SIMILAR PATTERNS OF AMINO ACIDS FOR 1PHG_A_MYTA422_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)


(Methanothermus
fervidus)
no annotation 5 VAL P 227
GLY P 157
VAL P 239
ASP P 235
ILE P 236
None
1.05A 1phgA-1cf2P:
undetectable
1phgA-1cf2P:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
5 THR A 125
LEU A 359
VAL A 363
GLY A 361
ILE A 124
None
1.11A 1phgA-1jioA:
42.2
1phgA-1jioA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D


(Thermotoga
maritima)
PF00072
(Response_reg)
PF00486
(Trans_reg_C)
5 LEU A  56
GLY A  38
VAL A  77
ILE A  51
VAL A  50
None
1.21A 1phgA-1kgsA:
undetectable
1phgA-1kgsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)


(Thermococcus
kodakarensis)
PF01035
(DNA_binding_1)
PF09153
(DUF1938)
5 VAL A 126
GLY A 127
ASP A 114
ILE A 110
VAL A 144
None
1.19A 1phgA-1mgtA:
undetectable
1phgA-1mgtA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE


(Escherichia
coli)
PF02965
(Met_synt_B12)
5 TYR A1181
LEU A1103
VAL A1063
GLY A 997
ILE A1151
None
1.21A 1phgA-1mskA:
undetectable
1phgA-1mskA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdw HYPOTHETICAL PROTEIN
PH1897


(Pyrococcus
horikoshii)
PF00459
(Inositol_P)
5 THR A 169
GLY A 159
THR A 155
VAL A 191
ILE A 151
None
EDO  A1003 (-3.8A)
EDO  A1003 ( 4.5A)
None
None
1.07A 1phgA-1vdwA:
undetectable
1phgA-1vdwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE


(Salmonella
enterica)
PF16363
(GDP_Man_Dehyd)
5 THR A  32
LEU A 241
GLY A  24
VAL A  14
VAL A  38
None
1.13A 1phgA-1wvgA:
undetectable
1phgA-1wvgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II


(Sporidiobolus
salmonicolor)
PF01370
(Epimerase)
5 THR A 131
LEU A  32
VAL A  28
GLY A 254
VAL A 204
NMN  A1001 (-4.2A)
None
None
None
None
1.04A 1phgA-1y1pA:
undetectable
1phgA-1y1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE


(Aquifex
aeolicus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
5 TYR A 117
GLY A 162
THR A  45
VAL A  51
VAL A  49
None
1.16A 1phgA-1zjrA:
undetectable
1phgA-1zjrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfu PROBABLE
2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE


(Thermus
thermophilus)
PF01557
(FAA_hydrolase)
PF10370
(DUF2437)
6 THR A 254
VAL A 144
GLY A 115
THR A 187
VAL A 189
ASP A 240
None
1.39A 1phgA-2dfuA:
undetectable
1phgA-2dfuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4l ACETAMIDASE,
PUTATIVE


(Thermotoga
maritima)
PF03069
(FmdA_AmdA)
5 VAL A 128
GLY A 127
VAL A 196
ILE A 198
VAL A  69
None
1.14A 1phgA-2f4lA:
undetectable
1phgA-2f4lA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN


(Escherichia
coli)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 THR A  92
LEU A 137
VAL A 140
GLY A 141
ILE A  91
None
1.18A 1phgA-2gepA:
undetectable
1phgA-2gepA:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
7 PHE A  87
TYR A  96
LEU A 244
GLY A 248
THR A 252
VAL A 396
ILE A 395
CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
None
1.36A 1phgA-2m56A:
67.7
1phgA-2m56A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
11 PHE A  87
TYR A  96
THR A 185
LEU A 244
VAL A 247
GLY A 248
THR A 252
VAL A 295
ASP A 297
ILE A 395
VAL A 396
CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
None
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
None
0.28A 1phgA-2m56A:
67.7
1phgA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5y PUTATIVE TUBERCULIN
RELATED PEPTIDE


(Mycobacterium
tuberculosis)
PF13399
(LytR_C)
5 LEU A  98
GLY A  95
VAL A  37
ILE A 117
VAL A 116
None
1.20A 1phgA-2m5yA:
undetectable
1phgA-2m5yA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5


