SIMILAR PATTERNS OF AMINO ACIDS FOR 1PK7_B_ADNB1246_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ati GLYCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ARG A 431
GLY A  35
VAL A  39
GLU A  40
 None
 0.71A 1pk7B-1atiA:
undetectable		 1pk7B-1atiA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A  55
VAL A 107
GLU A  77
ILE A  41
 None
 0.70A 1pk7B-1bvuA:
undetectable		 1pk7B-1bvuA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 ARG A 467
GLY A 483
GLU A 510
GLU A 520
 None
 0.88A 1pk7B-1ebvA:
undetectable		 1pk7B-1ebvA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1erz N-CARBAMYL-D-AMINO
ACID AMIDOHYDROLASE

(Agrobacterium
sp. KNK712) 		PF00795
(CN_hydrolase) 		4 GLY A   9
VAL A 268
GLU A 267
ILE A  42
 None
 0.90A 1pk7B-1erzA:
undetectable		 1pk7B-1erzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f89 32.5 KDA PROTEIN
YLR351C

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		4 GLY A 165
VAL A 166
SER A 181
ILE A 157
 None
 0.83A 1pk7B-1f89A:
undetectable		 1pk7B-1f89A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9a HYPOTHETICAL PROTEIN
MJ0541

(Methanocaldococcus
jannaschii) 		PF01467
(CTP_transf_like) 		4 ARG A 130
GLY A   7
GLU A  44
ILE A   6
 ATP  A 700 (-2.7A)
ATP  A 700 (-3.6A)
None
None
 0.88A 1pk7B-1f9aA:
undetectable		 1pk7B-1f9aA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggm GLYCINE--TRNA LIGASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ARG A 431
GLY A  35
VAL A  39
GLU A  40
 None
 0.76A 1pk7B-1ggmA:
undetectable		 1pk7B-1ggmA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		4 ARG A 501
GLY A 477
VAL A 424
ILE A 476
 None
 0.79A 1pk7B-1gm5A:
undetectable		 1pk7B-1gm5A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		4 GLY A 102
VAL A   7
MET A   5
ILE A  12
 None
 0.79A 1pk7B-1hi9A:
undetectable		 1pk7B-1hi9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsl HISTIDINE-BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		4 GLY A   9
VAL A  48
GLU A  49
ILE A  64
 None
 0.89A 1pk7B-1hslA:
undetectable		 1pk7B-1hslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv3 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Thermus
thermophilus) 		PF02542
(YgbB) 		4 GLY A   4
VAL A 147
SER A  50
ILE A   3
 None
 0.73A 1pk7B-1iv3A:
undetectable		 1pk7B-1iv3A:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		7 ARG A  86
GLY A  91
VAL A 179
GLU A 180
MET A 181
GLU A 182
SER A 204
 SO4  A 250 ( 3.1A)
FMB  A 270 (-3.3A)
FMB  A 270 (-4.6A)
FMB  A 270 (-4.6A)
FMB  A 270 (-3.8A)
FMB  A 270 (-2.8A)
FMB  A 270 (-3.2A)
 0.70A 1pk7B-1jdzA:
34.0		 1pk7B-1jdzA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLY A2535
VAL A2527
SER A2532
ILE A2539
 None
 0.68A 1pk7B-1js8A:
undetectable		 1pk7B-1js8A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A  99
GLY A  53
VAL A 107
ILE A 517
 None
None
PQQ  A 701 (-4.7A)
None
 0.64A 1pk7B-1lrwA:
undetectable		 1pk7B-1lrwA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D

