SIMILAR PATTERNS OF AMINO ACIDS FOR 1PJ7_A_FFOA2887

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		5 GLY A 324
ASN A 421
LEU A 327
TYR A 321
TYR A 484
 None
 1.38A 1pj7A-1b2hA:
0.0		 1pj7A-1b2hA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9y FEZ-1 B-LACTAMASE

(Fluoribacter
gormanii) 		PF00753
(Lactamase_B) 		5 MET A 205
LEU A 207
PHE A 267
LEU A 260
PHE A  42
 None
 1.45A 1pj7A-1l9yA:
0.0		 1pj7A-1l9yA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		5 GLY A 482
ASN A 488
PHE A 478
LEU A 417
PHE A 532
 None
 1.33A 1pj7A-1uikA:
undetectable		 1pj7A-1uikA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 TYR A  87
PHE A 179
TYR A 198
TYR A 207
TYR A 260
PHE A 289
 None
 0.91A 1pj7A-1v5vA:
44.4		 1pj7A-1v5vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 TYR A  83
ASN A 112
TYR A 168
TYR A 188
TYR A 236
 FFO  A2887 (-3.9A)
FFO  A2887 (-3.3A)
None
FFO  A2887 (-3.5A)
FFO  A2887 (-3.9A)
 0.64A 1pj7A-1wopA:
48.4		 1pj7A-1wopA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		5 TYR A 246
GLY A 177
TYR A 310
LEU A 245
TYR A 233
 None
SAH  A4261 (-3.8A)
None
None
None
 1.22A 1pj7A-1x1bA:
3.0		 1pj7A-1x1bA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfr PHEROMONE-BINDING
PROTEIN

(Bombyx mori) 		PF01395
(PBP_GOBP) 		5 MET A  23
LEU A  25
ASN A  45
PHE A  12
LEU A  55
 None
 1.28A 1pj7A-1xfrA:
undetectable		 1pj7A-1xfrA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfz HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		5 MET A  51
LEU A  54
TYR A  33
GLY A  26
LEU A  62
 None
 1.15A 1pj7A-1yfzA:
0.5		 1pj7A-1yfzA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		6 TYR A  84
ASN A 113
PHE A 169
TYR A 189
TYR A 198
PHE A 257
 None
 0.82A 1pj7A-1yx2A:
43.8		 1pj7A-1yx2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLY A 296
ASN A 423
TYR A 151
LEU A 177
TYR A 176
 None
 1.28A 1pj7A-2b24A:
0.0		 1pj7A-2b24A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 TYR A 561
GLY A 331
ASN A 337
LEU A 554
PHE A 100
 None
 1.19A 1pj7A-2obeA:
undetectable		 1pj7A-2obeA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 LEU B1932
TYR B1762
GLY B1931
ASN B1922
TYR B1943
 None
 1.44A 1pj7A-2r7eB:
undetectable		 1pj7A-2r7eB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		5 LEU A 127
GLY A  89
LEU A 176
TYR A 140
PHE A 257
 None
 1.35A 1pj7A-2yn0A:
undetectable		 1pj7A-2yn0A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 GLY A 324
ASN A 421
LEU A 327
TYR A 321
TYR A 484
 None
 1.41A 1pj7A-2z23A:
1.6		 1pj7A-2z23A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 MET A  52
LEU A  55
TYR A  34
GLY A  27
LEU A  63
 None
None
DIO  A 991 (-3.8A)
None
None
 0.91A 1pj7A-3accA:
undetectable		 1pj7A-3accA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2215
GLY A2212
ASN A2193
LEU A2126
PHE A3217
 None
 1.41A 1pj7A-3cmvA:
undetectable		 1pj7A-3cmvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8t TAKEOUT-LIKE PROTEIN
1

(Epiphyas
postvittana) 		PF06585
(JHBP) 		5 MET A 174
LEU A 163
GLY A 110
LEU A  54
PHE A  47
 None
 1.15A 1pj7A-3e8tA:
undetectable		 1pj7A-3e8tA:
14.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		12 MET A 505
LEU A 508
TYR A 539
GLY A 566
ASN A 568
TYR A 631
PHE A 632
LEU A 649
TYR A 651
TYR A 660
TYR A 699
PHE A 719
 None
THG  A2887 (-4.8A)
THG  A2887 (-3.9A)
THG  A2887 (-3.6A)
THG  A2887 ( 4.1A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-4.3A)
None
THG  A2887 (-4.1A)
THG  A2887 (-4.6A)
 0.21A 1pj7A-3gsiA:
72.8		 1pj7A-3gsiA:
99.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLY B 231
PHE B 223
LEU B 315
TYR B 313
PHE B 253
 None
 1.19A 1pj7A-3hkzB:
undetectable		 1pj7A-3hkzB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsi PHOSPHATIDYLSERINE
SYNTHASE