(Arabidopsis
thaliana)
PF00071
(Ras)
5 PHE C 170
THR C  11
GLY C  18
VAL C 116
ILE C  82
None
None
GDP  C1200 (-2.6A)
None
None
1.14A 1phgA-2ntyC:
undetectable
1phgA-2ntyC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obn HYPOTHETICAL PROTEIN

(Trichormus
variabilis)
PF07755
(DUF1611)
PF17396
(DUF1611_N)
5 VAL A 157
GLY A 158
THR A 159
ILE A 282
VAL A 281
None
1.12A 1phgA-2obnA:
undetectable
1phgA-2obnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE


(Thermotoga
maritima)
PF00342
(PGI)
5 VAL A 205
GLY A 206
VAL A 109
ASP A 111
VAL A  71
None
0.86A 1phgA-2q8nA:
undetectable
1phgA-2q8nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus)
PF00423
(HN)
5 PHE A 319
VAL A 367
GLY A 411
THR A 369
ILE A 306
None
1.05A 1phgA-2rkcA:
undetectable
1phgA-2rkcA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE


(Bacillus
clausii)
PF00082
(Peptidase_S8)
5 THR A 151
VAL A  94
GLY A 258
ILE A 150
VAL A 178
None
1.19A 1phgA-2xrmA:
undetectable
1phgA-2xrmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yps SORTING NEXIN-3

(Homo sapiens)
PF00787
(PX)
5 PHE A 144
LEU A  92
GLY A 121
ILE A  51
VAL A  33
None
1.17A 1phgA-2ypsA:
undetectable
1phgA-2ypsA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
5 THR A 310
GLY A 279
THR A 358
VAL A 328
ILE A 309
None
1.17A 1phgA-3afgA:
undetectable
1phgA-3afgA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150


(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct)
PF00423
(HN)
PF06214
(SLAM)
5 PHE A 319
VAL A 367
GLY A 411
THR A 369
ILE A 306
None
0.97A 1phgA-3alxA:
undetectable
1phgA-3alxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1


(Saccharomyces
cerevisiae)
PF00128
(Alpha-amylase)
5 PHE A  62
TYR A  63
VAL A 209
GLY A 211
ILE A  59
None
1.13A 1phgA-3axiA:
undetectable
1phgA-3axiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A1051
GLY A1151
ASP A1117
ILE A1118
VAL A1121
None
1.16A 1phgA-3c1xA:
undetectable
1phgA-3c1xA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE


(Lactobacillus
delbrueckii)
PF00155
(Aminotran_1_2)
5 PHE A 337
LEU A 347
VAL A 325
ILE A 327
VAL A 312
None
1.22A 1phgA-3dzzA:
undetectable
1phgA-3dzzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA


(Methanocaldococcus
jannaschii)
PF00282
(Pyridoxal_deC)
5 LEU A  99
GLY A 138
ASP A 206
ILE A 175
VAL A 127
None
None
PLP  A 500 (-2.6A)
None
None
1.13A 1phgA-3f9tA:
undetectable
1phgA-3f9tA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE


(Moraxella sp.)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
6 LEU A 217
VAL A 194
GLY A 195
THR A 252
VAL A 155
VAL A 158
None
1.41A 1phgA-3fn4A:
undetectable
1phgA-3fn4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE


(Eubacterium
barkeri)
PF04303
(PrpF)
5 THR A 320
VAL A 199
THR A 311
ILE A 321
VAL A 322
None
1.21A 1phgA-3g7kA:
undetectable
1phgA-3g7kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1


(Arabidopsis
thaliana)
PF00282
(Pyridoxal_deC)
5 PHE A 108
GLY A 211
ASP A 262
ILE A 271
VAL A 243
None
1.19A 1phgA-3hbxA:
undetectable
1phgA-3hbxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y BL21

(Homo sapiens)
PF00829
(Ribosomal_L21p)
5 LEU S 149
VAL S 136
THR S 142
VAL S  83
ILE S  87
None
1.12A 1phgA-3j7yS:
undetectable
1phgA-3j7yS:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11


(Schizosaccharomyces
pombe)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
5 PHE X1120
VAL X1166
GLY X1167
ILE X1182
VAL X1181
None
1.16A 1phgA-3jb9X:
undetectable
1phgA-3jb9X:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 LEU A  87
GLY A 234
THR A 238
VAL A 281
VAL A 384
HEM  A 417 (-4.1A)
HEM  A 417 (-4.0A)
HEM  A 417 (-3.6A)
HEM  A 417 ( 4.8A)
None
1.00A 1phgA-3oftA:
50.4
1phgA-3oftA:
42.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN


(Escherichia
coli)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
5 GLY B 112
VAL B  64
ASP B  76
ILE B  77
VAL B  78
None
1.21A 1phgA-3pcoB:
undetectable
1phgA-3pcoB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2r GLIOMA
PATHOGENESIS-RELATED
PROTEIN 1


(Homo sapiens)
PF00188
(CAP)
5 VAL A 149
GLY A 150
VAL A 110
ASP A  36
ILE A  40
None
1.18A 1phgA-3q2rA:
undetectable
1phgA-3q2rA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0x PEPTIDASE A24B, FLAK
DOMAIN PROTEIN


(Methanococcus
maripaludis)
PF01478
(Peptidase_A24)
PF06847
(Arc_PepC_II)
5 THR A 710
LEU A 532
GLY A 507
VAL A 617
ILE A 709
None
1.20A 1phgA-3s0xA:
undetectable
1phgA-3s0xA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4x OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY


(Bacillus
anthracis)
PF00106
(adh_short)
5 GLY A 117
THR A 121
VAL A 179
ILE A 137
VAL A 136
None
0.92A 1phgA-3t4xA:
undetectable
1phgA-3t4xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Campylobacter
jejuni)
PF00290
(Trp_syntA)
5 PHE A 105
VAL A  46
GLY A  45
VAL A 119
ILE A  97
None
1.15A 1phgA-3thaA:
undetectable
1phgA-3thaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
5 LEU A 290
GLY A 279
THR A 252
ASP A 262
VAL A 229
None
1.18A 1phgA-3tsdA:
undetectable
1phgA-3tsdA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsv L-LACTATE
DEHYDROGENASE


(Enterococcus
mundtii)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 THR A 102
VAL A 120
VAL A 109
ILE A 105
VAL A 106
None
1.08A 1phgA-3wsvA:
undetectable
1phgA-3wsvA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
1.03A 1phgA-3zbyA:
42.4
1phgA-3zbyA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Flaveria
pringlei)
PF00311
(PEPcase)
5 PHE A 816
GLY A 789
THR A 861
VAL A 823
ILE A 820
None
1.07A 1phgA-3zgbA:
undetectable
1phgA-3zgbA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I


(Anas
platyrhynchos)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 PHE A 369
LEU A 299
VAL A 349
ILE A 341
VAL A 337
None
1.17A 1phgA-4a2pA:
undetectable
1phgA-4a2pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ano ESSB

(Geobacillus
thermodenitrificans)
PF10140
(YukC)
5 LEU A 103
VAL A 127
GLY A 126
VAL A  62
ILE A  53
None
0.98A 1phgA-4anoA:
undetectable
1phgA-4anoA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ano ESSB

(Geobacillus
thermodenitrificans)
PF10140
(YukC)
5 VAL A 125
GLY A 126
VAL A  24
ILE A  64
VAL A  62
None
1.18A 1phgA-4anoA:
undetectable
1phgA-4anoA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 NOP5/NOP56 RELATED
PROTEIN


(Pyrococcus
furiosus)
PF01798
(Nop)
5 LEU C 253
VAL C 257
GLY C 258
VAL C 307
ILE C 308
None
1.00A 1phgA-4by9C:
undetectable
1phgA-4by9C:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
9 TYR A  98
THR A 187
LEU A 252
GLY A 256
THR A 260
VAL A 303
ASP A 305
ILE A 403
VAL A 404
None
None
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
None
GOL  A1419 (-3.5A)
0.57A 1phgA-4c9mA:
58.7
1phgA-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckm SAS-6

(Leishmania
major)
PF16531
(SAS-6_N)
5 LEU A 177
VAL A 157
GLY A 156
THR A 138
ILE A 223
None
0.96A 1phgA-4ckmA:
undetectable
1phgA-4ckmA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckn SAS-6

(Leishmania
major)
PF16531
(SAS-6_N)
5 LEU A 177
VAL A 157
GLY A 156
THR A 138
ILE A 223
None
1.07A 1phgA-4cknA:
undetectable
1phgA-4cknA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE


(Salmonella
enterica)
PF00291
(PALP)
5 THR A 315
LEU A 275
GLY A 289
VAL A 190
ILE A 313
LLP  A  51 ( 3.4A)
None
None
None
None
1.14A 1phgA-4d8uA:
undetectable
1phgA-4d8uA:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
6 PHE A  87
GLY A 254
THR A 258
VAL A 301
ILE A 401
VAL A 402
None
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
None
0.81A 1phgA-4dxyA:
52.0
1phgA-4dxyA:
46.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
6 PHE A  87
LEU A 250
GLY A 254
THR A 258
VAL A 301
ILE A 401
None
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
1.06A 1phgA-4dxyA:
52.0
1phgA-4dxyA:
46.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT


(Escherichia
coli)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 THR A  92
LEU A 137
VAL A 140
GLY A 141
ILE A  91
None
1.19A 1phgA-4g38A:
undetectable
1phgA-4g38A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN


(Streptomyces
himastatinicus)
PF00067
(p450)
5 THR A 109
LEU A 354
VAL A 358
GLY A 356
ILE A 108
None
1.18A 1phgA-4ggvA:
35.5
1phgA-4ggvA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00169
(PH)
PF00621
(RhoGEF)
5 PHE A 998
VAL A 954
GLY A 937
VAL A1023
ILE A1024
None
1.19A 1phgA-4h6yA:
undetectable
1phgA-4h6yA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdw ANTIFREEZE PROTEIN

(Marinomonas
primoryensis)
no annotation 5 THR A  56
GLY A  32
VAL A  83
ASP A  43
VAL A  45
None
None
None
GOL  A 208 (-4.4A)
None
1.16A 1phgA-4kdwA:
undetectable
1phgA-4kdwA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 VAL A 284
GLY A 285
THR A 340
VAL A 203
ILE A 200
None
1.03A 1phgA-4kg7A:
undetectable
1phgA-4kg7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus)
PF03328
(HpcH_HpaI)
5 LEU A  59
VAL A  91
GLY A  57
VAL A  78
VAL A  79
None
1.06A 1phgA-4l7zA:
undetectable
1phgA-4l7zA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE


(Sulfolobus
solfataricus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 PHE A 386
TYR A  69
VAL A  53
THR A  48
ILE A 148
None
1.09A 1phgA-4mmoA:
undetectable
1phgA-4mmoA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Anaerococcus
prevotii)
PF03480
(DctP)
5 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
None
None
None
GCU  A 401 ( 2.7A)
None
0.95A 1phgA-4n91A:
undetectable
1phgA-4n91A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4


(Drosophila
melanogaster)
no annotation 5 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
None
1.13A 1phgA-4nk7A:
undetectable
1phgA-4nk7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER


(Marinomonas
primoryensis)
no annotation 5 THR A  56
GLY A  32
VAL A  83
ASP A  43
VAL A  45
None
None
None
CA  A 510 ( 4.9A)
None
1.18A 1phgA-4p99A:
undetectable
1phgA-4p99A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER


(Marinomonas
primoryensis)
no annotation 5 THR A 160
GLY A 136
VAL A 187
ASP A 147
VAL A 149
None
None
None
CA  A 507 ( 4.9A)
None
1.14A 1phgA-4p99A:
undetectable
1phgA-4p99A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER


(Marinomonas
primoryensis)
no annotation 5 THR A 264
GLY A 240
VAL A 291
ASP A 251
VAL A 253
None
None
None
CA  A 520 ( 4.7A)
None
1.17A 1phgA-4p99A:
undetectable
1phgA-4p99A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER


(Marinomonas
primoryensis)
no annotation 5 THR A 368
GLY A 344
VAL A 395
ASP A 355
VAL A 357
None
1.17A 1phgA-4p99A:
undetectable
1phgA-4p99A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum)
PF01734
(Patatin)
5 PHE X 114
GLY X  36
THR X 260
ASP X 332
ILE X  39
None
MIS  X  77 ( 3.4A)
None
None
None
1.16A 1phgA-4pkaX:
undetectable
1phgA-4pkaX:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1p UNCHARACTERIZED
PROTEIN


(Slackia
heliotrinireducens)
PF13472
(Lipase_GDSL_2)
5 PHE A 131
THR A 103
LEU A  38
GLY A   7
THR A  11
None
1.04A 1phgA-4s1pA:
undetectable
1phgA-4s1pA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1p UNCHARACTERIZED
PROTEIN