(Saccharomyces
cerevisiae) 		PF01466
(Skp1)
PF03931
(Skp1_POZ) 		4 ARG A 159
GLY A 150
VAL A 154
ILE A 135
 None
 0.84A 1pk7B-1nexA:
undetectable		 1pk7B-1nexA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		7 ARG A  87
GLY A  92
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 SO4  A1236 ( 2.8A)
ADN  A1237 (-3.4A)
ADN  A1237 (-4.9A)
ADN  A1237 (-3.7A)
ADN  A1237 (-3.0A)
ADN  A1237 ( 3.7A)
ADN  A1237 (-4.4A)
 0.68A 1pk7B-1odiA:
35.4		 1pk7B-1odiA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		8 ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 PO4  A 309 ( 2.8A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
2FA  A 306 ( 3.9A)
None
 0.42A 1pk7B-1pk9A:
43.2		 1pk7B-1pk9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		6 ARG A  87
GLY A 177
VAL A 178
GLU A 179
MET A 180
GLU A 181
 PO4  A 309 ( 2.8A)
None
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
2FA  A 306 (-2.9A)
 1.35A 1pk7B-1pk9A:
43.2		 1pk7B-1pk9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLY A 133
VAL A 148
MET A 146
ILE A 126
 None
 0.85A 1pk7B-1przA:
undetectable		 1pk7B-1przA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		4 ARG A 218
GLY A 212
VAL A 214
ILE A 273
 GDP  A1601 (-3.0A)
GDP  A1601 (-3.3A)
None
None
 0.79A 1pk7B-1rpnA:
3.2		 1pk7B-1rpnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)

(Solanum
tuberosum) 		PF00834
(Ribul_P_3_epim) 		4 GLY A 189
VAL A 188
GLU A 160
ILE A 223
 None
 0.91A 1pk7B-1rpxA:
undetectable		 1pk7B-1rpxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 ARG C 131
GLY B  54
GLU C 135
ILE B  23
 AGS  B 802 ( 2.7A)
AGS  B 802 (-3.2A)
None
AGS  B 802 (-4.4A)
 0.85A 1pk7B-1sxjC:
undetectable		 1pk7B-1sxjC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1)
PF10423
(AMNp_N) 		4 GLY A 307
MET A 404
GLU A 405
SER A 427
 None
 0.60A 1pk7B-1t8wA:
24.5		 1pk7B-1t8wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		4 GLY A 345
GLU A 343
SER A 316
ILE A 359
 None
 0.76A 1pk7B-1tg5A:
undetectable		 1pk7B-1tg5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 GLY A  76
VAL A  78
SER A 131
ILE A  89
 None
 0.76A 1pk7B-1u1hA:
undetectable		 1pk7B-1u1hA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 GLY A 199
GLU A 197
SER A 499
ILE A 492
 None
 0.70A 1pk7B-1upxA:
undetectable		 1pk7B-1upxA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkf GLYCEROL UPTAKE
OPERON
ANTITERMINATOR-RELAT
ED PROTEIN

(Thermotoga
maritima) 		PF04309
(G3P_antiterm) 		4 VAL A 146
GLU A 147
SER A 166
ILE A 162
 None
 0.86A 1pk7B-1vkfA:
undetectable		 1pk7B-1vkfA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 VAL B 191
GLU B 190
SER B 164
ILE B 183
 None
 0.80A 1pk7B-1wytB:
undetectable		 1pk7B-1wytB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		4 GLY A  12
VAL A  39
GLU A  40
ILE A  56
 None
 0.76A 1pk7B-1xs5A:
undetectable		 1pk7B-1xs5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx6 THYMIDINE KINASE

