SIMILAR PATTERNS OF AMINO ACIDS FOR 1PJ7_A_FFOA2887_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		5 GLY A 324
ASN A 421
LEU A 327
TYR A 321
TYR A 484
 None
 1.38A 1pj7A-1b2hA:
0.0		 1pj7A-1b2hA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9y FEZ-1 B-LACTAMASE

(Fluoribacter
gormanii) 		PF00753
(Lactamase_B) 		5 MET A 205
LEU A 207
PHE A 267
LEU A 260
PHE A  42
 None
 1.45A 1pj7A-1l9yA:
0.0		 1pj7A-1l9yA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		5 GLY A 482
ASN A 488
PHE A 478
LEU A 417
PHE A 532
 None
 1.33A 1pj7A-1uikA:
undetectable		 1pj7A-1uikA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 TYR A  87
PHE A 179
TYR A 198
TYR A 207
TYR A 260
PHE A 289
 None
 0.91A 1pj7A-1v5vA:
44.4		 1pj7A-1v5vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 TYR A  83
ASN A 112
TYR A 168
TYR A 188
TYR A 236
 FFO  A2887 (-3.9A)
FFO  A2887 (-3.3A)
None
FFO  A2887 (-3.5A)
FFO  A2887 (-3.9A)
 0.64A 1pj7A-1wopA:
48.4		 1pj7A-1wopA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		5 TYR A 246
GLY A 177
TYR A 310
LEU A 245
TYR A 233
 None
SAH  A4261 (-3.8A)
None
None
None
 1.22A 1pj7A-1x1bA:
3.0		 1pj7A-1x1bA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfr PHEROMONE-BINDING
PROTEIN

(Bombyx mori) 		PF01395
(PBP_GOBP) 		5 MET A  23
LEU A  25
ASN A  45
PHE A  12
LEU A  55
 None
 1.28A 1pj7A-1xfrA:
undetectable		 1pj7A-1xfrA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		5 MET A  51
LEU A  54
TYR A  33
GLY A  26
LEU A  62
 None
 1.15A 1pj7A-1yfzA:
0.5		 1pj7A-1yfzA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 TYR A  84
ASN A 113
PHE A 169
TYR A 189
TYR A 198
PHE A 257
 None
 0.82A 1pj7A-1yx2A:
43.8		 1pj7A-1yx2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLY A 296
ASN A 423
TYR A 151
LEU A 177
TYR A 176
 None
 1.28A 1pj7A-2b24A:
0.0		 1pj7A-2b24A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 TYR A 561
GLY A 331
ASN A 337
LEU A 554
PHE A 100
 None
 1.19A 1pj7A-2obeA:
undetectable		 1pj7A-2obeA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 LEU B1932
TYR B1762
GLY B1931
ASN B1922
TYR B1943
 None
 1.44A 1pj7A-2r7eB:
undetectable		 1pj7A-2r7eB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		5 LEU A 127
GLY A  89
LEU A 176
TYR A 140
PHE A 257
 None
 1.35A 1pj7A-2yn0A:
undetectable		 1pj7A-2yn0A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 GLY A 324
ASN A 421
LEU A 327
TYR A 321
TYR A 484
 None
 1.41A 1pj7A-2z23A:
1.6		 1pj7A-2z23A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 MET A  52
LEU A  55
TYR A  34
GLY A  27
LEU A  63
 None
None
DIO  A 991 (-3.8A)
None
None
 0.91A 1pj7A-3accA:
undetectable		 1pj7A-3accA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2215
GLY A2212
ASN A2193
LEU A2126
PHE A3217
 None
 1.41A 1pj7A-3cmvA:
undetectable		 1pj7A-3cmvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8t TAKEOUT-LIKE PROTEIN
1

(Epiphyas
postvittana) 		PF06585
(JHBP) 		5 MET A 174
LEU A 163
GLY A 110
LEU A  54
PHE A  47
 None
 1.15A 1pj7A-3e8tA:
undetectable		 1pj7A-3e8tA:
14.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		12 MET A 505
LEU A 508
TYR A 539
GLY A 566
ASN A 568
TYR A 631
PHE A 632
LEU A 649
TYR A 651
TYR A 660
TYR A 699
PHE A 719
 None
THG  A2887 (-4.8A)
THG  A2887 (-3.9A)
THG  A2887 (-3.6A)
THG  A2887 ( 4.1A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-4.3A)
None
THG  A2887 (-4.1A)
THG  A2887 (-4.6A)
 0.21A 1pj7A-3gsiA:
72.8		 1pj7A-3gsiA:
99.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLY B 231
PHE B 223
LEU B 315
TYR B 313
PHE B 253
 None
 1.19A 1pj7A-3hkzB:
undetectable		 1pj7A-3hkzB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		5 LEU A 256
GLY A 391
PHE A  18
LEU A  16
TYR A 371
 None
 1.30A 1pj7A-3hsiA:
undetectable		 1pj7A-3hsiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 GLY A 350
ASN A 447
LEU A 353
TYR A 347
TYR A 510
 None
 1.34A 1pj7A-3tchA:
undetectable		 1pj7A-3tchA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 LEU A 175
TYR A 225
GLY A 171
PHE A 223
LEU A 214
 None
 1.35A 1pj7A-4aq4A:
undetectable		 1pj7A-4aq4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 LEU A  66
TYR A  84
GLY A  71
ASN A  90
LEU A  82
 None
 1.22A 1pj7A-4az3A:
1.7		 1pj7A-4az3A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 TYR A 289
GLY A 374
ASN A 341
PHE A  19
LEU A 293
 None
 1.47A 1pj7A-4ex4A:
undetectable		 1pj7A-4ex4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqz PUTATIVE PERIPLASMIC
OR EXPORTED PROTEIN

