SIMILAR PATTERNS OF AMINO ACIDS FOR 1Q0Y_H_MOIH401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		4 GLU A 158
GLU A 187
ILE A 183
LEU A 150
 None
 1.43A 1q0yH-1cf5A:
undetectable
1q0yL-1cf5A:
undetectable		 1q0yH-1cf5A:
21.20
1q0yL-1cf5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		4 GLU A 158
GLU A 187
ILE A 184
LEU A 150
 None
 1.38A 1q0yH-1cf5A:
undetectable
1q0yL-1cf5A:
undetectable		 1q0yH-1cf5A:
21.20
1q0yL-1cf5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwv INVASIN

(Yersinia
pseudotuberculosis) 		PF02369
(Big_1)
PF07979
(Intimin_C)
PF09134
(Invasin_D3) 		4 TRP A 936
ILE A 858
LEU A 932
TRP A 889
 None
 1.15A 1q0yH-1cwvA:
6.1
1q0yL-1cwvA:
6.5		 1q0yH-1cwvA:
18.11
1q0yL-1cwvA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 GLU A 503
GLU A 526
ILE A 135
LEU A 338
 GOL  A 900 (-3.3A)
GOL  A 900 (-3.1A)
None
None
 1.48A 1q0yH-1dl2A:
0.0
1q0yL-1dl2A:
undetectable		 1q0yH-1dl2A:
15.78
1q0yL-1dl2A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 TRP A 368
GLU A 375
ILE A 257
LEU A 397
 None
 1.29A 1q0yH-1eyyA:
undetectable
1q0yL-1eyyA:
0.0		 1q0yH-1eyyA:
17.84
1q0yL-1eyyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 TRP A 230
GLU A 340
ILE A 236
LEU A 361
 None
 1.48A 1q0yH-1f5aA:
undetectable
1q0yL-1f5aA:
undetectable		 1q0yH-1f5aA:
19.09
1q0yL-1f5aA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0y INTERLEUKIN-1
RECEPTOR, TYPE I

(Homo sapiens) 		PF07679
(I-set)
PF13895
(Ig_2) 		4 GLU R  11
GLU R 217
ILE R 308
LEU R  88
 None
 0.92A 1q0yH-1g0yR:
5.6
1q0yL-1g0yR:
4.9		 1q0yH-1g0yR:
19.94
1q0yL-1g0yR:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		4 GLU A 187
GLU A 135
ILE A 109
LEU A  59
 None
 1.47A 1q0yH-1j5tA:
undetectable
1q0yL-1j5tA:
undetectable		 1q0yH-1j5tA:
22.51
1q0yL-1j5tA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		4 GLU A 172
GLU A 203
ILE A 200
LEU A 164
 None
 1.38A 1q0yH-1llnA:
undetectable
1q0yL-1llnA:
0.0		 1q0yH-1llnA:
20.96
1q0yL-1llnA:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU B  35
ILE B  69
TRP B  33
LEU B  52
 None
 1.44A 1q0yH-1pz5B:
20.3
1q0yL-1pz5B:
17.3		 1q0yH-1pz5B:
54.22
1q0yL-1pz5B:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq0 33 KDA CHAPERONIN

(Thermotoga
maritima) 		PF01430
(HSP33) 		4 GLU A 148
ILE A 150
TRP A  60
LEU A  54
 EDO  A 303 (-2.7A)
None
EDO  A 303 (-4.3A)
None
 1.21A 1q0yH-1vq0A:
undetectable
1q0yL-1vq0A:
undetectable		 1q0yH-1vq0A:
19.20
1q0yL-1vq0A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		4 ILE A 544
TRP A 632
LEU A 630
TRP A 493
 None
 1.37A 1q0yH-1z7eA:
undetectable
1q0yL-1z7eA:
undetectable		 1q0yH-1z7eA:
14.52
1q0yL-1z7eA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		4 GLU A 135
ILE A  96
LEU A  60
TRP A  16
 None
 1.39A 1q0yH-2a9jA:
undetectable
1q0yL-2a9jA:
undetectable		 1q0yH-2a9jA:
22.10
1q0yL-2a9jA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 TRP X  29
GLU X  32
LEU X  13
TRP X 356
 None
 1.34A 1q0yH-2b5dX:
undetectable
1q0yL-2b5dX:
undetectable		 1q0yH-2b5dX:
17.52
1q0yL-2b5dX:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 ILE A 544
TRP A 632
LEU A 630
TRP A 493
 None
 1.47A 1q0yH-2bllA:
undetectable
1q0yL-2bllA:
undetectable		 1q0yH-2bllA:
19.65
1q0yL-2bllA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		4 GLU A 210
GLU A 159
ILE A 133
LEU A  83
 None
 1.47A 1q0yH-2c3zA:
undetectable
1q0yL-2c3zA:
undetectable		 1q0yH-2c3zA:
19.34
1q0yL-2c3zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbr GLYOXYLATE REDUCTASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLU A  26
ILE A  38
LEU A  49
TRP A  28
 None
 1.36A 1q0yH-2dbrA:
undetectable
1q0yL-2dbrA:
undetectable		 1q0yH-2dbrA:
19.00
1q0yL-2dbrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		4 TRP A 351
ILE A 340
LEU A 405
TRP A 397
 None
 1.13A 1q0yH-2frxA:
undetectable
1q0yL-2frxA:
undetectable		 1q0yH-2frxA:
18.58
1q0yL-2frxA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 GLU A 385
GLU A 296
TRP A 387
LEU A 392
 None
 1.29A 1q0yH-2gj4A:
undetectable
1q0yL-2gj4A:
undetectable		 1q0yH-2gj4A:
13.43
1q0yL-2gj4A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i88 COLICIN-E1

