SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q13_A_TESA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
4 TYR A 484
HIS A 585
PRO A 531
VAL A 537
None
1.36A 1q13A-1br2A:
undetectable
1q13A-1br2A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7a PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE


(Escherichia
coli)
PF00731
(AIRC)
4 TYR A  63
HIS A  38
PRO A  77
VAL A  42
None
1.11A 1q13A-1d7aA:
undetectable
1q13A-1d7aA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE


(Penicillium
roqueforti)
no annotation 4 TYR A 129
GLU A 149
PRO A 148
VAL A 110
None
1.34A 1q13A-1dgpA:
undetectable
1q13A-1dgpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 TYR A 217
GLU A 117
PRO A 115
VAL A 242
None
1.37A 1q13A-1f8wA:
undetectable
1q13A-1f8wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glo CATHEPSIN S

(Homo sapiens)
PF00112
(Peptidase_C1)
4 TYR A 148
HIS A 205
GLU A 192
VAL A 182
None
1.15A 1q13A-1gloA:
undetectable
1q13A-1gloA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)


(Paracoccus
denitrificans)
PF06433
(Me-amine-dh_H)
4 HIS H 169
GLU H 360
PRO H  39
VAL H 122
None
1.43A 1q13A-1mdaH:
undetectable
1q13A-1mdaH:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE


(Oryctolagus
cuniculus)
PF00248
(Aldo_ket_red)
5 TYR A  24
TYR A  55
HIS A 117
GLU A 224
VAL A 306
None
NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
None
None
0.19A 1q13A-1q5mA:
55.8
1q13A-1q5mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT


(Thermus
thermophilus)
PF00676
(E1_dh)
4 TYR A  94
TYR A  95
HIS A 273
GLU A 202
TDP  A1402 (-4.5A)
TDP  A1402 (-4.3A)
TDP  A1402 (-4.3A)
None
0.95A 1q13A-1umbA:
undetectable
1q13A-1umbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
4 TYR A 457
GLU A 372
PRO A 371
VAL A 434
None
1.38A 1q13A-1w07A:
undetectable
1q13A-1w07A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)


(Thermus
thermophilus)
PF02347
(GDC-P)
4 TYR A   3
HIS B  83
PRO A  42
VAL A  50
None
1.43A 1q13A-1wytA:
undetectable
1q13A-1wytA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE


(Ipomoea batatas)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
4 TYR A 289
TYR A 378
GLU A 307
PRO A 308
None
1.37A 1q13A-1xzwA:
undetectable
1q13A-1xzwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437


(Archaeoglobus
fulgidus)
no annotation 4 TYR A  53
TYR A  49
GLU A 185
VAL A 178
None
1.25A 1q13A-1y8aA:
undetectable
1q13A-1y8aA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE


(Escherichia
coli)
PF04996
(AstB)
4 TYR A  18
HIS A  16
GLU A 324
PRO A 322
None
1.29A 1q13A-1yniA:
undetectable
1q13A-1yniA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans)
PF00248
(Aldo_ket_red)
4 TYR A 243
GLU A 180
PRO A 179
VAL A 195
None
1.25A 1q13A-1ynqA:
23.9
1q13A-1ynqA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans)
PF00248
(Aldo_ket_red)
4 TYR A 243
GLU A 180
PRO A 179
VAL A 250
None
1.11A 1q13A-1ynqA:
23.9
1q13A-1ynqA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904


(Enterococcus
faecalis)
PF12706
(Lactamase_B_2)
4 TYR A 186
HIS A  97
PRO A 408
VAL A 218
None
ZN  A 602 (-3.3A)
None
None
1.20A 1q13A-2az4A:
undetectable
1q13A-2az4A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Desulfovibrio
africanus)
PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II)
4 TYR A 479
HIS A 467
GLU A 285
PRO A 414
None
1.27A 1q13A-2c3oA:
undetectable
1q13A-2c3oA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 TYR A 119
TYR A 116
GLU A 318
PRO A 315
None
1.30A 1q13A-2f9gA:
undetectable
1q13A-2f9gA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4


