SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q23_B_FUAB703

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 SER A 388
PHE A 392
LEU A 284
VAL A 286
VAL A 210
 None
 1.25A 1q23B-1c4kA:
3.2		 1q23B-1c4kA:
13.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		6 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
THR A 174
 None
 0.58A 1q23B-1ciaA:
32.2		 1q23B-1ciaA:
44.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 TYR A 131
PHE A 310
LEU A 298
PHE A 240
VAL A 313
 None
 1.10A 1q23B-1cvrA:
0.0		 1q23B-1cvrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		5 TYR A 192
VAL A 147
PHE A 143
VAL A 171
THR A 166
 SO4  A 502 (-4.9A)
None
None
None
None
 1.22A 1q23B-1d5tA:
0.0		 1q23B-1d5tA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 PHE A 263
LEU A 601
VAL A 605
VAL A 262
THR A 256
 None
 1.19A 1q23B-1ewrA:
undetectable		 1q23B-1ewrA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		5 LEU P 436
VAL P 438
PHE P 448
VAL P 450
THR P 452
 None
 1.32A 1q23B-1h71P:
0.0		 1q23B-1h71P:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 PHE A 121
LEU A  20
VAL A  24
VAL A  98
THR A 100
 None
 0.88A 1q23B-1iirA:
0.0		 1q23B-1iirA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A 172
PHE A  62
LEU A 300
VAL A  22
VAL A   8
 None
 1.22A 1q23B-1ml4A:
0.5		 1q23B-1ml4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A 368
LEU A 312
VAL A 308
PHE A 299
THR A 324
 None
 1.31A 1q23B-1n5xA:
0.1		 1q23B-1n5xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 PHE A 263
LEU A 601
VAL A 605
VAL A 262
THR A 256
 None
 1.22A 1q23B-1nneA:
undetectable		 1q23B-1nneA:
13.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		12 THR A  93
SER A 104
TYR A 133
PHE A 134
PHE A 144
SER A 146
PHE A 156
LEU A 158
VAL A 160
PHE A 166
VAL A 170
THR A 172
 None
 0.44A 1q23B-1pd5A:
35.8		 1q23B-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		5 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.16A 1q23B-1pk6A:
undetectable		 1q23B-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT

(Homo sapiens) 		PF08785
(Ku_PK_bind) 		5 PHE A  84
PHE A 146
VAL A 108
PHE A 116
VAL A 120
 None
 1.21A 1q23B-1rw2A:
undetectable		 1q23B-1rw2A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		5 SER A 192
LEU A 175
VAL A 174
VAL A  15
THR A  18
 None
 1.29A 1q23B-1ywfA:
undetectable		 1q23B-1ywfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PHE A 213
LEU A 206
VAL A 195
PHE A 182
VAL A 210
 None
 1.29A 1q23B-1yzyA:
undetectable		 1q23B-1yzyA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Bacteroides
thetaiotaomicron) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.04A 1q23B-1zybA:
undetectable		 1q23B-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 THR A 148
LEU A  19
VAL A   3
PHE A   5
VAL A  15
 None
 1.34A 1q23B-2ag8A:
undetectable		 1q23B-2ag8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjs REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2)
no annotation 		5 THR C  98
PHE A  49
LEU A  60
VAL A  62
VAL A   6
 ZN  C 201 ( 4.7A)
None
None
None
None
 1.28A 1q23B-2cjsC:
undetectable		 1q23B-2cjsC:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eng ENDOGLUCANASE V

(Humicola
insolens) 		PF02015
(Glyco_hydro_45) 		5 PHE A  72
LEU A  70
VAL A  64
PHE A  68
VAL A 105
 None
 1.20A 1q23B-2engA:
undetectable		 1q23B-2engA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg5 RAS-RELATED PROTEIN
RAB-31

(Homo sapiens) 		PF00071
(Ras) 		5 SER A  41
LEU A  10
VAL A  82
PHE A 159
VAL A  22
 None
 1.33A 1q23B-2fg5A:
undetectable		 1q23B-2fg5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs5 CONSERVED
HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF02622
(DUF179) 		5 THR A  94
LEU A  38
VAL A  50
PHE A 135
VAL A 165
 None
 1.12A 1q23B-2gs5A:
undetectable		 1q23B-2gs5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld7 PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF02671
(PAH) 		5 PHE B 468
LEU B 509
VAL B 505
PHE B 484
VAL B 471
 None
 1.33A 1q23B-2ld7B:
undetectable		 1q23B-2ld7B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		5 THR A 152
LEU A 222
VAL A 248
VAL A 194
THR A 196
 None
 1.23A 1q23B-2p4zA:
undetectable		 1q23B-2p4zA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkh HISTIDINE
UTILIZATION
REPRESSOR

