SIMILAR PATTERNS OF AMINO ACIDS FOR 1PHG_A_MYTA422_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cf2 | PROTEIN(GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE) (Methanothermusfervidus) |
no annotation | 5 | VAL P 227GLY P 157VAL P 239ASP P 235ILE P 236 | None | 1.05A | 1phgA-1cf2P:undetectable | 1phgA-1cf2P:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 5 | THR A 125LEU A 359VAL A 363GLY A 361ILE A 124 | None | 1.11A | 1phgA-1jioA:42.2 | 1phgA-1jioA:24.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kgs | DNA BINDING RESPONSEREGULATOR D (Thermotogamaritima) |
PF00072(Response_reg)PF00486(Trans_reg_C) | 5 | LEU A 56GLY A 38VAL A 77ILE A 51VAL A 50 | None | 1.21A | 1phgA-1kgsA:undetectable | 1phgA-1kgsA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mgt | PROTEIN(O6-METHYLGUANINE-DNA METHYLTRANSFERASE) (Thermococcuskodakarensis) |
PF01035(DNA_binding_1)PF09153(DUF1938) | 5 | VAL A 126GLY A 127ASP A 114ILE A 110VAL A 144 | None | 1.19A | 1phgA-1mgtA:undetectable | 1phgA-1mgtA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1msk | COBALAMIN-DEPENDENTMETHIONINE SYNTHASE (Escherichiacoli) |
PF02965(Met_synt_B12) | 5 | TYR A1181LEU A1103VAL A1063GLY A 997ILE A1151 | None | 1.21A | 1phgA-1mskA:undetectable | 1phgA-1mskA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdw | HYPOTHETICAL PROTEINPH1897 (Pyrococcushorikoshii) |
PF00459(Inositol_P) | 5 | THR A 169GLY A 159THR A 155VAL A 191ILE A 151 | NoneEDO A1003 (-3.8A)EDO A1003 ( 4.5A)NoneNone | 1.07A | 1phgA-1vdwA:undetectable | 1phgA-1vdwA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wvg | CDP-GLUCOSE4,6-DEHYDRATASE (Salmonellaenterica) |
PF16363(GDP_Man_Dehyd) | 5 | THR A 32LEU A 241GLY A 24VAL A 14VAL A 38 | None | 1.13A | 1phgA-1wvgA:undetectable | 1phgA-1wvgA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1p | ALDEHYDE REDUCTASEII (Sporidiobolussalmonicolor) |
PF01370(Epimerase) | 5 | THR A 131LEU A 32VAL A 28GLY A 254VAL A 204 | NMN A1001 (-4.2A)NoneNoneNoneNone | 1.04A | 1phgA-1y1pA:undetectable | 1phgA-1y1pA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjr | TRNA(GUANOSINE-2'-O-)-METHYLTRANSFERASE (Aquifexaeolicus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 5 | TYR A 117GLY A 162THR A 45VAL A 51VAL A 49 | None | 1.16A | 1phgA-1zjrA:undetectable | 1phgA-1zjrA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfu | PROBABLE2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATEISOMERASE (Thermusthermophilus) |
PF01557(FAA_hydrolase)PF10370(DUF2437) | 6 | THR A 254VAL A 144GLY A 115THR A 187VAL A 189ASP A 240 | None | 1.39A | 1phgA-2dfuA:undetectable | 1phgA-2dfuA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f4l | ACETAMIDASE,PUTATIVE (Thermotogamaritima) |
