SIMILAR PATTERNS OF AMINO ACIDS FOR 1PBC_A_BHAA396

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bmt METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 GLY A 865
VAL A 866
LEU A 831
TYR A 775
ALA A 869
 None
None
COB  A 122 (-4.4A)
None
None
 1.25A 1pbcA-1bmtA:
3.3		 1pbcA-1bmtA:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		10 GLY A  46
VAL A  47
TRP A 185
LEU A 199
TYR A 201
LEU A 210
SER A 212
ARG A 214
TYR A 222
ALA A 296
 PHB  A 396 ( 3.6A)
FAD  A 395 (-4.1A)
None
None
PHB  A 396 ( 4.6A)
None
PHB  A 396 ( 2.7A)
PHB  A 396 ( 3.0A)
PHB  A 396 (-4.6A)
FAD  A 395 (-3.6A)
 0.25A 1pbcA-1cj2A:
67.3		 1pbcA-1cj2A:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 GLY A 622
VAL A 623
LEU A 587
TYR A 570
ALA A 510
 None
 1.30A 1pbcA-1dgjA:
undetectable		 1pbcA-1dgjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		5 GLY A 350
LEU A 242
TYR A 238
ARG A 186
TYR A 225
 None
 1.32A 1pbcA-1fn9A:
undetectable		 1pbcA-1fn9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		5 VAL A 237
LEU A 300
TYR A 220
LEU A 296
TYR A 293
 None
 1.30A 1pbcA-1inpA:
undetectable		 1pbcA-1inpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		5 GLY A 286
VAL A 249
LEU A 271
LEU A 308
TYR A 305
 None
 1.21A 1pbcA-1ituA:
undetectable		 1pbcA-1ituA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjv MATURE ALPHA CHAIN
OF MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
ANTIGEN (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 TRP A  51
LEU A   5
SER A 167
ARG A  62
ALA A  34
 None
 1.30A 1pbcA-1kjvA:
undetectable		 1pbcA-1kjvA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lhu SEX HORMONE-BINDING
GLOBULIN

(Homo sapiens) 		PF00054
(Laminin_G_1) 		5 GLY A 145
VAL A  54
TRP A  66
LEU A 157
LEU A 153
 None
 1.31A 1pbcA-1lhuA:
undetectable		 1pbcA-1lhuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  12
VAL A  34
LEU A   9
LEU A 138
ALA A 118
 FAD  A 459 (-3.2A)
FAD  A 459 ( 4.9A)
None
None
FAD  A 459 (-3.6A)
 1.20A 1pbcA-1lvlA:
10.3		 1pbcA-1lvlA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 GLY A 274
VAL A 273
LEU A 265
LEU A 258
ALA A 246
 None
 1.22A 1pbcA-1m2pA:
undetectable		 1pbcA-1m2pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 GLY A 136
VAL A 137
LEU A  79
LEU A 292
ALA A 179
 None
 1.43A 1pbcA-1mt5A:
undetectable		 1pbcA-1mt5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf9 PHENAZINE
BIOSYNTHESIS PROTEIN
PHZD

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		5 GLY A 149
LEU A  12
TYR A  10
LEU A  51
ALA A 152
 None
 1.20A 1pbcA-1nf9A:
undetectable		 1pbcA-1nf9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psw ADP-HEPTOSE LPS
HEPTOSYLTRANSFERASE
II

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 GLY A 184
TRP A 197
LEU A 209
LEU A 205
TYR A 202
 None
 1.39A 1pbcA-1pswA:
3.4		 1pbcA-1pswA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj5 SUCROSE-PHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF05116
(S6PP) 		5 GLY A  56
VAL A  55
LEU A  51
LEU A  10
TYR A  39
 None
 1.28A 1pbcA-1tj5A:
undetectable		 1pbcA-1tj5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE

(Mycobacterium
tuberculosis) 		PF01451
(LMWPc) 		5 GLY A  77
VAL A  76
LEU A  97
LEU A  86
ALA A  43
 None
 1.27A 1pbcA-1u2qA:
3.6		 1pbcA-1u2qA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		5 GLY A  75
VAL A  56
TRP A 103
LEU A  44
ALA A  51
 None
 1.43A 1pbcA-1ua4A:
3.0		 1pbcA-1ua4A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 GLY A 250
VAL A 249
LEU A  60
LEU A 173
TYR A 172
 None
 0.99A 1pbcA-1uzrA:
undetectable		 1pbcA-1uzrA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		5 GLY A 227
TRP A 360
LEU A 306
TYR A 304
LEU A 361
 None
 1.41A 1pbcA-1wcgA:
undetectable		 1pbcA-1wcgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		5 GLY A 137
LEU A  49
SER A  36
TYR A  50
ALA A 135
 None
 1.36A 1pbcA-1wd3A:
undetectable		 1pbcA-1wd3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4h RNA-BINDING PROTEIN
28

