SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_C_FUAC701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 ALA A 620
VAL A 619
ALA A 878
HIS A 876
 None
 1.18A 1q23A-1dgjA:
0.0		 1q23A-1dgjA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ALA B 314
VAL B 312
ALA B 313
HIS B 260
 None
 1.12A 1q23A-1e6vB:
1.0		 1q23A-1e6vB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		4 ALA A 134
VAL A 144
ALA A 183
HIS A 141
 None
 1.02A 1q23A-1eyeA:
0.0		 1q23A-1eyeA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri) 		PF00808
(CBFD_NFYB_HMF) 		4 ALA A 100
VAL A 105
ALA A 104
HIS A  62
 None
None
CL  A1001 ( 4.9A)
None
 1.12A 1q23A-1f1eA:
undetectable		 1q23A-1f1eA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ALA A 554
VAL A 558
ALA A 555
HIS A 552
 None
 1.03A 1q23A-1i8qA:
0.0		 1q23A-1i8qA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ALA A 226
VAL A 322
ALA A 321
HIS A 258
 None
 1.17A 1q23A-1kijA:
0.0		 1q23A-1kijA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrh AUXIN-BINDING
PROTEIN 1

(Zea mays) 		PF02041
(Auxin_BP) 		4 ALA A 142
VAL A 144
ALA A 143
HIS A 140
 None
 0.98A 1q23A-1lrhA:
0.0		 1q23A-1lrhA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrv LEUCINE-RICH REPEAT
VARIANT

(Azotobacter
vinelandii) 		PF01816
(LRV)
PF05484
(LRV_FeS) 		4 ALA A 191
VAL A 210
ALA A 213
HIS A 217
 None
 1.17A 1q23A-1lrvA:
0.0		 1q23A-1lrvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		4 ALA A 163
VAL A 133
ALA A 132
HIS A 170
 None
 0.80A 1q23A-1nijA:
1.9		 1q23A-1nijA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 ALA A  24
VAL A  28
ALA A  29
HIS A 193
 None
 0.36A 1q23A-1pd5A:
37.1		 1q23A-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		4 ALA A 221
VAL A 218
ALA A 217
HIS A 137
 None
 1.18A 1q23A-1t0bA:
undetectable		 1q23A-1t0bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqx D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00834
(Ribul_P_3_epim) 		4 ALA A 195
VAL A 221
ALA A 191
HIS A 193
 None
 1.12A 1q23A-1tqxA:
undetectable		 1q23A-1tqxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 ALA A 100
VAL A  81
ALA A  80
HIS A 200
 None
None
None
FE  A1293 (-3.2A)
 1.09A 1q23A-1uzrA:
undetectable		 1q23A-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		4 ALA A 120
VAL A 117
ALA A 116
HIS A  98
 None
 1.19A 1q23A-1v9cA:
undetectable		 1q23A-1v9cA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 ALA A 230
VAL A 226
ALA A 225
HIS A 180
 None
 1.06A 1q23A-1vliA:
undetectable		 1q23A-1vliA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A 360
VAL A 363
ALA A 364
HIS A 103
 None
 1.07A 1q23A-1ysjA:
undetectable		 1q23A-1ysjA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z47 PUTATIVE
ABC-TRANSPORTER
ATP-BINDING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ALA A 266
VAL A 263
ALA A 264
HIS A 344
 None
 1.20A 1q23A-1z47A:
undetectable		 1q23A-1z47A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
HG  A1001 (-3.1A)
 1.08A 1q23A-2di4A:
undetectable		 1q23A-2di4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 ALA A  69
VAL C 658
ALA C 657
HIS C 646
 FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.6A)
None
 1.13A 1q23A-2e1mA:
undetectable		 1q23A-2e1mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ALA A 310
VAL A 313
ALA A 314
HIS A 339
 None
 1.20A 1q23A-2eg5A:
undetectable		 1q23A-2eg5A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		4 ALA A 101
VAL A  98
ALA A  91
HIS A  94
 None
 1.15A 1q23A-2fe1A:
undetectable		 1q23A-2fe1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0b FEEM

