SIMILAR PATTERNS OF AMINO ACIDS FOR 1PK2_A_ACAA91_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 VAL A 127
TYR A 130
ASP A  54
LEU A  46
 FAD  A 801 ( 4.9A)
None
None
FAD  A 801 (-3.5A)
 1.18A 1pk2A-1e1kA:
undetectable		 1pk2A-1e1kA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elt ELASTASE

(Salmo salar) 		PF00089
(Trypsin) 		4 VAL A 203
TYR A 208
HIS A 210
LEU A 130
 None
 1.15A 1pk2A-1eltA:
0.0		 1pk2A-1eltA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 VAL A 204
TRP A 185
HIS A 291
LEU A 288
 None
 1.23A 1pk2A-1gl6A:
0.0		 1pk2A-1gl6A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxn HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		4 VAL A 411
HIS A 345
LEU A 352
TRP A 354
 None
 1.13A 1pk2A-1hxnA:
undetectable		 1pk2A-1hxnA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kiv APOLIPOPROTEIN A

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
TRP A  72
 None
 0.96A 1pk2A-1kivA:
8.9		 1pk2A-1kivA:
43.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 VAL A 129
TYR A 132
ASP A  56
LEU A  48
 FAD  A2457 ( 4.3A)
None
ACT  A1869 (-3.7A)
FAD  A2457 (-2.9A)
 1.18A 1pk2A-1lqtA:
undetectable		 1pk2A-1lqtA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 302
ASP A 343
LEU A 220
TRP A 219
 None
 1.26A 1pk2A-1mdfA:
0.0		 1pk2A-1mdfA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 VAL A 295
ASP A 325
TRP A 328
LEU A 407
 None
 1.17A 1pk2A-1mqsA:
undetectable		 1pk2A-1mqsA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		4 VAL A 444
ASP A 494
ASP A 496
TRP A 192
 None
 1.16A 1pk2A-1obhA:
undetectable		 1pk2A-1obhA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		4 VAL A  33
TYR A  34
ASP A 204
HIS A 189
 None
T5A  A 501 (-3.9A)
None
None
 1.19A 1pk2A-1p75A:
undetectable		 1pk2A-1p75A:
14.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2

(Homo sapiens) 		PF00051
(Kringle) 		6 ASP A  55
ASP A  57
TRP A  62
HIS A  64
LEU A  70
TRP A  72
 None
None
None
CL  A 289 (-4.8A)
None
None
 0.87A 1pk2A-1pmlA:
12.7		 1pk2A-1pmlA:
95.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2

(Homo sapiens) 		PF00051
(Kringle) 		4 TYR A  35
ASP A  57
TRP A  62
HIS A  64
 CL  A 289 (-4.8A)
None
None
CL  A 289 (-4.8A)
 0.77A 1pk2A-1pmlA:
12.7		 1pk2A-1pmlA:
95.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		4 VAL A 412
HIS A 346
LEU A 353
TRP A 355
 None
 1.11A 1pk2A-1qjsA:
undetectable		 1pk2A-1qjsA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkb PROTEIN AD-004

(Homo sapiens) 		PF13238
(AAA_18) 		4 VAL A  34
TYR A  78
ASP A  82
LEU A  65
 None
 1.24A 1pk2A-1rkbA:
undetectable		 1pk2A-1rkbA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2
ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT

(Bos taurus) 		PF00022
(Actin)
PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 VAL F  30
TYR B 225
ASP G  17
ASP G  15
 None
 1.25A 1pk2A-1u2vF:
undetectable		 1pk2A-1u2vF:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		4 VAL A 151
ASP A 170
HIS A 107
LEU A  53
 None
 1.22A 1pk2A-1upsA:
undetectable		 1pk2A-1upsA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmy LECTIN CEL-I,
N-ACETYL-D-GALACTOSA
MINE-SPECIFIC C-TYPE

