SIMILAR PATTERNS OF AMINO ACIDS FOR 1PTH_B_SALB711

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.35A 1pthB-1ebvA:
63.0		 1pthB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A  81
LEU A 270
ALA A  99
LEU A  76
 None
 0.71A 1pthB-1gsoA:
0.0		 1pthB-1gsoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 VAL A 235
VAL A 274
LEU A 277
LEU A 237
 None
 0.70A 1pthB-1ik6A:
0.0		 1pthB-1ik6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		4 VAL A 227
TYR A 537
ALA A 332
LEU A 335
 None
 0.81A 1pthB-1jy1A:
undetectable		 1pthB-1jy1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjw POSTSYNAPTIC DENSITY
PROTEIN 95

(Rattus
norvegicus) 		PF00018
(SH3_1)
PF00625
(Guanylate_kin) 		4 ARG A 637
VAL A 616
ALA A 641
LEU A 638
 None
 0.88A 1pthB-1kjwA:
0.0		 1pthB-1kjwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		4 VAL A 260
LEU A 263
TYR A 273
ALA A 235
 None
 0.70A 1pthB-1ks8A:
0.0		 1pthB-1ks8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 ARG A 338
VAL A 451
ALA A 334
LEU A 337
 None
 0.86A 1pthB-1m22A:
undetectable		 1pthB-1m22A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 VAL A 500
VAL A 402
LEU A 430
ALA A 466
 None
 0.84A 1pthB-1oa1A:
0.0		 1pthB-1oa1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 VAL A 500
VAL A 402
LEU A 430
LEU A 504
 None
 0.79A 1pthB-1oa1A:
0.0		 1pthB-1oa1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 VAL A 493
VAL A 395
LEU A 423
ALA A 459
 None
 0.85A 1pthB-1upxA:
0.0		 1pthB-1upxA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 VAL A 127
LEU A  79
ALA A  50
LEU A 113
 None
 0.82A 1pthB-1uz4A:
undetectable		 1pthB-1uz4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL A 291
VAL A 160
ALA A 262
LEU A 270
 None
 0.86A 1pthB-1vc2A:
undetectable		 1pthB-1vc2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 VAL A 256
LEU A 302
ALA A 264
LEU A 261
 None
 0.79A 1pthB-1ve5A:
undetectable		 1pthB-1ve5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl1 6-PHOSPHOGLUCONOLACT
ONASE

(Thermotoga
maritima) 		PF01182
(Glucosamine_iso) 		4 VAL A  38
VAL A 208
ALA A 140
LEU A 131
 None
 0.70A 1pthB-1vl1A:
undetectable		 1pthB-1vl1A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xez HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		4 VAL A 610
VAL A 711
LEU A 590
LEU A 608
 None
 0.89A 1pthB-1xezA:
undetectable		 1pthB-1xezA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq9 PHOSPHOGLYCERATE
MUTASE

(Plasmodium
falciparum) 		PF00300
(His_Phos_1) 		4 VAL A  78
LEU A  79
ALA A 190
LEU A  17
 None
 0.78A 1pthB-1xq9A:
undetectable		 1pthB-1xq9A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		4 VAL A  75
VAL A  32
LEU A   7
LEU A  51
 None
 0.65A 1pthB-2bexA:
undetectable		 1pthB-2bexA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eeh PDZ
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00595
(PDZ) 		4 VAL A  28
VAL A  63
ALA A  76
LEU A  80
 None
 0.81A 1pthB-2eehA:
undetectable		 1pthB-2eehA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 VAL A 214
LEU A 176
ALA A 204
LEU A 205
 None
 0.88A 1pthB-2elcA:
undetectable		 1pthB-2elcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 VAL X 536
VAL X 450
LEU X 451
LEU X 532
 None
 0.69A 1pthB-2epkX:
undetectable		 1pthB-2epkX:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		4 VAL A 437
VAL A 546
LEU A 553
ALA A 521
 None
 0.88A 1pthB-2gp4A:
0.2		 1pthB-2gp4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		4 VAL A 110
LEU A 114
ALA A  55
LEU A  72
 None
 0.85A 1pthB-2hujA:
undetectable		 1pthB-2hujA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		4 VAL A 608
VAL A 594
ALA A 524
LEU A 528
 None
 0.88A 1pthB-2iutA:
undetectable		 1pthB-2iutA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjp CYTOCHROME P450
113A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		4 VAL A 254
LEU A 125
ALA A 140
LEU A 250
 None
 0.83A 1pthB-2jjpA:
undetectable		 1pthB-2jjpA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 VAL A 168
LEU A 106
ALA A 133
LEU A 134
 None
 0.88A 1pthB-2nq9A:
undetectable		 1pthB-2nq9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 VAL A 565
VAL A 527
LEU A 526
LEU A 589
 None
 0.70A 1pthB-2nyaA:
0.3		 1pthB-2nyaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob5 HYPOTHETICAL PROTEIN
ATU2016