(Salmonella
enterica) 		no annotation 5 LEU A 101
TYR A  83
ASN A 135
LEU A  65
TYR A  56
 None
 1.32A 1pj7A-4gqzA:
undetectable		 1pj7A-4gqzA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 5 MET A 195
GLY A  23
ASN A  25
PHE A 348
PHE A 282
 None
 1.17A 1pj7A-4lypA:
undetectable		 1pj7A-4lypA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 LEU A  66
TYR A  84
GLY A  71
ASN A  90
LEU A  82
 LEU  A  66 ( 0.5A)
TYR  A  84 ( 1.3A)
GLY  A  71 ( 0.0A)
ASN  A  90 ( 0.6A)
LEU  A  82 ( 0.6A)
 1.20A 1pj7A-4mwtA:
1.4		 1pj7A-4mwtA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 370
TYR A 432
GLY A 436
LEU A 399
PHE A 417
 HEM  A 600 (-3.2A)
None
HEM  A 600 ( 3.8A)
None
None
 1.07A 1pj7A-4nkyA:
undetectable		 1pj7A-4nkyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 ASN A 290
PHE A  59
LEU A 301
TYR A 209
PHE A  50
 None
 1.28A 1pj7A-4ntjA:
undetectable		 1pj7A-4ntjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 TYR A 817
GLY A 803
TYR A 859
LEU A 855
TYR A 844
 None
 1.45A 1pj7A-4o9xA:
undetectable		 1pj7A-4o9xA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		5 LEU A 249
ASN A 185
PHE A 282
LEU A 245
TYR A 182
 None
 1.46A 1pj7A-4u9cA:
undetectable		 1pj7A-4u9cA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4url DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 GLY A 322
ASN A 235
PHE A 297
LEU A 377
PHE A 247
 None
 1.41A 1pj7A-4urlA:
1.5		 1pj7A-4urlA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		5 LEU C 125
GLY C 227
PHE C 165
LEU C  52
PHE C 102
 None
 1.24A 1pj7A-5a53C:
undetectable		 1pj7A-5a53C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		5 LEU A 260
TYR A 322
GLY A 263
ASN A 224
TYR A 360
 None
 1.22A 1pj7A-5bv9A:
undetectable		 1pj7A-5bv9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		5 MET A1011
LEU A1015
TYR A1030
PHE A1052
PHE A1066
 None
 1.47A 1pj7A-5fv0A:
undetectable		 1pj7A-5fv0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		5 LEU A 499
TYR A 466
PHE A 528
LEU A 529
TYR A 487
 None
 1.44A 1pj7A-5kijA:
undetectable		 1pj7A-5kijA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9f ORF68

(Staphylococcus
virus K) 		no annotation 5 LEU A 358
GLY A 431
TYR A 394
LEU A 395
TYR A 365
 None
 1.45A 1pj7A-5m9fA:
undetectable		 1pj7A-5m9fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY

(Staphylococcus
aureus) 		no annotation 6 LEU A 160
TYR A 280
GLY A 277
TYR A 128
LEU A 120
PHE A 225
 PLM  A 301 ( 4.4A)
None
PLM  A 301 (-3.8A)
None
None
None
 1.40A 1pj7A-5utoA:
undetectable		 1pj7A-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wj7 DNA REPAIR PROTEIN
XRCC4,MYOSIN-7

(Homo sapiens) 		PF06632
(XRCC4) 		5 GLY A  77
PHE A  97
LEU A  74
TYR A  66
PHE A 106
 None
 1.42A 1pj7A-5wj7A:
undetectable		 1pj7A-5wj7A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xox TRNA(HIS)
GUANYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF04446
(Thg1)
PF14413
(Thg1C) 		5 LEU A 222
TYR A  79
GLY A 212
LEU A  51
PHE A 105
 None
 1.43A 1pj7A-5xoxA:
2.9		 1pj7A-5xoxA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C2451
TYR C2474
LEU C2477
TYR C2440
TYR C2484
 None
 1.44A 1pj7A-5y3rC:
undetectable		 1pj7A-5y3rC:
11.38