SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_E_FUAE706_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		4 ALA A 119
VAL A 123
ALA A 120
HIS A 172
 None
 1.22A 1q23F-1cwuA:
0.0		 1q23F-1cwuA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 ALA A 442
VAL A 447
ALA A 379
HIS A 440
 None
 1.03A 1q23F-1ehkA:
0.0		 1q23F-1ehkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		4 ALA A 134
VAL A 144
ALA A 183
HIS A 141
 None
 1.01A 1q23F-1eyeA:
0.0		 1q23F-1eyeA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri) 		PF00808
(CBFD_NFYB_HMF) 		4 ALA A 100
VAL A 105
ALA A 104
HIS A  62
 None
None
CL  A1001 ( 4.9A)
None
 1.21A 1q23F-1f1eA:
undetectable		 1q23F-1f1eA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ALA A 554
VAL A 558
ALA A 555
HIS A 552
 None
 1.05A 1q23F-1i8qA:
0.0		 1q23F-1i8qA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ALA A 402
VAL A 405
ALA A 406
HIS A 484
 None
 1.03A 1q23F-1mroA:
1.2		 1q23F-1mroA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		4 ALA A 163
VAL A 133
ALA A 132
HIS A 170
 None
 0.89A 1q23F-1nijA:
1.9		 1q23F-1nijA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 ALA A  99
VAL A 287
ALA A  89
HIS A 116
 None
 1.11A 1q23F-1nt4A:
0.0		 1q23F-1nt4A:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 ALA A  24
VAL A  28
ALA A  29
HIS A 193
 None
 0.51A 1q23F-1pd5A:
36.2		 1q23F-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		4 ALA A 195
VAL A 221
ALA A 191
HIS A 193
 None
 1.13A 1q23F-1tqxA:
0.0		 1q23F-1tqxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 ALA A 141
VAL A 144
ALA A 145
HIS A  47
 None
 1.24A 1q23F-1txgA:
undetectable		 1q23F-1txgA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 ALA A  46
VAL A  49
ALA A  51
HIS A  52
 None
 1.06A 1q23F-1ulsA:
undetectable		 1q23F-1ulsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 ALA A 100
VAL A  81
ALA A  80
HIS A 200
 None
None
None
FE  A1293 (-3.2A)
 1.12A 1q23F-1uzrA:
undetectable		 1q23F-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 ALA A 230
VAL A 226
ALA A 225
HIS A 180
 None
 1.15A 1q23F-1vliA:
undetectable		 1q23F-1vliA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 360
VAL A 363
ALA A 364
HIS A 103
 None
 1.00A 1q23F-1ysjA:
undetectable		 1q23F-1ysjA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		4 ALA A  13
VAL A  20
ALA A  19
HIS A 169
 None
 1.16A 1q23F-1yzfA:
undetectable		 1q23F-1yzfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ALA A 266
VAL A 263
ALA A 264
HIS A 344
 None
 1.11A 1q23F-1z47A:
undetectable		 1q23F-1z47A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
HG  A1001 (-3.1A)
 1.16A 1q23F-2di4A:
undetectable		 1q23F-2di4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 ALA A  69
VAL C 658
ALA C 657
HIS C 646
 FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.6A)
None
 1.24A 1q23F-2e1mA:
undetectable		 1q23F-2e1mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		4 ALA A 101
VAL A  98
ALA A  91
HIS A  94
 None
 1.09A 1q23F-2fe1A:
undetectable		 1q23F-2fe1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 ALA A 303
VAL A 307
ALA A 304
HIS A 301
 None
 0.96A 1q23F-2g4oA:
undetectable		 1q23F-2g4oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		4 ALA A 955
VAL A1094
ALA A1091
HIS A1088
 None
 1.20A 1q23F-2psoA:
2.7		 1q23F-2psoA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		4 ALA A 281
VAL A 284
ALA A 283
HIS A 260
 None
 1.21A 1q23F-2qr6A:
undetectable		 1q23F-2qr6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rrk CTP
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 ALA A  88
VAL A  72
ALA A  73
HIS A  75
 None
 0.95A 1q23F-2rrkA:
undetectable		 1q23F-2rrkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 212
VAL A 246
ALA A 245
HIS A 214
 ALA  A 212 ( 0.0A)
VAL  A 246 ( 0.6A)
ALA  A 245 ( 0.0A)
HIS  A 214 ( 1.0A)
 1.20A 1q23F-2vbfA:
undetectable		 1q23F-2vbfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ALA A 198
VAL A 273
ALA A 199
HIS A 201
 None
 1.06A 1q23F-2x3kA:
undetectable		 1q23F-2x3kA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 ALA A 148
VAL A  36
ALA A 131
HIS A 152
 None
 1.21A 1q23F-2xfbA:
undetectable		 1q23F-2xfbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.10A 1q23F-3a0hB:
undetectable		 1q23F-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ALA A 222
VAL A 220
ALA A 221
HIS A  62
 None
 1.26A 1q23F-3be7A:
undetectable		 1q23F-3be7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		4 ALA A 159
VAL A 207
ALA A 213
HIS A 215
 None
 1.22A 1q23F-3bptA:
undetectable		 1q23F-3bptA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 ALA A 707
VAL A 711
ALA A 708
HIS A 705
 None
 0.94A 1q23F-3cqcA:
undetectable		 1q23F-3cqcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvj PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Bacillus
halodurans) 		PF13580
(SIS_2) 		4 ALA A  71
VAL A  46
ALA A  56
HIS A  53
 None
None
None
MG  A 243 (-3.5A)
 1.17A 1q23F-3cvjA:
undetectable		 1q23F-3cvjA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		4 ALA A  54
VAL A  58
ALA A  55
HIS A  52
 None
 0.90A 1q23F-3e03A:
undetectable		 1q23F-3e03A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ALA A 280
VAL A 300
ALA A 283
HIS A 271
 None
 1.05A 1q23F-3eoqA:
undetectable		 1q23F-3eoqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0i ARSENATE REDUCTASE