PF03069(FmdA_AmdA) | 5 | VAL A 128GLY A 127VAL A 196ILE A 198VAL A 69 | None | 1.14A | 1phgA-2f4lA:undetectable | 1phgA-2f4lA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gep | SULFITE REDUCTASEHEMOPROTEIN (Escherichiacoli) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | THR A 92LEU A 137VAL A 140GLY A 141ILE A 91 | None | 1.18A | 1phgA-2gepA:undetectable | 1phgA-2gepA:22.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 7 | PHE A 87TYR A 96LEU A 244GLY A 248THR A 252VAL A 396ILE A 395 | CAM A 502 (-4.6A)CAM A 502 (-4.5A)HEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)NoneNone | 1.36A | 1phgA-2m56A:67.7 | 1phgA-2m56A:99.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 11 | PHE A 87TYR A 96THR A 185LEU A 244VAL A 247GLY A 248THR A 252VAL A 295ASP A 297ILE A 395VAL A 396 | CAM A 502 (-4.6A)CAM A 502 (-4.5A)NoneHEM A 501 (-4.5A)NoneHEM A 501 (-3.9A)HEM A 501 (-3.4A)HEM A 501 (-4.6A)HEM A 501 (-2.8A)NoneNone | 0.28A | 1phgA-2m56A:67.7 | 1phgA-2m56A:99.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m5y | PUTATIVE TUBERCULINRELATED PEPTIDE (Mycobacteriumtuberculosis) |
PF13399(LytR_C) | 5 | LEU A 98GLY A 95VAL A 37ILE A 117VAL A 116 | None | 1.20A | 1phgA-2m5yA:undetectable | 1phgA-2m5yA:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nty | RAC-LIKE GTP-BINDINGPROTEIN ARAC5 (Arabidopsisthaliana) |
PF00071(Ras) | 5 | PHE C 170THR C 11GLY C 18VAL C 116ILE C 82 | NoneNoneGDP C1200 (-2.6A)NoneNone | 1.14A | 1phgA-2ntyC:undetectable | 1phgA-2ntyC:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obn | HYPOTHETICAL PROTEIN (Trichormusvariabilis) |
PF07755(DUF1611)PF17396(DUF1611_N) | 5 | VAL A 157GLY A 158THR A 159ILE A 282VAL A 281 | None | 1.12A | 1phgA-2obnA:undetectable | 1phgA-2obnA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8n | GLUCOSE-6-PHOSPHATEISOMERASE (Thermotogamaritima) |
PF00342(PGI) | 5 | VAL A 205GLY A 206VAL A 109ASP A 111VAL A 71 | None | 0.86A | 1phgA-2q8nA:undetectable | 1phgA-2q8nA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkc | HEMAGGLUTININ (Measlesmorbillivirus) |
PF00423(HN) | 5 | PHE A 319VAL A 367GLY A 411THR A 369ILE A 306 | None | 1.05A | 1phgA-2rkcA:undetectable | 1phgA-2rkcA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xrm | INTRACELLULARSUBTILISIN PROTEASE (Bacillusclausii) |
PF00082(Peptidase_S8) | 5 | THR A 151VAL A 94GLY A 258ILE A 150VAL A 178 | None | 1.19A | 1phgA-2xrmA:undetectable | 1phgA-2xrmA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yps | SORTING NEXIN-3 (Homo sapiens) |
PF00787(PX) | 5 | PHE A 144LEU A 92GLY A 121ILE A 51VAL A 33 | None | 1.17A | 1phgA-2ypsA:undetectable | 1phgA-2ypsA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | THR A 310GLY A 279THR A 358VAL A 328ILE A 309 | None | 1.17A | 1phgA-3afgA:undetectable | 1phgA-3afgA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3alx | HEMAGGLUTININ,LINKER,CDW150 (Measlesmorbillivirus;Saguinusoedipus;syntheticconstruct) |
PF00423(HN)PF06214(SLAM) | 5 | PHE A 319VAL A 367GLY A 411THR A 369ILE A 306 | None | 0.97A | 1phgA-3alxA:undetectable | 1phgA-3alxA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3axi | OLIGO-1,6-GLUCOSIDASE IMA1 (Saccharomycescerevisiae) |
PF00128(Alpha-amylase) | 5 | PHE A 62TYR A 63VAL A 209GLY A 211ILE A 59 | None | 1.13A | 1phgA-3axiA:undetectable | 1phgA-3axiA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A1051GLY A1151ASP A1117ILE A1118VAL A1121 | None | 1.16A | 1phgA-3c1xA:undetectable | 1phgA-3c1xA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzz | PUTATIVE PYRIDOXAL5'-PHOSPHATE-DEPENDENT C-S LYASE (Lactobacillusdelbrueckii) |