(Homo sapiens)
PF00248
(Aldo_ket_red)
4 TYR A  24
TYR A  55
HIS A 117
VAL A 306
None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
0.58A 1q13A-2fvlA:
52.3
1q13A-2fvlA:
78.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
4 TYR A 186
GLU A 489
PRO A 490
VAL A 206
None
1.13A 1q13A-2g3nA:
4.7
1q13A-2g3nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh8 HYPOTHETICAL PROTEIN
YDFO


(Escherichia
coli)
PF07166
(DUF1398)
4 TYR A  42
TYR A  40
GLU A  47
VAL A  19
None
1.24A 1q13A-2hh8A:
undetectable
1q13A-2hh8A:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2


(Homo sapiens)
PF00248
(Aldo_ket_red)
4 TYR A  55
HIS A 117
GLU A 224
PRO A 226
FFA  A 325 ( 4.3A)
FFA  A 325 ( 3.8A)
None
None
0.85A 1q13A-2ipjA:
52.1
1q13A-2ipjA:
78.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg3 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC


(Pectobacterium
atrosepticum)
PF06508
(QueC)
4 TYR A  25
GLU A 157
PRO A 159
VAL A   6
None
1.40A 1q13A-2pg3A:
undetectable
1q13A-2pg3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv PROTEIN SIP2

(Saccharomyces
cerevisiae)
PF04739
(AMPKBI)
PF16561
(AMPK1_CBM)
4 TYR B 323
GLU B 320
PRO B 316
VAL B 312
None
1.42A 1q13A-2qlvB:
undetectable
1q13A-2qlvB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1


(Sulfolobus
solfataricus)
PF03070
(TENA_THI-4)
4 TYR A 140
TYR A 162
HIS A  88
GLU A 198
GOL  A 215 ( 3.5A)
GOL  A 215 (-4.7A)
None
IMD  A 214 (-2.7A)
1.24A 1q13A-2qzcA:
undetectable
1q13A-2qzcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2)
no annotation 4 TYR A 297
GLU A 523
PRO A 524
VAL A 454
None
1.22A 1q13A-2wb7A:
undetectable
1q13A-2wb7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125


(Mycobacterium
tuberculosis)
PF00067
(p450)
4 TYR A 208
GLU A 408
PRO A 407
VAL A 167
None
1.34A 1q13A-2xn8A:
undetectable
1q13A-2xn8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE


(Rhodothermus
marinus)
no annotation 4 TYR A 207
TYR A 122
GLU A 254
PRO A 256
EDO  A 502 ( 4.5A)
EDO  A 506 ( 3.7A)
None
None
1.37A 1q13A-2y4lA:
undetectable
1q13A-2y4lA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
no annotation 4 HIS B 306
GLU B 292
PRO B 293
VAL B 333
None
1.18A 1q13A-3bxwB:
9.0
1q13A-3bxwB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME


(Lactobacillus
acidophilus)
PF01263
(Aldose_epim)
4 TYR A 207
GLU A 253
PRO A 144
VAL A 250
None
1.36A 1q13A-3dcdA:
undetectable
1q13A-3dcdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1


(Homo sapiens)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
4 TYR A 682
TYR A 679
HIS A 752
PRO A 593
None
1.42A 1q13A-3dwbA:
undetectable
1q13A-3dwbA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Azotobacter
vinelandii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TYR A  23
HIS A 320
GLU A 362
PRO A 363
None
TLA  A 501 (-4.3A)
None
None
1.39A 1q13A-3ekgA:
5.5
1q13A-3ekgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 TYR A1054
HIS A 752
PRO A 593
VAL A 997
None
None
None
ACY  A2203 (-4.5A)
1.43A 1q13A-3fg4A:
undetectable
1q13A-3fg4A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
4 TYR A 349
TYR A 345
GLU A 265
VAL A 242
None
1.20A 1q13A-3fiiA:
undetectable
1q13A-3fiiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE


(Psychrobacter
arcticus)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 TYR A  35
HIS A 491
PRO A 432
VAL A 462
None
1.28A 1q13A-3hn7A:
undetectable
1q13A-3hn7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)


(Agrobacterium
fabrum)
PF13458
(Peripla_BP_6)
4 TYR A 345
TYR A 333
GLU A 273
PRO A 272
None
1.30A 1q13A-3ipcA:
undetectable
1q13A-3ipcA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1u CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1, SERYL
T-RNA SYNTHETASE
CHIMERA


(Mus musculus)
PF12777
(MT)
4 TYR A3400
GLU A3408
PRO A3409
VAL A3276
None
1.38A 1q13A-3j1uA:
undetectable
1q13A-3j1uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2


(Thermus
thermophilus)
PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2)
4 TYR A 206
GLU A 190
PRO A 189
VAL A 212
None
1.43A 1q13A-3j4jA:
undetectable
1q13A-3j4jA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ln3 DIHYDRODIOL
DEHYDROGENASE


(Mus musculus)
PF00248
(Aldo_ket_red)
4 TYR A  24
TYR A  55
HIS A 117
GLU A 226
MLY  A  25 (-3.6A)
NAD  A 327 ( 4.7A)
MRD  A 328 ( 3.9A)
MLY  A  27 ( 3.3A)
0.89A 1q13A-3ln3A:
50.6
1q13A-3ln3A:
65.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 TYR A 504
GLU A 416
PRO A 415
VAL A 456
None
1.40A 1q13A-3mi6A:
9.7
1q13A-3mi6A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 TYR A 504
GLU A 416
PRO A 415
VAL A 457
None
1.37A 1q13A-3mi6A:
9.7
1q13A-3mi6A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n26 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Chlamydia
pneumoniae)
PF00497
(SBP_bac_3)
4 TYR A  41
GLU A 186
PRO A 187
VAL A 192
ARG  A 500 (-3.5A)
ARG  A 500 (-2.9A)
None
None
1.14A 1q13A-3n26A:
undetectable
1q13A-3n26A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otl PUTATIVE
UNCHARACTERIZED
PROTEIN


(Rhizobium
leguminosarum)
PF08327
(AHSA1)
4 TYR A  90
TYR A  73
GLU A 121
VAL A 106
None
MES  A 159 ( 4.9A)
None
None
0.91A 1q13A-3otlA:
undetectable
1q13A-3otlA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE


(Cryptosporidium
parvum)
PF00069
(Pkinase)
4 TYR A 116
TYR A 113
GLU A 341
PRO A 338
None
1.37A 1q13A-3oz6A:
undetectable
1q13A-3oz6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qax PROBABLE ABC
TRANSPORTER
ARGININE-BINDING
PROTEIN ARTJ


(Chlamydia
pneumoniae)
PF00497
(SBP_bac_3)
4 TYR A  20
GLU A 165
PRO A 166
VAL A 171
ARG  A 600 (-3.4A)
ARG  A 600 (-3.1A)
None
None
1.12A 1q13A-3qaxA:
undetectable
1q13A-3qaxA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120)
PF00561
(Abhydrolase_1)
4 TYR A  34
HIS A  32
PRO A 168
VAL A 203
None
1.39A 1q13A-3qyjA:
undetectable
1q13A-3qyjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT


(Cryptococcus
neoformans)
PF01239
(PPTA)
4 TYR A  35
TYR A  39
HIS A  73
PRO A  29
None
1.35A 1q13A-3sfyA:
undetectable
1q13A-3sfyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
4 TYR A 118
HIS A 113
PRO A  99
VAL A 123
None
1.41A 1q13A-3tsdA:
10.5
1q13A-3tsdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
agalactiae)
PF00092
(VWA)
4 TYR A 272
HIS A 381
PRO A 542
VAL A 538
None
1.42A 1q13A-3txaA:
undetectable
1q13A-3txaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ueb PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermococcus
onnurineus)
PF11419
(DUF3194)
4 TYR A  69
GLU A  71
PRO A  73
VAL A  80
None
1.42A 1q13A-3uebA:
undetectable
1q13A-3uebA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)