(Cucumaria
echinata) 		PF00059
(Lectin_C) 		4 VAL A  57
TYR A  15
ASP A  88
LEU A  71
 None
 1.12A 1pk2A-1wmyA:
undetectable		 1pk2A-1wmyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 VAL A  79
TYR A 106
ASP A 113
HIS A  28
 None
 1.20A 1pk2A-1zoiA:
undetectable		 1pk2A-1zoiA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		4 VAL A 231
ASP A  13
ASP A 247
HIS A  80
 None
None
RIB  A1312 ( 2.5A)
None
 1.15A 1pk2A-2c40A:
undetectable		 1pk2A-2c40A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ASP H  57
HIS H  35
LEU L  96
TRP H  50
 None
 1.06A 1pk2A-2d7tH:
undetectable		 1pk2A-2d7tH:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 TYR H  33
ASP H  57
HIS H  35
LEU L  96
 None
 1.23A 1pk2A-2d7tH:
undetectable		 1pk2A-2d7tH:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 TYR A 427
ASP A 560
ASP A 557
LEU A 446
 None
 1.02A 1pk2A-2fj0A:
undetectable		 1pk2A-2fj0A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 471
ASP A 260
HIS A 141
LEU A 503
 None
None
C2O  A 602 (-3.2A)
None
 0.97A 1pk2A-2fqdA:
undetectable		 1pk2A-2fqdA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyp HYPOTHETICAL PROTEIN
RV0805

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 TYR A  73
ASP A  99
ASP A  63
LEU A  91
 None
None
MN  A 555 (-2.6A)
None
 1.21A 1pk2A-2hypA:
undetectable		 1pk2A-2hypA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty EMB|CAB41934.1
RAC-LIKE GTP-BINDING
PROTEIN ARAC5

(Arabidopsis
thaliana) 		PF00071
(Ras)
PF03759
(PRONE) 		4 TYR A 333
ASP A 121
TRP A  69
LEU C  70
 None
 1.24A 1pk2A-2ntyA:
undetectable		 1pk2A-2ntyA:
13.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pk4 HUMAN PLASMINOGEN
KRINGLE 4

(Homo sapiens) 		PF00051
(Kringle) 		4 ASP A  55
ASP A  57
TRP A  62
TRP A  72
 ACA  A 100 ( 2.6A)
ACA  A 100 ( 3.7A)
ACA  A 100 ( 3.6A)
ACA  A 100 ( 3.1A)
 0.79A 1pk2A-2pk4A:
9.5		 1pk2A-2pk4A:
42.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rha TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF14514
(TetR_C_9) 		4 VAL A 166
ASP A 102
HIS A  96
LEU A  93
 None
 1.04A 1pk2A-2rhaA:
undetectable		 1pk2A-2rhaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 422
ASP A 258
HIS A 142
LEU A 453
 None
 1.04A 1pk2A-2uxtA:
undetectable		 1pk2A-2uxtA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		4 VAL A 370
TYR A 335
ASP A 297
TRP A 394
 None
 1.09A 1pk2A-2v5dA:
undetectable		 1pk2A-2v5dA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 TYR A 476
ASP A 507
ASP A 509
LEU A 329
 None
 1.27A 1pk2A-2vcaA:
undetectable		 1pk2A-2vcaA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 538
ASP A 540
ASP A 542
LEU A 608
 None
 0.90A 1pk2A-2vwkA:
undetectable		 1pk2A-2vwkA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq8 SENSOR PROTEIN PHOQ

(Escherichia
coli) 		PF08918
(PhoQ_Sensor) 		4 VAL A 176
ASP A 112
TRP A 113
LEU A 105
 None
 1.10A 1pk2A-3bq8A:
undetectable		 1pk2A-3bq8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 576
ASP A 339
HIS A 201
LEU A 606
 None
None
C2O  A1002 (-3.7A)
None
 1.09A 1pk2A-3gyrA:
undetectable		 1pk2A-3gyrA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 332
ASP A 417
TRP A 303
HIS A 334
 None
 1.26A 1pk2A-3gyrA:
undetectable		 1pk2A-3gyrA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		4 TYR A  73
ASP A  99
ASP A  63
LEU A  91
 None
None
MN  A 555 (-2.7A)
None
 1.23A 1pk2A-3ib7A:
undetectable		 1pk2A-3ib7A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 VAL A 532
ASP A 330
TRP A 333
LEU A 503
 None
 1.02A 1pk2A-3ihgA:
undetectable		 1pk2A-3ihgA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 224
TRP A  67
HIS A  64
LEU A  30
 None
 1.26A 1pk2A-3iplA:
undetectable		 1pk2A-3iplA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 VAL W 617
TYR W 579
ASP W 490
LEU W 510
 None
 1.24A 1pk2A-3iylW:
undetectable		 1pk2A-3iylW:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 VAL A 755
ASP A 694
ASP A 681
LEU A 816
 None
 1.00A 1pk2A-3j0aA:
undetectable		 1pk2A-3j0aA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks7 PUTATIVE PUTATIVE
PNGASE F