(Mus musculus) 		PF00076
(RRM_1) 		5 GLY A  33
VAL A  35
LEU A  88
LEU A  23
SER A  27
 None
 1.03A 1pbcA-1x4hA:
undetectable		 1pbcA-1x4hA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 5 GLY P  78
VAL P  77
LEU P  70
LEU P  66
ALA P 284
 None
 1.40A 1pbcA-2btvP:
undetectable		 1pbcA-2btvP:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		5 GLY A 223
VAL A 222
LEU A 191
LEU A 193
TYR A 269
 None
 1.34A 1pbcA-2c1cA:
undetectable		 1pbcA-2c1cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee7 SPERM FLAGELLAR
PROTEIN 1

(Homo sapiens) 		PF06294
(CH_2) 		5 GLY A 105
VAL A 107
LEU A  36
SER A  37
TYR A  21
 None
 1.25A 1pbcA-2ee7A:
undetectable		 1pbcA-2ee7A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fep CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		5 GLY A 120
VAL A 118
LEU A 114
LEU A 110
SER A 139
 None
 1.27A 1pbcA-2fepA:
undetectable		 1pbcA-2fepA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 GLY A  72
VAL A  37
LEU A  44
LEU A  80
ALA A 100
 None
 0.88A 1pbcA-2gkoA:
undetectable		 1pbcA-2gkoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		5 GLY A 142
VAL A 141
LEU A  66
TYR A 122
ALA A 102
 None
None
WO4  A 401 (-4.1A)
None
None
 1.16A 1pbcA-2i34A:
undetectable		 1pbcA-2i34A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 VAL A 130
LEU A 122
LEU A 118
TYR A 115
ALA A  74
 None
 1.37A 1pbcA-2i9uA:
undetectable		 1pbcA-2i9uA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 145
VAL A 147
LEU A 224
LEU A 277
ALA A 150
 None
 1.09A 1pbcA-2iwiA:
undetectable		 1pbcA-2iwiA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		5 GLY A 119
VAL A 254
LEU A 114
LEU A  72
ALA A 123
 None
 1.41A 1pbcA-2jh3A:
undetectable		 1pbcA-2jh3A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		5 VAL A  41
LEU A  66
LEU A 158
TYR A 161
ALA A 127
 None
 1.41A 1pbcA-2nt8A:
undetectable		 1pbcA-2nt8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q34 CURF

(Moorea
producens) 		PF00378
(ECH_1) 		5 VAL A 129
LEU A 124
LEU A 120
TYR A 137
ALA A 109
 None
 1.36A 1pbcA-2q34A:
undetectable		 1pbcA-2q34A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG

(Helicobacter
pylori) 		PF00004
(AAA) 		5 GLY A 205
VAL A 313
LEU A 297
LEU A 327
ALA A 315
 None
 1.39A 1pbcA-2r62A:
undetectable		 1pbcA-2r62A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyf REPLICATIVE DNA
HELICASE

(Geobacillus
kaustophilus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 GLY A  84
VAL A  83
LEU A  89
LEU A  92
ALA A  47
 None
 1.27A 1pbcA-2vyfA:
undetectable		 1pbcA-2vyfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		5 GLY A  90
VAL A 120
LEU A  93
TYR A  85
ALA A 137
 None
 1.22A 1pbcA-2w8iA:
undetectable		 1pbcA-2w8iA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlt L-ASPARAGINASE

(Helicobacter
pylori) 		PF00710
(Asparaginase) 		5 GLY A  35
VAL A  36
LEU A  40
LEU A 135
ALA A  12
 None
 1.23A 1pbcA-2wltA:
undetectable		 1pbcA-2wltA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		5 GLY C  81
VAL C  80
LEU C 109
LEU C 359
TYR C 357
 None
 1.16A 1pbcA-2wy0C:
undetectable		 1pbcA-2wy0C:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		5 GLY A 246
VAL A 247
LEU A 393
LEU A 379
ALA A 251
 None
 0.97A 1pbcA-2x9pA:
undetectable		 1pbcA-2x9pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 GLY A1041
LEU A1136
TYR A1132
LEU A1103
TYR A1099
 None
 1.41A 1pbcA-2xkkA:
undetectable		 1pbcA-2xkkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xws SIROHYDROCHLORIN
COBALTOCHELATASE