(Agrobacterium
fabrum) 		PF05025
(RbsD_FucU) 		4 VAL A  53
VAL A  13
LEU A  14
ALA A  61
 None
 0.88A 1pthB-2ob5A:
undetectable		 1pthB-2ob5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		4 VAL A 228
LEU A 229
ALA A 255
LEU A 256
 None
 0.76A 1pthB-2og7A:
undetectable		 1pthB-2og7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz4 INTERCELLULAR
ADHESION MOLECULE 1

(Homo sapiens) 		no annotation 4 VAL A 295
VAL A 303
LEU A 329
LEU A 363
 None
 0.85A 1pthB-2oz4A:
undetectable		 1pthB-2oz4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2y ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE

(Thermus
thermophilus) 		PF00300
(His_Phos_1) 		4 VAL A 150
VAL A 158
LEU A   3
LEU A 141
 None
 0.74A 1pthB-2p2yA:
undetectable		 1pthB-2p2yA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A  83
LEU A 273
ALA A 101
LEU A  78
 None
 0.77A 1pthB-2qk4A:
undetectable		 1pthB-2qk4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		4 VAL A  16
VAL A 236
LEU A 239
LEU A  14
 None
 0.89A 1pthB-2vrtA:
undetectable		 1pthB-2vrtA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.73A 1pthB-2xd4A:
undetectable		 1pthB-2xd4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.70A 1pthB-2ys6A:
undetectable		 1pthB-2ys6A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.72A 1pthB-2yw2A:
undetectable		 1pthB-2yw2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A  79
VAL A 286
LEU A 268
ALA A  96
 None
 0.88A 1pthB-2yw2A:
undetectable		 1pthB-2yw2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 VAL A  19
LEU A  22
ALA A  39
LEU A  37
 None
 0.76A 1pthB-2zvwA:
undetectable		 1pthB-2zvwA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP3

(Rhinovirus A) 		PF00073
(Rhv) 		4 VAL C 127
LEU C 209
ALA C 206
LEU C  72
 None
 0.82A 1pthB-3dprC:
undetectable		 1pthB-3dprC:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		4 VAL A 500
VAL A 517
LEU A 518
LEU A 498
 None
 0.63A 1pthB-3f6tA:
undetectable		 1pthB-3f6tA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fza GLUTAREDOXIN

(Populus tremula
x Populus
tremuloides) 		PF00462
(Glutaredoxin) 		4 VAL A  64
LEU A  68
TYR A  24
ALA A  11
 None
 0.89A 1pthB-3fzaA:
undetectable		 1pthB-3fzaA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)