PF00155(Aminotran_1_2) | 5 | PHE A 337LEU A 347VAL A 325ILE A 327VAL A 312 | None | 1.22A | 1phgA-3dzzA:undetectable | 1phgA-3dzzA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f9t | L-TYROSINEDECARBOXYLASE MFNA (Methanocaldococcusjannaschii) |
PF00282(Pyridoxal_deC) | 5 | LEU A 99GLY A 138ASP A 206ILE A 175VAL A 127 | NoneNonePLP A 500 (-2.6A)NoneNone | 1.13A | 1phgA-3f9tA:undetectable | 1phgA-3f9tA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fn4 | NAD-DEPENDENTFORMATEDEHYDROGENASE (Moraxella sp.) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 6 | LEU A 217VAL A 194GLY A 195THR A 252VAL A 155VAL A 158 | None | 1.41A | 1phgA-3fn4A:undetectable | 1phgA-3fn4A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7k | 3-METHYLITACONATEISOMERASE (Eubacteriumbarkeri) |
PF04303(PrpF) | 5 | THR A 320VAL A 199THR A 311ILE A 321VAL A 322 | None | 1.21A | 1phgA-3g7kA:undetectable | 1phgA-3g7kA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbx | GLUTAMATEDECARBOXYLASE 1 (Arabidopsisthaliana) |
PF00282(Pyridoxal_deC) | 5 | PHE A 108GLY A 211ASP A 262ILE A 271VAL A 243 | None | 1.19A | 1phgA-3hbxA:undetectable | 1phgA-3hbxA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j7y | BL21 (Homo sapiens) |
PF00829(Ribosomal_L21p) | 5 | LEU S 149VAL S 136THR S 142VAL S 83ILE S 87 | None | 1.12A | 1phgA-3j7yS:undetectable | 1phgA-3j7yS:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF11 (Schizosaccharomycespombe) |
PF13087(AAA_12)PF16399(Aquarius_N) | 5 | PHE X1120VAL X1166GLY X1167ILE X1182VAL X1181 | None | 1.16A | 1phgA-3jb9X:undetectable | 1phgA-3jb9X:16.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3oft | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | LEU A 87GLY A 234THR A 238VAL A 281VAL A 384 | HEM A 417 (-4.1A)HEM A 417 (-4.0A)HEM A 417 (-3.6A)HEM A 417 ( 4.8A)None | 1.00A | 1phgA-3oftA:50.4 | 1phgA-3oftA:42.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pco | PHENYLALANYL-TRNASYNTHETASE, BETACHAIN (Escherichiacoli) |
PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 5 | GLY B 112VAL B 64ASP B 76ILE B 77VAL B 78 | None | 1.21A | 1phgA-3pcoB:undetectable | 1phgA-3pcoB:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q2r | GLIOMAPATHOGENESIS-RELATEDPROTEIN 1 (Homo sapiens) |
PF00188(CAP) | 5 | VAL A 149GLY A 150VAL A 110ASP A 36ILE A 40 | None | 1.18A | 1phgA-3q2rA:undetectable | 1phgA-3q2rA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s0x | PEPTIDASE A24B, FLAKDOMAIN PROTEIN (Methanococcusmaripaludis) |
PF01478(Peptidase_A24)PF06847(Arc_PepC_II) | 5 | THR A 710LEU A 532GLY A 507VAL A 617ILE A 709 | None | 1.20A | 1phgA-3s0xA:undetectable | 1phgA-3s0xA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t4x | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY (Bacillusanthracis) |
PF00106(adh_short) | 5 | GLY A 117THR A 121VAL A 179ILE A 137VAL A 136 | None | 0.92A | 1phgA-3t4xA:undetectable | 1phgA-3t4xA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tha | TRYPTOPHAN SYNTHASEALPHA CHAIN (Campylobacterjejuni) |