(Clostridium
acetobutylicum) 		PF00265
(TK) 		4 ARG A  28
VAL A  10
GLU A  11
ILE A 134
 None
 0.84A 1pk7B-1xx6A:
undetectable		 1pk7B-1xx6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybf AMP NUCLEOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01048
(PNP_UDP_1) 		5 GLY A  98
VAL A 184
MET A 186
GLU A 187
SER A 209
 None
 0.74A 1pk7B-1ybfA:
24.7		 1pk7B-1ybfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		4 GLY A  81
VAL A  82
GLU A  83
ILE A 109
 None
 0.92A 1pk7B-1ypxA:
undetectable		 1pk7B-1ypxA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		8 ARG A  87
GLY A  92
VAL A 178
GLU A 179
MET A 180
GLU A 181
SER A 203
ILE A 206
 2FD  A 300 ( 4.5A)
2FD  A 300 (-3.1A)
2FD  A 300 (-4.7A)
None
2FD  A 300 (-3.7A)
2FD  A 300 (-2.8A)
2FD  A 300 (-3.6A)
None
 0.66A 1pk7B-1z34A:
39.0		 1pk7B-1z34A:
58.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		5 GLY A  49
VAL A  52
GLU A  53
GLU A  33
ILE A  21
 None
 1.19A 1pk7B-1zl0A:
undetectable		 1pk7B-1zl0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 GLY I 274
VAL I 269
GLU I 270
GLU I 389
 None
 0.85A 1pk7B-1zo1I:
2.9		 1pk7B-1zo1I:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		6 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.6A)
MTM  A 301 (-3.4A)
 0.71A 1pk7B-1zosA:
22.7		 1pk7B-1zosA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		4 ARG C 412
GLY C 334
GLU C 410
ILE C 323
 None
 0.80A 1pk7B-1zq1C:
undetectable		 1pk7B-1zq1C:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrr E-2/E-2' PROTEIN

(Klebsiella
oxytoca) 		PF03079
(ARD) 		4 VAL A 107
GLU A 108
SER A  77
ILE A 153
 None
 0.81A 1pk7B-1zrrA:
undetectable		 1pk7B-1zrrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		6 ARG A  88
GLY A  93
VAL A 181
GLU A 182
MET A 183
GLU A 184
 NOS  A1248 ( 4.5A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-3.1A)
 0.48A 1pk7B-2bsxA:
32.3		 1pk7B-2bsxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ARG A 449
GLY A  76
GLU A  64
ILE A  30
 None
 0.73A 1pk7B-2bvgA:
undetectable		 1pk7B-2bvgA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 GLY A 249
VAL A 192
GLU A 125
ILE A 224
 FMN  A1312 (-3.5A)
None
None
FMN  A1312 ( 4.9A)
 0.91A 1pk7B-2bx7A:
undetectable		 1pk7B-2bx7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3b PPIASE

(Aspergillus
fumigatus) 		PF00160
(Pro_isomerase) 		4 GLY A  21
VAL A   8
GLU A   9
ILE A  23
 None
 0.92A 1pk7B-2c3bA:
undetectable		 1pk7B-2c3bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cja SERYL-TRNA
SYNTHETASE

(Methanosarcina
barkeri) 		no annotation 4 GLY A 463
VAL A 464
GLU A 467
ILE A 356
 None
 0.86A 1pk7B-2cjaA:
undetectable		 1pk7B-2cjaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		4 ARG C 400
GLY C 321
GLU C 398
ILE C 310
 None
 0.90A 1pk7B-2d6fC:
undetectable		 1pk7B-2d6fC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewn BIRA BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 ARG A 212
GLY A  17
GLU A  62
SER A  59
 None
 0.72A 1pk7B-2ewnA:
undetectable		 1pk7B-2ewnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gey ACLR PROTEIN