(Pseudomonas
syringae group
genomosp. 3) 		PF07702
(UTRA) 		5 PHE A 139
SER A 141
LEU A 181
VAL A 184
VAL A 159
 None
 0.93A 1q23B-2pkhA:
undetectable		 1q23B-2pkhA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PHE A 154
LEU A 152
VAL A 150
VAL A 215
THR A 211
 None
 1.24A 1q23B-2pljA:
undetectable		 1q23B-2pljA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus) 		PF00079
(Serpin) 		5 PHE A 210
LEU A 401
VAL A 399
PHE A 124
THR A 132
 None
 1.22A 1q23B-2r9yA:
undetectable		 1q23B-2r9yA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		5 THR A 114
VAL A  68
PHE A 141
VAL A 128
THR A 109
 None
 1.34A 1q23B-2rafA:
undetectable		 1q23B-2rafA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 TYR A 293
PHE A 294
PHE A  84
LEU A  59
VAL A  57
 None
 1.13A 1q23B-2vp1A:
undetectable		 1q23B-2vp1A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		5 PHE A  92
LEU A  42
VAL A  40
VAL A 108
THR A 106
 None
 1.33A 1q23B-2z4tA:
undetectable		 1q23B-2z4tA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 PHE A 294
LEU A 460
VAL A 489
VAL A 390
THR A 386
 None
 1.26A 1q23B-3bmwA:
undetectable		 1q23B-3bmwA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl1 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Klebsiella
pneumoniae) 		PF06167
(Peptidase_M90) 		5 PHE A  88
LEU A 130
VAL A 147
PHE A  73
VAL A  91
 None
 1.26A 1q23B-3dl1A:
undetectable		 1q23B-3dl1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 SER A1203
PHE A1243
SER A1159
VAL A1168
THR A1166
 None
 1.11A 1q23B-3dm0A:
undetectable		 1q23B-3dm0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A 165
VAL A 161
PHE A 295
VAL A 258
THR A 253
 None
 1.05A 1q23B-3docA:
undetectable		 1q23B-3docA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.13A 1q23B-3e77A:
undetectable		 1q23B-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 PHE A 433
PHE A 112
LEU A 150
VAL A 149
VAL A 107
 ANP  A 480 (-3.6A)
ANP  A 480 (-3.5A)
None
None
None
 1.23A 1q23B-3fhtA:
undetectable		 1q23B-3fhtA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0o 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 SER A  56
PHE A  60
LEU A  67
VAL A  97
VAL A  87
 None
 1.32A 1q23B-3g0oA:
undetectable		 1q23B-3g0oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.29A 1q23B-3i6sA:
undetectable		 1q23B-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		5 PHE A 877
LEU A 822
VAL A 818
VAL A1103
THR A 932
 None
 1.34A 1q23B-3jclA:
undetectable		 1q23B-3jclA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 THR A 375
SER A 592
LEU A 604
PHE A 633
VAL A 590
 None
 1.04A 1q23B-3mc2A:
undetectable		 1q23B-3mc2A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		5 PHE A 276
PHE A  66
LEU A  28
VAL A  35
VAL A  24
 None
 1.21A 1q23B-3n0vA:
undetectable		 1q23B-3n0vA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n54 SPORE GERMINATION
PROTEIN B3

(Bacillus
subtilis) 		PF05504
(Spore_GerAC) 		5 SER B 256
LEU B 308
VAL B 312
VAL B 275
THR B 277
 None
 0.99A 1q23B-3n54B:
undetectable		 1q23B-3n54B:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n54 SPORE GERMINATION
PROTEIN B3

(Bacillus
subtilis) 		PF05504
(Spore_GerAC) 		5 SER B 256
PHE B 364
VAL B 312
VAL B 275
THR B 277
 None
 1.25A 1q23B-3n54B:
undetectable		 1q23B-3n54B:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 TYR A  55
LEU A 348
VAL A 335
PHE A 169
VAL A 352
 ATP  A 763 (-4.5A)
None
None
None
None
 1.13A 1q23B-3o8lA:
undetectable		 1q23B-3o8lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 PHE A  14
LEU A  52
VAL A  39
PHE A  30
VAL A  17
 None
 1.34A 1q23B-3p91A:
undetectable		 1q23B-3p91A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy9 DIHYDRODIPICOLINATE
REDUCTASE

(Staphylococcus
aureus) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 SER A 156
LEU A 117
VAL A 195
PHE A 197
VAL A 121
 None
 1.20A 1q23B-3qy9A:
undetectable		 1q23B-3qy9A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN

(Leishmania
infantum) 		PF00857
(Isochorismatase) 		5 THR A 183
LEU A 211
VAL A  21
PHE A  65
VAL A  59
 None
 1.24A 1q23B-3r2jA:
undetectable		 1q23B-3r2jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 SER A 228
TYR A 247
LEU A 178
VAL A 179
PHE A  83
 None
 1.27A 1q23B-3r4vA:
undetectable		 1q23B-3r4vA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd6 MLL3558 PROTEIN