(Haemophilus
influenzae) 		PF13091
(PLDc_2) 		5 LEU A 256
GLY A 391
PHE A  18
LEU A  16
TYR A 371
 None
 1.30A 1pj7A-3hsiA:
undetectable		 1pj7A-3hsiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 GLY A 350
ASN A 447
LEU A 353
TYR A 347
TYR A 510
 None
 1.34A 1pj7A-3tchA:
undetectable		 1pj7A-3tchA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 LEU A 175
TYR A 225
GLY A 171
PHE A 223
LEU A 214
 None
 1.35A 1pj7A-4aq4A:
undetectable		 1pj7A-4aq4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 LEU A  66
TYR A  84
GLY A  71
ASN A  90
LEU A  82
 None
 1.22A 1pj7A-4az3A:
1.7		 1pj7A-4az3A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 TYR A 289
GLY A 374
ASN A 341
PHE A  19
LEU A 293
 None
 1.47A 1pj7A-4ex4A:
undetectable		 1pj7A-4ex4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqz PUTATIVE PERIPLASMIC
OR EXPORTED PROTEIN

(Salmonella
enterica) 		no annotation 5 LEU A 101
TYR A  83
ASN A 135
LEU A  65
TYR A  56
 None
 1.32A 1pj7A-4gqzA:
undetectable		 1pj7A-4gqzA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 5 MET A 195
GLY A  23
ASN A  25
PHE A 348
PHE A 282
 None
 1.17A 1pj7A-4lypA:
undetectable		 1pj7A-4lypA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 LEU A  66
TYR A  84
GLY A  71
ASN A  90
LEU A  82
 LEU  A  66 ( 0.5A)
TYR  A  84 ( 1.3A)
GLY  A  71 ( 0.0A)
ASN  A  90 ( 0.6A)
LEU  A  82 ( 0.6A)
 1.20A 1pj7A-4mwtA:
1.4		 1pj7A-4mwtA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 370
TYR A 432
GLY A 436
LEU A 399
PHE A 417
 HEM  A 600 (-3.2A)
None
HEM  A 600 ( 3.8A)
None
None
 1.07A 1pj7A-4nkyA:
undetectable		 1pj7A-4nkyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntj P2Y PURINOCEPTOR
12,SOLUBLE
CYTOCHROME B562,P2Y
PURINOCEPTOR 12

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 ASN A 290
PHE A  59
LEU A 301
TYR A 209
PHE A  50
 None
 1.28A 1pj7A-4ntjA:
undetectable		 1pj7A-4ntjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 TYR A 817
GLY A 803
TYR A 859
LEU A 855
TYR A 844
 None
 1.45A 1pj7A-4o9xA:
undetectable		 1pj7A-4o9xA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9c LACTOFERRIN-BINDING
PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		5 LEU A 249
ASN A 185
PHE A 282
LEU A 245
TYR A 182
 None
 1.46A 1pj7A-4u9cA:
undetectable		 1pj7A-4u9cA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4url DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 GLY A 322
ASN A 235
PHE A 297
LEU A 377
PHE A 247
 None
 1.41A 1pj7A-4urlA:
1.5		 1pj7A-4urlA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix) 		5 LEU C 125
GLY C 227
PHE C 165
LEU C  52
PHE C 102
 None
 1.24A 1pj7A-5a53C:
undetectable		 1pj7A-5a53C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		5 LEU A 260
TYR A 322
GLY A 263
ASN A 224
TYR A 360
 None
 1.22A 1pj7A-5bv9A:
undetectable		 1pj7A-5bv9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		5 MET A1011
LEU A1015
TYR A1030
PHE A1052
PHE A1066
 None
 1.47A 1pj7A-5fv0A:
undetectable		 1pj7A-5fv0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		5 LEU A 499
TYR A 466
PHE A 528
LEU A 529
TYR A 487
 None
 1.44A 1pj7A-5kijA:
undetectable		 1pj7A-5kijA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9f ORF68

