SIMILAR PATTERNS OF AMINO ACIDS FOR 1PN0_B_IPHB6022

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		5 VAL A 202
MET A 131
ILE A 129
TYR A 170
GLY A 195
 None
 1.07A 1pn0B-1bs9A:
2.6		 1pn0B-1bs9A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 290
GLN A 108
ARG A 110
MET A  42
GLY A 293
 FAD  A 510 (-3.5A)
None
FAD  A 510 (-4.3A)
FAD  A 510 (-3.7A)
FAD  A 510 ( 4.3A)
 1.07A 1pn0B-1coyA:
14.1		 1pn0B-1coyA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.08A 1pn0B-1fohA:
66.5		 1pn0B-1fohA:
98.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 GLY A 203
VAL A 206
ILE A 115
TYR A 148
GLY A 117
 None
None
None
None
SAF  A1998 (-3.1A)
 1.42A 1pn0B-1gqrA:
0.0		 1pn0B-1gqrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 GLY A 685
GLN A 684
VAL A 636
ILE A 604
GLY A 688
 None
 1.44A 1pn0B-1h54A:
0.0		 1pn0B-1h54A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
PF02256
(Fe_hyd_SSU) 		5 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.22A 1pn0B-1hfeL:
0.0		 1pn0B-1hfeL:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		5 GLY A 247
VAL A  95
ILE A  76
TYR A 282
GLY A 234
 None
 1.20A 1pn0B-1j32A:
0.0		 1pn0B-1j32A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.43A 1pn0B-1k4yA:
0.0		 1pn0B-1k4yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 345
VAL A 348
ARG A 277
ILE A 105
GLY A 343
 FAD  A3000 ( 4.6A)
None
None
None
None
 1.50A 1pn0B-1m64A:
14.2		 1pn0B-1m64A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 GLY A 108
VAL A 107
MET A 235
ILE A 231
TYR A 132
 None
 1.26A 1pn0B-1mroA:
undetectable		 1pn0B-1mroA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
PROTEIN (IMPORTIN
ALPHA-2 SUBUNIT)

(Homo sapiens;
Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
PF01749
(IBB) 		5 GLY A 771
MET B  47
GLN A 774
ARG B  50
GLY A 775
 None
 1.27A 1pn0B-1qgrA:
undetectable		 1pn0B-1qgrA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY B 677
MET B 741
GLN B 678
VAL B 675
GLY B 681
 None
MCN  B4921 (-4.2A)
MCN  B4921 (-3.0A)
MCN  B4921 (-4.7A)
None
 1.45A 1pn0B-1t3qB:
undetectable		 1pn0B-1t3qB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0v PUTATIVE PROTEASE LA
HOMOLOG TYPE

(Archaeoglobus
fulgidus) 		PF05362
(Lon_C) 		5 MET A 492
VAL A 449
ARG A 487
ILE A 522
GLY A 524
 None
 1.46A 1pn0B-1z0vA:
undetectable		 1pn0B-1z0vA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 GLY A 110
GLN A  45
VAL A 109
MET A  98
ILE A 100
 None
 1.35A 1pn0B-1zchA:
undetectable		 1pn0B-1zchA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.42A 1pn0B-2a3kA:
undetectable		 1pn0B-2a3kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy9 THIOESTERASE
SUPERFAMILY MEMBER 2

(Mus musculus) 		PF03061
(4HBT) 		5 MET A  86
VAL A  64
ILE A  88
TYR A  90
GLY A  58
 None
 1.36A 1pn0B-2cy9A:
undetectable		 1pn0B-2cy9A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ASP A  55
GLY A  57
VAL A  56
MET A 202
TYR A 203
 GLC  A 605 ( 4.7A)
None
None
GLC  A 605 ( 3.5A)
GLC  A 603 (-4.0A)
 1.46A 1pn0B-2d3lA:
undetectable		 1pn0B-2d3lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		5 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.13A 1pn0B-2du7A:
undetectable		 1pn0B-2du7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.32A 1pn0B-2h03A:
undetectable		 1pn0B-2h03A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.17A 1pn0B-2i5gA:
undetectable		 1pn0B-2i5gA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 GLY A 362
VAL A 360
MET A 414
ILE A 411
GLY A 364
 None
 1.40A 1pn0B-2jgdA:
undetectable		 1pn0B-2jgdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mou STAR-RELATED LIPID
TRANSFER PROTEIN 6

