersinia pestis)
PF00248
(Aldo_ket_red)
3 VAL A 184
ALA A 183
HIS A 152
None
SO4  A 303 (-3.7A)
SO4  A 305 (-4.3A)
0.68A 1q23H-4mhbA:
undetectable
1q23H-4mhbA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2


(Mycobacterium
tuberculosis)
PF00557
(Peptidase_M24)
3 VAL A  52
ALA A  53
HIS A 140
None
NA  A 305 ( 4.5A)
None
0.71A 1q23H-4ookA:
undetectable
1q23H-4ookA:
19.34