(Mesorhizobium
loti) 		PF08327
(AHSA1) 		5 THR A  11
LEU A 107
VAL A  23
PHE A  27
VAL A 105
 None
 1.34A 1q23B-3rd6A:
2.8		 1q23B-3rd6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 PHE B 797
PHE B 731
VAL B 663
PHE B 658
THR B 786
 None
 1.17A 1q23B-3s4wB:
undetectable		 1q23B-3s4wB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 SER A1227
PHE A 930
SER A1187
VAL A1194
THR A1192
 None
 1.33A 1q23B-3sfzA:
undetectable		 1q23B-3sfzA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 PHE A 254
LEU A 265
VAL A 267
PHE A 285
VAL A 290
 None
 1.29A 1q23B-3tefA:
undetectable		 1q23B-3tefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vba ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
SMALL SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00694
(Aconitase_C) 		5 PHE A  89
SER A  82
LEU A 120
VAL A 114
VAL A 122
 None
 1.33A 1q23B-3vbaA:
undetectable		 1q23B-3vbaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsb FARNESYLTRANSFERASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF00494
(SQS_PSY) 		5 PHE A 298
PHE A 202
LEU A 261
VAL A 257
THR A 206
 None
 1.13A 1q23B-3wsbA:
undetectable		 1q23B-3wsbA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zph CHALCONE ISOMERASE

(Eubacterium
ramulus) 		no annotation 5 PHE A 221
PHE A 183
LEU A 182
PHE A 249
VAL A 186
 None
 1.20A 1q23B-3zphA:
undetectable		 1q23B-3zphA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abk POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		5 TYR A1209
PHE A1229
LEU A1315
VAL A1311
VAL A1366
 None
 1.33A 1q23B-4abkA:
undetectable		 1q23B-4abkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abn TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Mus musculus) 		PF16669
(TTC5_OB) 		5 LEU A 416
VAL A 384
PHE A 355
VAL A 369
THR A 412
 None
 1.14A 1q23B-4abnA:
undetectable		 1q23B-4abnA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 PHE A 557
SER A 578
LEU A 617
PHE A 371
VAL A 612
 None
THG  A1652 (-4.2A)
None
None
None
 1.22A 1q23B-4cczA:
undetectable		 1q23B-4cczA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		5 PHE A 439
SER A 364
LEU A 451
VAL A 453
VAL A 366
 None
 1.30A 1q23B-4fwwA:
undetectable		 1q23B-4fwwA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 THR A 203
SER A 193
LEU A 357
VAL A 178
THR A 174
 PO4  A 601 ( 3.9A)
PO4  A 601 (-2.9A)
None
None
None
 1.22A 1q23B-4ga4A:
undetectable		 1q23B-4ga4A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 397
PHE A 434
PHE A 360
LEU A 421
VAL A 408
 None
 1.35A 1q23B-4i5jA:
undetectable		 1q23B-4i5jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 PHE A 294
LEU A 461
VAL A 490
VAL A 391
THR A 387
 None
 1.28A 1q23B-4jclA:
undetectable		 1q23B-4jclA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 THR A 343
LEU A 461
VAL A 490
VAL A 391
THR A 387
 None
 1.34A 1q23B-4jclA:
undetectable		 1q23B-4jclA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 THR A 332
LEU A 450
VAL A 479
VAL A 380
THR A 376
 None
None
None
None
SO4  A 725 (-3.5A)
 1.31A 1q23B-4jcmA:
undetectable		 1q23B-4jcmA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA
POLYMERASE-BINDING
TRANSCRIPTION FACTOR
CARD

(Mycobacterium
tuberculosis) 		PF02559
(CarD_CdnL_TRCF)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		5 THR A 138
LEU B  37
VAL B  19
PHE B   3
VAL B  58
 None
 1.23A 1q23B-4kbmA:
undetectable		 1q23B-4kbmA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 PHE A  43
LEU A  23
VAL A  25
PHE A 586
VAL A 502
 None
 1.19A 1q23B-4lnvA:
undetectable		 1q23B-4lnvA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		5 SER A  49
LEU A 309
VAL A  97
PHE A 326
VAL A 330
 None
 1.34A 1q23B-4mfiA:
undetectable		 1q23B-4mfiA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 PHE A 274
LEU A 209
VAL A 213
PHE A 184
VAL A 246
 None
 1.34A 1q23B-4mrmA:
undetectable		 1q23B-4mrmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlb RIBOSOMAL RNA
PROCESSING PROTEIN 6

(Trypanosoma
brucei) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 THR A 398
PHE A 323
LEU A 258
VAL A 259
VAL A 298
 None
 1.19A 1q23B-4nlbA:
undetectable		 1q23B-4nlbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 SER A 127
LEU A  81
VAL A 116
PHE A 111
VAL A  77
 None
 1.23A 1q23B-4od7A:
undetectable		 1q23B-4od7A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1

(Homo sapiens) 		PF05014
(Nuc_deoxyrib_tr) 		5 PHE A  25
PHE A  49
LEU A 154
VAL A 150
VAL A  91
 None
 1.32A 1q23B-4p5eA:
undetectable		 1q23B-4p5eA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		no annotation 5 PHE B 439
SER B 364
LEU B 451
VAL B 453
VAL B 366
 None
 1.23A 1q23B-4qt8B:
undetectable		 1q23B-4qt8B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 LEU A 220
VAL A 216
PHE A 106
VAL A 102
THR A 235
 None
 1.35A 1q23B-4tpnA:
undetectable		 1q23B-4tpnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w64 TYPE VI SECRETION
SYSTEM EFFECTOR,
HCP1 FAMILY