(Bacteroides
fragilis) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 VAL A 247
TYR A 248
ASP A 210
LEU A 115
 None
 1.25A 1pk2A-3ks7A:
undetectable		 1pk2A-3ks7A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg0 ORNITHINE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00202
(Aminotran_3) 		4 VAL A 340
ASP A 411
ASP A 412
LEU A 330
 None
 1.16A 1pk2A-3lg0A:
undetectable		 1pk2A-3lg0A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ASP A 356
HIS A 303
LEU A 293
TRP A 301
 NI  A 501 ( 2.4A)
CL  A 503 (-4.1A)
None
CL  A 503 ( 4.8A)
 1.20A 1pk2A-3n0qA:
undetectable		 1pk2A-3n0qA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0v FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N) 		4 VAL A 122
TYR A 140
ASP A 128
LEU A 107
 None
 1.25A 1pk2A-3n0vA:
undetectable		 1pk2A-3n0vA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		4 TYR A 595
TRP A 663
HIS A 620
LEU A 619
 None
 1.21A 1pk2A-3n9oA:
undetectable		 1pk2A-3n9oA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwc SMC PROTEIN

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		4 VAL A 610
TYR A 602
ASP A 598
LEU A 545
 None
 1.23A 1pk2A-3nwcA:
undetectable		 1pk2A-3nwcA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ome ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 VAL A 143
TRP A 118
HIS A 148
LEU A 161
 None
 0.82A 1pk2A-3omeA:
undetectable		 1pk2A-3omeA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		4 VAL A 379
ASP A 345
TRP A 348
LEU A 390
 None
 1.20A 1pk2A-3pt1A:
undetectable		 1pk2A-3pt1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		4 VAL A 379
ASP A 345
TRP A 348
LEU A 409
 None
 1.13A 1pk2A-3pt1A:
undetectable		 1pk2A-3pt1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 VAL A 158
ASP A 353
TRP A 311
LEU A 201
 None
 1.12A 1pk2A-3rx8A:
undetectable		 1pk2A-3rx8A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3w ENOYL-COA HYDRATASE

(Mycolicibacterium
thermoresistibile) 		PF00378
(ECH_1) 		4 VAL A 159
TRP A 134
HIS A 164
LEU A 177
 None
 0.80A 1pk2A-3t3wA:
undetectable		 1pk2A-3t3wA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8y CHEMOTAXIS RESPONSE
REGULATOR
PROTEIN-GLUTAMATE
METHYLESTERASE

(Thermotoga
maritima) 		PF00072
(Response_reg) 		4 VAL A  20
ASP A  12
ASP A  13
LEU A 116
 None
PB  A 145 ( 4.4A)
PB  A 145 (-2.7A)
None
 1.25A 1pk2A-3t8yA:
undetectable		 1pk2A-3t8yA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Francisella
tularensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A  14
TYR A 154
ASP A  83
LEU A  22
 None
 0.93A 1pk2A-3tqvA:
undetectable		 1pk2A-3tqvA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up6 HYPOTHETICAL PROTEIN
BACOVA_04078

(Bacteroides
ovatus) 		no annotation 4 VAL A  70
ASP A 101
ASP A 158
LEU A 125
 None
 1.23A 1pk2A-3up6A:
undetectable		 1pk2A-3up6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		4 VAL A 102
ASP A 158
HIS A 187
LEU A 191
 None
 1.03A 1pk2A-3vc1A:
undetectable		 1pk2A-3vc1A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 VAL A 269
ASP A 329
HIS A 243
LEU A 276
 None
 1.08A 1pk2A-3vr5A:
undetectable		 1pk2A-3vr5A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 VAL A 116
TYR A 117
ASP A 196
LEU A 355
 None
 1.13A 1pk2A-3w36A:
undetectable		 1pk2A-3w36A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 469
ASP A 290
HIS A 180
LEU A 498
 None
None
CU  A 602 ( 3.1A)
None
 0.86A 1pk2A-3zx1A:
undetectable		 1pk2A-3zx1A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 465
ASP A 279
HIS A 153
LEU A 495
 None
None
CU  A 602 ( 3.2A)
None
 1.02A 1pk2A-4akoA:
undetectable		 1pk2A-4akoA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 VAL A 779
ASP A 789
ASP A 783
HIS A 811
 None
CA  A1003 (-3.3A)
CA  A1003 (-2.5A)
None
 1.26A 1pk2A-4b56A:
undetectable		 1pk2A-4b56A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7