(uncultured
bacterium) 		no annotation 4 ALA A 109
VAL A 108
ALA A 107
HIS A 102
 None
 1.16A 1q23A-2g0bA:
undetectable		 1q23A-2g0bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 ALA A 303
VAL A 307
ALA A 304
HIS A 301
 None
 0.99A 1q23A-2g4oA:
undetectable		 1q23A-2g4oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		4 ALA A  83
VAL A  85
ALA A  86
HIS A 338
 None
None
None
CL  A 605 (-4.2A)
 0.98A 1q23A-2gwnA:
undetectable		 1q23A-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13

(Homo sapiens) 		PF01852
(START) 		4 ALA A 955
VAL A1094
ALA A1091
HIS A1088
 None
 1.18A 1q23A-2psoA:
2.7		 1q23A-2psoA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ALA A 520
VAL A 547
ALA A 521
HIS A 875
 None
 1.13A 1q23A-2qo3A:
undetectable		 1q23A-2qo3A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r01 NITROREDUCTASE
FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF00881
(Nitroreductase) 		4 ALA A  94
VAL A  33
ALA A  32
HIS A  30
 None
 1.19A 1q23A-2r01A:
undetectable		 1q23A-2r01A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rrk CTP
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 ALA A  88
VAL A  72
ALA A  73
HIS A  75
 None
 1.01A 1q23A-2rrkA:
undetectable		 1q23A-2rrkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 212
VAL A 246
ALA A 245
HIS A 214
 ALA  A 212 ( 0.0A)
VAL  A 246 ( 0.6A)
ALA  A 245 ( 0.0A)
HIS  A 214 ( 1.0A)
 1.13A 1q23A-2vbfA:
undetectable		 1q23A-2vbfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		4 ALA A  42
VAL A 268
ALA A 265
HIS A 261
 None
 1.11A 1q23A-2vmxA:
undetectable		 1q23A-2vmxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ALA A 198
VAL A 273
ALA A 199
HIS A 201
 None
 1.04A 1q23A-2x3kA:
undetectable		 1q23A-2x3kA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		4 ALA A 126
VAL A 187
ALA A 190
HIS A 198
 None
 1.12A 1q23A-2yg6A:
undetectable		 1q23A-2yg6A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 ALA A 324
VAL A 105
ALA A 104
HIS A 326
 None
 1.10A 1q23A-2ykyA:
undetectable		 1q23A-2ykyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.18A 1q23A-3a0hB:
undetectable		 1q23A-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		4 ALA A 159
VAL A 207
ALA A 213
HIS A 215
 None
 1.19A 1q23A-3bptA:
undetectable		 1q23A-3bptA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 ALA A 244
VAL A 267
ALA A 266
HIS A 283
 None
 1.14A 1q23A-3bxhA:
undetectable		 1q23A-3bxhA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 ALA A 707
VAL A 711
ALA A 708
HIS A 705
 None
 0.98A 1q23A-3cqcA:
undetectable		 1q23A-3cqcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqg NUCLEAR PORE COMPLEX
PROTEIN NUP107

(Homo sapiens) 		PF04121
(Nup84_Nup100) 		4 ALA A 707
VAL A 711
ALA A 708
HIS A 705
 None
 1.02A 1q23A-3cqgA:
undetectable		 1q23A-3cqgA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		4 ALA A  54
VAL A  58
ALA A  55
HIS A  52
 None
 0.99A 1q23A-3e03A:
undetectable		 1q23A-3e03A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ALA A 280
VAL A 300
ALA A 283
HIS A 271
 None
 1.18A 1q23A-3eoqA:
undetectable		 1q23A-3eoqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0i ARSENATE REDUCTASE

(Vibrio cholerae) 		PF03960
(ArsC) 		4 ALA A  83
VAL A  40
ALA A  86
HIS A  88
 None
 0.82A 1q23A-3f0iA:
undetectable		 1q23A-3f0iA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 ALA A  94
VAL A 337
ALA A 334
HIS A 329
 None
 1.16A 1q23A-3fcrA:
undetectable		 1q23A-3fcrA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ALA A   9
VAL A  35
ALA A  10
HIS A  19
 None
 1.17A 1q23A-3fhlA:
undetectable		 1q23A-3fhlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8r PROBABLE SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
E