(Acinetobacter
baumannii) 		PF05638
(T6SS_HCP) 		5 THR A 115
PHE A 128
VAL A  14
PHE A   8
VAL A 111
 None
 1.30A 1q23B-4w64A:
undetectable		 1q23B-4w64A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 THR C  72
SER C  71
PHE C 297
SER C 280
LEU C 290
 None
 1.26A 1q23B-4yfaC:
undetectable		 1q23B-4yfaC:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A 367
LEU A 311
VAL A 307
PHE A 298
THR A 323
 None
 1.30A 1q23B-4yswA:
undetectable		 1q23B-4yswA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmi TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		PF08558
(TRF) 		5 PHE A 340
PHE A 230
LEU A 184
VAL A 181
VAL A 155
 None
 1.33A 1q23B-4zmiA:
undetectable		 1q23B-4zmiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 THR A 274
SER A 273
PHE A 499
SER A 482
LEU A 492
 None
 1.25A 1q23B-5c9iA:
undetectable		 1q23B-5c9iA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK

(Pseudomonas
putida) 		no annotation 5 THR A 166
PHE A 168
PHE A 263
VAL A 259
VAL A  92
 None
 1.33A 1q23B-5d2jA:
undetectable		 1q23B-5d2jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 THR A  20
LEU A 269
VAL A 267
VAL A 377
THR A 373
 None
None
None
None
ADP  A 501 (-3.8A)
 1.14A 1q23B-5dmhA:
undetectable		 1q23B-5dmhA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eur UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		no annotation 5 THR A  43
SER A  42
LEU A   8
VAL A  21
PHE A  31
 None
 1.13A 1q23B-5eurA:
undetectable		 1q23B-5eurA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewo STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		5 THR A 591
PHE A 438
LEU A 436
VAL A 434
THR A 482
 None
 1.04A 1q23B-5ewoA:
undetectable		 1q23B-5ewoA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.18A 1q23B-5gkvA:
undetectable		 1q23B-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 THR A 280
SER A 279
PHE A 322
VAL A 136
VAL A 184
 HEM  A 501 (-4.3A)
HEM  A 501 (-3.3A)
HEM  A 501 (-4.6A)
None
None
 1.25A 1q23B-5hdiA:
undetectable		 1q23B-5hdiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 SER A  58
LEU A  64
VAL A 108
PHE A  24
VAL A  56
 None
 1.18A 1q23B-5hkjA:
undetectable		 1q23B-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		5 THR A 366
SER A 229
VAL A  97
PHE A 265
VAL A 194
 None
 1.27A 1q23B-5hkjA:
undetectable		 1q23B-5hkjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.29A 1q23B-5k3hA:
undetectable		 1q23B-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		5 TYR A 433
VAL A 449
PHE A 506
VAL A 457
THR A 467
 None
 1.24A 1q23B-5la0A:
undetectable		 1q23B-5la0A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m31 APPR-1-P PROCESSING
DOMAIN PROTEIN

(Thermus
aquaticus) 		PF01661
(Macro) 		5 PHE A  75
LEU A 113
VAL A 144
VAL A  18
THR A  20
 None
 1.23A 1q23B-5m31A:
undetectable		 1q23B-5m31A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		5 PHE C 552
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.32A 1q23B-5mioC:
undetectable		 1q23B-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		5 SER C 551
PHE C 345
SER C 489
PHE C 402
VAL C 491
 None
 1.30A 1q23B-5mioC:
undetectable		 1q23B-5mioC:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.33A 1q23B-5oltA:
undetectable		 1q23B-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		5 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.25A 1q23B-5t2kA:
undetectable		 1q23B-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Bacillus
subtilis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		5 THR A 125
SER A 159
TYR A 186
PHE A  28
THR A  79
 None
None
None
7C5  A 302 (-4.2A)
None
 1.31A 1q23B-5th5A:
undetectable		 1q23B-5th5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 SER A  79
LEU A 104
VAL A  51
PHE A  36
VAL A 100
 None
 1.19A 1q23B-5ti1A:
undetectable		 1q23B-5ti1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umw GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE

(Streptomyces
sp. CB03234) 		no annotation 5 PHE A 120
SER A 124
LEU A  56
VAL A  44
VAL A  10
 None
 1.22A 1q23B-5umwA:
undetectable		 1q23B-5umwA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 SER A 110
LEU A 166
VAL A 164
VAL A 188
THR A 190
 None
 1.21A 1q23B-5xgsA:
undetectable		 1q23B-5xgsA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 5 THR A 156
SER A 200
LEU A 290
VAL A 258
VAL A 190
 None
 1.24A 1q23B-5z5kA:
undetectable		 1q23B-5z5kA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zdh TYPE II SECRETION
SYSTEM LIPOPROTEIN