(Vibrio cholerae) 		PF03960
(ArsC) 		4 ALA A  83
VAL A  40
ALA A  86
HIS A  88
 None
 0.89A 1q23F-3f0iA:
undetectable		 1q23F-3f0iA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdj DEGV FAMILY PROTEIN

([Eubacterium]
eligens) 		PF02645
(DegV) 		4 ALA A 173
VAL A 168
ALA A 163
HIS A 160
 None
 1.23A 1q23F-3fdjA:
undetectable		 1q23F-3fdjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A  96
VAL A 100
ALA A  97
HIS A  94
 None
 1.21A 1q23F-3glqA:
undetectable		 1q23F-3glqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 ALA A 218
VAL A 217
ALA A 183
HIS A 180
 ALA  A 218 ( 0.0A)
VAL  A 217 ( 0.6A)
ALA  A 183 ( 0.0A)
HIS  A 180 ( 1.0A)
 1.21A 1q23F-3gnrA:
undetectable		 1q23F-3gnrA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hin PUTATIVE
3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Rhodopseudomonas
palustris) 		PF00378
(ECH_1) 		4 ALA A 201
VAL A 132
ALA A 112
HIS A  65
 None
 1.03A 1q23F-3hinA:
undetectable		 1q23F-3hinA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Salmonella
enterica) 		PF00881
(Nitroreductase) 		4 ALA A  86
VAL A 143
ALA A 140
HIS A 136
 None
None
SIN  A 219 (-3.1A)
None
 1.17A 1q23F-3hznA:
undetectable		 1q23F-3hznA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i07 ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Vibrio cholerae) 		PF02566
(OsmC) 		4 ALA A  73
VAL A  75
ALA A  70
HIS A  68
 None
None
None
GOL  A 302 ( 3.9A)
 1.09A 1q23F-3i07A:
undetectable		 1q23F-3i07A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01512
(Complex1_51K)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10531
(SLBB)
PF10588
(NADH-G_4Fe-4S_3)
PF10589
(NADH_4Fe-4S)
PF13510
(Fer2_4) 		4 ALA 1 349
VAL 1 363
ALA 1 364
HIS 3 208
 None
 1.22A 1q23F-3i9v1:
undetectable		 1q23F-3i9v1:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 ALA A 472
VAL A 474
ALA A 473
HIS A 432
 None
 1.25A 1q23F-3js8A:
2.7		 1q23F-3js8A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ALA E 484
VAL E 488
ALA E 485
HIS E 423
 None
None
None
ZN  E 996 ( 3.3A)
 1.16A 1q23F-3kdsE:
undetectable		 1q23F-3kdsE:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		4 ALA A 392
VAL A 408
ALA A 411
HIS A 387
 None
 1.21A 1q23F-3l4dA:
undetectable		 1q23F-3l4dA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A 103
VAL A 181
ALA A 207
HIS A 340
 None
 1.13A 1q23F-3ledA:
undetectable		 1q23F-3ledA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ALA A 346
VAL A 339
ALA A 338
HIS A 270
 None
 1.15A 1q23F-3lk6A:
undetectable		 1q23F-3lk6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncv DNA MISMATCH REPAIR
PROTEIN MUTL