(Chromobacterium
violaceum) 		PF03102
(NeuB)
PF08666
(SAF) 		4 ALA A 219
VAL A 215
ALA A 214
HIS A 168
 None
 1.00A 1q23A-3g8rA:
undetectable		 1q23A-3g8rA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ALA A  95
VAL A 338
ALA A 335
HIS A 330
 None
 1.14A 1q23A-3gjuA:
undetectable		 1q23A-3gjuA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A  96
VAL A 100
ALA A  97
HIS A  94
 None
 1.13A 1q23A-3glqA:
undetectable		 1q23A-3glqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hin PUTATIVE
3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Rhodopseudomonas
palustris) 		PF00378
(ECH_1) 		4 ALA A 201
VAL A 132
ALA A 112
HIS A  65
 None
 1.03A 1q23A-3hinA:
undetectable		 1q23A-3hinA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Salmonella
enterica) 		PF00881
(Nitroreductase) 		4 ALA A  86
VAL A 143
ALA A 140
HIS A 136
 None
None
SIN  A 219 (-3.1A)
None
 1.09A 1q23A-3hznA:
undetectable		 1q23A-3hznA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i07 ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Vibrio cholerae) 		PF02566
(OsmC) 		4 ALA A  73
VAL A  75
ALA A  70
HIS A  68
 None
None
None
GOL  A 302 ( 3.9A)
 1.13A 1q23A-3i07A:
undetectable		 1q23A-3i07A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01512
(Complex1_51K)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10531
(SLBB)
PF10588
(NADH-G_4Fe-4S_3)
PF10589
(NADH_4Fe-4S)
PF13510
(Fer2_4) 		4 ALA 1 349
VAL 1 363
ALA 1 364
HIS 3 208
 None
 1.16A 1q23A-3i9v1:
undetectable		 1q23A-3i9v1:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		4 ALA A 298
VAL A 301
ALA A 302
HIS A 293
 None
 1.07A 1q23A-3im8A:
undetectable		 1q23A-3im8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		4 ALA A  31
VAL A 104
ALA A 107
HIS A  28
 None
 1.20A 1q23A-3iomA:
undetectable		 1q23A-3iomA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k60 HEAT SHOCK PROTEIN
86

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ALA A 127
VAL A 130
ALA A 131
HIS A 133
 None
 1.02A 1q23A-3k60A:
undetectable		 1q23A-3k60A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ALA E 484
VAL E 488
ALA E 485
HIS E 423
 None
None
None
ZN  E 996 ( 3.3A)
 1.10A 1q23A-3kdsE:
undetectable		 1q23A-3kdsE:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A 103
VAL A 181
ALA A 207
HIS A 340
 None
 1.04A 1q23A-3ledA:
undetectable		 1q23A-3ledA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ALA A 346
VAL A 339
ALA A 338
HIS A 270
 None
 1.05A 1q23A-3lk6A:
undetectable		 1q23A-3lk6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncv DNA MISMATCH REPAIR
PROTEIN MUTL

(Neisseria
gonorrhoeae) 		PF08676
(MutL_C) 		4 ALA A 495
VAL A 499
ALA A 496
HIS A 493
 None
 0.83A 1q23A-3ncvA:
undetectable		 1q23A-3ncvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		4 ALA A 319
VAL A 326
ALA A 325
HIS A 323
 None
 1.10A 1q23A-3o6xA:
undetectable		 1q23A-3o6xA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgy SERINE
HYDROXYMETHYLTRANSFE
RASE