(Escherichia
coli) 		no annotation 5 THR P  88
TYR P  65
PHE P  61
LEU P  23
VAL P  33
 None
 1.25A 1q23B-5zdhP:
undetectable		 1q23B-5zdhP:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 THR C 173
SER C 171
LEU C 245
VAL C 316
VAL C 267
 None
 1.29A 1q23B-6cajC:
undetectable		 1q23B-6cajC:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 PHE A 708
LEU A 710
VAL A 715
PHE A 726
VAL A 793
 None
 1.33A 1q23B-6gl3A:
undetectable		 1q23B-6gl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  88
ALA A  89
HIS A 190
 None
 0.54A 1q23C-1cliA:
0.0		 1q23C-1cliA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		3 VAL A 266
ALA A 267
HIS A 269
 None
 0.69A 1q23C-1ey2A:
0.0		 1q23C-1ey2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1e HISTONE FOLD PROTEIN

(Methanopyrus
kandleri) 		PF00808
(CBFD_NFYB_HMF) 		3 VAL A 105
ALA A 104
HIS A  62
 None
CL  A1001 ( 4.9A)
None
 0.68A 1q23C-1f1eA:
undetectable		 1q23C-1f1eA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		3 VAL A 271
ALA A 203
HIS A 221
 None
NAD  A1382 (-3.5A)
UDP  A1383 (-4.2A)
 0.77A 1q23C-1gy8A:
0.0		 1q23C-1gy8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		3 VAL C 506
ALA C 505
HIS C 553
 None
 0.74A 1q23C-1h2tC:
undetectable		 1q23C-1h2tC:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 VAL A 348
ALA A 341
HIS A 327
 None
None
DHE  A 602 (-4.3A)
 0.76A 1q23C-1hzvA:
0.0		 1q23C-1hzvA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqc DI-HEME PEROXIDASE

(Nitrosomonas
europaea) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 VAL A 113
ALA A 110
HIS A 107
 None
 0.74A 1q23C-1iqcA:
0.0		 1q23C-1iqcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L21E

(Haloarcula
marismortui) 		PF01157
(Ribosomal_L21e) 		3 VAL R  30
ALA R  29
HIS R  90
 None
 0.56A 1q23C-1kc8R:
undetectable		 1q23C-1kc8R:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		3 VAL A  50
ALA A  49
HIS A  60
 None
 0.69A 1q23C-1lt8A:
0.0		 1q23C-1lt8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxn HYPOTHETICAL PROTEIN
MTH1187

(Methanothermobacter
thermautotrophicus) 		PF01910
(Thiamine_BP) 		3 VAL A  26
ALA A  25
HIS A  61
 None
 0.77A 1q23C-1lxnA:
undetectable		 1q23C-1lxnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 VAL A 113
ALA A 114
HIS A 117
 None
 0.74A 1q23C-1n8pA:
0.7		 1q23C-1n8pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		3 VAL A 133
ALA A 132
HIS A 170
 None
 0.58A 1q23C-1nijA:
undetectable		 1q23C-1nijA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 VAL A  65
ALA A  66
HIS A 230
 None
 0.72A 1q23C-1nuqA:
undetectable		 1q23C-1nuqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Methylophilus
methylotrophus) 		PF01012
(ETF) 		3 VAL C 145
ALA C 144
HIS C 142
 None
 0.74A 1q23C-1o94C:
undetectable		 1q23C-1o94C:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		3 VAL A  28
ALA A  29
HIS A 193
 None
 0.43A 1q23C-1pd5A:
36.3		 1q23C-1pd5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		3 VAL A 108
ALA A 107
HIS A 156
 None
 0.61A 1q23C-1pn3A:
undetectable		 1q23C-1pn3A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 VAL A 370
ALA A 371
HIS A 366
 None
 0.73A 1q23C-1q8iA:
undetectable		 1q23C-1q8iA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind) 		3 VAL B 302
ALA B 301
HIS A 491
 None
 0.73A 1q23C-1r4nB:
undetectable		 1q23C-1r4nB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9u PUTATIVE COMPONENT
OF ANAEROBIC
DEHYDROGENASES

(Salmonella
enterica) 		PF02613
(Nitrate_red_del) 		3 VAL A  34
ALA A  31
HIS A  28
 None
 0.76A 1q23C-1s9uA:
undetectable		 1q23C-1s9uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t57 CONSERVED PROTEIN
MTH1675