(Neisseria
gonorrhoeae) 		PF08676
(MutL_C) 		4 ALA A 495
VAL A 499
ALA A 496
HIS A 493
 None
 0.80A 1q23F-3ncvA:
undetectable		 1q23F-3ncvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng3 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycobacterium
avium) 		PF01791
(DeoC) 		4 ALA A  80
VAL A 115
ALA A  77
HIS A  78
 None
 1.24A 1q23F-3ng3A:
undetectable		 1q23F-3ng3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsj PERFORIN-1

(Mus musculus) 		PF00168
(C2)
PF01823
(MACPF) 		4 ALA A 117
VAL A 116
ALA A 154
HIS A 150
 None
 1.25A 1q23F-3nsjA:
undetectable		 1q23F-3nsjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		4 ALA A  97
VAL A 285
ALA A  87
HIS A 114
 None
 1.13A 1q23F-3ntlA:
undetectable		 1q23F-3ntlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ALA A  34
VAL A 121
ALA A  30
HIS A  31
 None
 1.19A 1q23F-3qdqA:
undetectable		 1q23F-3qdqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 ALA A 241
VAL A 213
ALA A 212
HIS A 206
 None
None
None
MN  A 365 (-3.4A)
 1.25A 1q23F-3rmjA:
undetectable		 1q23F-3rmjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 ALA B 580
VAL B 577
ALA B 576
HIS B 554
 None
 1.16A 1q23F-3s4wB:
undetectable		 1q23F-3s4wB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 ALA A  31
VAL A  28
ALA A  27
HIS A 203
 None
 1.07A 1q23F-3tr1A:
undetectable		 1q23F-3tr1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		4 ALA A 375
VAL A 176
ALA A 376
HIS A 261
 None
 1.20A 1q23F-3v7iA:
undetectable		 1q23F-3v7iA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wad GLYCOSYLTRANSFERASE

(Streptomyces
halstedii) 		PF06722
(DUF1205) 		4 ALA A 142
VAL A 116
ALA A 139
HIS A 147
 None
 1.11A 1q23F-3wadA:
undetectable		 1q23F-3wadA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE

(Methanocaldococcus
jannaschii) 		PF05889
(SepSecS) 		4 ALA A 210
VAL A 229
ALA A 101
HIS A 233
 LLP  A 234 ( 3.4A)
None
LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.5A)
 1.14A 1q23F-3wksA:
undetectable		 1q23F-3wksA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC

(Leishmania
major) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ALA A  59
VAL A  63
ALA A  60
HIS A  57
 None
 1.07A 1q23F-4a26A:
undetectable		 1q23F-4a26A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ALA B1820
VAL B1741
ALA B1738
HIS B1735
 None
 1.25A 1q23F-4f92B:
undetectable		 1q23F-4f92B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		4 ALA A 152
VAL A 154
ALA A 149
HIS A  99
 None
 1.18A 1q23F-4g09A:
undetectable		 1q23F-4g09A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 ALA A 393
VAL A 408
ALA A 411
HIS A 388
 None
 1.22A 1q23F-4g3jA:
undetectable		 1q23F-4g3jA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id0 GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF

(Pseudomonas
fluorescens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 ALA A 157
VAL A 161
ALA A 158
HIS A 153
 None
None
None
GOL  A 304 (-4.3A)
 1.26A 1q23F-4id0A:
undetectable		 1q23F-4id0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		4 ALA A 128
VAL A 318
ALA A 173
HIS A  58
 None
 1.26A 1q23F-4mnrA:
undetectable		 1q23F-4mnrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nic DNA-BINDING
TRANSCRIPTIONAL
REGULATOR RSTA

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 ALA A 110
VAL A 107
ALA A 106
HIS A  24
 None
 1.23A 1q23F-4nicA:
undetectable		 1q23F-4nicA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		4 ALA A 173
VAL A  48
ALA A  47
HIS A  35
 None
 1.08A 1q23F-4o48A:
undetectable		 1q23F-4o48A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7h GLUTATHIONE
S-TRANSFERASE

(Rhodospirillum
rubrum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 ALA A  12
VAL A  16
ALA A  13
HIS A   7
 None
 1.20A 1q23F-4o7hA:
undetectable		 1q23F-4o7hA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		4 ALA A 237
VAL A 236
ALA A 109
HIS A 240
 None
None
LLP  A 241 ( 3.9A)
LLP  A 241 ( 3.7A)
 1.26A 1q23F-4q76A:
undetectable		 1q23F-4q76A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		4 ALA A 346
VAL A 343
ALA A 342
HIS A 809
 None
 1.26A 1q23F-4r0yA:
undetectable		 1q23F-4r0yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 ALA A 414
VAL A 560
ALA A 415
HIS A 355
 BCR  A6007 ( 3.8A)
None
None
CLA  A1103 (-3.6A)
 1.23A 1q23F-4rkuA:
undetectable		 1q23F-4rkuA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		4 ALA A  91
VAL A  95
ALA A  92
HIS A  89
 None
 0.92A 1q23F-4u4eA:
undetectable		 1q23F-4u4eA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		4 ALA A 226
VAL A 235
ALA A 280
HIS A 287
 None
 1.26A 1q23F-4wrlA:
undetectable		 1q23F-4wrlA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		4 ALA A 226
VAL A 235
ALA A 280
HIS A 287
 None
 1.25A 1q23F-4wrmA:
undetectable		 1q23F-4wrmA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		4 ALA A  40
VAL A 267
ALA A 264
HIS A 260
 None
 1.16A 1q23F-4wxbA:
undetectable		 1q23F-4wxbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		4 ALA A 280
VAL A 291
ALA A 290
HIS A 244
 None
None
None
ZN  A 402 (-3.3A)
 1.26A 1q23F-4xukA:
undetectable		 1q23F-4xukA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		4 ALA A 178
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.16A 1q23F-4y4nA:
undetectable		 1q23F-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		4 ALA A 227
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.23A 1q23F-4y4nA:
undetectable		 1q23F-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
ZN  A 701 (-3.3A)
 1.09A 1q23F-4z8xA:
undetectable		 1q23F-4z8xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		4 ALA A1009
VAL A1013
ALA A1010
HIS A1007
 None
 1.22A 1q23F-5f3yA:
undetectable		 1q23F-5f3yA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA C 709
VAL C 706
ALA C 705
HIS C 433
 None
 1.14A 1q23F-5g5gC:
undetectable		 1q23F-5g5gC:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 4 ALA A  77
VAL A  74
ALA A  86
HIS A  88
 None
 1.08A 1q23F-5gufA:
undetectable		 1q23F-5gufA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 ALA A 382
VAL A 442
ALA A 381
HIS A 462
 None
None
None
ZN  A 901 (-3.2A)
 1.23A 1q23F-5gz4A:
undetectable		 1q23F-5gz4A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		4 ALA B 524
VAL A  13
ALA A  14
HIS A  16
 None
 1.23A 1q23F-5hftB:
undetectable		 1q23F-5hftB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 ALA A  59
VAL A 184
ALA A  62
HIS A  61
 None
 1.18A 1q23F-5hx9A:
undetectable		 1q23F-5hx9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 ALA A  55
VAL A  38
ALA A  56
HIS A  62
 None
 1.24A 1q23F-5l7zA:
undetectable		 1q23F-5l7zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 ALA A 265
VAL A  38
ALA A  56
HIS A  62
 None
 1.26A 1q23F-5l7zA:
undetectable		 1q23F-5l7zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 ALA A  55
VAL A  38
ALA A  56
HIS A  62
 None
 1.24A 1q23F-5l80A:
undetectable		 1q23F-5l80A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 ALA A 212
VAL A  38
ALA A  56
HIS A  62
 None
 1.26A 1q23F-5l80A:
undetectable		 1q23F-5l80A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 4 ALA A 289
VAL A 274
ALA A 290
HIS A 105
 PG4  A 403 ( 4.2A)
None
None
PG4  A 403 (-4.5A)
 1.22A 1q23F-5o25A:
undetectable		 1q23F-5o25A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ook PHYCOCYANIN, ALPHA
SUBUNIT