(Staphylococcus
virus K) 		no annotation 5 LEU A 358
GLY A 431
TYR A 394
LEU A 395
TYR A 365
 None
 1.45A 1pj7A-5m9fA:
undetectable		 1pj7A-5m9fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY

(Staphylococcus
aureus) 		no annotation 6 LEU A 160
TYR A 280
GLY A 277
TYR A 128
LEU A 120
PHE A 225
 PLM  A 301 ( 4.4A)
None
PLM  A 301 (-3.8A)
None
None
None
 1.40A 1pj7A-5utoA:
undetectable		 1pj7A-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wj7 DNA REPAIR PROTEIN
XRCC4,MYOSIN-7

(Homo sapiens) 		PF06632
(XRCC4) 		5 GLY A  77
PHE A  97
LEU A  74
TYR A  66
PHE A 106
 None
 1.42A 1pj7A-5wj7A:
undetectable		 1pj7A-5wj7A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xox TRNA(HIS)
GUANYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF04446
(Thg1)
PF14413
(Thg1C) 		5 LEU A 222
TYR A  79
GLY A 212
LEU A  51
PHE A 105
 None
 1.43A 1pj7A-5xoxA:
2.9		 1pj7A-5xoxA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C2451
TYR C2474
LEU C2477
TYR C2440
TYR C2484
 None
 1.44A 1pj7A-5y3rC:
undetectable		 1pj7A-5y3rC:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		3 ASP A  57
THR A  90
GLU A 181
 None
 0.85A 1pj7A-1bhwA:
undetectable		 1pj7A-1bhwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		3 ASP A  87
THR A  89
GLU A 225
 None
 0.86A 1pj7A-1bqcA:
undetectable		 1pj7A-1bqcA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 ASP A 111
THR A 109
GLU A 405
 None
SO4  A2001 (-3.4A)
None
 0.80A 1pj7A-1c7tA:
0.7		 1pj7A-1c7tA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ed3 CLASS I MAJOR
HISTOCOMPATIBILITY
ANTIGEN RT1-AA

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASP A 198
THR A 200
GLU A 229
 None
 0.80A 1pj7A-1ed3A:
undetectable		 1pj7A-1ed3A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		3 ASP A 113
THR A  34
GLU A  15
 None
 0.73A 1pj7A-1fmlA:
1.9		 1pj7A-1fmlA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ASP A  43
THR A  84
GLU A 130
 None
 0.69A 1pj7A-1i2dA:
2.3		 1pj7A-1i2dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ifv PROTEIN LLR18B

(Lupinus luteus) 		PF00407
(Bet_v_1) 		3 ASP A  25
THR A  23
GLU A  75
 None
 0.71A 1pj7A-1ifvA:
undetectable		 1pj7A-1ifvA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ASP A  44
THR A  85
GLU A 128
 None
 0.67A 1pj7A-1jedA:
undetectable		 1pj7A-1jedA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjv MATURE ALPHA CHAIN
OF MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
ANTIGEN (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASP A 198
THR A 200
GLU A 229
 None
 0.86A 1pj7A-1kjvA:
undetectable		 1pj7A-1kjvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 ASP A 102
THR A 100
GLU A 268
 None
PLP  A 540 ( 4.5A)
PLP  A 540 (-3.5A)
 0.66A 1pj7A-1ko0A:
undetectable		 1pj7A-1ko0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhc MHC CLASS I ANTIGEN
H2-M3

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASP A 198
THR A 200
GLU A 229
 None
 0.81A 1pj7A-1mhcA:
undetectable		 1pj7A-1mhcA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		3 ASP A 301
THR A 298
GLU A 149
 None
 0.80A 1pj7A-1nt4A:
undetectable		 1pj7A-1nt4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3b ENDONUCLEASE VIII