(Streptomyces
galilaeus) 		PF07366
(SnoaL) 		4 ARG A 108
VAL A  34
GLU A 116
SER A  30
 None
 0.91A 1pk7B-2geyA:
undetectable		 1pk7B-2geyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		5 ARG A 172
GLY A 138
VAL A 139
GLU A 135
ILE A 111
 None
 1.49A 1pk7B-2gjnA:
undetectable		 1pk7B-2gjnA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		5 GLY A 246
VAL A 238
GLU A 237
GLU A  19
ILE A 432
 None
 1.18A 1pk7B-2glfA:
5.7		 1pk7B-2glfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 GLY A 293
GLU A 230
GLU A 219
ILE A 298
 None
 0.67A 1pk7B-2hakA:
undetectable		 1pk7B-2hakA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 GLY B 386
VAL B 308
GLU B 307
ILE B 376
 None
 0.85A 1pk7B-2hdnB:
4.4		 1pk7B-2hdnB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 GLY A 131
VAL A  99
MET A 101
ILE A  26
 None
 0.84A 1pk7B-2hq6A:
undetectable		 1pk7B-2hq6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 GLY A 133
VAL A 148
MET A 146
ILE A 126
 None
 0.77A 1pk7B-2istA:
undetectable		 1pk7B-2istA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ARG A 372
GLY A 722
VAL A 378
GLU A 369
 None
 0.88A 1pk7B-2iukA:
undetectable		 1pk7B-2iukA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF02861
(Clp_N) 		4 GLY A  37
VAL A  13
GLU A  41
ILE A  34
 None
 0.90A 1pk7B-2k77A:
undetectable		 1pk7B-2k77A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5t LIPOAMIDE
ACYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00364
(Biotin_lipoyl) 		4 GLY A  53
VAL A  29
GLU A  30
ILE A  75
 None
 0.80A 1pk7B-2l5tA:
undetectable		 1pk7B-2l5tA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		4 VAL A  62
GLU A  63
SER A 103
ILE A 392
 None
 0.89A 1pk7B-2owmA:
undetectable		 1pk7B-2owmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		5 VAL A  87
GLU A  86
MET A  83
SER A  39
ILE A  51
 None
 1.48A 1pk7B-2p10A:
undetectable		 1pk7B-2p10A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtn NICOTINATE
(NICOTINAMIDE)
NUCLEOTIDE
ADENYLYLTRANSFERASE

(Bacillus
anthracis) 		PF01467
(CTP_transf_like) 		4 GLY A   5
VAL A  34
GLU A  33
ILE A 104
 None
 0.92A 1pk7B-2qtnA:
undetectable		 1pk7B-2qtnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvs CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT

(Mus musculus) 		PF00027
(cNMP_binding) 		4 GLY B 349
VAL B 302
GLU B 301
ILE B 284
 GLY  B 349 ( 0.0A)
VAL  B 302 ( 0.6A)
GLU  B 301 ( 0.6A)
ILE  B 284 ( 0.7A)
 0.76A 1pk7B-2qvsB:
undetectable		 1pk7B-2qvsB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		5 ARG A 108
GLY A   8
GLU A   9
SER A 134
ILE A  53
 KDF  A1314 ( 3.0A)
None
None
None
None
 1.28A 1pk7B-2varA:
undetectable		 1pk7B-2varA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 GLY A 173
VAL A 169
GLU A 168
GLU A 146
 None
 0.85A 1pk7B-2w3pA:
undetectable		 1pk7B-2w3pA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		4 GLY A 462
GLU A 468
SER A 328
ILE A 461
 None
 0.80A 1pk7B-2whxA:
undetectable		 1pk7B-2whxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa0 APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 ARG A 109
GLY A 155
GLU A 114
ILE A 173
 None
 0.89A 1pk7B-2xa0A:
undetectable		 1pk7B-2xa0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		4 GLY A 454
VAL A 457
GLU A 422
ILE A 450
 None
 0.89A 1pk7B-2xa7A:
undetectable		 1pk7B-2xa7A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 GLY A  78
VAL A  63
GLU A  64
ILE A  81
 None
 0.85A 1pk7B-2yb4A:
undetectable		 1pk7B-2yb4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 ARG A 454
GLY A  58
VAL A  61
GLU A  63
SER A  95
 None
 1.48A 1pk7B-2zxhA:
undetectable		 1pk7B-2zxhA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 VAL A 482
GLU A 483
GLU A 382
ILE A 440
 None
 0.90A 1pk7B-3a5iA:
undetectable		 1pk7B-3a5iA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7l GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Escherichia
coli) 		PF01597
(GCV_H) 		4 GLY A  75
VAL A  51
SER A 107
ILE A 104
 None
 0.81A 1pk7B-3a7lA:
undetectable		 1pk7B-3a7lA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 GLY A 272
VAL A 271
GLU A 274
ILE A 244
 None
 0.79A 1pk7B-3anyA:
undetectable		 1pk7B-3anyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bba INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10) 		4 GLY A 311
VAL A 124
GLU A 123
SER A 319
 None
 0.88A 1pk7B-3bbaA:
undetectable		 1pk7B-3bbaA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		6 ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.06A 1pk7B-3bjeA:
28.6		 1pk7B-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		6 GLY A  77
VAL A 170
GLU A 171
MET A 172
GLU A 173
SER A 195
 FMC  A 229 (-3.6A)
FMC  A 229 ( 4.7A)
FMC  A 229 (-4.7A)
FMC  A 229 (-3.5A)
FMC  A 229 (-2.5A)
FMC  A 229 (-3.5A)
 0.57A 1pk7B-3bl6A:
24.5		 1pk7B-3bl6A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 ARG A 212
GLY A 203
VAL A 194
GLU A 187
ILE A 196
 None
 0.90A 1pk7B-3c0kA:
undetectable		 1pk7B-3c0kA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3del ARGININE BINDING
PROTEIN

