SIMILAR PATTERNS OF AMINO ACIDS FOR 1PXX_B_DIFB1701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 370
VAL A 345
GLY A 343
ALA A 342
 None
 1.14A 1pxxB-1b3bA:
0.0		 1pxxB-1b3bA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		5 LEU A  15
VAL A 248
GLY A 200
ALA A 195
SER A 202
 None
 1.30A 1pxxB-1bt4A:
0.0		 1pxxB-1bt4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 372
VAL A 347
GLY A 345
ALA A 344
 None
 1.07A 1pxxB-1bvuA:
undetectable		 1pxxB-1bvuA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 VAL A 349
LEU A 352
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.40A 1pxxB-1ebvA:
58.1		 1pxxB-1ebvA:
63.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  96
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
None
SO4  A 601 (-3.8A)
None
None
 1.23A 1pxxB-1euzA:
0.0		 1pxxB-1euzA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC

(Neisseria
meningitidis) 		PF01501
(Glyco_transf_8) 		5 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.15A 1pxxB-1ga8A:
undetectable		 1pxxB-1ga8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 LEU A   6
VAL A  15
GLY A  17
ALA A  60
SER A  61
 None
None
None
None
NAG  A1996 (-3.6A)
 1.28A 1pxxB-1gqrA:
0.0		 1pxxB-1gqrA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.13A 1pxxB-1gtmA:
1.0		 1pxxB-1gtmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E

(Fusarium
verticillioides) 		PF00295
(Glyco_hydro_28) 		5 VAL A  46
LEU A  47
LEU A 144
GLY A  99
ALA A 100
 None
 1.12A 1pxxB-1hg8A:
0.0		 1pxxB-1hg8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 VAL A 249
LEU A 252
VAL A 265
GLY A 483
ALA A 484
 None
None
None
PYR  A1601 (-3.8A)
BEZ  A1501 (-4.2A)
 1.28A 1pxxB-1i7qA:
undetectable		 1pxxB-1i7qA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 VAL A  26
LEU A  27
LEU A 120
GLY A  78
ALA A  79
 None
 1.12A 1pxxB-1ia5A:
undetectable		 1pxxB-1ia5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 121
LEU A 457
VAL A 382
GLY A 380
ALA A 379
 None
 1.17A 1pxxB-1l1fA:
undetectable		 1pxxB-1l1fA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 128
LEU A  15
VAL A 143
GLY A 176
SER A  12
 None
 1.12A 1pxxB-1mzjA:
undetectable		 1pxxB-1mzjA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 LEU A  65
LEU A 312
VAL A 101
GLY A  80
ALA A  81
 None
 1.17A 1pxxB-1sc6A:
undetectable		 1pxxB-1sc6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		5 LEU A  30
VAL A  44
GLY A  46
ALA A  48
SER A  50
 None
 1.18A 1pxxB-1taqA:
undetectable		 1pxxB-1taqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 117
LEU A   5
VAL A 132
GLY A 165
SER A   2
 None
 1.10A 1pxxB-1ub7A:
undetectable		 1pxxB-1ub7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 VAL A 101
LEU A  23
VAL A 106
GLY A 109
ALA A 110
 None
 1.18A 1pxxB-1uiyA:
undetectable		 1pxxB-1uiyA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		6 VAL A 332
LEU A 316
VAL A 216
GLY A 214
ALA A 213
SER A 239
 None
 1.49A 1pxxB-1ukcA:
undetectable		 1pxxB-1ukcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00797
(Acetyltransf_2) 		5 VAL A 129
LEU A  76
LEU A   4
TYR A  12
ALA A  81
 None
 1.29A 1pxxB-1w4tA:
undetectable		 1pxxB-1w4tA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF05833
(FbpA)
PF09239
(Topo-VIb_trans) 		5 LEU A 451
LEU A 326
VAL A 411
GLY A 355
ALA A 354
 None
 1.19A 1pxxB-1z5aA:
undetectable		 1pxxB-1z5aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A  15
LEU A 130
VAL A 140
GLY A 139
SER A  25
 None
 1.29A 1pxxB-2b42A:
undetectable		 1pxxB-2b42A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 VAL A 182
LEU A 181
LEU A 164
GLY A  82
ALA A  83
 None
 1.21A 1pxxB-2djzA:
2.4		 1pxxB-2djzA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvl ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  91
LEU A 112
VAL A  87
GLY A 119
ALA A 120
 None
 1.30A 1pxxB-2dvlA:
undetectable		 1pxxB-2dvlA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 VAL A 162
LEU A 165
LEU A 106
GLY A 180
ALA A 225
 None
 1.13A 1pxxB-2e0pA:
undetectable		 1pxxB-2e0pA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU A 472
VAL A 168
GLY A 166
ALA A 165
SER A 164
 None
 1.18A 1pxxB-2gaiA:
undetectable		 1pxxB-2gaiA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
 None
 0.94A 1pxxB-2gk9A:
undetectable		 1pxxB-2gk9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl5 PUTATIVE DEHYDRATASE
PROTEIN

