SIMILAR PATTERNS OF AMINO ACIDS FOR 1PJ6_A_FOLA2887_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 TYR A  83
TYR A 168
TYR A 188
GLU A 195
TYR A 236
 FFO  A2887 (-3.9A)
None
FFO  A2887 (-3.5A)
FFO  A2887 (-2.8A)
FFO  A2887 (-3.9A)
 0.73A 1pj6A-1wopA:
48.0		 1pj6A-1wopA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		8 LEU A 508
TYR A 539
THR A 554
TYR A 631
PHE A 632
LEU A 649
GLU A 658
TYR A 699
 THG  A2887 (-4.8A)
THG  A2887 (-3.9A)
THG  A2887 (-2.6A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-2.8A)
THG  A2887 (-4.1A)
 0.21A 1pj6A-3gsiA:
72.7		 1pj6A-3gsiA:
99.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		6 TYR A 539
TYR A 631
PHE A 632
LEU A 649
TYR A 651
TYR A 699
 THG  A2887 (-3.9A)
None
THG  A2887 (-4.2A)
None
THG  A2887 (-4.3A)
THG  A2887 (-4.1A)
 0.56A 1pj6A-3gsiA:
72.7		 1pj6A-3gsiA:
99.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 5 TYR A  74
TYR A 233
LEU A 230
GLU A 161
TYR A  62
 None
 1.46A 1pj6A-5xmdA:
0.4		 1pj6A-5xmdA:
undetectable