(Archaeoglobus
fulgidus) 		PF01903
(CbiX) 		5 GLY A   9
VAL A   8
LEU A  79
LEU A  82
ALA A  40
 None
 1.36A 1pbcA-2xwsA:
undetectable		 1pbcA-2xwsA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 VAL A  34
LEU A 138
LEU A 257
ARG A 261
ALA A  31
 None
 1.24A 1pbcA-2yr0A:
undetectable		 1pbcA-2yr0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A 217
VAL A 216
LEU A 248
LEU A 288
ALA A 269
 None
 1.22A 1pbcA-2zxoA:
undetectable		 1pbcA-2zxoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 GLY A  72
VAL A  37
LEU A  44
LEU A  80
ALA A 101
 None
 0.93A 1pbcA-3d43A:
2.1		 1pbcA-3d43A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dea CUTINASE

(Colletotrichum
gloeosporioides) 		PF01083
(Cutinase) 		5 GLY A 159
VAL A 131
LEU A  75
TYR A  79
ALA A 129
 None
 1.31A 1pbcA-3deaA:
undetectable		 1pbcA-3deaA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		5 GLY A 104
VAL A  81
LEU A 151
LEU A 126
ALA A  79
 None
 1.25A 1pbcA-3dmpA:
undetectable		 1pbcA-3dmpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		5 VAL A  41
LEU A  66
LEU A 158
TYR A 161
ALA A 127
 None
 1.37A 1pbcA-3gajA:
undetectable		 1pbcA-3gajA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		5 GLY A 269
VAL A 244
LEU A 278
TYR A 200
ALA A 273
 None
 1.35A 1pbcA-3io0A:
undetectable		 1pbcA-3io0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 GLY A 123
VAL A 124
LEU A 346
LEU A 220
SER A 342
 None
 1.19A 1pbcA-3js8A:
undetectable		 1pbcA-3js8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2m PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF00017
(SH2) 		5 VAL A 151
LEU A 169
LEU A 160
SER A 183
ALA A 155
 None
 1.37A 1pbcA-3k2mA:
undetectable		 1pbcA-3k2mA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 GLY A  24
VAL A  23
LEU A 202
LEU A 347
ALA A 289
 LEU  A 601 ( 3.4A)
NA  A 752 (-4.5A)
None
None
None
 1.18A 1pbcA-3mpnA:
undetectable		 1pbcA-3mpnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc5 TOXIN COREGULATED
PILUS BIOSYNTHESIS
PROTEIN F

(Vibrio cholerae) 		PF06340
(TcpF) 		5 VAL A 168
LEU A 118
TYR A 135
LEU A 127
ALA A 166
 None
 1.36A 1pbcA-3oc5A:
undetectable		 1pbcA-3oc5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 VAL A 283
TRP A 262
LEU A 274
LEU A 291
ALA A 183
 None
 1.42A 1pbcA-3p2mA:
undetectable		 1pbcA-3p2mA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		5 GLY A 383
LEU A 465
LEU A 495
TYR A 510
ALA A 377
 None
 0.99A 1pbcA-3pgbA:
undetectable		 1pbcA-3pgbA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		5 GLY A 167
LEU A 155
LEU A 185
TYR A 186
ALA A 140
 None
 1.21A 1pbcA-3rysA:
undetectable		 1pbcA-3rysA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		5 VAL A 277
LEU A  38
TYR A  34
LEU A  58
ALA A 271
 None
 1.35A 1pbcA-3s6dA:
undetectable		 1pbcA-3s6dA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		5 GLY A 172
VAL A 171
LEU A 308
LEU A 305
ALA A 298
 None
None
None
UNL  A 601 ( 4.5A)
None
 1.27A 1pbcA-3tsnA:
3.0		 1pbcA-3tsnA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyr TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF13443
(HTH_26) 		5 GLY A  48
VAL A  47
LEU A  43
LEU A  57
ALA A  70
 None
 1.29A 1pbcA-3tyrA:
undetectable		 1pbcA-3tyrA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 332
VAL A 250
LEU A 233
LEU A 306
ALA A 248
 None
 1.07A 1pbcA-3u0oA:
undetectable		 1pbcA-3u0oA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		5 VAL A 169
TRP A 188
LEU A 156
TYR A 152
TYR A 192
 None
 1.33A 1pbcA-3uetA:
undetectable		 1pbcA-3uetA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLY A 149
VAL A 150
TYR A 186
LEU A 196
ALA A 146
 None
 0.89A 1pbcA-3uggA:
undetectable		 1pbcA-3uggA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 GLY A 114
VAL A 113
LEU A  67
LEU A 178
ALA A 136
 None
 1.03A 1pbcA-3uhjA:
undetectable		 1pbcA-3uhjA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 427
VAL A 415
LEU A 148
LEU A 446
TYR A 452
 None
 1.40A 1pbcA-3uk1A:
undetectable		 1pbcA-3uk1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		5 GLY A  20
VAL A  21
LEU A  56
LEU A  53
ALA A  26
 None
 1.35A 1pbcA-3uoeA:
undetectable		 1pbcA-3uoeA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		5 GLY A  25
VAL A  26
LEU A  21
LEU A  52
ALA A  29
 None
 1.33A 1pbcA-3uzuA:
2.6		 1pbcA-3uzuA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		5 GLY B 409
TRP B 456
LEU B 416
SER B 414
ALA B 405
 None
 1.31A 1pbcA-3zg8B:
undetectable		 1pbcA-3zg8B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 GLY A 225
VAL A  39
LEU A 199
LEU A 200
ALA A  35
 None
 1.36A 1pbcA-3zh4A:
undetectable		 1pbcA-3zh4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 GLY A  35
VAL A  36
LEU A   4
SER A   2
ALA A  31
 None
 1.13A 1pbcA-4ac0A:
undetectable		 1pbcA-4ac0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eih ABELSON
TYROSINE-PROTEIN
KINASE 2