(Chlamydia
trachomatis) 		PF00497
(SBP_bac_3) 		4 GLY B 221
VAL B  97
GLU B  48
ILE B 111
 None
 0.67A 1pk7B-3delB:
undetectable		 1pk7B-3delB:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doa FIBRINOGEN BINDING
PROTEIN

(Staphylococcus
aureus) 		PF05833
(FbpA) 		4 GLY A  85
VAL A  23
GLU A  83
SER A 105
 None
 0.87A 1pk7B-3doaA:
undetectable		 1pk7B-3doaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		6 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.61A 1pk7B-3dp9A:
23.8		 1pk7B-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 GLY B  46
VAL B  52
SER B  32
ILE B  99
 None
 0.83A 1pk7B-3dw8B:
undetectable		 1pk7B-3dw8B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		6 GLY A  81
VAL A 175
GLU A 176
MET A 177
GLU A 178
SER A 200
 MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-2.6A)
MTM  A 234 (-3.4A)
 0.58A 1pk7B-3eeiA:
23.9		 1pk7B-3eeiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE

(Plasmodium
vivax) 		PF01048
(PNP_UDP_1) 		6 ARG A  89
GLY A  94
VAL A 182
GLU A 183
MET A 184
GLU A 185
 SO4  A 254 (-3.2A)
None
None
None
None
None
 0.24A 1pk7B-3emvA:
32.2		 1pk7B-3emvA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 ARG A 138
GLY A 143
GLU A 248
MET A 249
GLU A 250
 PO4  A 401 (-3.0A)
BAU  A 400 (-3.3A)
None
BAU  A 400 (-3.8A)
PO4  A 401 ( 4.2A)
 0.32A 1pk7B-3eufA:
25.3		 1pk7B-3eufA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezl ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF00106
(adh_short) 		4 GLY A  82
VAL A  77
GLU A  80
ILE A  84
 None
 0.77A 1pk7B-3ezlA:
2.9		 1pk7B-3ezlA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 GLY A 296
GLU A 233
GLU A 222
ILE A 301
 None
 0.77A 1pk7B-3fe3A:
undetectable		 1pk7B-3fe3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A  94
VAL A 353
GLU A 354
ILE A  91
 None
 0.84A 1pk7B-3gb0A:
7.5		 1pk7B-3gb0A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		4 GLY A 351
VAL A 354
SER A 181
ILE A 350
 None
 0.69A 1pk7B-3hd6A:
undetectable		 1pk7B-3hd6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		4 GLY A 309
VAL A 310
SER A 157
ILE A 307
 None
 0.91A 1pk7B-3ka7A:
undetectable		 1pk7B-3ka7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		4 GLY A 115
VAL A 214
MET A 216
ILE A 242
 None
None
TRS  A 294 (-3.7A)
None
 0.58A 1pk7B-3khsA:
22.3		 1pk7B-3khsA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		4 GLY A 115
VAL A 214
MET A 216
SER A 239
 None
None
TRS  A 294 (-3.7A)
None
 0.50A 1pk7B-3khsA:
22.3		 1pk7B-3khsA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		5 ARG A 137
GLY A 142