(Malassezia
globosa)
PF01764
(Lipase_3)
4 TYR A 285
HIS A 170
GLU A 275
VAL A 230
None
1.40A 1q13A-3uufA:
undetectable
1q13A-3uufA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Deinococcus
radiodurans)
PF01063
(Aminotran_4)
4 TYR A 190
HIS A 233
GLU A 216
VAL A 225
None
1.06A 1q13A-3uzbA:
undetectable
1q13A-3uzbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235


(Bacillus
licheniformis)
PF13535
(ATP-grasp_4)
4 TYR A 339
TYR A 404
HIS A 394
VAL A 358
None
1.35A 1q13A-3votA:
undetectable
1q13A-3votA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE


(Archaeoglobus
fulgidus;
Escherichia
coli)
PF13416
(SBP_bac_8)
4 TYR A 708
GLU A 727
PRO A 738
VAL A 745
None
1.40A 1q13A-3waiA:
undetectable
1q13A-3waiA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE


(Archaeoglobus
fulgidus)
PF02516
(STT3)
4 TYR A 708
GLU A 727
PRO A 738
VAL A 745
None
1.37A 1q13A-3wajA:
undetectable
1q13A-3wajA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus)
PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD)
4 TYR A  84
HIS A 151
GLU A 673
VAL A 108
None
1.29A 1q13A-3wqyA:
undetectable
1q13A-3wqyA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
4 TYR A 164
TYR A 161
GLU A 356
PRO A 353
None
1.26A 1q13A-4b99A:
undetectable
1q13A-4b99A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8


(Saccharomyces
cerevisiae)
PF08084
(PROCT)
4 TYR C2305
HIS C2260
PRO C2331
VAL C2274
None
1.37A 1q13A-4bgdC:
undetectable
1q13A-4bgdC:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3


(Homo sapiens)
PF04054
(Not1)
PF04153
(NOT2_3_5)
4 TYR C 613
HIS A1978
PRO A2087
VAL A2035
None
1.34A 1q13A-4c0dC:
undetectable
1q13A-4c0dC:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum)
PF00703
(Glyco_hydro_2)
4 TYR A 573
TYR A 575
HIS A 628
GLU A 594
None
1.33A 1q13A-4cvuA:
6.7
1q13A-4cvuA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 TYR A 503
GLU A 415
PRO A 414
VAL A 455
None
1.40A 1q13A-4fnqA:
7.4
1q13A-4fnqA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C)
4 TYR A 464
HIS A 519
GLU A 440
PRO A 310
None
None
SAH  A 701 (-2.5A)
None
1.31A 1q13A-4g56A:
4.2
1q13A-4g56A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE


(Bacillus
anthracis)
PF00144
(Beta-lactamase)
4 TYR A 123
TYR A 127
GLU A 121
VAL A 387
None
1.30A 1q13A-4gb7A:
undetectable
1q13A-4gb7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5


(Homo sapiens)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C)
4 TYR A 468
HIS A 523
GLU A 444
PRO A 314
None
None
0XU  A 701 (-4.3A)
None
1.33A 1q13A-4gqbA:
3.1
1q13A-4gqbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE


(Photorhabdus
laumondii)
PF01494
(FAD_binding_3)
4 TYR A 171
HIS A 136
GLU A 362
VAL A 156
EDO  A 509 (-4.0A)
None
None
None
1.39A 1q13A-4hb9A:
undetectable
1q13A-4hb9A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE


(Campylobacter
jejuni)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
4 TYR A 177
TYR A   2
GLU A 135
PRO A 141
None
1.29A 1q13A-4le5A:
undetectable
1q13A-4le5A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis)
PF00561
(Abhydrolase_1)
4 TYR A 193
HIS A 206
GLU A 307
VAL A 300
None
1.43A 1q13A-4meaA:
undetectable
1q13A-4meaA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv7 ARYLAMINE
N-ACETYLTRANSFERASE