PF00290(Trp_syntA) | 5 | PHE A 105VAL A 46GLY A 45VAL A 119ILE A 97 | None | 1.15A | 1phgA-3thaA:undetectable | 1phgA-3thaA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsd | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH)PF00571(CBS) | 5 | LEU A 290GLY A 279THR A 252ASP A 262VAL A 229 | None | 1.18A | 1phgA-3tsdA:undetectable | 1phgA-3tsdA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wsv | L-LACTATEDEHYDROGENASE (Enterococcusmundtii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | THR A 102VAL A 120VAL A 109ILE A 105VAL A 106 | None | 1.08A | 1phgA-3wsvA:undetectable | 1phgA-3wsvA:23.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zby | P450 HEME-THIOLATEPROTEIN (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | LEU A 229GLY A 233THR A 237VAL A 280VAL A 383 | HEM A1402 ( 4.6A)EDO A1406 ( 3.4A)HEM A1402 (-3.7A)HEM A1402 (-4.4A)None | 1.03A | 1phgA-3zbyA:42.4 | 1phgA-3zbyA:30.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zgb | PHOSPHOENOLPYRUVATECARBOXYLASE (Flaveriapringlei) |
PF00311(PEPcase) | 5 | PHE A 816GLY A 789THR A 861VAL A 823ILE A 820 | None | 1.07A | 1phgA-3zgbA:undetectable | 1phgA-3zgbA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2p | RETINOIC ACIDINDUCIBLE PROTEIN I (Anasplatyrhynchos) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | PHE A 369LEU A 299VAL A 349ILE A 341VAL A 337 | None | 1.17A | 1phgA-4a2pA:undetectable | 1phgA-4a2pA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ano | ESSB (Geobacillusthermodenitrificans) |
PF10140(YukC) | 5 | LEU A 103VAL A 127GLY A 126VAL A 62ILE A 53 | None | 0.98A | 1phgA-4anoA:undetectable | 1phgA-4anoA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ano | ESSB (Geobacillusthermodenitrificans) |
PF10140(YukC) | 5 | VAL A 125GLY A 126VAL A 24ILE A 64VAL A 62 | None | 1.18A | 1phgA-4anoA:undetectable | 1phgA-4anoA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4by9 | NOP5/NOP56 RELATEDPROTEIN (Pyrococcusfuriosus) |
PF01798(Nop) | 5 | LEU C 253VAL C 257GLY C 258VAL C 307ILE C 308 | None | 1.00A | 1phgA-4by9C:undetectable | 1phgA-4by9C:21.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 9 | TYR A 98THR A 187LEU A 252GLY A 256THR A 260VAL A 303ASP A 305ILE A 403VAL A 404 | NoneNoneHEM A1418 (-4.0A)HEM A1418 (-3.8A)HEM A1418 (-3.6A)GOL A1419 (-3.9A)HEM A1418 (-2.7A)NoneGOL A1419 (-3.5A) | 0.57A | 1phgA-4c9mA:58.7 | 1phgA-4c9mA:44.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckm | SAS-6 (Leishmaniamajor) |
PF16531(SAS-6_N) | 5 | LEU A 177VAL A 157GLY A 156THR A 138ILE A 223 | None | 0.96A | 1phgA-4ckmA:undetectable | 1phgA-4ckmA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckn | SAS-6 (Leishmaniamajor) |
PF16531(SAS-6_N) | 5 | LEU A 177VAL A 157GLY A 156THR A 138ILE A 223 | None | 1.07A | 1phgA-4cknA:undetectable | 1phgA-4cknA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d8u | D-CYSTEINEDESULFHYDRASE (Salmonellaenterica) |