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 ASP A  61
THR A  63
GLU A  48
 None
 0.82A 1pj7A-1q3bA:
undetectable		 1pj7A-1q3bA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 ASP A 597
THR A 268
GLU A 321
 None
 0.85A 1pj7A-1qf7A:
undetectable		 1pj7A-1qf7A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00557
(Peptidase_M24) 		3 ASP A  40
THR A  36
GLU A  73
 None
 0.82A 1pj7A-1qxyA:
undetectable		 1pj7A-1qxyA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ASP A  44
THR A  85
GLU A 128
 None
 0.62A 1pj7A-1r6xA:
2.3		 1pj7A-1r6xA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		3 ASP A  19
THR A 201
GLU A 153
 None
None
ZN  A3001 (-3.3A)
 0.80A 1pj7A-1t0bA:
2.1		 1pj7A-1t0bA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmc CLASS I
HISTOCOMPATIBILITY
ANTIGEN (HLA-AW68)

(Homo sapiens) 		PF00129
(MHC_I) 		3 ASP A 122
THR A 134
GLU A 128
 None
 0.82A 1pj7A-1tmcA:
undetectable		 1pj7A-1tmcA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ASP A 262
THR A 255
GLU A 138
 None
 0.86A 1pj7A-1uxiA:
6.1		 1pj7A-1uxiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9d DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2) 		3 ASP A 992
THR A1001
GLU A1134
 None
 0.81A 1pj7A-1v9dA:
undetectable		 1pj7A-1v9dA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 ASP A 412
THR A 500
GLU A 642
 None
 0.83A 1pj7A-1w8oA:
undetectable		 1pj7A-1w8oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		3 ASP A 120
THR A 122
GLU A 253
 None
None
NA  A 505 (-2.8A)
 0.82A 1pj7A-1wkyA:
undetectable		 1pj7A-1wkyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		3 ASP A 149
THR A 147
GLU A  21
 None
 0.78A 1pj7A-1yloA:
2.2		 1pj7A-1yloA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 ASP A 403
THR A 698
GLU A 398
 None
 0.81A 1pj7A-2b5mA:
undetectable		 1pj7A-2b5mA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASP A  45
THR A  76
GLU A 115
 None
 0.71A 1pj7A-2f7lA:
undetectable		 1pj7A-2f7lA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 ASP A  19
THR A  60
GLU A 103
 None
 0.76A 1pj7A-2gksA:
undetectable		 1pj7A-2gksA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		3 ASP A 253
THR A 255
GLU A 131
 None
 0.82A 1pj7A-2gtxA:
undetectable		 1pj7A-2gtxA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE

(Cellulomonas
fimi) 		PF00331
(Glyco_hydro_10) 		3 ASP A 296
THR A 276
GLU A  26
 None
 0.78A 1pj7A-2hisA:
undetectable		 1pj7A-2hisA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5i UPF0249 PROTEIN
EF_3048

(Enterococcus
faecalis) 		PF04794
(YdjC) 		3 ASP A  12
THR A  36
GLU A 209
 None
 0.73A 1pj7A-2i5iA:
undetectable		 1pj7A-2i5iA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1d DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1

(Homo sapiens) 		PF02181
(FH2) 		3 ASP G 845
THR G 855
GLU G 989
 None
 0.75A 1pj7A-2j1dG:
undetectable		 1pj7A-2j1dG:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 ASP A 340
THR A 338
GLU A 327
 None
 0.85A 1pj7A-2ji4A:
2.2		 1pj7A-2ji4A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ASP A 375
THR A 399
GLU A 422
 None
 0.86A 1pj7A-2oaeA:
2.0		 1pj7A-2oaeA:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 ASP A 609
THR A 605
GLU A 680
 None
ALY  A 604 ( 3.9A)
None
 0.44A 1pj7A-2ozuA:
undetectable		 1pj7A-2ozuA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 ASP A  89
THR A  91
GLU A 222
 None
MAN  A1301 ( 4.4A)
None
 0.76A 1pj7A-2whlA:
undetectable		 1pj7A-2whlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		3 ASP A  97
THR A  93
GLU A 185
 None
 0.56A 1pj7A-2xkaA:
3.3		 1pj7A-2xkaA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6e DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1

(Homo sapiens) 		PF02181
(FH2) 		3 ASP A 845
THR A 855
GLU A 989
 None
 0.84A 1pj7A-2z6eA:
undetectable		 1pj7A-2z6eA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		3 ASP A 174
THR A 172
GLU A 144
 None
 0.83A 1pj7A-3aytA:
undetectable		 1pj7A-3aytA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		3 ASP A 264
THR A 235
GLU A 191
 None
 0.74A 1pj7A-3bdkA:
undetectable		 1pj7A-3bdkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgu PROTEIN GIANT-LENS