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  60
VAL A  92
GLY A  96
ALA A  95
SER A  98
 None
 1.22A 1pxxB-2gl5A:
undetectable		 1pxxB-2gl5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guh PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 LEU A 104
TYR A 101
VAL A  23
GLY A  27
ALA A  26
 None
 1.26A 1pxxB-2guhA:
undetectable		 1pxxB-2guhA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		5 LEU A  36
LEU A   5
VAL A  64
GLY A  66
ALA A  68
 None
 1.27A 1pxxB-2or0A:
undetectable		 1pxxB-2or0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 189
LEU A  38
VAL A 204
GLY A 243
ALA A 196
 None
 1.13A 1pxxB-2p0uA:
undetectable		 1pxxB-2p0uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 VAL A 105
LEU A 125
VAL A 199
GLY A 200
ALA A 152
 None
 1.24A 1pxxB-2p3eA:
undetectable		 1pxxB-2p3eA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 1.07A 1pxxB-2pplA:
undetectable		 1pxxB-2pplA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		5 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.11A 1pxxB-2r48A:
undetectable		 1pxxB-2r48A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 VAL A  12
LEU A  35
LEU A 146
GLY A  17
ALA A  18
 None
None
None
FAD  A 601 (-4.2A)
FAD  A 601 (-3.8A)
 1.26A 1pxxB-2wu5A:
undetectable		 1pxxB-2wu5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 VAL A 163
LEU A 166
LEU A 107
GLY A 181
ALA A 226
 None
 1.10A 1pxxB-2yjqA:
undetectable		 1pxxB-2yjqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		5 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.05A 1pxxB-2ylzA:
undetectable		 1pxxB-2ylzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 267
VAL A 108
GLY A 111
ALA A 112
SER A 115
 None
None
None
FAD  A 700 ( 4.6A)
None
 1.17A 1pxxB-2z1qA:
undetectable		 1pxxB-2z1qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 181
LEU A  30
VAL A 196
GLY A 235
ALA A 188
 None
 1.11A 1pxxB-3awkA:
undetectable		 1pxxB-3awkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 LEU A  80
LEU A 200
VAL A 108
GLY A  94
ALA A  95
 None
 1.25A 1pxxB-3dlaA:
undetectable		 1pxxB-3dlaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwy LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Rhodobacter
sphaeroides) 		PF00142
(Fer4_NifH) 		5 VAL A 154
LEU A 155
VAL A 159
GLY A 161
ALA A 164
 None
 1.29A 1pxxB-3fwyA:
undetectable		 1pxxB-3fwyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2s PUTATIVE NADH-FLAVIN
REDUCTASE