(Mesorhizobium
japonicum)
PF00797
(Acetyltransf_2)
4 TYR A 189
HIS A  82
PRO A 183
VAL A  91
None
1.43A 1q13A-4nv7A:
undetectable
1q13A-4nv7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oby ARGININE--TRNA
LIGASE


(Escherichia
coli)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
4 TYR A 323
TYR A 261
HIS A 158
VAL A 116
None
None
ARG  A 601 (-3.7A)
None
1.11A 1q13A-4obyA:
undetectable
1q13A-4obyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbn NUCLEASE

(Salmonella
virus SETP3)
PF08774
(VRR_NUC)
4 TYR A  28
GLU A  50
PRO A  59
VAL A  77
None
1.43A 1q13A-4qbnA:
undetectable
1q13A-4qbnA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
4 TYR A 240
TYR A 241
GLU A  93
VAL A 112
None
1.39A 1q13A-4qs9A:
undetectable
1q13A-4qs9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
4 TYR A 148
TYR A 145
GLU A 339
PRO A 336
None
EDO  A 407 (-3.8A)
None
None
1.35A 1q13A-4qtbA:
undetectable
1q13A-4qtbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN


(Ruegeria
pomeroyi)
PF00884
(Sulfatase)
4 TYR A  65
HIS A 495
GLU A 375
VAL A 444
None
1.29A 1q13A-4upiA:
undetectable
1q13A-4upiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis)
PF10079
(BshC)
4 TYR A 511
HIS A 104
GLU A 384
VAL A 537
ADP  A 601 (-4.7A)
None
ADP  A 601 (-3.1A)
None
1.10A 1q13A-4wbdA:
undetectable
1q13A-4wbdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
4 TYR A 442
GLU A 682
PRO A 613
VAL A 408
None
1.39A 1q13A-4wd9A:
undetectable
1q13A-4wd9A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
4 TYR A 442
GLU A 682
PRO A 613
VAL A 605
None
1.38A 1q13A-4wd9A:
undetectable
1q13A-4wd9A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xu4 UNCHARACTERIZED
PROTEIN


(Mycolicibacterium
vanbaalenii)
no annotation 4 TYR A 150
HIS A  26
PRO A 103
VAL A 108
None
DDQ  A 303 (-4.3A)
None
None
1.00A 1q13A-4xu4A:
undetectable
1q13A-4xu4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
4 TYR A 164
TYR A 161
GLU A 356
PRO A 353
None
1.28A 1q13A-4zslA:
undetectable
1q13A-4zslA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8g PP-BRD20

(Trypanosoma
brucei)
PF00439
(Bromodomain)
4 TYR A  33
TYR A  30
GLU A  44
PRO A   6
None
1.43A 1q13A-5c8gA:
undetectable
1q13A-5c8gA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGJ
YBGK


(Escherichia
coli)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
4 TYR B   7
GLU A 181
PRO A 256
VAL A 233
None
1.39A 1q13A-5dudB:
undetectable
1q13A-5dudB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE


(Mycobacterium
marinum)
PF03492
(Methyltransf_7)
4 TYR A  63
GLU A 202
PRO A 140
VAL A  59
None
1.27A 1q13A-5f2oA:
undetectable
1q13A-5f2oA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx0 UNCHARACTERIZED
PROTEIN DFER_1899


(Dyadobacter
fermentans)
PF13088
(BNR_2)
4 TYR A 365
TYR A 381
HIS A  54
GLU A 262
ACT  A 402 (-4.5A)
None
None
ACT  A 402 ( 4.6A)
1.31A 1q13A-5hx0A:
undetectable
1q13A-5hx0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4


(Saccharomyces
cerevisiae)
PF03105
(SPX)
PF09359
(VTC)
4 HIS A 461
GLU A 451
PRO A 452
VAL A 424
None
1.29A 1q13A-5iigA:
undetectable
1q13A-5iigA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kg9 ANTIBODY RE505-22
FAB LIGHT CHAIN


(Homo sapiens;
Mus musculus)
no annotation 4 TYR L 173
HIS L 198
GLU L  83
PRO L  80
None
1.38A 1q13A-5kg9L:
undetectable
1q13A-5kg9L:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lo9 CYTOCHROME C