(Escherichia
coli) 		PF01024
(Colicin) 		4 ILE A 503
TRP A 495
LEU A 400
TRP A 460
 None
 1.39A 1q0yH-2i88A:
undetectable
1q0yL-2i88A:
undetectable		 1q0yH-2i88A:
19.05
1q0yL-2i88A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		4 GLU A1472
GLU A1502
ILE A1125
LEU A1330
 GOL  A1901 (-2.7A)
GOL  A1901 (-3.3A)
None
None
 1.50A 1q0yH-2ri8A:
undetectable
1q0yL-2ri8A:
undetectable		 1q0yH-2ri8A:
17.36
1q0yL-2ri8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqd BIOTIN CARBOXYLASE

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 241
GLU A 336
ILE A 389
LEU A 384
 None
 1.34A 1q0yH-2vqdA:
undetectable
1q0yL-2vqdA:
0.7		 1q0yH-2vqdA:
17.82
1q0yL-2vqdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 GLU A 405
ILE A 408
LEU A 347
TRP A 351
 None
 1.10A 1q0yH-2x9xA:
4.7
1q0yL-2x9xA:
3.9		 1q0yH-2x9xA:
17.49
1q0yL-2x9xA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9z CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 GLU A 405
ILE A 408
LEU A 347
TRP A 351
 None
 1.11A 1q0yH-2x9zA:
4.9
1q0yL-2x9zA:
4.9		 1q0yH-2x9zA:
21.27
1q0yL-2x9zA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 4 GLU A 150
GLU A  82
ILE A 131
LEU A  42
 ARS  A1176 (-4.1A)
ZN  A1173 (-2.6A)
None
None
 1.33A 1q0yH-2y0oA:
undetectable
1q0yL-2y0oA:
undetectable		 1q0yH-2y0oA:
20.91
1q0yL-2y0oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynp COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 ILE A  71
TRP A 124
LEU A 123
TRP A 130
 None
 1.27A 1q0yH-2ynpA:
undetectable
1q0yL-2ynpA:
undetectable		 1q0yH-2ynpA:
18.43
1q0yL-2ynpA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwh CUCURMOSIN

(Cucurbita
moschata) 		PF00161
(RIP) 		4 GLU A 158
GLU A 187
ILE A 183
LEU A 150
 EDO  A 253 ( 4.6A)
None
None
None
 1.40A 1q0yH-3bwhA:
undetectable
1q0yL-3bwhA:
undetectable		 1q0yH-3bwhA:
18.08
1q0yL-3bwhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ceu THIAMINE PHOSPHATE
PYROPHOSPHORYLASE

(Bacteroides
thetaiotaomicron) 		PF02581
(TMP-TENI) 		4 TRP A 176
GLU A  15
ILE A  19
LEU A 172
 None
 1.46A 1q0yH-3ceuA:
undetectable
1q0yL-3ceuA:
undetectable		 1q0yH-3ceuA:
20.00
1q0yL-3ceuA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		4 GLU A 145
GLU A 195
ILE A  70
LEU A 154
 NRQ  A  65 ( 3.3A)
None
None
None
 1.25A 1q0yH-3cfhA:
undetectable
1q0yL-3cfhA:
undetectable		 1q0yH-3cfhA:
22.64
1q0yL-3cfhA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TRP A 267
ILE A 286
LEU A 298
TRP A 308
 None
 1.47A 1q0yH-3dfhA:
undetectable
1q0yL-3dfhA:
undetectable		 1q0yH-3dfhA:
17.31
1q0yL-3dfhA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 GLU A 282
GLU A 286
ILE A 253
LEU A 261
 None
 1.39A 1q0yH-3gbrA:
undetectable
1q0yL-3gbrA:
undetectable		 1q0yH-3gbrA:
18.16
1q0yL-3gbrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		4 TRP A  81
ILE A 127
LEU A 341
TRP A 120
 None
 1.26A 1q0yH-3gzaA:
undetectable
1q0yL-3gzaA:
undetectable		 1q0yH-3gzaA:
19.19
1q0yL-3gzaA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		4 GLU A 175
GLU A 204
ILE A 200
LEU A 167
 None
 1.42A 1q0yH-3h5kA:
undetectable
1q0yL-3h5kA:
undetectable		 1q0yH-3h5kA:
21.34
1q0yL-3h5kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfo NUCLEOPORIN NUP133