(Homo sapiens) 		PF01852
(START) 		5 GLY A  16
VAL A  14
MET A 124
ILE A 126
TYR A 120
 None
 1.43A 1pn0B-2mouA:
undetectable		 1pn0B-2mouA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.39A 1pn0B-2nyfA:
undetectable		 1pn0B-2nyfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium;
Bacillus
megaterium) 		PF13377
(Peripla_BP_3)
PF00381
(PTS-HPr) 		5 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.22A 1pn0B-2nzuG:
undetectable		 1pn0B-2nzuG:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		5 GLY B 321
VAL B 322
ILE B 211
TYR B  59
GLY B 319
 None
 1.13A 1pn0B-2odrB:
undetectable		 1pn0B-2odrB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		5 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.23A 1pn0B-2w8iA:
undetectable		 1pn0B-2w8iA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		5 GLY B 355
ARG B  69
MET B 264
ILE B  67
TYR B 271
 FAD  B   1 (-3.4A)
None
None
FAD  B   1 (-3.7A)
None
 1.16A 1pn0B-3adaB:
5.0		 1pn0B-3adaB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvg PUTATIVE METAL
BINDING PROTEIN

(Coccidioides
immitis) 		PF12849
(PBP_like_2) 		5 GLY A  48
VAL A  53
ILE A  97
TYR A  99
GLY A  45
 None
 1.16A 1pn0B-3cvgA:
undetectable		 1pn0B-3cvgA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfu UNCHARACTERIZED
PROTEIN FROM
6-PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
FAMILY

(Corynebacterium
glutamicum) 		PF10727
(Rossmann-like) 		5 GLY A  55
MET A  82
VAL A  57
ILE A  48
GLY A  52
 None
 1.13A 1pn0B-3dfuA:
undetectable		 1pn0B-3dfuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)

(Clostridium
acetobutylicum) 		PF13377
(Peripla_BP_3) 		5 MET A 168
VAL A 163
ARG A 199
MET A 279
ILE A 297
 None
None
GOL  A 401 (-2.9A)
None
None
 1.18A 1pn0B-3g85A:
undetectable		 1pn0B-3g85A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 147
GLY A 377
MET A 305
GLN A 339
GLY A 379
 None
 1.41A 1pn0B-3ijlA:
undetectable		 1pn0B-3ijlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.37A 1pn0B-3kzvA:
undetectable		 1pn0B-3kzvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 GLY A 233
VAL A 234
ILE A 215
TYR A   3
GLY A 231
 None
 1.27A 1pn0B-3niwA:
undetectable		 1pn0B-3niwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		5 GLY A 299
MET S  51
VAL A 301
ILE S  47
GLY A  82
 None
None
None
SEP  S  46 ( 4.1A)
None
 1.19A 1pn0B-3oqnA:
undetectable		 1pn0B-3oqnA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1
USHER SYNDROME
TYPE-1G PROTEIN