(Marichromatium
purpuratum)
PF00034
(Cytochrom_C)
PF13442
(Cytochrome_CBB3)
4 TYR A 398
TYR A 469
HIS A 473
PRO A 422
None
None
None
HEC  A1004 (-4.0A)
1.36A 1q13A-5lo9A:
undetectable
1q13A-5lo9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE


(Anabaena)
no annotation 4 TYR B  66
GLU B  75
PRO B  76
VAL B  80
None
0.96A 1q13A-5ltmB:
undetectable
1q13A-5ltmB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE


(Nocardia
iowensis)
PF00501
(AMP-binding)
4 TYR A 441
GLU A 499
PRO A 459
VAL A 497
None
1.27A 1q13A-5mscA:
undetectable
1q13A-5mscA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz2 RUBISCO SMALL
SUBUNIT


(Thalassiosira
antarctica)
no annotation 4 TYR I  79
GLU I 106
PRO I 107
VAL I 130
None
None
None
EDO  I 202 ( 4.2A)
1.39A 1q13A-5mz2I:
undetectable
1q13A-5mz2I:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus)
no annotation 4 TYR A 634
GLU A 576
PRO A 573
VAL A 568
None
0.82A 1q13A-5no8A:
undetectable
1q13A-5no8A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE


(Bacteroides
thetaiotaomicron)
no annotation 4 TYR A 646
HIS A 642
PRO A 338
VAL A 394
None
1.31A 1q13A-5opjA:
undetectable
1q13A-5opjA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE


(Zobellia
galactanivorans)
no annotation 4 TYR A 492
HIS A 316
GLU A 494
VAL A 242
None
1.36A 1q13A-5opqA:
7.5
1q13A-5opqA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio)
PF14752
(RBP_receptor)
4 TYR A 200
TYR A 150
HIS A 145
VAL A  78
None
1.41A 1q13A-5sy1A:
undetectable
1q13A-5sy1A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT


(Oryctolagus
cuniculus)
no annotation 4 TYR B 333
TYR B 319
HIS B 330
PRO B 193
None
1.31A 1q13A-5w7aB:
undetectable
1q13A-5w7aB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE


(Homo sapiens)
no annotation 4 TYR C 334
TYR C 320
HIS C 331
PRO C 194
None
1.28A 1q13A-5w7cC:
undetectable
1q13A-5w7cC:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7d ACYLOXYACYL
HYDROLASE


(Mus musculus)
no annotation 4 TYR A 333
TYR A 319
HIS A 330
PRO A 193
None
1.33A 1q13A-5w7dA:
undetectable
1q13A-5w7dA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA


(Chaetomium
thermophilum)
no annotation 4 TYR B 809
TYR B 878
HIS B 307
PRO B 299
A97  B8009 (-4.7A)
A97  B8009 (-4.9A)
A97  B8009 (-4.4A)
None
1.40A 1q13A-5wfcB:
undetectable
1q13A-5wfcB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii)
no annotation 4 TYR A 605
GLU A 611
PRO A  32
VAL A  87
None
1.11A 1q13A-5wugA:
undetectable
1q13A-5wugA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US7
RIBOSOMAL PROTEIN
US9


(Toxoplasma
gondii)
PF00177
(Ribosomal_S7)
PF00380
(Ribosomal_S9)
4 TYR Q  84
GLU F  58
PRO F  55
VAL F  37
None
1.43A 1q13A-5xxuQ:
undetectable
1q13A-5xxuQ:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Moorella
thermoacetica)
no annotation 4 TYR A 476
HIS A 464
GLU A 283
PRO A 411
None
1.27A 1q13A-6cipA:
undetectable
1q13A-6cipA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY


(Brevundimonas
sp. BAL3)
no annotation 4 TYR A 399
GLU A 346
PRO A 347
VAL A 268
None
1.23A 1q13A-6frlA:
undetectable
1q13A-6frlA:
13.67