(Acaryochloris
marina) 		no annotation 4 ALA A  52
VAL A  85
ALA A  56
HIS A 135
 None
 1.16A 1q23F-5ookA:
undetectable		 1q23F-5ookA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 ALA 2 563
VAL 2 556
ALA 2 560
HIS 2 561
 None
 1.18A 1q23F-5udb2:
undetectable		 1q23F-5udb2:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		4 ALA A 110
VAL A 153
ALA A 114
HIS A 126
 None
 1.25A 1q23F-5uj6A:
undetectable		 1q23F-5uj6A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A  87
VAL A  91
ALA A  88
HIS A  85
 None
 1.19A 1q23F-5utuA:
undetectable		 1q23F-5utuA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1

(Xenopus laevis) 		PF00520
(Ion_trans)
PF03520
(KCNQ_channel) 		4 ALA A 501
VAL A 505
ALA A 502
HIS A 499
 None
 0.94A 1q23F-5vmsA:
undetectable		 1q23F-5vmsA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 ALA A 854
VAL A 858
ALA A 855
HIS A 476
 None
 1.12A 1q23F-5wmmA:
undetectable		 1q23F-5wmmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		4 ALA A 282
VAL A 285
ALA A 286
HIS A 299
 None
 1.21A 1q23F-5x9rA:
undetectable		 1q23F-5x9rA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 4 ALA A 126
VAL A 117
ALA A 125
HIS A  44
 None
 1.23A 1q23F-5z24A:
undetectable		 1q23F-5z24A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 ALA A 302
VAL A 306
ALA A 303
HIS A 300
 None
 0.92A 1q23F-5z9sA:
undetectable		 1q23F-5z9sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Paraburkholderia
phymatum) 		no annotation 4 ALA A 238
VAL A 241
ALA A 242
HIS A 312
 None
None
None
EDO  A 507 (-4.2A)
 1.07A 1q23F-6c0dA:
undetectable		 1q23F-6c0dA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 ALA A 268
VAL A 272
ALA A 269
HIS A 266
 None
 0.91A 1q23F-6c26A:
undetectable		 1q23F-6c26A:
20.20