(Methanothermobacter
thermautotrophicus) 		PF02887
(PK_C) 		3 VAL A  37
ALA A  38
HIS A  61
 None
FMN  A 200 (-3.7A)
FMN  A 200 (-4.2A)
 0.71A 1q23C-1t57A:
undetectable		 1q23C-1t57A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 VAL A  44
ALA A  43
HIS A  28
 None
 0.73A 1q23C-1taqA:
undetectable		 1q23C-1taqA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		3 VAL A 105
ALA A 106
HIS A  95
 None
 0.77A 1q23C-1u0kA:
undetectable		 1q23C-1u0kA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 VAL A 219
ALA A 218
HIS A 246
 None
None
CSO  A 110 ( 3.9A)
 0.70A 1q23C-1ub7A:
undetectable		 1q23C-1ub7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 VAL A  88
ALA A  89
HIS A 327
 None
None
152  A 613 (-4.3A)
 0.60A 1q23C-1xl8A:
9.9		 1q23C-1xl8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 3 VAL B 512
ALA B 509
HIS B 506
 None
 0.77A 1q23C-1xnjB:
undetectable		 1q23C-1xnjB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		3 VAL A 236
ALA A 237
HIS A 239
 None
 0.70A 1q23C-1xnyA:
undetectable		 1q23C-1xnyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A 253
ALA A 250
HIS A 247
 None
None
OHS  A 245 ( 3.7A)
 0.74A 1q23C-1y9aA:
undetectable		 1q23C-1y9aA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		3 VAL A  45
ALA A 194
HIS A  62
 None
None
ZN  A1446 (-3.3A)
 0.76A 1q23C-1yloA:
undetectable		 1q23C-1yloA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		3 VAL A 437
ALA A 438
HIS A 496
 None
 0.71A 1q23C-1zvdA:
undetectable		 1q23C-1zvdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		3 VAL A  78
ALA A 147
HIS A  97
 None
None
ZN  A 502 (-3.3A)
 0.72A 1q23C-2anpA:
undetectable		 1q23C-2anpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btu PHOSPHORIBOSYL-AMINO
IMIDAZOLE SYNTHETASE

(Bacillus
anthracis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  85
ALA A  86
HIS A 187
 None
 0.53A 1q23C-2btuA:
undetectable		 1q23C-2btuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		3 VAL A  18
ALA A  17
HIS A 234
 None
 0.59A 1q23C-2c20A:
undetectable		 1q23C-2c20A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1e PROTEIN APAG

(Xanthomonas
citri) 		PF04379
(DUF525) 		3 VAL A  48
ALA A  49
HIS A  51
 None
 0.68A 1q23C-2f1eA:
undetectable		 1q23C-2f1eA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 VAL A  60
ALA A 122
HIS A 105
 None
 0.65A 1q23C-2fgeA:
undetectable		 1q23C-2fgeA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		3 VAL A  16
ALA A  17
HIS A 106
 None
 0.71A 1q23C-2gtxA:
undetectable		 1q23C-2gtxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		3 VAL A  85
ALA A  86
HIS A 338
 None
None
CL  A 605 (-4.2A)
 0.76A 1q23C-2gwnA:
undetectable		 1q23C-2gwnA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h9f HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF04303
(PrpF) 		3 VAL A 322
ALA A 321
HIS A 351
 None
 0.78A 1q23C-2h9fA:
undetectable		 1q23C-2h9fA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isb FUMARASE

(Archaeoglobus
fulgidus) 		PF05683
(Fumerase_C) 		3 VAL A 155
ALA A  34
HIS A  63
 None
 0.75A 1q23C-2isbA:
undetectable		 1q23C-2isbA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isj BLUB

(Sinorhizobium
meliloti) 		PF00881
(Nitroreductase) 		3 VAL A 149
ALA A 148
HIS A  55
 None
 0.60A 1q23C-2isjA:
undetectable		 1q23C-2isjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		3 VAL A 101
ALA A 100
HIS A  42
 None
ATP  A1296 (-3.6A)
ATP  A1296 (-4.4A)
 0.48A 1q23C-2jaxA:
undetectable		 1q23C-2jaxA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 VAL A  20
ALA A  19
HIS A  69
 None
None
PO4  A 503 (-4.1A)
 0.69A 1q23C-2plaA:
undetectable		 1q23C-2plaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A 517
ALA A 518
HIS A 620
 None
 0.54A 1q23C-2v9yA:
undetectable		 1q23C-2v9yA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25

(Homo sapiens) 		PF03801
(Ndc80_HEC)
PF08234
(Spindle_Spc25) 		3 VAL A 186
ALA A 183
HIS A 180
 None
 0.76A 1q23C-2ve7A:
undetectable		 1q23C-2ve7A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 VAL A 273
ALA A 199
HIS A 201
 None
 0.77A 1q23C-2x3kA:
undetectable		 1q23C-2x3kA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		3 VAL A 172
ALA A 205
HIS A 211
 None
 0.75A 1q23C-2y7dA:
undetectable		 1q23C-2y7dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  85
ALA A  86
HIS A 187
 None
 0.56A 1q23C-2z01A:
undetectable		 1q23C-2z01A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		3 VAL A 112
ALA A 113
HIS A 170
 None
 0.77A 1q23C-3b9yA:
undetectable		 1q23C-3b9yA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		3 VAL A  58
ALA A  55
HIS A  52
 None
 0.72A 1q23C-3e03A:
undetectable		 1q23C-3e03A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A 253
ALA A 250
HIS A 247
 None
 0.77A 1q23C-3fpcA:
undetectable		 1q23C-3fpcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8d BIOTIN CARBOXYLASE