PF00291(PALP) | 5 | THR A 315LEU A 275GLY A 289VAL A 190ILE A 313 | LLP A 51 ( 3.4A)NoneNoneNoneNone | 1.14A | 1phgA-4d8uA:undetectable | 1phgA-4d8uA:23.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 6 | PHE A 87GLY A 254THR A 258VAL A 301ILE A 401VAL A 402 | NonePEG A 502 (-3.8A)HEM A 501 (-3.7A)PEG A 502 ( 4.5A)NoneNone | 0.81A | 1phgA-4dxyA:52.0 | 1phgA-4dxyA:46.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 6 | PHE A 87LEU A 250GLY A 254THR A 258VAL A 301ILE A 401 | NoneHEM A 501 (-4.3A)PEG A 502 (-3.8A)HEM A 501 (-3.7A)PEG A 502 ( 4.5A)None | 1.06A | 1phgA-4dxyA:52.0 | 1phgA-4dxyA:46.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g38 | SULFITE REDUCTASE[NADPH] HEMOPROTEINBETA-COMPONENT (Escherichiacoli) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | THR A 92LEU A 137VAL A 140GLY A 141ILE A 91 | None | 1.19A | 1phgA-4g38A:undetectable | 1phgA-4g38A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ggv | CYTOCHROME P450SUPERFAMILY PROTEIN (Streptomyceshimastatinicus) |
PF00067(p450) | 5 | THR A 109LEU A 354VAL A 358GLY A 356ILE A 108 | None | 1.18A | 1phgA-4ggvA:35.5 | 1phgA-4ggvA:25.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6y | FERM, RHOGEF ANDPLECKSTRINDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00169(PH)PF00621(RhoGEF) | 5 | PHE A 998VAL A 954GLY A 937VAL A1023ILE A1024 | None | 1.19A | 1phgA-4h6yA:undetectable | 1phgA-4h6yA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kdw | ANTIFREEZE PROTEIN (Marinomonasprimoryensis) |
no annotation | 5 | THR A 56GLY A 32VAL A 83ASP A 43VAL A 45 | NoneNoneNoneGOL A 208 (-4.4A)None | 1.16A | 1phgA-4kdwA:undetectable | 1phgA-4kdwA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kg7 | PEPTIDASE S8 ANDS53, SUBTILISIN,KEXIN, SEDOLISIN (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | VAL A 284GLY A 285THR A 340VAL A 203ILE A 200 | None | 1.03A | 1phgA-4kg7A:undetectable | 1phgA-4kg7A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l7z | HPCH/HPAI ALDOLASE (Chloroflexusaurantiacus) |
PF03328(HpcH_HpaI) | 5 | LEU A 59VAL A 91GLY A 57VAL A 78VAL A 79 | None | 1.06A | 1phgA-4l7zA:undetectable | 1phgA-4l7zA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mmo | SSO-CP2METALLO-CARBOXYPETIDASE (Sulfolobussolfataricus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | PHE A 386TYR A 69VAL A 53THR A 48ILE A 148 | None | 1.09A | 1phgA-4mmoA:undetectable | 1phgA-4mmoA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n91 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Anaerococcusprevotii) |
PF03480(DctP) | 5 | THR A 147GLY A 48VAL A 93ASP A 242VAL A 244 | NoneNoneNoneGCU A 401 ( 2.7A)None | 0.95A | 1phgA-4n91A:undetectable | 1phgA-4n91A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nk7 | SERINE/THREONINE-PROTEIN KINASE PLK4 (Drosophilamelanogaster) |
no annotation | 5 | LEU A 409GLY A 412THR A 391VAL A 495VAL A 492 | None | 1.13A | 1phgA-4nk7A:undetectable | 1phgA-4nk7A:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p99 | MPAFP_RIITETRA-TANDEMER (Marinomonasprimoryensis) |
no annotation | 5 | THR A 56GLY A 32VAL A 83ASP A 43VAL A 45 | NoneNoneNone CA A 510 ( 4.9A)None | 1.18A | 1phgA-4p99A:undetectable | 1phgA-4p99A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p99 | MPAFP_RIITETRA-TANDEMER (Marinomonasprimoryensis) |