(Drosophila
melanogaster) 		PF11581
(Argos) 		3 ASP A 274
THR A 276
GLU A 373
 None
 0.83A 1pj7A-3cguA:
undetectable		 1pj7A-3cguA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		3 ASP A 275
THR A 248
GLU A 218
 MG  A   1 (-3.3A)
None
None
 0.81A 1pj7A-3cuxA:
undetectable		 1pj7A-3cuxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 3 ASP A 180
THR A 178
GLU A 140
 None
 0.73A 1pj7A-3cv3A:
2.8		 1pj7A-3cv3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8l SERINE PROTEINASE
INHIBITOR A

(Sagittaria
sagittifolia) 		PF00197
(Kunitz_legume) 		3 ASP C 113
THR C 110
GLU C  99
 None
 0.84A 1pj7A-3e8lC:
undetectable		 1pj7A-3e8lC:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 ASP A 229
THR A 188
GLU A 152
 None
 0.75A 1pj7A-3f3zA:
undetectable		 1pj7A-3f3zA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)

(Homo sapiens) 		PF00702
(Hydrolase) 		3 ASP A 525
THR A 278
GLU A 506
 None
None
MG  A 701 (-3.8A)
 0.87A 1pj7A-3hb0A:
undetectable		 1pj7A-3hb0A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 3 ASP K 544
THR K 540
GLU K 824
 None
 0.52A 1pj7A-3jblK:
undetectable		 1pj7A-3jblK:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrp FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ASP A 237
THR A 235
GLU A 283
 None
 0.73A 1pj7A-3jrpA:
undetectable		 1pj7A-3jrpA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ASP A 221
THR A 196
GLU A 154
 GOL  A 387 (-2.9A)
None
None
 0.76A 1pj7A-3jtmA:
undetectable		 1pj7A-3jtmA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		3 ASP A 120
THR A 122
GLU A 253
 None
 0.77A 1pj7A-3jugA:
undetectable		 1pj7A-3jugA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 3 ASP Q 315
THR Q 287
GLU Q  23
 None
 0.56A 1pj7A-3ksdQ:
4.9		 1pj7A-3ksdQ:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 ASP A 265
THR A 224
GLU A 188
 None
 0.79A 1pj7A-3lijA:
undetectable		 1pj7A-3lijA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		3 ASP A 344
THR A 351
GLU A 128
 NA  A 394 (-3.1A)
None
None
 0.83A 1pj7A-3lkbA:
4.5		 1pj7A-3lkbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		3 ASP A 255
THR A 253
GLU A  62
 None
 0.82A 1pj7A-3luyA:
undetectable		 1pj7A-3luyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4a PUTATIVE TYPE I
TOPOISOMERASE

(Deinococcus
radiodurans) 		PF01028
(Topoisom_I) 		3 ASP A 208
THR A 206
GLU A 221
 None
 0.72A 1pj7A-3m4aA:
undetectable		 1pj7A-3m4aA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
EPSILON

(Bos taurus) 		PF04733
(Coatomer_E) 		3 ASP A 200
THR A 186
GLU A 177
 None
 0.75A 1pj7A-3mkrA:
undetectable		 1pj7A-3mkrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obv PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2)
PF06345
(Drf_DAD) 		3 ASP E 992
THR E1001
GLU E1134
 None
 0.80A 1pj7A-3obvE:
undetectable		 1pj7A-3obvE:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		3 ASP A 279
THR A 298
GLU A 205
 MD0  A 993 (-3.6A)
MD0  A 993 (-3.4A)
None
 0.71A 1pj7A-3t7vA:
undetectable		 1pj7A-3t7vA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88

(Pedobacter
heparinus) 		PF07470
(Glyco_hydro_88) 		3 ASP A 116
THR A  74
GLU A 369
 EPE  A 501 (-2.8A)
None
None
 0.69A 1pj7A-3wiwA:
undetectable		 1pj7A-3wiwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		3 ASP A 137
THR A 139
GLU A 273
 None
None
NA  A 402 (-2.8A)
 0.84A 1pj7A-3wsuA:
undetectable		 1pj7A-3wsuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x27 CUCUMOPINE SYNTHASE