(Escherichia
coli) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 VAL A  76
ALA A  77
HIS A  79
 None
 0.62A 1q23C-3g8dA:
undetectable		 1q23C-3g8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdi PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus musculus) 		PF08447
(PAS_3) 		3 VAL A 349
ALA A 348
HIS A 430
 None
 0.58A 1q23C-3gdiA:
undetectable		 1q23C-3gdiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		3 VAL A 409
ALA A 408
HIS A 493
 None
 0.71A 1q23C-3gecA:
undetectable		 1q23C-3gecA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 VAL A 320
ALA A 319
HIS A  57
 None
 0.78A 1q23C-3gm8A:
undetectable		 1q23C-3gm8A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		3 VAL A 108
ALA A 107
HIS A 156
 None
 0.48A 1q23C-3h4iA:
undetectable		 1q23C-3h4iA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8y MAJOR CARBOXYSOME
SHELL PROTEIN 1C

(Halothiobacillus
neapolitanus) 		PF00936
(BMC) 		3 VAL A  76
ALA A  77
HIS A  79
 None
 0.73A 1q23C-3h8yA:
undetectable		 1q23C-3h8yA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiu UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF05974
(DUF892) 		3 VAL A 156
ALA A 153
HIS A 150
 None
EDO  A 170 ( 4.9A)
None
 0.74A 1q23C-3hiuA:
undetectable		 1q23C-3hiuA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		3 VAL A 735
ALA A 399
HIS A1358
 None
 0.60A 1q23C-3hmjA:
undetectable		 1q23C-3hmjA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		3 VAL A 148
ALA A 147
HIS A 120
 None
 0.61A 1q23C-3iq0A:
undetectable		 1q23C-3iq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		3 VAL A  42
ALA A  24
HIS A 151
 None
 0.73A 1q23C-3it4A:
undetectable		 1q23C-3it4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k60 HEAT SHOCK PROTEIN
86

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 VAL A 130
ALA A 131
HIS A 133
 None
 0.70A 1q23C-3k60A:
undetectable		 1q23C-3k60A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki6 CHOLIX TOXIN

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly) 		3 VAL A 465
ALA A 466
HIS A 460
 None
None
G9L  A   1 (-3.9A)
 0.71A 1q23C-3ki6A:
undetectable		 1q23C-3ki6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 3 VAL X 490
ALA X 526
HIS X 546
 None
 0.77A 1q23C-3kvnX:
undetectable		 1q23C-3kvnX:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 VAL A 101
ALA A 100
HIS A 130
 None
None
GOL  A6502 ( 3.8A)
 0.72A 1q23C-3l01A:
undetectable		 1q23C-3l01A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l23 SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		3 VAL A 173
ALA A 170
HIS A 167
 None
 0.78A 1q23C-3l23A:
undetectable		 1q23C-3l23A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 VAL A 181
ALA A 207
HIS A 340
 None
 0.44A 1q23C-3ledA:
undetectable		 1q23C-3ledA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvy CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY

(Streptococcus
mutans) 		PF02627
(CMD) 		3 VAL A 182
ALA A  83
HIS A  85
 None
None
BME  A 191 (-3.7A)
 0.68A 1q23C-3lvyA:
undetectable		 1q23C-3lvyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncv DNA MISMATCH REPAIR
PROTEIN MUTL

(Neisseria
gonorrhoeae) 		PF08676
(MutL_C) 		3 VAL A 499
ALA A 496
HIS A 493
 None
 0.71A 1q23C-3ncvA:
undetectable		 1q23C-3ncvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		3 VAL A 450
ALA A 449
HIS A 408
 None
 0.74A 1q23C-3nmzA:
undetectable		 1q23C-3nmzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		3 VAL A 274
ALA A 249
HIS A 280
 None
None
EDO  A 312 (-4.7A)
 0.76A 1q23C-3nwoA:
undetectable		 1q23C-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		3 VAL A 305
ALA A 304
HIS A 242
 None
 0.62A 1q23C-3os6A:
undetectable		 1q23C-3os6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p01 TWO-COMPONENT
RESPONSE REGULATOR

(Nostoc sp. PCC
7120) 		PF13185
(GAF_2) 		3 VAL A 304
ALA A 301
HIS A 298
 None
 0.77A 1q23C-3p01A:
undetectable		 1q23C-3p01A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 VAL A  89
ALA A  90
HIS A 191
 None
 0.54A 1q23C-3p4eA:
undetectable		 1q23C-3p4eA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp7 PYRUVATE KINASE

(Leishmania
mexicana) 		PF00224
(PK)
PF02887
(PK_C) 		3 VAL A 461
ALA A 458
HIS A 455
 None
 0.75A 1q23C-3pp7A:
undetectable		 1q23C-3pp7A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		3 VAL A 192
ALA A 163
HIS A  88
 None
 0.69A 1q23C-3qh4A:
undetectable		 1q23C-3qh4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7g PROTEIN SPIRE
HOMOLOG 1