no annotation | 5 | THR A 160GLY A 136VAL A 187ASP A 147VAL A 149 | NoneNoneNone CA A 507 ( 4.9A)None | 1.14A | 1phgA-4p99A:undetectable | 1phgA-4p99A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p99 | MPAFP_RIITETRA-TANDEMER (Marinomonasprimoryensis) |
no annotation | 5 | THR A 264GLY A 240VAL A 291ASP A 251VAL A 253 | NoneNoneNone CA A 520 ( 4.7A)None | 1.17A | 1phgA-4p99A:undetectable | 1phgA-4p99A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p99 | MPAFP_RIITETRA-TANDEMER (Marinomonasprimoryensis) |
no annotation | 5 | THR A 368GLY A 344VAL A 395ASP A 355VAL A 357 | None | 1.17A | 1phgA-4p99A:undetectable | 1phgA-4p99A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pka | PATATIN-17 (Solanumcardiophyllum) |
PF01734(Patatin) | 5 | PHE X 114GLY X 36THR X 260ASP X 332ILE X 39 | NoneMIS X 77 ( 3.4A)NoneNoneNone | 1.16A | 1phgA-4pkaX:undetectable | 1phgA-4pkaX:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1p | UNCHARACTERIZEDPROTEIN (Slackiaheliotrinireducens) |
PF13472(Lipase_GDSL_2) | 5 | PHE A 131THR A 103LEU A 38GLY A 7THR A 11 | None | 1.04A | 1phgA-4s1pA:undetectable | 1phgA-4s1pA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1p | UNCHARACTERIZEDPROTEIN (Slackiaheliotrinireducens) |
PF13472(Lipase_GDSL_2) | 5 | TYR A 80THR A 103LEU A 38GLY A 7THR A 11 | None | 1.11A | 1phgA-4s1pA:undetectable | 1phgA-4s1pA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u02 | AMINO ACID ABCTRANSPORTER,ATP-BINDING PROTEIN (Thermusthermophilus) |
PF00005(ABC_tran) | 5 | THR A 195LEU A 242GLY A 199VAL A 208VAL A 34 | None | 1.21A | 1phgA-4u02A:undetectable | 1phgA-4u02A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wxa | EKC/KEOPS COMPLEXSUBUNIT GON7 (Saccharomycescerevisiae) |
PF08738(Gon7) | 5 | PHE D 18GLY D 87THR D 86ASP D 80ILE D 81 | None | 1.13A | 1phgA-4wxaD:undetectable | 1phgA-4wxaD:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ymw | ABC-TYPE POLAR AMINOACID TRANSPORTSYSTEM, ATPASECOMPONENT (Caldanaerobactersubterraneus) |
no annotation | 5 | THR J 188LEU J 22VAL J 24VAL J 79VAL J 157 | None | 1.15A | 1phgA-4ymwJ:undetectable | 1phgA-4ymwJ:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aca | VP3 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 5 | PHE 3 76THR 3 74VAL 3 203VAL 3 122VAL 3 188 | None | 1.17A | 1phgA-5aca3:undetectable | 1phgA-5aca3:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aee | ALPHA-GLUCOSIDASEYIHQ (Escherichiacoli) |
PF01055(Glyco_hydro_31) | 5 | PHE A 207LEU A 148GLY A 133THR A 496ILE A 129 | None | 1.08A | 1phgA-5aeeA:undetectable | 1phgA-5aeeA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Geobactersulfurreducens) |
PF13847(Methyltransf_31) | 5 | LEU A 26GLY A 30VAL A 41ASP A 43VAL A 107 | NoneNoneNoneSAH A 301 ( 4.5A)None | 0.86A | 1phgA-5bp7A:undetectable | 1phgA-5bp7A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5btb | AFR263CP (Eremotheciumgossypii) |
PF08652(RAI1) | 5 | THR A 316LEU A 18VAL A 205GLY A 204VAL A 109 | None | 1.22A | 1phgA-5btbA:undetectable | 1phgA-5btbA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ddb | MENIN (Homo sapiens) |