(Mus musculus) 		PF00957
(Synaptobrevin)
PF13774
(Longin) 		4 VAL A   8
TYR A  62
ASP A  58
LEU A  33
 None
 1.24A 1pk2A-4b93A:
undetectable		 1pk2A-4b93A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 VAL A 510
TYR A 513
ASP A 100
LEU A 125
 None
 1.22A 1pk2A-4bc7A:
undetectable		 1pk2A-4bc7A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 VAL A 454
ASP A 426
ASP A 428
LEU A 504
 None
 1.23A 1pk2A-4cakA:
undetectable		 1pk2A-4cakA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		4 TYR A 200
ASP A 219
TRP A 225
TRP A 235
 None
 1.05A 1pk2A-4duuA:
8.3		 1pk2A-4duuA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 TYR A 579
ASP A 419
HIS A 383
LEU A 391
 None
 1.12A 1pk2A-4ecoA:
undetectable		 1pk2A-4ecoA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egu HISTIDINE TRIAD
(HIT) PROTEIN

(Clostridioides
difficile) 		PF01230
(HIT) 		4 VAL A  69
TYR A  22
ASP A  24
ASP A  25
 None
 1.13A 1pk2A-4eguA:
undetectable		 1pk2A-4eguA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
lasaliensis) 		PF02353
(CMAS) 		4 VAL A 110
ASP A 166
HIS A 195
LEU A 199
 None
 1.00A 1pk2A-4f85A:
undetectable		 1pk2A-4f85A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 VAL B1452
TYR B1378
ASP B1392
TRP B1393
 None
 1.25A 1pk2A-4f92B:
undetectable		 1pk2A-4f92B:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 538
ASP A 540
ASP A 542
LEU A 608
 TYR  A 538 ( 1.3A)
ASP  A 540 (-0.5A)
ASP  A 542 ( 0.5A)
LEU  A 608 ( 0.5A)
 1.19A 1pk2A-4flxA:
undetectable		 1pk2A-4flxA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 ASP A 331
ASP A 333
TRP A 334
HIS A 111
 None
None
CTT  A 401 ( 3.8A)
CTT  A 401 (-3.7A)
 1.20A 1pk2A-4hu0A:
undetectable		 1pk2A-4hu0A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 478
ASP A 481
HIS A 525
LEU A 499
 None
 1.14A 1pk2A-4i3gA:
undetectable		 1pk2A-4i3gA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 VAL A 405
ASP A 342
ASP A 339
LEU A 395
 None
 1.06A 1pk2A-4jhzA:
undetectable		 1pk2A-4jhzA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		4 TYR A 167
ASP A 215
ASP A 233
LEU A 152
 None
 1.04A 1pk2A-4lobA:
undetectable		 1pk2A-4lobA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		4 VAL A 256
ASP A 199
HIS A 260
LEU A  49
 None
 1.23A 1pk2A-4ly4A:
undetectable		 1pk2A-4ly4A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		4 VAL A 172
ASP A 196
LEU A 272
TRP A 175
 None
 1.14A 1pk2A-4mq0A:
undetectable		 1pk2A-4mq0A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		4 ASP A  68
HIS A 162
LEU A 459
TRP A  54
 None
 1.19A 1pk2A-4mt0A:
undetectable		 1pk2A-4mt0A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 VAL A 220
ASP A 116
HIS A 148
LEU A 212
 None
None
ZN  A 401 (-3.3A)
None
 1.22A 1pk2A-4n0gA:
undetectable		 1pk2A-4n0gA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		4 TYR A 193
ASP A 244
ASP A 261
LEU A 173
 None
None
MG  A 404 ( 3.7A)
None
 1.03A 1pk2A-4p0vA:
undetectable		 1pk2A-4p0vA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 VAL A 248
TYR A 249
ASP A 211
LEU A 116
 None
 1.22A 1pk2A-4qhbA:
undetectable		 1pk2A-4qhbA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Weissella
paramesenteroides) 		PF13377
(Peripla_BP_3) 		4 VAL A 330
ASP A 169
HIS A 176
LEU A 333
 None
 1.21A 1pk2A-4rk6A:
undetectable		 1pk2A-4rk6A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zih APOPTOSIS REGULATOR
BAX