(Slackia
heliotrinireducens)
PF13472
(Lipase_GDSL_2)
5 TYR A  80
THR A 103
LEU A  38
GLY A   7
THR A  11
None
1.11A 1phgA-4s1pA:
undetectable
1phgA-4s1pA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN


(Thermus
thermophilus)
PF00005
(ABC_tran)
5 THR A 195
LEU A 242
GLY A 199
VAL A 208
VAL A  34
None
1.21A 1phgA-4u02A:
undetectable
1phgA-4u02A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxa EKC/KEOPS COMPLEX
SUBUNIT GON7


(Saccharomyces
cerevisiae)
PF08738
(Gon7)
5 PHE D  18
GLY D  87
THR D  86
ASP D  80
ILE D  81
None
1.13A 1phgA-4wxaD:
undetectable
1phgA-4wxaD:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT


(Caldanaerobacter
subterraneus)
no annotation 5 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
None
1.15A 1phgA-4ymwJ:
undetectable
1phgA-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP3

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
5 PHE 3  76
THR 3  74
VAL 3 203
VAL 3 122
VAL 3 188
None
1.17A 1phgA-5aca3:
undetectable
1phgA-5aca3:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ


(Escherichia
coli)
PF01055
(Glyco_hydro_31)
5 PHE A 207
LEU A 148
GLY A 133
THR A 496
ILE A 129
None
1.08A 1phgA-5aeeA:
undetectable
1phgA-5aeeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 LEU A  26
GLY A  30
VAL A  41
ASP A  43
VAL A 107
None
None
None
SAH  A 301 ( 4.5A)
None
0.86A 1phgA-5bp7A:
undetectable
1phgA-5bp7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii)
PF08652
(RAI1)
5 THR A 316
LEU A  18
VAL A 205
GLY A 204
VAL A 109
None
1.22A 1phgA-5btbA:
undetectable
1phgA-5btbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens)
PF05053
(Menin)
5 PHE A 146
GLY A  99
VAL A 121
ILE A 125
VAL A 124
None
1.20A 1phgA-5ddbA:
undetectable
1phgA-5ddbA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  25
GLY A  29
VAL A  40
ASP A  42
VAL A 106
None
None
None
SAH  A 301 ( 4.5A)
None
0.88A 1phgA-5epeA:
undetectable
1phgA-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PROTEIN TRANSLOCASE
SUBUNIT SECY


(Geobacillus
thermodenitrificans)
PF00344
(SecY)
5 PHE Y 374
VAL Y 406
GLY Y 407
VAL Y 266
ILE Y 234
None
0.84A 1phgA-5eulY:
undetectable
1phgA-5eulY:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgl NICR

(Pseudomonas
putida)
PF00440
(TetR_N)
5 THR A 107
VAL A 177
GLY A 180
ILE A 110
VAL A 111
None
1.06A 1phgA-5fglA:
undetectable
1phgA-5fglA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 PHE C 204
LEU C 139
VAL C  17
GLY C  18
ILE C 234
None
1.20A 1phgA-5flzC:
undetectable
1phgA-5flzC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 VAL A1311
GLY A1310
THR A1308
VAL A1118
ILE A1327
None
1.14A 1phgA-5ip9A:
undetectable
1phgA-5ip9A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis)
no annotation 5 THR A 446
GLY A 422
VAL A 473
ASP A 433
VAL A 435
None
1.18A 1phgA-5irbA:
undetectable
1phgA-5irbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE


(Oscillatoria
sp.)
PF11266
(Ald_deCOase)
5 TYR A  17
LEU A  74
VAL A  76
VAL A  28
ILE A  24
None
None
None
STE  A 502 ( 4.8A)
STE  A 502 (-4.4A)
1.16A 1phgA-5k53A:
undetectable
1phgA-5k53A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis)
no annotation 5 THR A  56
GLY A  32
VAL A  84
ASP A  43
VAL A  45
None
None
None
CA  A 615 ( 4.7A)
None
1.14A 1phgA-5k8gA:
undetectable
1phgA-5k8gA:
21.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kyo CYP101J2

