SIMILAR PATTERNS OF AMINO ACIDS FOR 1PN0_D_IPHD6042_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		5 VAL A 202
MET A 131
ILE A 129
TYR A 170
GLY A 195
 None
 1.05A 1pn0D-1bs9A:
0.0		 1pn0D-1bs9A:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.18A 1pn0D-1fohA:
56.6		 1pn0D-1fohA:
98.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 GLY A 203
VAL A 206
ILE A 115
TYR A 148
GLY A 117
 None
None
None
None
SAF  A1998 (-3.1A)
 1.37A 1pn0D-1gqrA:
0.0		 1pn0D-1gqrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ASP A  30
GLN A 122
ARG A 233
ILE A  29
GLY A  27
 None
 1.47A 1pn0D-1gv3A:
0.0		 1pn0D-1gv3A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
PF02256
(Fe_hyd_SSU) 		5 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.20A 1pn0D-1hfeL:
0.0		 1pn0D-1hfeL:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.39A 1pn0D-1k4yA:
0.8		 1pn0D-1k4yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 345
VAL A 348
ARG A 277
ILE A 105
GLY A 343
 FAD  A3000 ( 4.6A)
None
None
None
None
 1.50A 1pn0D-1m64A:
13.9		 1pn0D-1m64A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 GLY A 108
VAL A 107
MET A 235
ILE A 231
TYR A 132
 None
 1.25A 1pn0D-1mroA:
1.5		 1pn0D-1mroA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
PROTEIN (IMPORTIN
ALPHA-2 SUBUNIT)

(Homo sapiens;
Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
PF01749
(IBB) 		5 GLY A 771
MET B  47
GLN A 774
ARG B  50
GLY A 775
 None
 1.21A 1pn0D-1qgrA:
0.0		 1pn0D-1qgrA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY B 677
MET B 741
GLN B 678
VAL B 675
GLY B 681
 None
MCN  B4921 (-4.2A)
MCN  B4921 (-3.0A)
MCN  B4921 (-4.7A)
None
 1.44A 1pn0D-1t3qB:
undetectable		 1pn0D-1t3qB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.44A 1pn0D-2a3kA:
undetectable		 1pn0D-2a3kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy9 THIOESTERASE
SUPERFAMILY MEMBER 2

(Mus musculus) 		PF03061
(4HBT) 		5 MET A  86
VAL A  64
ILE A  88
TYR A  90
GLY A  58
 None
 1.34A 1pn0D-2cy9A:
undetectable		 1pn0D-2cy9A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ASP A  55
GLY A  57
VAL A  56
MET A 202
TYR A 203
 GLC  A 605 ( 4.7A)
None
None
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 1.43A 1pn0D-2d3lA:
undetectable		 1pn0D-2d3lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		5 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.09A 1pn0D-2du7A:
undetectable		 1pn0D-2du7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.34A 1pn0D-2h03A:
1.3		 1pn0D-2h03A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.13A 1pn0D-2i5gA:
undetectable		 1pn0D-2i5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 GLY A 362
VAL A 360
MET A 414
ILE A 411
GLY A 364
 None
 1.40A 1pn0D-2jgdA:
undetectable		 1pn0D-2jgdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.40A 1pn0D-2nyfA:
0.8		 1pn0D-2nyfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium;
Bacillus
megaterium) 		PF13377
(Peripla_BP_3)
PF00381
(PTS-HPr) 		5 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.25A 1pn0D-2nzuG:
undetectable		 1pn0D-2nzuG:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		5 GLY B 321
VAL B 322
ILE B 211
TYR B  59
GLY B 319
 None
 1.09A 1pn0D-2odrB:
undetectable		 1pn0D-2odrB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.10A 1pn0D-2uutA:
undetectable		 1pn0D-2uutA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		5 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.27A 1pn0D-2w8iA:
undetectable		 1pn0D-2w8iA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 GLY B 355
ARG B  69
MET B 264
ILE B  67
TYR B 271
 FAD  B   1 (-3.4A)
None
None
FAD  B   1 (-3.7A)
None
 1.18A 1pn0D-3adaB:
2.6		 1pn0D-3adaB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 GLY A 411
VAL A 412
ILE A 350
TYR A 354
GLY A 407
 None
 1.46A 1pn0D-3ayfA:
undetectable		 1pn0D-3ayfA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1pn0D-3b05A:
1.5		 1pn0D-3b05A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		5 GLY A 284
VAL A 287
ILE A 199
TYR A 230
GLY A 201
 None
 1.41A 1pn0D-3biwA:
undetectable		 1pn0D-3biwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfu UNCHARACTERIZED
PROTEIN FROM
6-PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
FAMILY

(Corynebacterium
glutamicum) 		PF10727
(Rossmann-like) 		5 GLY A  55
MET A  82
VAL A  57
ILE A  48
GLY A  52
 None
 1.18A 1pn0D-3dfuA:
undetectable		 1pn0D-3dfuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 5 GLY S 499
GLN S 501
VAL S 500
ILE S 455
GLY S 518
 None
 1.10A 1pn0D-3g9kS:
undetectable		 1pn0D-3g9kS:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		5 GLY A 153
MET A 160
VAL A 154
ILE A 124
GLY A 151
 CL  A 600 ( 4.5A)
None
None
CL  A 600 (-4.2A)
None
 1.46A 1pn0D-3griA:
undetectable		 1pn0D-3griA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A1224
VAL A1227
ILE A1139
TYR A1170
GLY A1141
 None
None
None
None
WW2  A 193 (-3.8A)
 1.38A 1pn0D-3k9bA:
undetectable		 1pn0D-3k9bA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 GLY A 233
VAL A 234
ILE A 215
TYR A   3
GLY A 231
 None
 1.24A 1pn0D-3niwA:
undetectable		 1pn0D-3niwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		5 GLY A 299
MET S  51
VAL A 301
ILE S  47
GLY A  82
 None
None
None
SEP  S  46 ( 4.1A)
None
 1.21A 1pn0D-3oqnA:
undetectable		 1pn0D-3oqnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1
USHER SYNDROME
TYPE-1G PROTEIN