(Rhodospirillum
rubrum) 		PF00072
(Response_reg) 		4 VAL A  84
VAL A  11
ALA A  45
LEU A  49
 None
 0.83A 1pthB-3hebA:
undetectable		 1pthB-3hebA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 VAL T 509
VAL T 496
LEU T 495
ALA T 461
 None
 0.86A 1pthB-3icqT:
undetectable		 1pthB-3icqT:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 VAL A1177
VAL A 901
LEU A 902
LEU A1173
 None
 0.87A 1pthB-3ikmA:
undetectable		 1pthB-3ikmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		4 VAL A  35
LEU A  39
TYR A 241
LEU A  25
 None
 0.89A 1pthB-3ke3A:
undetectable		 1pthB-3ke3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE

(Coccidioides
immitis) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 VAL A 204
VAL A 157
ALA A 177
LEU A 181
 None
 0.83A 1pthB-3lg6A:
undetectable		 1pthB-3lg6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A  81
LEU A 270
ALA A  99
LEU A  76
 None
 0.71A 1pthB-3mjfA:
undetectable		 1pthB-3mjfA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		4 VAL A 280
LEU A 283
ALA A 307
LEU A 311
 None
 0.88A 1pthB-3o4zA:
1.5		 1pthB-3o4zA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A 221
VAL A 288
LEU A 291
LEU A 216
 None
 0.88A 1pthB-3oa0A:
undetectable		 1pthB-3oa0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415

(Drosophila
melanogaster) 		PF00106
(adh_short)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 VAL A 527
VAL A 360
LEU A 361
LEU A 523
 None
 0.72A 1pthB-3omlA:
undetectable		 1pthB-3omlA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 VAL A 186
VAL A  43
LEU A  31
LEU A 188
 None
 0.75A 1pthB-3p54A:
undetectable		 1pthB-3p54A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		4 VAL A 153
ARG A 157
VAL A 192
LEU A 174
 None
 0.81A 1pthB-3puaA:
undetectable		 1pthB-3puaA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		4 VAL A 322
LEU A 323
ALA A 154
LEU A 219
 None
 0.63A 1pthB-3tc8A:
undetectable		 1pthB-3tc8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 VAL A 760
LEU A 764
ALA A 715
LEU A 800
 None
 0.64A 1pthB-3ummA:
undetectable		 1pthB-3ummA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhc PHYTASE

(Citrobacter
braakii) 		PF00328
(His_Phos_2) 		4 ARG A  63
VAL A  83
ALA A 105
LEU A 104
 None
 0.85A 1pthB-3zhcA:
undetectable		 1pthB-3zhcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 VAL A 644
VAL A 618
LEU A 621
LEU A 605
 None
 0.77A 1pthB-4b8bA:
undetectable		 1pthB-4b8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 VAL A 337
LEU A 336
ALA A 307
LEU A 311
 None
 0.82A 1pthB-4dppA:
undetectable		 1pthB-4dppA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		4 VAL A  58
VAL A 235
LEU A 234
LEU A 221
 None
 0.89A 1pthB-4e1eA:
undetectable		 1pthB-4e1eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 6

(Saccharomyces
cerevisiae) 		no annotation 4 VAL C 158
VAL C 129
LEU C 130
LEU C 154
 None
 0.77A 1pthB-4ejsC:
undetectable		 1pthB-4ejsC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 VAL D 279
LEU D 484
ALA D 167
LEU D 168
 None
 0.75A 1pthB-4em6D:
undetectable		 1pthB-4em6D:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etz PELD

(Pseudomonas
aeruginosa) 		PF13492
(GAF_3)
PF16963
(PelD_GGDEF) 		4 VAL A 188
LEU A 191
ALA A 300
LEU A 267
 None
 0.83A 1pthB-4etzA:
undetectable		 1pthB-4etzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 410
VAL A 386
ALA A 236
LEU A 228
 None
 0.88A 1pthB-4f9oA:
undetectable		 1pthB-4f9oA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		4 VAL A 323
LEU A 324
ALA A 156
LEU A 222
 None
 0.66A 1pthB-4fuuA:
undetectable		 1pthB-4fuuA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 118
LEU A 119
ALA A 171
LEU A 155
 None
 0.71A 1pthB-4g2nA:
undetectable		 1pthB-4g2nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN

(Vibrio cholerae) 		PF16458
(Beta-prism_lec) 		4 VAL A 610
VAL A 711
LEU A 590
LEU A 608
 None
 0.86A 1pthB-4gx7A:
undetectable		 1pthB-4gx7A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcj THIJ/PFPI DOMAIN
PROTEIN

(Brachyspira
murdochii) 		PF01965
(DJ-1_PfpI) 		4 VAL A 144
VAL A 169
LEU A 170
ALA A 102
 None
 0.73A 1pthB-4hcjA:
undetectable		 1pthB-4hcjA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8j PUTATIVE EFFLUX
TRANSPORTER

(Bacteroides
eggerthii) 		PF16576
(HlyD_D23) 		4 VAL A 179
LEU A  59
ALA A  85
LEU A  70
 None
 0.85A 1pthB-4l8jA:
undetectable		 1pthB-4l8jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nav HYPOTHETICAL PROTEIN
XCC279

(Xanthomonas
campestris) 		no annotation 4 VAL D 133
VAL D 166
LEU D 167
LEU D 114
 None
 0.84A 1pthB-4navD:
undetectable		 1pthB-4navD:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		4 VAL A 391
LEU A 390
ALA A 369
LEU A 370
 None
 0.74A 1pthB-4oe1A:
undetectable		 1pthB-4oe1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		4 VAL B 188
VAL B 231
LEU B 232
LEU B 198
 None
 0.84A 1pthB-4ol0B:
2.2		 1pthB-4ol0B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		4 VAL A 169
VAL A 191
ALA A 103
LEU A 119
 None
 0.76A 1pthB-4onyA:
undetectable		 1pthB-4onyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		4 VAL B  71
VAL B  28
LEU B   3
LEU B  47
 None
 0.77A 1pthB-4peqB:
undetectable		 1pthB-4peqB:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 VAL A 117
ARG A 121
VAL A 350
LEU A 353
TYR A 356
ALA A 528
LEU A 532
 BOG  A 604 (-3.9A)
BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.53A 1pthB-4ph9A:
58.7		 1pthB-4ph9A:
63.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5y MATERNAL PROTEIN
TUDOR

(Drosophila
melanogaster) 		PF00567
(TUDOR) 		4 VAL A2180
LEU A2272
ALA A2320
LEU A2322
 None
 0.83A 1pthB-4q5yA:
undetectable		 1pthB-4q5yA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 4 VAL B 193
LEU B 236
ALA B 214
LEU B 198
 None
 0.73A 1pthB-4tqoB:
undetectable		 1pthB-4tqoB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 VAL B  61
VAL B 139
LEU B  39
LEU B  68
 None
 0.85A 1pthB-4tx2B:
undetectable		 1pthB-4tx2B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		4 VAL A 390
VAL A 320
ALA A 377
LEU A 387
 None
 0.82A 1pthB-4uqgA:
undetectable		 1pthB-4uqgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe3 CYTOCHROME P-450

(Streptomyces
antibioticus) 		PF00067
(p450) 		4 VAL A 257
LEU A 131
ALA A 369
LEU A 373
 None
 0.80A 1pthB-4xe3A:
undetectable		 1pthB-4xe3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 VAL A  29
VAL A  42
LEU A  43
ALA A  77
 None
 0.79A 1pthB-4yfjA:
undetectable		 1pthB-4yfjA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2

(Rattus
norvegicus) 		no annotation 4 VAL A 584
VAL A 503
LEU A 502
LEU A 582
 None
 0.81A 1pthB-5a9iA:
undetectable		 1pthB-5a9iA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0u ALKYLMERCURY LYASE