(Staphylococcus
aureus) 		PF00464
(SHMT) 		4 ALA A  42
VAL A 268
ALA A 265
HIS A 261
 None
 1.14A 1q23A-3pgyA:
undetectable		 1q23A-3pgyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		4 ALA A 128
VAL A 189
ALA A 192
HIS A 200
 None
 1.11A 1q23A-3rhaA:
undetectable		 1q23A-3rhaA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 ALA B 580
VAL B 577
ALA B 576
HIS B 554
 None
 1.15A 1q23A-3s4wB:
undetectable		 1q23A-3s4wB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 143
VAL A 178
ALA A 179
HIS A 207
 None
 1.15A 1q23A-3t8qA:
undetectable		 1q23A-3t8qA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 ALA A  31
VAL A  28
ALA A  27
HIS A 203
 None
 1.01A 1q23A-3tr1A:
undetectable		 1q23A-3tr1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt9 PLAKOPHILIN-2

(Homo sapiens) 		PF00514
(Arm) 		4 ALA A 374
VAL A 415
ALA A 414
HIS A 379
 None
 1.20A 1q23A-3tt9A:
undetectable		 1q23A-3tt9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wad GLYCOSYLTRANSFERASE

(Streptomyces
halstedii) 		PF06722
(DUF1205) 		4 ALA A 142
VAL A 116
ALA A 139
HIS A 147
 None
 1.20A 1q23A-3wadA:
undetectable		 1q23A-3wadA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 ALA A 223
VAL A 231
ALA A 234
HIS A 238
 None
 1.16A 1q23A-3zjkA:
undetectable		 1q23A-3zjkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a26 PUTATIVE
C-1-TETRAHYDROFOLATE
SYNTHASE,
CYTOPLASMIC

(Leishmania
major) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 ALA A  59
VAL A  63
ALA A  60
HIS A  57
 None
 1.10A 1q23A-4a26A:
undetectable		 1q23A-4a26A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 ALA A 365
VAL A 344
ALA A 343
HIS A 375
 None
 1.01A 1q23A-4blaA:
undetectable		 1q23A-4blaA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 301
VAL A 305
ALA A 302
HIS A 299
 None
None
None
CAJ  A 503 (-4.1A)
 1.03A 1q23A-4emwA:
undetectable		 1q23A-4emwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A  69
VAL A 148
ALA A 174
HIS A 317
 None
 1.18A 1q23A-4ewpA:
undetectable		 1q23A-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A 172
VAL A 148
ALA A 174
HIS A 317
 None
 0.91A 1q23A-4ewpA:
undetectable		 1q23A-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 ALA A  46
VAL A 273
ALA A 270
HIS A 266
 None
 1.10A 1q23A-4j5uA:
undetectable		 1q23A-4j5uA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE

(Amycolatopsis
mediterranei) 		PF14765
(PS-DH) 		4 ALA A 221
VAL A 181
ALA A 180
HIS A 215
 None
 1.04A 1q23A-4ln9A:
undetectable		 1q23A-4ln9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		4 ALA A 173
VAL A  48
ALA A  47
HIS A  35
 None
 1.01A 1q23A-4o48A:
undetectable		 1q23A-4o48A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		4 ALA A 346
VAL A 343
ALA A 342
HIS A 809
 None
 1.18A 1q23A-4r0yA:
undetectable		 1q23A-4r0yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		4 ALA A  91
VAL A  95
ALA A  92
HIS A  89
 None
 0.89A 1q23A-4u4eA:
undetectable		 1q23A-4u4eA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		4 ALA A  40
VAL A 267
ALA A 264
HIS A 260
 None
 1.07A 1q23A-4wxbA:
undetectable		 1q23A-4wxbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 ALA A  80
VAL A  77
ALA A  58
HIS A  53
 None
 1.17A 1q23A-4xpdA:
undetectable		 1q23A-4xpdA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		4 ALA A 178
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.16A 1q23A-4y4nA:
undetectable		 1q23A-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		4 ALA A 227
VAL A 231
ALA A 230
HIS A 176
 None
None
None
FE2  A 301 ( 3.4A)
 1.15A 1q23A-4y4nA:
undetectable		 1q23A-4y4nA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Aquifex
aeolicus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
ZN  A 701 (-3.3A)
 1.07A 1q23A-4z8xA:
undetectable		 1q23A-4z8xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b22 NECTIN-3