(Marinactinospora
thermotolerans) 		no annotation 3 ASP A  77
THR A  79
GLU A  70
 None
 0.87A 1pj7A-3x27A:
undetectable		 1pj7A-3x27A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 273
THR A 306
GLU A 283
 None
 0.83A 1pj7A-4aipA:
undetectable		 1pj7A-4aipA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 ASP A 466
THR A 421
GLU A 710
 None
 0.79A 1pj7A-4areA:
2.5		 1pj7A-4areA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ASP A 429
THR A 347
GLU A 520
 None
 0.87A 1pj7A-4cgyA:
undetectable		 1pj7A-4cgyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 327
THR A 300
GLU A 249
 None
 0.80A 1pj7A-4dwdA:
undetectable		 1pj7A-4dwdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		3 ASP A 431
THR A 433
GLU A 456
 None
 0.84A 1pj7A-4dweA:
undetectable		 1pj7A-4dweA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		3 ASP A 286
THR A 317
GLU A 137
 None
 0.84A 1pj7A-4eysA:
undetectable		 1pj7A-4eysA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fay MICROCOMPARTMENTS
PROTEIN

(Lactobacillus
reuteri) 		PF00936
(BMC) 		3 ASP A  53
THR A  84
GLU A 195
 None
GOL  A 304 ( 3.9A)
GOL  A 303 ( 2.9A)
 0.78A 1pj7A-4fayA:
3.2		 1pj7A-4fayA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk9 CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF00150
(Cellulase) 		3 ASP A 137
THR A 139
GLU A 273
 None
 0.86A 1pj7A-4fk9A:
undetectable		 1pj7A-4fk9A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		3 ASP A 273
THR A 262
GLU A 302
 None
 0.83A 1pj7A-4fnmA:
undetectable		 1pj7A-4fnmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechococcus
elongatus;
Synechococcus
elongatus) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		3 ASP B 101
THR B   6
GLU A 109
 None
 0.79A 1pj7A-4h0mB:
undetectable		 1pj7A-4h0mB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASP A 421
THR A 281
GLU A 216
 None
EDO  A 548 (-4.6A)
G6Q  A 544 (-4.3A)
 0.77A 1pj7A-4hjhA:
2.9		 1pj7A-4hjhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		3 ASP A 347
THR A 345
GLU A 187
 None
 0.76A 1pj7A-4i59A:
15.1		 1pj7A-4i59A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN

(Streptococcus
mutans) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		3 ASP A 324
THR A 329
GLU A 253
 None
 0.65A 1pj7A-4i5sA:
undetectable		 1pj7A-4i5sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		3 ASP A 214
THR A 195
GLU A 236
 None
 0.80A 1pj7A-4idaA:
3.9		 1pj7A-4idaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		3 ASP A  82
THR A  80
GLU A 274
 None
 0.86A 1pj7A-4kegA:
undetectable		 1pj7A-4kegA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyk CYCLIC DI-GMP
PHOSPHODIESTERASE
YAHA

(Escherichia
coli) 		PF00563
(EAL) 		3 ASP A 263
THR A 234
GLU A 164
 None
 0.86A 1pj7A-4lykA:
undetectable		 1pj7A-4lykA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		3 ASP A 321
THR A 367
GLU A 197
 None
 0.84A 1pj7A-4pxqA:
undetectable		 1pj7A-4pxqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql9 ALKYLHYDROPEROXIDE
REDUCTASE SUBUNIT C

(Escherichia
coli) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 ASP A  42
THR A  44
GLU A 139
 None
 0.52A 1pj7A-4ql9A:
2.4		 1pj7A-4ql9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm7 ACYL-COA
DEHYDROGENASE

(Slackia
heliotrinireducens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASP A 176
THR A 174
GLU A 221
 None
 0.83A 1pj7A-4rm7A:
undetectable		 1pj7A-4rm7A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 3 ASP A  12
THR A  73
GLU A 115
 INS  A 301 (-2.8A)
None
None
 0.84A 1pj7A-4xf7A:
5.3		 1pj7A-4xf7A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xia D-XYLOSE ISOMERASE