(Sphingobium
yanoikuyae)
PF00067
(p450)
6 VAL A 249
GLY A 250
THR A 254
VAL A 297
ILE A 397
VAL A 398
None
HEM  A 501 (-3.8A)
HEM  A 501 (-3.5A)
HEM  A 501 (-4.3A)
None
None
0.98A 1phgA-5kyoA:
50.4
1phgA-5kyoA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kyo CYP101J2

(Sphingobium
yanoikuyae)
PF00067
(p450)
6 VAL A 249
GLY A 251
THR A 254
VAL A 297
ILE A 397
VAL A 398
None
HEM  A 501 (-3.3A)
HEM  A 501 (-3.5A)
HEM  A 501 (-4.3A)
None
None
1.00A 1phgA-5kyoA:
50.4
1phgA-5kyoA:
40.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocp -

(-)
no annotation 5 LEU A  33
VAL A   3
GLY A   4
VAL A  87
VAL A  85
None
1.12A 1phgA-5ocpA:
undetectable
1phgA-5ocpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR


(Mus musculus)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
5 LEU A 225
VAL A 179
GLY A 184
THR A 208
VAL A 213
None
1.08A 1phgA-5sy5A:
undetectable
1phgA-5sy5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR


(Mus musculus)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
5 PHE A 263
VAL A 179
GLY A 184
THR A 208
VAL A 213
None
1.09A 1phgA-5sy5A:
undetectable
1phgA-5sy5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t96 HE PROTEIN

(Salmon isavirus)
PF06215
(ISAV_HA)
5 THR A 157
GLY A 135
VAL A 160
ILE A 158
VAL A 159
None
None
None
FMT  A 406 (-4.2A)
None
1.22A 1phgA-5t96A:
undetectable
1phgA-5t96A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF17207
(MCM_OB)
5 THR 3 432
VAL 3 440
GLY 3 441
VAL 3 512
VAL 3 470
None
1.17A 1phgA-5udb3:
undetectable
1phgA-5udb3:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
5 LEU A 290
GLY A 279
THR A 252
ASP A 262
VAL A 229
None
None
8N1  A 502 (-2.9A)
None
None
1.19A 1phgA-5uuwA:
undetectable
1phgA-5uuwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE


(Citrus sinensis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 PHE A 484
THR A 446
THR A 340
ASP A 488
ILE A 445
LA6  A 704 (-4.6A)
LA6  A 704 (-3.5A)
LA6  A 704 (-3.4A)
MN  A 703 ( 2.8A)
None
0.98A 1phgA-5uv2A:
undetectable
1phgA-5uv2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU A  31
VAL A  12
GLY A  29
THR A  54
ILE A  49
None
1.11A 1phgA-5vm1A:
undetectable
1phgA-5vm1A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa2 SURFACE ANTIGEN

(Toxoplasma
gondii)
no annotation 5 LEU A 307
VAL A 308
GLY A 309
VAL A 210
ILE A 233
None
1.12A 1phgA-5wa2A:
undetectable
1phgA-5wa2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woy PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Caldanaerobacter
subterraneus)
no annotation 5 LEU A 130
VAL A 133
GLY A 134
VAL A  89
ILE A  86
None
1.16A 1phgA-5woyA:
undetectable
1phgA-5woyA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bld CYTOCHROME P450
268A2 CYP268A2


(Mycobacterium
marinum)
no annotation 5 LEU A 256
VAL A 259
GLY A 261
THR A 264
VAL A 308
HEM  A 501 ( 4.8A)
DXJ  A 502 (-4.5A)
HEM  A 501 (-3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 4.6A)
1.08A 1phgA-6bldA:
42.3
1phgA-6bldA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE
TELOMERASE-ASSOCIATE
D PROTEIN 82


(Tetrahymena
thermophila)
no annotation 5 PHE D 590
THR A 114
GLY A 111
ILE A 115
VAL A 119
None
1.19A 1phgA-6d6vD:
undetectable
1phgA-6d6vD:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE


(Mycobacterium
tuberculosis)
no annotation 5 LEU C 214
VAL C 121
GLY C 120
VAL C 137
VAL C 203
None
1.22A 1phgA-6eicC:
undetectable
1phgA-6eicC:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE


(Mycobacterium
tuberculosis)
no annotation 5 THR C 206
LEU C 214
VAL C 121
GLY C 120
VAL C 137
None
1.13A 1phgA-6eicC:
undetectable
1phgA-6eicC:
12.53