(Homo sapiens) 		PF00452
(Bcl-2) 		4 TYR A 115
ASP A  71
ASP A  68
LEU A  27
 None
 1.13A 1pk2A-4zihA:
undetectable		 1pk2A-4zihA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		4 ASP A 333
ASP A 335
TRP A 336
HIS A 107
 None
None
BGC  A1368 (-3.8A)
BGC  A1368 (-3.9A)
 1.18A 1pk2A-5a8qA:
undetectable		 1pk2A-5a8qA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 TYR A 297
ASP A 442
HIS A 133
LEU A 137
 None
 1.25A 1pk2A-5djsA:
undetectable		 1pk2A-5djsA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd4 COMR

(Streptococcus
suis) 		PF13560
(HTH_31) 		4 TYR A 276
ASP A 302
TRP A 259
LEU A 291
 None
 1.21A 1pk2A-5fd4A:
undetectable		 1pk2A-5fd4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 ASP A  88
ASP A  90
TRP A  94
TRP A 106
 None
 0.89A 1pk2A-5fwsA:
8.2		 1pk2A-5fwsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 TYR A  66
ASP A  88
ASP A  90
TRP A  94
 None
 0.83A 1pk2A-5fwsA:
8.2		 1pk2A-5fwsA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		4 TYR B  66
ASP B  88
ASP B  90
TRP B  94
 None
 0.98A 1pk2A-5fwwB:
7.6		 1pk2A-5fwwB:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2

(Deformed wing
virus) 		PF00073
(Rhv) 		4 TYR B 184
ASP B 194
TRP B 195
HIS B 182
 None
 1.22A 1pk2A-5g52B:
undetectable		 1pk2A-5g52B:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2

(Deformed wing
virus) 		PF00073
(Rhv) 		4 VAL B 183
TYR B 184
ASP B 194
TRP B 195
 None
 1.06A 1pk2A-5g52B:
undetectable		 1pk2A-5g52B:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzv ADENYLATE KINASE
ISOENZYME 6

(Homo sapiens) 		PF13238
(AAA_18) 		4 VAL A  34
TYR A  78
ASP A  82
LEU A  65
 None
 1.19A 1pk2A-5jzvA:
undetectable		 1pk2A-5jzvA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128

(Ruminococcus
flavefaciens) 		no annotation 4 VAL B 899
ASP B 894
HIS B 938
LEU B 924
 None
CA  B1001 (-2.9A)
None
None
 1.19A 1pk2A-5lxvB:
undetectable		 1pk2A-5lxvB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128

(Ruminococcus
flavefaciens) 		no annotation 4 VAL B 899
ASP B 894
HIS B 938
LEU B 949
 None
CA  B1001 (-2.9A)
None
None
 1.20A 1pk2A-5lxvB:
undetectable		 1pk2A-5lxvB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		4 TYR A 138
ASP A  97
TRP A 101
LEU A 131
 None
 1.18A 1pk2A-5ly3A:
undetectable		 1pk2A-5ly3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 ASP A 179
ASP A 182
HIS A 151
LEU A  93
 None
 1.09A 1pk2A-5mqsA:
undetectable		 1pk2A-5mqsA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 VAL B 554
ASP A 872
HIS B 437
LEU B 157
 None
 1.13A 1pk2A-5nd1B:
undetectable		 1pk2A-5nd1B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 TYR A 292
ASP A 518
HIS A 612
TRP A 613
 None
ACR  A1015 (-3.1A)
None
ACR  A1015 (-4.8A)
 1.22A 1pk2A-5nn8A:
undetectable		 1pk2A-5nn8A:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofu FBP PROTEIN

(Leishmania
major) 		PF00316
(FBPase) 		4 VAL A 180
ASP A 121
HIS A 257
LEU A 261
 None
F6P  A 402 (-2.6A)
None
None
 1.23A 1pk2A-5ofuA:
undetectable		 1pk2A-5ofuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 VAL A 434
ASP A 386
ASP A 383
LEU A 424
 None
 1.11A 1pk2A-5t98A:
undetectable		 1pk2A-5t98A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w62 APOPTOSIS REGULATOR
BAX

(Mus musculus) 		no annotation 4 TYR A 115
ASP A  71
ASP A  68
LEU A  27
 None
 1.23A 1pk2A-5w62A:
undetectable		 1pk2A-5w62A:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 4 VAL A 153
TYR A  94
ASP A 198
LEU A 114
 None
 1.15A 1pk2A-6byxA:
undetectable		 1pk2A-6byxA:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 4 VAL L 150
ASP L 140
HIS L 109
LEU L 113
 None
 1.07A 1pk2A-6cfwL:
undetectable		 1pk2A-6cfwL:
20.20