(Arthrobacter
sp. NRRL B3728) 		PF01261
(AP_endonuc_2) 		3 ASP A  56
THR A  89
GLU A 180
 None
SOR  A 400 (-3.3A)
MG  A 399 ( 2.5A)
 0.88A 1pj7A-4xiaA:
undetectable		 1pj7A-4xiaA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 ASP A 403
THR A 880
GLU A 451
 None
 0.85A 1pj7A-4zmhA:
4.3		 1pj7A-4zmhA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		3 ASP B 266
THR B 269
GLU B 277
 None
 0.63A 1pj7A-5b47B:
undetectable		 1pj7A-5b47B:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		3 ASP A  99
THR A  65
GLU A 348
 None
None
ADP  A 501 (-3.0A)
 0.80A 1pj7A-5dmhA:
2.3		 1pj7A-5dmhA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		3 ASP A 210
THR A 213
GLU A 180
 MG  A 401 (-2.8A)
None
T6P  A 402 (-2.7A)
 0.75A 1pj7A-5dx9A:
undetectable		 1pj7A-5dx9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 ASP A  38
THR A  40
GLU A 356
 CA  A1521 ( 2.8A)
None
None
 0.81A 1pj7A-5g2vA:
undetectable		 1pj7A-5g2vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 ASP b  85
THR b  62
GLU b 379
 None
 0.79A 1pj7A-5gw5b:
undetectable		 1pj7A-5gw5b:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA

(Listeria
monocytogenes) 		PF01297
(ZnuA) 		3 ASP A 100
THR A  94
GLU A 136
 None
 0.88A 1pj7A-5i4kA:
2.0		 1pj7A-5i4kA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 ASP A 420
THR A 423
GLU A  65
 None
 0.81A 1pj7A-5jbgA:
undetectable		 1pj7A-5jbgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus;
Staphylococcus
aureus) 		no annotation
no annotation 		3 ASP D 140
THR D 142
GLU B 139
 None
 0.84A 1pj7A-5k59D:
undetectable		 1pj7A-5k59D:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		3 ASP B 350
THR B 352
GLU B 192
 None
 0.81A 1pj7A-5k7mB:
undetectable		 1pj7A-5k7mB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6e N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		3 ASP B 350
THR B 352
GLU B 192
 None
 0.86A 1pj7A-5l6eB:
undetectable		 1pj7A-5l6eB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 3 ASP A 116
THR A 119
GLU A  14
 None
None
EDO  A 408 ( 4.2A)
 0.73A 1pj7A-5o9wA:
undetectable		 1pj7A-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 3 ASP A 339
THR A 342
GLU A  47
 None
 0.51A 1pj7A-5olcA:
2.1		 1pj7A-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB

(Shigella
flexneri) 		PF00006
(ATP-synt_ab) 		3 ASP A 249
THR A 252
GLU A 307
 None
 0.77A 1pj7A-5swjA:
undetectable		 1pj7A-5swjA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tey N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14

(Homo sapiens) 		PF05063
(MT-A70) 		3 ASP B 350
THR B 352
GLU B 192
 None
UNX  B 406 ( 4.6A)
None
 0.87A 1pj7A-5teyB:
undetectable		 1pj7A-5teyB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis;
Gracilaria
chilensis) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		3 ASP B 100
THR B   6
GLU A 106
 None
 0.77A 1pj7A-5tjfB:
undetectable		 1pj7A-5tjfB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x15 PUTATIVE TRANSFERASE

(Streptomyces
coelicolor) 		PF03737
(RraA-like) 		3 ASP A 209
THR A  50
GLU A 235
 None
 0.85A 1pj7A-5x15A:
undetectable		 1pj7A-5x15A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyb -

(-) 		no annotation 3 ASP A 328
THR A 164
GLU A 132
 None
 0.86A 1pj7A-5xybA:
undetectable		 1pj7A-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4j XYLOSE ISOMERASE

(Streptomyces
rubiginosus) 		PF01261
(AP_endonuc_2) 		3 ASP A  57
THR A  90
GLU A 181
 None
XYL  A 402 ( 4.1A)
XYL  A 402 ( 2.4A)
 0.79A 1pj7A-5y4jA:
undetectable		 1pj7A-5y4jA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 3 ASP A  40
THR A  42
GLU A  56
 None
 0.83A 1pj7A-5ys9A:
undetectable		 1pj7A-5ys9A:
undetectable