(Lactobacillus
paracasei) 		PF13460
(NAD_binding_10) 		5 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.17A 1pxxB-3h2sA:
undetectable		 1pxxB-3h2sA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A  17
LEU A 132
VAL A 142
GLY A 141
SER A  27
 None
 1.29A 1pxxB-3hd8A:
undetectable		 1pxxB-3hd8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B 792
TYR B 789
VAL B 774
GLY B 812
SER B 836
 None
 1.14A 1pxxB-3hkzB:
undetectable		 1pxxB-3hkzB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL A 247
LEU A 117
VAL A 104
GLY A  40
ALA A  39
 None
 1.07A 1pxxB-3hrdA:
undetectable		 1pxxB-3hrdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 VAL A 156
LEU A 159
LEU A 100
GLY A 174
ALA A 219
 None
 1.15A 1pxxB-3ik2A:
undetectable		 1pxxB-3ik2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 5 LEU B  37
LEU B 114
VAL B  77
GLY B  23
ALA B  24
 None
 1.10A 1pxxB-3jruB:
undetectable		 1pxxB-3jruB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kev GALIERIA SULFURARIA
DCUN1
DOMAIN-CONTAINING
PROTEIN

(Galdieria
sulphuraria) 		PF03556
(Cullin_binding) 		5 LEU A  12
LEU A  52
VAL A  66
GLY A  68
ALA A  70
 None
None
ACT  A 202 ( 4.4A)
None
None
 1.14A 1pxxB-3kevA:
undetectable		 1pxxB-3kevA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A 126
VAL A 109
GLY A 106
ALA A 105
SER A 102
 None
 1.24A 1pxxB-3l2zA:
undetectable		 1pxxB-3l2zA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 LEU A1006
LEU A 563
TYR A 566
GLY A 561
SER A 998
 None
 1.27A 1pxxB-3ob8A:
undetectable		 1pxxB-3ob8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 181
LEU A  30
VAL A 196
GLY A 235
ALA A 188
 None
 1.13A 1pxxB-3oitA:
undetectable		 1pxxB-3oitA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyf CRISPR-ASSOCIATED
PROTEIN

(Sulfolobus
solfataricus) 		PF09651
(Cas_APE2256) 		5 LEU A  73
LEU A 122
VAL A 108
GLY A 106
ALA A 105
 None
 1.16A 1pxxB-3qyfA:
undetectable		 1pxxB-3qyfA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 VAL A 128
LEU A 131
LEU A 195
GLY A 176
ALA A 177
 None
 1.23A 1pxxB-3rkuA:
undetectable		 1pxxB-3rkuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx3 UNCHARACTERIZED
PROTEIN INVOLVED IN
CYSTEINE
BIOSYNTHESIS

(Idiomarina
loihiensis) 		PF07264
(EI24) 		5 VAL A 211
LEU A  20
VAL A 229
GLY A 231
ALA A 232
 None
 1.27A 1pxxB-3tx3A:
undetectable		 1pxxB-3tx3A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 VAL A 191
LEU A 254
VAL A 232
GLY A 230
ALA A 229
 None
 1.13A 1pxxB-3u4jA:
undetectable		 1pxxB-3u4jA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 LEU A  29
LEU A  14
VAL A 569
GLY A 567
SER A  35
 None
 1.28A 1pxxB-3ux8A:
undetectable		 1pxxB-3ux8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		5 VAL A 373
VAL A 139
GLY A 137
ALA A 337
SER A 132
 None
 1.30A 1pxxB-3va8A:
undetectable		 1pxxB-3va8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9w MONOOXYGENASE

(Stenotrophomonas
maltophilia) 		PF13738
(Pyr_redox_3) 		5 VAL A 336
LEU A  91
TYR A  85
GLY A  19
ALA A  18
 None
 1.08A 1pxxB-4a9wA:
undetectable		 1pxxB-4a9wA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9a PROBABLE EPOXIDE
HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 VAL A 103
LEU A  34
LEU A  64
GLY A 109
ALA A 110
 None
 1.26A 1pxxB-4b9aA:
undetectable		 1pxxB-4b9aA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es6 UROPORPHYRINOGEN-III
SYNTHASE

(Pseudomonas
aeruginosa) 		PF02602
(HEM4) 		5 LEU A 243
VAL A  27
GLY A  23
ALA A  25
SER A  21
 None
 1.28A 1pxxB-4es6A:
undetectable		 1pxxB-4es6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		5 LEU A 231
VAL A 220
GLY A 267
ALA A 270
SER A 269
 None
None
None
None
10D  A 402 (-2.7A)
 1.19A 1pxxB-4h4cA:
undetectable		 1pxxB-4h4cA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		5 VAL A  31
LEU A  32
LEU A 170
GLY A 162
ALA A 163
 None
 1.28A 1pxxB-4k22A:
1.4		 1pxxB-4k22A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2h INTRACELLULAR
PROTEASE/AMIDASE