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A1116
GLU A1112
ILE A 980
LEU A1090
 None
 1.27A 1q0yH-3kfoA:
undetectable
1q0yL-3kfoA:
undetectable		 1q0yH-3kfoA:
19.80
1q0yL-3kfoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 GLU A 548
GLU A 511
ILE A 507
LEU A 822
 None
 1.19A 1q0yH-3s5kA:
1.4
1q0yL-3s5kA:
undetectable		 1q0yH-3s5kA:
9.39
1q0yL-3s5kA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsm INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Brucella
abortus) 		PF00218
(IGPS) 		4 GLU A 222
GLU A 171
ILE A 145
LEU A 120
 None
 1.48A 1q0yH-3tsmA:
undetectable
1q0yL-3tsmA:
undetectable		 1q0yH-3tsmA:
19.16
1q0yL-3tsmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 GLU A 422
ILE A 718
TRP A 382
LEU A 379
 None
 1.48A 1q0yH-3wfzA:
undetectable
1q0yL-3wfzA:
undetectable		 1q0yH-3wfzA:
14.15
1q0yL-3wfzA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acj WU:FB25H12 PROTEIN,

(Danio rerio) 		PF07534
(TLD) 		4 GLU A 796
ILE A 701
TRP A 798
LEU A 691
 None
 1.45A 1q0yH-4acjA:
undetectable
1q0yL-4acjA:
undetectable		 1q0yH-4acjA:
21.65
1q0yL-4acjA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 GLU A 339
ILE A 378
TRP A 341
LEU A 394
 None
None
TOE  A1420 ( 3.9A)
TOE  A1420 ( 4.9A)
 1.41A 1q0yH-4arvA:
undetectable
1q0yL-4arvA:
undetectable		 1q0yH-4arvA:
18.51
1q0yL-4arvA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		4 TRP A  84
ILE A 124
LEU A  80
TRP A 172
 None
 1.47A 1q0yH-4bvxA:
undetectable
1q0yL-4bvxA:
undetectable		 1q0yH-4bvxA:
20.44
1q0yL-4bvxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 GLU A 171
TRP A 296
LEU A 219
TRP A 176
 ZN  A 401 ( 2.1A)
ZN  A 401 (-4.8A)
None
PBD  A 402 (-4.0A)
 1.31A 1q0yH-4f9uA:
undetectable
1q0yL-4f9uA:
undetectable		 1q0yH-4f9uA:
20.52
1q0yL-4f9uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 GLU C 189
ILE C 193
TRP C 130
LEU C 126
 None
 1.37A 1q0yH-4hb4C:
undetectable
1q0yL-4hb4C:
undetectable		 1q0yH-4hb4C:
11.47
1q0yL-4hb4C:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j73 COATOMER SUBUNIT
BETA'

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE A  71
TRP A 124
LEU A 123
TRP A 130
 None
 1.34A 1q0yH-4j73A:
undetectable
1q0yL-4j73A:
undetectable		 1q0yH-4j73A:
20.26
1q0yL-4j73A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 GLU A 239
GLU A 200
ILE A 205
LEU A 254
 None
 1.27A 1q0yH-4ksaA:
undetectable
1q0yL-4ksaA:
undetectable		 1q0yH-4ksaA:
17.35
1q0yL-4ksaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt6 POLY(A) POLYMERASE
GAMMA