(Mus musculus;
Homo sapiens) 		PF00784
(MyTH4)
no annotation 		5 GLY B 313
VAL A1309
ARG A1347
MET A1265
GLY B 311
 PO4  B  10 (-3.5A)
None
None
None
PO4  B  10 ( 3.4A)
 1.21A 1pn0B-3pvlB:
undetectable		 1pn0B-3pvlB:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.31A 1pn0B-3sopA:
undetectable		 1pn0B-3sopA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		5 GLY A 192
VAL A 190
ILE A 201
TYR A 344
GLY A 194
 NAP  A 552 (-3.4A)
None
None
None
NAP  A 552 (-3.4A)
 0.92A 1pn0B-3up4A:
7.0		 1pn0B-3up4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		5 ASP G  45
GLY G  46
VAL G 213
ILE G   4
GLY G   7
 None
 1.42A 1pn0B-4adsG:
undetectable		 1pn0B-4adsG:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		5 GLY A 198
VAL A 196
ILE A 207
TYR A 349
GLY A 200
 None
None
None
None
NAP  A1553 (-3.5A)
 0.95A 1pn0B-4ap3A:
10.5		 1pn0B-4ap3A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		5 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 1.00A 1pn0B-4aweA:
undetectable		 1pn0B-4aweA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 ASP A 624
GLY A 625
MET A 632
ILE A 643
GLY A 606
 None
 1.40A 1pn0B-4ci8A:
undetectable		 1pn0B-4ci8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ASP A 226
GLY A 241
VAL A 239
ILE A 229
GLY A 219
 None
 1.34A 1pn0B-4h1sA:
1.8		 1pn0B-4h1sA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 ASP B 163
GLY B 337
VAL B 336
ILE B 428
TYR B  13
 PO4  B 504 (-2.8A)
PO4  B 504 ( 3.8A)
None
None
None
 1.27A 1pn0B-4i6mB:
undetectable		 1pn0B-4i6mB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 GLY A 330
MET A 337
VAL A 333
ILE A 318
GLY A 121
 None
 1.09A 1pn0B-4maaA:
3.4		 1pn0B-4maaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		5 VAL X 155
MET X 102
ILE X 119
TYR X 104
GLY X 148
 None
 1.23A 1pn0B-4n5iX:
undetectable		 1pn0B-4n5iX:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(unidentified) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 GLY A 259
VAL A 254
MET A 292
ILE A 280
GLY A 236
 None
 1.48A 1pn0B-4pytA:
undetectable		 1pn0B-4pytA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 5 GLY A 101
VAL A 104
MET A  55
ILE A  52
GLY A 431
 None
 1.48A 1pn0B-5ah1A:
undetectable		 1pn0B-5ah1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MAJOR STRUCTURAL
PROTEIN 1

(Lactococcus
phage Tuc2009) 		no annotation 5 ASP G 153
MET G 132
ILE G 104
TYR G  92
GLY G 158
 None
 1.50A 1pn0B-5e7tG:
undetectable		 1pn0B-5e7tG:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.22A 1pn0B-5grhB:
undetectable		 1pn0B-5grhB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 ASP A 226
GLY A 241
VAL A 239
ILE A 229
GLY A 219
 None
 1.35A 1pn0B-5h7wA:
2.5		 1pn0B-5h7wA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 TRANSLATION
INITIATION FACTOR 1A

(Pyrococcus
abyssi) 		PF01176
(eIF-1a) 		5 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.30A 1pn0B-5jb36:
undetectable		 1pn0B-5jb36:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwv L,D-TRANSPEPTIDASE 2

(Mycobacteroides
abscessus) 		no annotation 5 GLY B 369
GLN B 165
VAL B 161
ILE B 246
GLY B 164
 None
 1.36A 1pn0B-5uwvB:
undetectable		 1pn0B-5uwvB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 GLY C 124
MET C 233
VAL C 154
ILE C 126
GLY C 122
 None
 1.27A 1pn0B-5xyiC:
undetectable		 1pn0B-5xyiC:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 GLY A 481
VAL A 483
ARG A 400
ILE A 463
GLY A 393
 None
 1.33A 1pn0B-6at7A:
undetectable		 1pn0B-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 5 MET H  48
GLN H 162
VAL H 209
ARG H 133
ILE H 212
 None
 1.00A 1pn0B-6df3H:
undetectable		 1pn0B-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3


(;
) 		no annotation
no annotation 		5 MET H  48
VAL H 209
ARG H 133
ILE H 212
GLY C  63
 None
 1.14A 1pn0B-6df3H:
undetectable		 1pn0B-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 GLY A 267
VAL A 334
ARG A 321
TYR A 281
GLY A 263
 None
 1.45A 1pn0B-6f5dA:
undetectable		 1pn0B-6f5dA:
undetectable