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		5 LEU A 116
TYR A 121
VAL A 109
GLY A 111
ALA A 112
 None
 1.18A 1pxxB-4k2hA:
undetectable		 1pxxB-4k2hA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		5 VAL A 135
LEU A 126
LEU A 285
GLY A 153
ALA A   8
 None
None
None
None
FAD  A 601 ( 4.3A)
 1.23A 1pxxB-4k2xA:
undetectable		 1pxxB-4k2xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 TYR A  68
VAL A  31
GLY A   8
ALA A   9
SER A  10
 None
None
NDP  A 500 (-2.9A)
NDP  A 500 (-3.6A)
NDP  A 500 (-3.9A)
 1.20A 1pxxB-4koaA:
undetectable		 1pxxB-4koaA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		5 VAL A  95
LEU A 207
TYR A 210
GLY A 196
ALA A 195
 None
 1.22A 1pxxB-4lcmA:
undetectable		 1pxxB-4lcmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 VAL A 336
LEU A 470
TYR A 467
VAL A 357
ALA A 353
 None
 1.17A 1pxxB-4m8uA:
undetectable		 1pxxB-4m8uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1u 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		5 VAL A  10
LEU A  11
TRP A 123
VAL A  67
GLY A  68
 None
None
2GE  A 201 (-4.9A)
None
None
 1.21A 1pxxB-4n1uA:
undetectable		 1pxxB-4n1uA:
14.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 VAL A 350
LEU A 353
LEU A 385
TYR A 386
TRP A 388
VAL A 524
GLY A 527
ALA A 528
SER A 531
 IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
 0.51A 1pxxB-4ph9A:
63.3		 1pxxB-4ph9A:
96.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwt PEPTIDOGLYCAN-ASSOCI
ATED LIPOPROTEIN

(Yersinia pestis) 		PF00691
(OmpA) 		5 VAL A 133
LEU A 128
LEU A  60
TYR A 168
ALA A  88
 None
 1.23A 1pxxB-4pwtA:
undetectable		 1pxxB-4pwtA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2902
VAL A2778
GLY A2737
ALA A2895
SER A2714
 None
 1.26A 1pxxB-4qyrA:
undetectable		 1pxxB-4qyrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8r TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		5 VAL A 237
LEU A 269
VAL A  40
GLY A  42
SER A 262
 None
 1.19A 1pxxB-4x8rA:
undetectable		 1pxxB-4x8rA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		5 LEU A 123
LEU A  43
VAL A  92
GLY A  63
ALA A  89
 None
 1.30A 1pxxB-4y90A:
undetectable		 1pxxB-4y90A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A1243
LEU A1266
VAL A1179
GLY A1156
SER A1154
 None
 1.16A 1pxxB-4yswA:
undetectable		 1pxxB-4yswA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		5 LEU A 120
TYR A 128
GLY A 251
ALA A 250
SER A 249
 None
 1.14A 1pxxB-5aexA:
0.8		 1pxxB-5aexA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.14A 1pxxB-5bz4A:
undetectable		 1pxxB-5bz4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.14A 1pxxB-5cwvA:
undetectable		 1pxxB-5cwvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgl NICR