(Homo sapiens) 		PF16474
(KIND) 		3 VAL A  61
ALA A  60
HIS A 216
 None
 0.77A 1q23C-3r7gA:
undetectable		 1q23C-3r7gA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rty PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		3 VAL A 409
ALA A 408
HIS A 493
 DTT  A 900 (-4.9A)
None
None
 0.52A 1q23C-3rtyA:
undetectable		 1q23C-3rtyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		3 VAL A  54
ALA A  55
HIS A  69
 None
 0.73A 1q23C-3wrfA:
undetectable		 1q23C-3wrfA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj0 ACETYLTRANSFERASE

(Oceanicola
granulosus) 		PF00583
(Acetyltransf_1) 		3 VAL A  48
ALA A  47
HIS A 135
 None
None
ACO  A1205 (-3.1A)
 0.77A 1q23C-3zj0A:
undetectable		 1q23C-3zj0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 VAL A 352
ALA A 353
HIS A 358
 None
FAD  A3005 (-3.6A)
FAD  A3005 (-3.8A)
 0.62A 1q23C-3zyvA:
undetectable		 1q23C-3zyvA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6

(Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		3 VAL A 327
ALA A 326
HIS A 288
 None
 0.78A 1q23C-4a05A:
undetectable		 1q23C-4a05A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		3 VAL A 609
ALA A 608
HIS A 226
 None
 0.68A 1q23C-4a5wA:
undetectable		 1q23C-4a5wA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq2 HOMOGENTISATE
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF04209
(HgmA) 		3 VAL A 262
ALA A 263
HIS A 265
 None
 0.66A 1q23C-4aq2A:
undetectable		 1q23C-4aq2A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axs CARBAMATE KINASE

(Mycoplasma
penetrans) 		PF00696
(AA_kinase) 		3 VAL A 227
ALA A   7
HIS A  45
 None
 0.76A 1q23C-4axsA:
undetectable		 1q23C-4axsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 VAL B2136
ALA B2137
HIS B2122
 None
None
CUO  B9006 (-3.2A)
 0.69A 1q23C-4bedB:
undetectable		 1q23C-4bedB:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		3 VAL A 173
ALA A 172
HIS A  95
 None
 0.70A 1q23C-4c3sA:
undetectable		 1q23C-4c3sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj3 PERIOD CIRCADIAN
PROTEIN HOMOLOG 3

(Mus musculus) 		PF08447
(PAS_3) 		3 VAL A 288
ALA A 287
HIS A 370
 None
 0.58A 1q23C-4dj3A:
undetectable		 1q23C-4dj3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 3 VAL A 379
ALA A 376
HIS A 373
 None
 0.77A 1q23C-4egvA:
undetectable		 1q23C-4egvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo3 BACTERIOFERRITIN
COMIGRATORY
PROTEIN/NADH
DEHYDROGENASE

(Thermotoga
maritima) 		PF00578
(AhpC-TSA)
PF00881
(Nitroreductase) 		3 VAL A 245
ALA A 244
HIS A 175
 None
 0.75A 1q23C-4eo3A:
undetectable		 1q23C-4eo3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 VAL A 148
ALA A 174
HIS A 317
 None
 0.69A 1q23C-4ewpA:
undetectable		 1q23C-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE

(Leishmania
major) 		PF00248
(Aldo_ket_red) 		3 VAL A  37
ALA A  36
HIS A 243
 None
 0.69A 1q23C-4f40A:
undetectable		 1q23C-4f40A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 VAL B1741
ALA B1738
HIS B1735
 None
 0.71A 1q23C-4f92B:
undetectable		 1q23C-4f92B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 VAL A 102
ALA A 103
HIS A 105
 None
 0.69A 1q23C-4fomA:
undetectable		 1q23C-4fomA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		3 VAL A 257
ALA A 256
HIS A 360
 None
 0.51A 1q23C-4isyA:
undetectable		 1q23C-4isyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 VAL A 543
ALA A 542
HIS A 497
 None
 0.66A 1q23C-4jhzA:
undetectable		 1q23C-4jhzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		3 VAL A 133
ALA A 130
HIS A 167
 None
 0.78A 1q23C-4k81A:
undetectable		 1q23C-4k81A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knt MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07732
(Cu-oxidase_3) 		3 VAL A 289
ALA A 273
HIS A 227
 None
 0.76A 1q23C-4kntA:
undetectable		 1q23C-4kntA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		3 VAL A 263
ALA A 260
HIS A 257
 None
 0.77A 1q23C-4kpnA:
undetectable		 1q23C-4kpnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		3 VAL B 206
ALA B 203
HIS B 240
 None
 0.75A 1q23C-4kvgB:
undetectable		 1q23C-4kvgB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		3 VAL A  67
ALA A  48
HIS A  43
 None
 0.64A 1q23C-4kvoA:
undetectable		 1q23C-4kvoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		3 VAL A 196
ALA A 197
HIS A 232
 None
 0.69A 1q23C-4lejA:
undetectable		 1q23C-4lejA:
19.76