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 TRP A 229
GLU A 339
ILE A 235
LEU A 360
 None
 1.41A 1q0yH-4lt6A:
undetectable
1q0yL-4lt6A:
undetectable		 1q0yH-4lt6A:
19.38
1q0yL-4lt6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 TRP A 432
ILE A 333
LEU A 430
TRP A 435
 None
 1.44A 1q0yH-4qwwA:
undetectable
1q0yL-4qwwA:
undetectable		 1q0yH-4qwwA:
18.22
1q0yL-4qwwA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 GLU A 257
GLU A 216
TRP A 373
TRP A 465
 None
GAL  A 701 (-2.8A)
LOG  A 702 ( 3.9A)
LOG  A 702 (-3.8A)
 1.35A 1q0yH-5bxpA:
undetectable
1q0yL-5bxpA:
undetectable		 1q0yH-5bxpA:
15.99
1q0yL-5bxpA:
16.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dfv FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TRP C 212
ILE C 292
LEU C 397
TRP C 197
 None
 1.24A 1q0yH-5dfvC:
23.8
1q0yL-5dfvC:
19.3		 1q0yH-5dfvC:
71.62
1q0yL-5dfvC:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 GLU A 146
ILE A 243
TRP A 173
LEU A 169
 None
None
None
COI  A 601 (-3.7A)
 1.36A 1q0yH-5ereA:
undetectable
1q0yL-5ereA:
undetectable		 1q0yH-5ereA:
18.02
1q0yL-5ereA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		4 GLU A 489
GLU A 247
ILE A 252
LEU A 268
 None
 1.42A 1q0yH-5ewqA:
undetectable
1q0yL-5ewqA:
undetectable		 1q0yH-5ewqA:
16.63
1q0yL-5ewqA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		4 TRP A  56
GLU A  60
ILE A   6
LEU A  13
 None
 0.96A 1q0yH-5f4zA:
undetectable
1q0yL-5f4zA:
undetectable		 1q0yH-5f4zA:
21.39
1q0yL-5f4zA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE

(Escherichia
coli) 		PF01814
(Hemerythrin)
PF04405
(ScdA_N) 		4 GLU A 133
GLU A 208
ILE A  79
LEU A 126
 ZN  A1221 (-2.3A)
ZN  A1222 (-2.2A)
ZN  A1222 ( 4.9A)
None
 1.46A 1q0yH-5fnpA:
undetectable
1q0yL-5fnpA:
undetectable		 1q0yH-5fnpA:
20.31
1q0yL-5fnpA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l08 CASPASE-8

(Homo sapiens) 		PF01335
(DED) 		4 GLU A  89
GLU A  64
ILE A  98
LEU A  75
 None
 1.47A 1q0yH-5l08A:
undetectable
1q0yL-5l08A:
undetectable		 1q0yH-5l08A:
20.43
1q0yL-5l08A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT
ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF02538
(Hydantoinase_B)
PF05378
(Hydant_A_N) 		4 TRP B 182
GLU B 223
GLU A 450
ILE B 221
 None
 1.39A 1q0yH-5l9wB:
undetectable
1q0yL-5l9wB:
undetectable		 1q0yH-5l9wB:
13.64
1q0yL-5l9wB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 GLU A 282
ILE A 321
TRP A 102
LEU A  98
 TLA  A 501 (-3.4A)
None
None
None
 1.36A 1q0yH-5muxA:
undetectable
1q0yL-5muxA:
undetectable		 1q0yH-5muxA:
20.88
1q0yL-5muxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5l ADENYLATE CYCLASE

(Mycobacterium
intracellulare) 		no annotation 4 GLU A 390
GLU A 394
TRP A 419
LEU A 402
 None
 1.25A 1q0yH-5o5lA:
undetectable
1q0yL-5o5lA:
undetectable		 1q0yH-5o5lA:
19.53
1q0yL-5o5lA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL

(Homo sapiens) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 TRP d 183
GLU d 244
ILE d 146
LEU d 222
 None
 1.42A 1q0yH-5oold:
undetectable
1q0yL-5oold:
undetectable		 1q0yH-5oold:
18.44
1q0yL-5oold:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0C15939P
KLLA0D15741P
KLLA0F02343P

(Kluyveromyces
lactis) 		PF05859
(Mis12)
PF08202
(MIS13)
PF08641
(Mis14) 		4 TRP N 107
GLU N 108
ILE A  21
LEU D 375
 None
 1.44A 1q0yH-5t58N:
undetectable
1q0yL-5t58N:
undetectable		 1q0yH-5t58N:
22.35
1q0yL-5t58N:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ug4 SPERMIDINE
N(1)-ACETYLTRANSFERA
SE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		4 GLU A  55
ILE A  74
TRP A  31
LEU A  45
 None
 1.16A 1q0yH-5ug4A:
undetectable
1q0yL-5ug4A:
undetectable		 1q0yH-5ug4A:
18.18
1q0yL-5ug4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 4 TRP A 397
GLU A 225
ILE A 389
LEU A 439
 None
 1.41A 1q0yH-6bk1A:
undetectable
1q0yL-6bk1A:
undetectable		 1q0yH-6bk1A:
18.65
1q0yL-6bk1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejg SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 4 TRP C 216
ILE C 228
LEU C 276
TRP C 202
 None
 1.26A 1q0yH-6ejgC:
15.8
1q0yL-6ejgC:
18.4		 1q0yH-6ejgC:
16.91
1q0yL-6ejgC:
17.67