PF05053(Menin) | 5 | PHE A 146GLY A 99VAL A 121ILE A 125VAL A 124 | None | 1.20A | 1phgA-5ddbA:undetectable | 1phgA-5ddbA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | LEU A 25GLY A 29VAL A 40ASP A 42VAL A 106 | NoneNoneNoneSAH A 301 ( 4.5A)None | 0.88A | 1phgA-5epeA:undetectable | 1phgA-5epeA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eul | PROTEIN TRANSLOCASESUBUNIT SECY (Geobacillusthermodenitrificans) |
PF00344(SecY) | 5 | PHE Y 374VAL Y 406GLY Y 407VAL Y 266ILE Y 234 | None | 0.84A | 1phgA-5eulY:undetectable | 1phgA-5eulY:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fgl | NICR (Pseudomonasputida) |
PF00440(TetR_N) | 5 | THR A 107VAL A 177GLY A 180ILE A 110VAL A 111 | None | 1.06A | 1phgA-5fglA:undetectable | 1phgA-5fglA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5flz | TUBULIN GAMMA CHAIN (Saccharomycescerevisiae) |
PF00091(Tubulin)PF03953(Tubulin_C) | 5 | PHE C 204LEU C 139VAL C 17GLY C 18ILE C 234 | None | 1.20A | 1phgA-5flzC:undetectable | 1phgA-5flzC:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1 (Saccharomycescerevisiae) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | VAL A1311GLY A1310THR A1308VAL A1118ILE A1327 | None | 1.14A | 1phgA-5ip9A:undetectable | 1phgA-5ip9A:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irb | RTX-ADHESIN (Marinomonasprimoryensis) |
no annotation | 5 | THR A 446GLY A 422VAL A 473ASP A 433VAL A 435 | None | 1.18A | 1phgA-5irbA:undetectable | 1phgA-5irbA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k53 | ALDEHYDEDEFORMYLATINGOXYGENASE (Oscillatoriasp.) |
PF11266(Ald_deCOase) | 5 | TYR A 17LEU A 74VAL A 76VAL A 28ILE A 24 | NoneNoneNoneSTE A 502 ( 4.8A)STE A 502 (-4.4A) | 1.16A | 1phgA-5k53A:undetectable | 1phgA-5k53A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8g | ANTIFREEZE PROTEIN (Marinomonasprimoryensis) |
no annotation | 5 | THR A 56GLY A 32VAL A 84ASP A 43VAL A 45 | NoneNoneNone CA A 615 ( 4.7A)None | 1.14A | 1phgA-5k8gA:undetectable | 1phgA-5k8gA:21.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kyo | CYP101J2 (Sphingobiumyanoikuyae) |
PF00067(p450) | 6 | VAL A 249GLY A 250THR A 254VAL A 297ILE A 397VAL A 398 | NoneHEM A 501 (-3.8A)HEM A 501 (-3.5A)HEM A 501 (-4.3A)NoneNone | 0.98A | 1phgA-5kyoA:50.4 | 1phgA-5kyoA:40.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kyo | CYP101J2 (Sphingobiumyanoikuyae) |
PF00067(p450) | 6 | VAL A 249GLY A 251THR A 254VAL A 297ILE A 397VAL A 398 | NoneHEM A 501 (-3.3A)HEM A 501 (-3.5A)HEM A 501 (-4.3A)NoneNone | 1.00A | 1phgA-5kyoA:50.4 | 1phgA-5kyoA:40.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ocp | - (-) |
no annotation | 5 | LEU A 33VAL A 3GLY A 4VAL A 87VAL A 85 | None | 1.12A | 1phgA-5ocpA:undetectable | 1phgA-5ocpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sy5 | ARYL HYDROCARBONRECEPTOR NUCLEARTRANSLOCATOR (Mus musculus) |
PF00010(HLH)PF00989(PAS)PF14598(PAS_11) | 5 | LEU A 225VAL A 179GLY A 184THR A 208VAL A 213 | None | 1.08A | 1phgA-5sy5A:undetectable | 1phgA-5sy5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sy5 | ARYL HYDROCARBONRECEPTOR NUCLEARTRANSLOCATOR (Mus musculus) |