GLU A 247
MET A 248
GLU A 249
 SO4  A 311 ( 3.0A)
URA  A 312 (-3.3A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
R2B  A 313 (-2.6A)
 0.26A 1pk7B-3kvyA:
25.5		 1pk7B-3kvyA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Toxoplasma
gondii) 		PF01048
(PNP_UDP_1) 		4 ARG A  93
GLY A  98
MET A 187
GLU A 188
 PO4  A 281 ( 3.0A)
IMH  A 280 (-3.2A)
IMH  A 280 (-3.8A)
IMH  A 280 (-2.5A)
 0.26A 1pk7B-3mb8A:
32.3		 1pk7B-3mb8A:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 GLY A1386
VAL A1308
GLU A1307
ILE A1376
 None
 0.75A 1pk7B-3mmpA:
3.5		 1pk7B-3mmpA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		6 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.53A 1pk7B-3o4vA:
24.0		 1pk7B-3o4vA:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		8 ARG A 101
GLY A 106
VAL A 192
GLU A 193
MET A 194
GLU A 195
SER A 217
ILE A 220
 PO4  A 501 (-2.8A)
DIH  A 500 (-4.0A)
DIH  A 500 (-4.8A)
None
DIH  A 500 (-3.8A)
DIH  A 500 (-2.9A)
DIH  A 500 (-3.3A)
None
 0.56A 1pk7B-3of3A:
40.4		 1pk7B-3of3A:
80.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 ARG A 101
GLY A 191
VAL A 192
MET A 194
GLU A 195
 PO4  A 501 (-2.8A)
None
DIH  A 500 (-4.8A)
DIH  A 500 (-3.8A)
DIH  A 500 (-2.9A)
 1.38A 1pk7B-3of3A:
40.4		 1pk7B-3of3A:
80.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 ARG A 144
GLY A 149
GLU A 254
MET A 255
GLU A 256
 None
BAU  A 400 (-3.5A)
None
BAU  A 400 (-3.9A)
None
 0.33A 1pk7B-3p0fA:
25.1		 1pk7B-3p0fA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 GLY A  94
VAL A  65
GLU A  66
ILE A  96
 None
 0.85A 1pk7B-3p4gA:
undetectable		 1pk7B-3p4gA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 GLY A 418
VAL A 593
SER A 420
ILE A 595
 None
 0.91A 1pk7B-3q9oA:
undetectable		 1pk7B-3q9oA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLY A 206
VAL A 232
GLU A 231
ILE A 263
 None
 0.92A 1pk7B-3qnkA:
undetectable		 1pk7B-3qnkA:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qpb URIDINE
PHOSPHORYLASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		5 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.28A 1pk7B-3qpbA:
32.1		 1pk7B-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		4 GLY A  84
VAL A  81
GLU A  80
ILE A  46
 GLY  A  84 ( 0.0A)
VAL  A  81 ( 0.6A)
GLU  A  80 ( 0.6A)
ILE  A  46 ( 0.7A)
 0.85A 1pk7B-3r6yA:
undetectable		 1pk7B-3r6yA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		7 ARG A  92
GLY A  97
VAL A 182
GLU A 183
MET A 184
GLU A 185
SER A 207
 SO4  A 239 (-3.2A)
None
None
None
None
SO4  A 239 ( 4.4A)
None
 0.52A 1pk7B-3tl6A:
35.7		 1pk7B-3tl6A:
48.35