SIMILAR PATTERNS OF AMINO ACIDS FOR 1PJ5_A_ACTA2145

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 ARG A 252
TYR A 259
TYR A 272
TRP A 361
TYR A 415
 None
FAD  A 902 (-4.8A)
None
None
None
 0.83A 1pj5A-3gsiA:
72.5		 1pj5A-3gsiA:
99.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5y FAB 5J8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG H  97
TYR H  34
TYR H  58
TYR H 100
 None
 1.41A 1pj5A-4m5yH:
0.0		 1pj5A-4m5yH:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ARG B 143
TYR B  96
TYR B 275
TYR B 142
 None
 1.45A 1pj5A-5ldrB:
0.0		 1pj5A-5ldrB:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofq CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		4 ARG A 255
TYR A 256
TYR A 284
TYR A 285
 None
1PE  A 502 ( 4.7A)
None
None
 0.90A 1pj5A-5ofqA:
0.0		 1pj5A-5ofqA:
18.23