(Escherichia
coli) 		PF03243
(MerB)
PF12324
(HTH_15) 		4 VAL A 189
VAL A 113
ALA A  97
LEU A 101
 None
 0.74A 1pthB-5c0uA:
undetectable		 1pthB-5c0uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		4 LEU A 183
TYR A 164
ALA A 157
LEU A 154
 None
 0.84A 1pthB-5c1iA:
undetectable		 1pthB-5c1iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwm DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 VAL A 187
LEU A 108
ALA A 161
LEU A 183
 None
 0.77A 1pthB-5cwmA:
undetectable		 1pthB-5cwmA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A 216
LEU A 217
ALA A 260
LEU A 249
 None
 0.87A 1pthB-5fg0A:
undetectable		 1pthB-5fg0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxg UNCHARACTERIZED
PROTEIN STM1697

(Salmonella
enterica) 		PF00563
(EAL) 		4 VAL A 101
VAL A  85
LEU A  84
LEU A 103
 None
 0.77A 1pthB-5hxgA:
undetectable		 1pthB-5hxgA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		4 VAL A 181
VAL A 202
ALA A 115
LEU A 131
 None
 0.85A 1pthB-5icqA:
undetectable		 1pthB-5icqA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		7 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
ALA A 527
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.48A 1pthB-5ikrA:
58.5		 1pthB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 VAL A 366
TYR A 386
ALA A 283
LEU A 419
 None
 0.82A 1pthB-5isuA:
undetectable		 1pthB-5isuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 VAL B1329
VAL B1380
LEU B 944
LEU B1331
 None
 0.76A 1pthB-5jtwB:
undetectable		 1pthB-5jtwB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		4 VAL A 233
LEU A 223
ALA A 199
LEU A 200
 None
 0.78A 1pthB-5jxmA:
undetectable		 1pthB-5jxmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9y ZINC TRANSPORT
PROTEIN ZNTB

(Escherichia
coli) 		no annotation 4 VAL A   9
LEU A  20
ALA A  17
LEU A  29
 None
 0.75A 1pthB-5n9yA:
undetectable		 1pthB-5n9yA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION

(Mus musculus) 		no annotation 4 VAL B 227
LEU B 230
ALA B 266
LEU B 269
 None
 0.75A 1pthB-5oenB:
undetectable		 1pthB-5oenB:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		4 ARG A  93
VAL A  97
LEU A 101
ALA A  20
 EDO  A 506 (-3.6A)
None
None
EDO  A 506 ( 4.9A)
 0.87A 1pthB-5tp4A:
undetectable		 1pthB-5tp4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		4 VAL A 203
VAL A  17
LEU A  20
LEU A 222
 None
 0.82A 1pthB-5tsqA:
0.7		 1pthB-5tsqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Neisseria
gonorrhoeae) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A  79
LEU A 268
ALA A  97
LEU A  74
 None
 0.71A 1pthB-5vevA:
undetectable		 1pthB-5vevA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkw ADENYLOSUCCINATE
LYASE

(Candida
albicans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 VAL A 458
LEU A 359
ALA A 169
LEU A 173
 None
 0.86A 1pthB-5vkwA:
undetectable		 1pthB-5vkwA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvw UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		4 VAL A 147
VAL A  34
LEU A  35
LEU A 167
 None
 0.86A 1pthB-5vvwA:
undetectable		 1pthB-5vvwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP0

(Hepatovirus A) 		PF00073
(Rhv) 		4 VAL B 204
VAL B  78
ALA B  66
LEU B 202
 None
 0.87A 1pthB-5wtfB:
undetectable		 1pthB-5wtfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 VAL D 903
LEU D 804
ALA D 878
LEU D 882
 None
 0.89A 1pthB-5xbkD:
undetectable		 1pthB-5xbkD:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywp JEV E PROTEIN

(Japanese
encephalitis
virus) 		no annotation 4 VAL A 186
VAL A  43
LEU A  31
LEU A 188
 None
 0.75A 1pthB-5ywpA:
undetectable		 1pthB-5ywpA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 VAL A 711
VAL A 810
LEU A 816
ALA A 779
LEU A 778
 None
 1.35A 1pthB-6bhuA:
undetectable		 1pthB-6bhuA:
0.00