(Mus musculus;
Homo sapiens) 		PF00784
(MyTH4)
no annotation 		5 GLY B 313
VAL A1309
ARG A1347
MET A1265
GLY B 311
 PO4  B  10 (-3.5A)
None
None
None
PO4  B  10 ( 3.4A)
 1.26A 1pn0D-3pvlB:
undetectable		 1pn0D-3pvlB:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.33A 1pn0D-3sopA:
undetectable		 1pn0D-3sopA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 ASP A 622
GLY A 621
VAL A 623
MET A 611
GLY A 617
 None
 1.24A 1pn0D-3zzuA:
undetectable		 1pn0D-3zzuA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		5 ASP G  45
GLY G  46
VAL G 213
ILE G   4
GLY G   7
 None
 1.41A 1pn0D-4adsG:
undetectable		 1pn0D-4adsG:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		5 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 0.97A 1pn0D-4aweA:
undetectable		 1pn0D-4aweA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		5 GLY A 528
MET A 637
VAL A 529
ILE A 520
TYR A 467
 None
 1.49A 1pn0D-4bq4A:
undetectable		 1pn0D-4bq4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		5 ASP A 118
GLY A  93
ARG A  88
ILE A 120
GLY A  91
 None
 1.13A 1pn0D-4hesA:
1.7		 1pn0D-4hesA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 ASP B 163
GLY B 337
VAL B 336
ILE B 428
TYR B  13
 PO4  B 504 (-2.8A)
PO4  B 504 ( 3.8A)
None
None
None
 1.24A 1pn0D-4i6mB:
undetectable		 1pn0D-4i6mB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 GLY A 330
MET A 337
VAL A 333
ILE A 318
GLY A 121
 None
 1.12A 1pn0D-4maaA:
4.2		 1pn0D-4maaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		5 VAL X 155
MET X 102
ILE X 119
TYR X 104
GLY X 148
 None
 1.26A 1pn0D-4n5iX:
undetectable		 1pn0D-4n5iX:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(unidentified) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 GLY A 259
VAL A 254
MET A 292
ILE A 280
GLY A 236
 None
 1.50A 1pn0D-4pytA:
undetectable		 1pn0D-4pytA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.43A 1pn0D-5b37A:
2.7		 1pn0D-5b37A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816
BD3460

(Bdellovibrio
bacteriovorus;
Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13)
PF12796
(Ank_2) 		5 ASP B 179
GLY B 175
GLN B 140
VAL B 171
GLY A 335
 None
 1.45A 1pn0D-5cerB:
undetectable		 1pn0D-5cerB:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MAJOR STRUCTURAL
PROTEIN 1

(Lactococcus
phage Tuc2009) 		no annotation 5 ASP G 153
MET G 132
ILE G 104
TYR G  92
GLY G 158
 None
 1.49A 1pn0D-5e7tG:
undetectable		 1pn0D-5e7tG:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 207
VAL A 210
ILE A 122
TYR A 153
GLY A 124
 None
 1.39A 1pn0D-5fv4A:
undetectable		 1pn0D-5fv4A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.30A 1pn0D-5grhB:
undetectable		 1pn0D-5grhB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		5 GLY A 514
GLN A 863
ILE A 498
TYR A 506
GLY A 509
 None
 1.45A 1pn0D-5guhA:
undetectable		 1pn0D-5guhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		5 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.48A 1pn0D-5gyzA:
undetectable		 1pn0D-5gyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 TRANSLATION
INITIATION FACTOR 1A

(Pyrococcus
abyssi) 		PF01176
(eIF-1a) 		5 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.34A 1pn0D-5jb36:
undetectable		 1pn0D-5jb36:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 GLY C 326
VAL C 323
ILE C 328
TYR C 179
GLY C 332
 None
 1.40A 1pn0D-5mg5C:
undetectable		 1pn0D-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.36A 1pn0D-5thmA:
undetectable		 1pn0D-5thmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 GLY C 124
MET C 233
VAL C 154
ILE C 126
GLY C 122
 None
 1.30A 1pn0D-5xyiC:
undetectable		 1pn0D-5xyiC:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 5 GLN A 108
VAL A 110
ILE A 105
TYR A 122
GLY A 271
 None
 1.37A 1pn0D-6cxhA:
undetectable		 1pn0D-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 5 MET H  48
GLN H 162
VAL H 209
ARG H 133
ILE H 212
 None
 1.00A 1pn0D-6df3H:
undetectable		 1pn0D-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3


(;
) 		no annotation
no annotation 		5 MET H  48
VAL H 209
ARG H 133
ILE H 212
GLY C  63
 None
 1.17A 1pn0D-6df3H:
undetectable		 1pn0D-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 GLY A 267
VAL A 334
ARG A 321
TYR A 281
GLY A 263
 None
 1.46A 1pn0D-6f5dA:
undetectable		 1pn0D-6f5dA:
undetectable