SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_G_FUAG708_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agr RGS4

(Rattus
norvegicus) 		PF00615
(RGS) 		5 PHE E 149
SER E 138
LEU E 129
VAL E 127
PHE E  91
 None
 1.46A 1q23G-1agrE:
undetectable		 1q23G-1agrE:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cee GTP-BINDING RHO-LIKE
PROTEIN
WISKOTT-ALDRICH
SYNDROME PROTEIN
WASP

(Homo sapiens) 		PF00071
(Ras)
PF00786
(PBD) 		5 THR A  17
TYR A  40
PHE A  56
VAL B  31
PHE B  42
 MG  A 180 ( 3.4A)
None
None
None
None
 1.03A 1q23G-1ceeA:
0.0		 1q23G-1ceeA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.58A 1q23G-1ciaA:
32.6		 1q23G-1ciaA:
44.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE

(Arabidopsis
thaliana) 		PF01053
(Cys_Met_Meta_PP) 		5 THR A 155
SER A 311
SER A 156
LEU A 187
VAL A 191
 None
None
PLP  A1400 (-3.6A)
None
None
 1.36A 1q23G-1ibjA:
1.8		 1q23G-1ibjA:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		11 THR A  93
SER A 104
TYR A 133
PHE A 134
PHE A 138
PHE A 144
SER A 146
PHE A 156
LEU A 158
VAL A 160
PHE A 166
 None
 0.49A 1q23G-1pd5A:
36.3		 1q23G-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah5 COG0546: PREDICTED
PHOSPHATASES

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 THR A 105
PHE A 126
PHE A 125
LEU A 178
VAL A 205
 None
 1.43A 1q23G-2ah5A:
0.0		 1q23G-2ah5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT

(Gallus gallus) 		PF00079
(Serpin) 		5 PHE A 402
PHE A 203
LEU A 301
VAL A 383
PHE A 387
 None
 1.25A 1q23G-2dutA:
0.0		 1q23G-2dutA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		5 SER A 470
TYR A 469
PHE A   5
SER A  29
PHE A  21
 None
 1.38A 1q23G-2f6dA:
0.0		 1q23G-2f6dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		5 PHE A 160
SER A 108
LEU A 148
VAL A 154
PHE A 157
 KCX  A 158 ( 4.2A)
None
None
None
None
 1.48A 1q23G-2ftwA:
0.0		 1q23G-2ftwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jww PARVALBUMIN ALPHA

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 SER A  71
PHE A  29
LEU A  35
VAL A  43
PHE A 102
 None
 1.49A 1q23G-2jwwA:
0.0		 1q23G-2jwwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		5 THR A 294
PHE A 326
SER A 249
LEU A 208
VAL A 357
 None
 1.30A 1q23G-2ntbA:
undetectable		 1q23G-2ntbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY

(Neisseria
meningitidis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		5 THR A 106
PHE A  86
LEU A 128
VAL A 124
PHE A 120
 None
 1.36A 1q23G-2p6tA:
undetectable		 1q23G-2p6tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv8 GENERAL SECRETION
PATHWAY PROTEIN H

(Vibrio cholerae) 		PF12019
(GspH) 		5 THR A  91
PHE A 101
PHE A  39
LEU A  46
VAL A 143
 None
 1.40A 1q23G-2qv8A:
undetectable		 1q23G-2qv8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus) 		PF00079
(Serpin) 		5 PHE A 391
PHE A 218
LEU A 309
VAL A 384
PHE A 388
 None
 1.19A 1q23G-2r9yA:
undetectable		 1q23G-2r9yA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.20A 1q23G-2vp1A:
undetectable		 1q23G-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 THR A 224
PHE A 144
LEU A 182
VAL A 167
PHE A 169
 None
 1.44A 1q23G-2zvwA:
undetectable		 1q23G-2zvwA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 THR A 224
PHE A 215
PHE A 144
VAL A 167
PHE A 169
 None
 1.46A 1q23G-2zvwA:
undetectable		 1q23G-2zvwA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj5 PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		5 THR A 302
PHE A 232
PHE A 288
PHE A 325
PHE A 243
 None
 1.46A 1q23G-3bj5A:
undetectable		 1q23G-3bj5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs4 UNCHARACTERIZED
PROTEIN PH0321