PF00010(HLH)PF00989(PAS)PF14598(PAS_11) | 5 | PHE A 263VAL A 179GLY A 184THR A 208VAL A 213 | None | 1.09A | 1phgA-5sy5A:undetectable | 1phgA-5sy5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t96 | HE PROTEIN (Salmon isavirus) |
PF06215(ISAV_HA) | 5 | THR A 157GLY A 135VAL A 160ILE A 158VAL A 159 | NoneNoneNoneFMT A 406 (-4.2A)None | 1.22A | 1phgA-5t96A:undetectable | 1phgA-5t96A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udb | DNA REPLICATIONLICENSING FACTORMCM3 (Saccharomycescerevisiae) |
PF00493(MCM)PF17207(MCM_OB) | 5 | THR 3 432VAL 3 440GLY 3 441VAL 3 512VAL 3 470 | None | 1.17A | 1phgA-5udb3:undetectable | 1phgA-5udb3:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuw | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Bacillusanthracis) |
PF00478(IMPDH) | 5 | LEU A 290GLY A 279THR A 252ASP A 262VAL A 229 | NoneNone8N1 A 502 (-2.9A)NoneNone | 1.19A | 1phgA-5uuwA:undetectable | 1phgA-5uuwA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uv2 | (+)-LIMONENESYNTHASE (Citrus sinensis) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | PHE A 484THR A 446THR A 340ASP A 488ILE A 445 | LA6 A 704 (-4.6A)LA6 A 704 (-3.5A)LA6 A 704 (-3.4A) MN A 703 ( 2.8A)None | 0.98A | 1phgA-5uv2A:undetectable | 1phgA-5uv2A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vm1 | XYLULOKINASE (Brucella ovis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | LEU A 31VAL A 12GLY A 29THR A 54ILE A 49 | None | 1.11A | 1phgA-5vm1A:undetectable | 1phgA-5vm1A:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wa2 | SURFACE ANTIGEN (Toxoplasmagondii) |
no annotation | 5 | LEU A 307VAL A 308GLY A 309VAL A 210ILE A 233 | None | 1.12A | 1phgA-5wa2A:undetectable | 1phgA-5wa2A:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5woy | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Caldanaerobactersubterraneus) |
no annotation | 5 | LEU A 130VAL A 133GLY A 134VAL A 89ILE A 86 | None | 1.16A | 1phgA-5woyA:undetectable | 1phgA-5woyA:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bld | CYTOCHROME P450268A2 CYP268A2 (Mycobacteriummarinum) |
no annotation | 5 | LEU A 256VAL A 259GLY A 261THR A 264VAL A 308 | HEM A 501 ( 4.8A)DXJ A 502 (-4.5A)HEM A 501 (-3.6A)HEM A 501 (-3.4A)HEM A 501 ( 4.6A) | 1.08A | 1phgA-6bldA:42.3 | 1phgA-6bldA:11.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6v | TELOMERASE REVERSETRANSCRIPTASETELOMERASE-ASSOCIATED PROTEIN 82 (Tetrahymenathermophila) |
no annotation | 5 | PHE D 590THR A 114GLY A 111ILE A 115VAL A 119 | None | 1.19A | 1phgA-6d6vD:undetectable | 1phgA-6d6vD:9.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eic | MYCOBACTERIUMTUBERCULOSISMONOGLYCERIDE LIPASE (Mycobacteriumtuberculosis) |
no annotation | 5 | LEU C 214VAL C 121GLY C 120VAL C 137VAL C 203 | None | 1.22A | 1phgA-6eicC:undetectable | 1phgA-6eicC:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eic | MYCOBACTERIUMTUBERCULOSISMONOGLYCERIDE LIPASE (Mycobacteriumtuberculosis) |
no annotation | 5 | THR C 206LEU C 214VAL C 121GLY C 120VAL C 137 | None | 1.13A | 1phgA-6eicC:undetectable | 1phgA-6eicC:12.53 |