(Mus musculus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 ALA A 138
VAL A 136
ALA A 137
HIS A 192
 None
 1.16A 1q23A-5b22A:
undetectable		 1q23A-5b22A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA C 709
VAL C 706
ALA C 705
HIS C 433
 None
 1.18A 1q23A-5g5gC:
undetectable		 1q23A-5g5gC:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 4 ALA A  77
VAL A  74
ALA A  86
HIS A  88
 None
 1.03A 1q23A-5gufA:
undetectable		 1q23A-5gufA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		4 ALA B 524
VAL A  13
ALA A  14
HIS A  16
 None
 1.08A 1q23A-5hftB:
undetectable		 1q23A-5hftB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm9 MAMO PROTEASE DOMAIN

(Magnetospirillum
magneticum) 		PF13365
(Trypsin_2) 		4 ALA A  59
VAL A  42
ALA A  41
HIS A 119
 None
 0.79A 1q23A-5hm9A:
undetectable		 1q23A-5hm9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7z MATERNAL PROTEIN
EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 ALA A  55
VAL A  38
ALA A  56
HIS A  62
 None
 1.15A 1q23A-5l7zA:
undetectable		 1q23A-5l7zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l80 MATERNAL PROTEIN
EXUPERANTIA,MATERNAL
PROTEIN EXUPERANTIA

(Drosophila
melanogaster) 		no annotation 4 ALA A  55
VAL A  38
ALA A  56
HIS A  62
 None
 1.15A 1q23A-5l80A:
undetectable		 1q23A-5l80A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 4 ALA A 289
VAL A 274
ALA A 290
HIS A 105
 PG4  A 403 ( 4.2A)
None
None
PG4  A 403 (-4.5A)
 1.20A 1q23A-5o25A:
undetectable		 1q23A-5o25A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovu BETA-PROTEOBACTERIA
PROTEASOME HOMOLOGUE

(Cupriavidus
metallidurans) 		no annotation 4 ALA A 162
VAL A   6
ALA A  13
HIS A 183
 None
 1.12A 1q23A-5ovuA:
undetectable		 1q23A-5ovuA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ALA A  87
VAL A  91
ALA A  88
HIS A  85
 None
 1.10A 1q23A-5utuA:
undetectable		 1q23A-5utuA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		4 ALA A  67
VAL A  71
ALA A  68
HIS A  65
 None
 1.01A 1q23A-5uvmA:
undetectable		 1q23A-5uvmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1

(Xenopus laevis) 		PF00520
(Ion_trans)
PF03520
(KCNQ_channel) 		4 ALA A 501
VAL A 505
ALA A 502
HIS A 499
 None
 0.96A 1q23A-5vmsA:
undetectable		 1q23A-5vmsA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 ALA A 854
VAL A 858
ALA A 855
HIS A 476
 None
 1.17A 1q23A-5wmmA:
undetectable		 1q23A-5wmmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 ALA A 302
VAL A 306
ALA A 303
HIS A 300
 None
 0.91A 1q23A-5z9sA:
undetectable		 1q23A-5z9sA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		no annotation 4 ALA A 813
VAL A 822
ALA A 821
HIS A 785
 None
 1.12A 1q23A-6by9A:
undetectable		 1q23A-6by9A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Paraburkholderia
phymatum) 		no annotation 4 ALA A 238
VAL A 241
ALA A 242
HIS A 312
 None
None
None
EDO  A 507 (-4.2A)
 1.05A 1q23A-6c0dA:
2.7		 1q23A-6c0dA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 ALA A 268
VAL A 272
ALA A 269
HIS A 266
 None
 0.86A 1q23A-6c26A:
undetectable		 1q23A-6c26A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2x PROTEIN TYROSINE
KINASE A

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 249
VAL A 245
ALA A 248
HIS A 251
 None
 1.16A 1q23A-6f2xA:
undetectable		 1q23A-6f2xA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 ALA E  44
VAL E  47
ALA E  45
HIS E  42
 None
 1.20A 1q23A-6g72E:
undetectable		 1q23A-6g72E:
17.70