(Pyrococcus
horikoshii) 		no annotation 5 THR A 165
SER A 166
PHE A  54
VAL A 153
PHE A  92
 None
 1.35A 1q23G-3bs4A:
undetectable		 1q23G-3bs4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 THR A3042
SER A3041
SER A3044
LEU A3277
VAL A3323
 None
 1.36A 1q23G-3cmvA:
undetectable		 1q23G-3cmvA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		5 THR A 249
PHE A 173
PHE A 199
SER A 250
VAL A 236
 None
 1.41A 1q23G-3h7nA:
undetectable		 1q23G-3h7nA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		5 SER A  55
PHE A  54
PHE A 146
LEU A  20
VAL A 110
 None
 1.30A 1q23G-3hhrA:
undetectable		 1q23G-3hhrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 THR A 569
SER A 750
PHE A 657
PHE A 674
LEU A 707
 None
 1.47A 1q23G-3i6sA:
undetectable		 1q23G-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 THR A1112
PHE A1212
PHE A1097
LEU A 985
VAL A 988
 None
 1.41A 1q23G-3jb9A:
undetectable		 1q23G-3jb9A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lao ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		5 TYR A  86
PHE A  84
PHE A  66
LEU A  24
VAL A  11
 None
 1.48A 1q23G-3laoA:
undetectable		 1q23G-3laoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 THR A 229
PHE A 224
SER A 231
LEU A  68
VAL A  71
 None
 1.44A 1q23G-3qghA:
2.2		 1q23G-3qghA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 SER A 228
TYR A 247
LEU A 178
VAL A 179
PHE A  83
 None
 1.10A 1q23G-3r4vA:
undetectable		 1q23G-3r4vA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		5 PHE A 380
SER A 340
LEU A 283
VAL A 361
PHE A 365
 None
 1.34A 1q23G-3vvjA:
undetectable		 1q23G-3vvjA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 SER A 259
PHE A 268
SER A 114
LEU A 125
VAL A  69
 None
 1.49A 1q23G-4bc5A:
undetectable		 1q23G-4bc5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqa UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735)
PF13385
(Laminin_G_3) 		5 THR A 365
PHE A 170
PHE A 304
LEU A 339
VAL A 313
 None
 1.40A 1q23G-4dqaA:
undetectable		 1q23G-4dqaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A 374
SER A 341
SER A 345
LEU A  16
VAL A  23
 None
 1.45A 1q23G-4f32A:
undetectable		 1q23G-4f32A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 TYR A   6
PHE A  11
PHE A 109
LEU A  71
VAL A 191
 None
 1.33A 1q23G-4go4A:
undetectable		 1q23G-4go4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 397
PHE A 434
PHE A 360
LEU A 421
VAL A 408
 None
 1.38A 1q23G-4i5jA:
undetectable		 1q23G-4i5jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5n SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA -
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG CHIMERIC
CONSTRUCT

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE B 270
PHE B 291
LEU B 298
VAL B 241
PHE B 237
 None
 1.36A 1q23G-4i5nB:
undetectable		 1q23G-4i5nB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5n SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA -
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG CHIMERIC
CONSTRUCT

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE B 434
PHE B 471
PHE B 397
LEU B 458
VAL B 445
 None
 1.46A 1q23G-4i5nB:
undetectable		 1q23G-4i5nB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 SER A 297
PHE A 284
PHE A 204
LEU A 193
VAL A 192
 None
 1.35A 1q23G-4iw7A:
undetectable		 1q23G-4iw7A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 THR B 323
PHE B 316
PHE B 377
PHE B 350
LEU B 361
 None
 1.39A 1q23G-4l37B:
undetectable		 1q23G-4l37B:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 270
PHE A 291
LEU A 298
VAL A 241
PHE A 237
 None
 1.36A 1q23G-4mewA:
undetectable		 1q23G-4mewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 434
PHE A 471
PHE A 397
LEU A 458
VAL A 445
 None
 1.43A 1q23G-4mewA:
undetectable		 1q23G-4mewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.43A 1q23G-4u7tA:
undetectable		 1q23G-4u7tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		5 THR A  70
SER A  68
PHE A 454
SER A  60
PHE A 312
 None
 1.45A 1q23G-4ug4A:
undetectable		 1q23G-4ug4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		5 PHE D 165
SER D 141
PHE D  79
LEU D  40
VAL D  36
 None
 1.35A 1q23G-4xgcD:
undetectable		 1q23G-4xgcD:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 5 THR E 249
PHE E 173
PHE E 199
SER E 250
VAL E 236
 None
 1.50A 1q23G-4xmmE:
undetectable		 1q23G-4xmmE:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN

(Homo sapiens) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 THR A 224
PHE A 144
LEU A 182
VAL A 167
PHE A 169
 None
 1.46A 1q23G-4ztdA:
undetectable		 1q23G-4ztdA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)

(synthetic
construct) 		PF00079
(Serpin) 		5 SER A  31
PHE A 354
PHE A 162
SER A  36
LEU A  73
 None
 1.41A 1q23G-5ce0A:
undetectable		 1q23G-5ce0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eur UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		no annotation 5 THR A  43
SER A  42
LEU A   8
VAL A  21
PHE A  31
 None
 1.15A 1q23G-5eurA:
undetectable		 1q23G-5eurA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewn STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF03115
(Astro_capsid_N) 		5 THR A 319
SER A 320
PHE A 367
VAL A 326
PHE A 297
 None
 1.49A 1q23G-5ewnA:
undetectable		 1q23G-5ewnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.20A 1q23G-5gkvA:
undetectable		 1q23G-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		5 THR A 225
SER A 228
PHE A 217
LEU A 312
VAL A 323
 None
 1.43A 1q23G-5jjpA:
undetectable		 1q23G-5jjpA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		5 PHE A 283
PHE A 324
LEU A 238
VAL A 242
PHE A 264
 None
 1.27A 1q23G-5jtvA:
undetectable		 1q23G-5jtvA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.28A 1q23G-5k3hA:
undetectable		 1q23G-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.36A 1q23G-5oltA:
undetectable		 1q23G-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PHE A 719
SER A 779
PHE A 847
VAL A 649
PHE A 644
 None
 1.38A 1q23G-5td2A:
undetectable		 1q23G-5td2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 5 TYR A 290
PHE A 287
SER A 260
VAL A 237
PHE A 253
 N4P  A 402 (-4.7A)
None
None
None
None
 1.46A 1q23G-5xncA:
undetectable		 1q23G-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 THR A1211
SER A1210
PHE A1247
PHE A1143
LEU A1133
 None
 1.38A 1q23G-5xsyA:
undetectable		 1q23G-5xsyA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 152
SER A 101
LEU A 140
VAL A 146
PHE A 149
 KCX  A 150 ( 4.0A)
None
None
None
None
 1.37A 1q23G-5ykdA:
undetectable		 1q23G-5ykdA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh6 -

(-) 		no annotation 5 THR A  30
PHE A  22
PHE A  28
VAL A  44
PHE A 100
 None
 1.41A 1q23G-5zh6A:
undetectable		 1q23G-5zh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR

(Desulfovibrio
vulgaris;
Homo sapiens) 		no annotation 5 PHE A1074
SER A1039
LEU A1004
VAL A1052
PHE A1046
 None
 1.09A 1q23G-5zkpA:
undetectable		 1q23G-5zkpA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 5 SER A 638
TYR A 660
PHE A 794
VAL A 895
PHE A 870
 None
 1.43A 1q23G-6brrA:
undetectable		 1q23G-6brrA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 PHE A 164
SER A 502
LEU A 520
VAL A 517
PHE A 496
 None
 1.37A 1q23G-6c01A:
undetectable		 1q23G-6c01A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4

(Homo sapiens) 		no annotation 5 TYR A 136
PHE A 138
PHE A 187
LEU A 282
VAL A 159
 None
ADP  A1101 (-3.9A)
None
None
None
 1.46A 1q23G-6c90A:
undetectable		 1q23G-6c90A:
15.53