(Pseudomonas
putida) 		PF00440
(TetR_N) 		5 VAL A 111
LEU A 229
VAL A 177
GLY A 180
ALA A 181
 None
 1.09A 1pxxB-5fglA:
2.0		 1pxxB-5fglA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 LEU A 139
LEU A  34
VAL A 151
GLY A 123
ALA A 124
 None
 0.99A 1pxxB-5fo1A:
undetectable		 1pxxB-5fo1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 VAL A  67
LEU A 113
VAL A  96
GLY A  76
ALA A  77
 None
 1.16A 1pxxB-5ggyA:
undetectable		 1pxxB-5ggyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 122
LEU A 401
VAL A 376
GLY A 374
ALA A 373
 None
None
AKG  A 502 (-4.1A)
None
None
 1.25A 1pxxB-5ijzA:
1.0		 1pxxB-5ijzA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		9 VAL A 349
LEU A 352
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.48A 1pxxB-5ikrA:
35.2		 1pxxB-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 LEU A 211
TYR A 170
VAL A   2
GLY A 291
ALA A   0
 None
 1.12A 1pxxB-5jh8A:
undetectable		 1pxxB-5jh8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 5 VAL A 163
LEU A 177
VAL A 104
GLY A 106
ALA A 174
 None
 1.15A 1pxxB-5jvbA:
undetectable		 1pxxB-5jvbA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		5 LEU A 305
VAL A 205
GLY A 207
ALA A 308
SER A 309
 None
None
NAD  A 608 (-3.3A)
NAD  A 608 ( 4.9A)
NAD  A 608 (-4.7A)
 1.21A 1pxxB-5jwbA:
undetectable		 1pxxB-5jwbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldx NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11

(Bos taurus) 		PF02466
(Tim17) 		5 VAL Y   4
LEU Y   5
GLY Y  28
ALA Y  30
SER Y  26
 None
 1.27A 1pxxB-5ldxY:
2.0		 1pxxB-5ldxY:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 193
VAL A 279
GLY A 281
ALA A 282
SER A 285
 None
 1.16A 1pxxB-5lewA:
undetectable		 1pxxB-5lewA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 VAL A  97
LEU A 102
VAL A  37
GLY A  20
ALA A  16
 None
 1.21A 1pxxB-5m10A:
undetectable		 1pxxB-5m10A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE

(Pyrococcus
furiosus) 		PF00535
(Glycos_transf_2)
PF04138
(GtrA) 		5 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.18A 1pxxB-5mlzA:
2.0		 1pxxB-5mlzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE

(Mus musculus) 		no annotation 5 VAL A  10
LEU A  11
TRP A 123
VAL A  67
GLY A  68
 None
 1.20A 1pxxB-5mzeA:
undetectable		 1pxxB-5mzeA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.96A 1pxxB-5nugA:
undetectable		 1pxxB-5nugA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 5 VAL 0  42
LEU 0  92
TYR 0  89
VAL 0  26
GLY 0  34
 None
 1.29A 1pxxB-5oa30:
undetectable		 1pxxB-5oa30:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens) 		no annotation 5 VAL B  96
LEU B  46
TRP A 114
VAL A  99
GLY A 110
 None
 1.19A 1pxxB-5odbB:
undetectable		 1pxxB-5odbB:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		5 LEU A 329
TYR A  26
TRP A  20
GLY A  29
ALA A  30
 None
 1.28A 1pxxB-5tgfA:
undetectable		 1pxxB-5tgfA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		5 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.02A 1pxxB-5wqkA:
undetectable		 1pxxB-5wqkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 LEU A 712
LEU A 428
VAL A 357
GLY A 355
ALA A 354
 None
 1.28A 1pxxB-5xapA:
undetectable		 1pxxB-5xapA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED

(Oryza sativa) 		no annotation 5 LEU A 328
LEU A 257
VAL A 295
GLY A 331
SER A 334
 None
 1.28A 1pxxB-5xoiA:
undetectable		 1pxxB-5xoiA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 LEU A 592
TYR A 654
VAL A 786
GLY A 788
SER A 713
 None
 1.25A 1pxxB-5xqoA:
undetectable		 1pxxB-5xqoA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 LEU A 178
VAL A 191
GLY A 169
ALA A 170
SER A 171
 None
 1.30A 1pxxB-6apeA:
undetectable		 1pxxB-6apeA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 VAL A 394
LEU A  22
VAL A 353
ALA A 357
SER A 360
 None
 1.28A 1pxxB-6at7A:
undetectable		 1pxxB-6at7A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 5 LEU A 326
TYR A 323
VAL A 314
GLY A 344
ALA A 345
 None
 1.17A 1pxxB-6c8zA:
undetectable		 1pxxB-6c8zA:
8.96