(Homo sapiens) 		PF00017
(SH2) 		5 VAL A 178
LEU A 196
LEU A 187
SER A 210
ALA A 182
 None
 1.24A 1pbcA-4eihA:
undetectable		 1pbcA-4eihA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A 635
LEU A 498
LEU A 502
SER A 584
ALA A 631
 None
 1.42A 1pbcA-4g3fA:
undetectable		 1pbcA-4g3fA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Methylobacillus
flagellatus) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 GLY A 160
VAL A 159
LEU A 182
LEU A 134
ALA A  97
 None
 1.29A 1pbcA-4gltA:
undetectable		 1pbcA-4gltA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 633
LEU A 496
LEU A 500
SER A 582
ALA A 629
 None
 1.42A 1pbcA-4idtA:
undetectable		 1pbcA-4idtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 223
LEU A 180
TYR A 169
LEU A 170
ALA A 219
 None
 1.42A 1pbcA-4jwgA:
2.7		 1pbcA-4jwgA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8t UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF01843
(DIL) 		5 VAL A1691
TRP A1639
LEU A1670
LEU A1640
ALA A1651
 None
 1.06A 1pbcA-4l8tA:
undetectable		 1pbcA-4l8tA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		5 GLY A 938
VAL A 937
LEU A 454
LEU A 873
TYR A 874
 None
 1.12A 1pbcA-4mt1A:
undetectable		 1pbcA-4mt1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Salmonella
enterica) 		PF04390
(LptE) 		5 GLY B  45
LEU B  77
LEU B  38
SER B  40
ALA B  50
 None
 0.96A 1pbcA-4n4rB:
undetectable		 1pbcA-4n4rB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhr LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Escherichia
coli) 		PF04390
(LptE) 		5 GLY A  45
LEU A  77
LEU A  38
SER A  40
ALA A  50
 None
 1.09A 1pbcA-4nhrA:
undetectable		 1pbcA-4nhrA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		5 GLY A  25
VAL A  26
LEU A  54
ARG A   5
ALA A  22
 None
 1.21A 1pbcA-4q2hA:
undetectable		 1pbcA-4q2hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6k SOLUTE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF13416
(SBP_bac_8) 		5 TRP A 150
LEU A 162
LEU A 158
TYR A 155
ALA A 133
 None
 1.16A 1pbcA-4r6kA:
undetectable		 1pbcA-4r6kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 GLY A 572
LEU A 669
TYR A 652
LEU A 657
ALA A 574
 None
 1.26A 1pbcA-4ra7A:
undetectable		 1pbcA-4ra7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		5 GLY A 158
VAL A 160
LEU A  83
LEU A 117
ALA A 167
 None
 1.42A 1pbcA-4rasA:
undetectable		 1pbcA-4rasA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Weissella
paramesenteroides) 		PF13377
(Peripla_BP_3) 		5 GLY A  64
VAL A  63
LEU A  82
LEU A 145
ALA A 119
 None
 1.14A 1pbcA-4rk6A:
2.7		 1pbcA-4rk6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 5 VAL F 265
TRP F 146
LEU F 176
LEU F 212
TYR F 216
 None
 1.34A 1pbcA-4wmoF:
undetectable		 1pbcA-4wmoF:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens) 		no annotation 5 TRP A 117
LEU A 147
LEU A 183
TYR A 187
ALA A 252
 None
 1.40A 1pbcA-4wmyA:
undetectable		 1pbcA-4wmyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens) 		no annotation 5 VAL A 236
TRP A 117
LEU A 147
LEU A 183
TYR A 187
 None
 1.25A 1pbcA-4wmyA:
undetectable		 1pbcA-4wmyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 GLY B 164
VAL B 138
LEU B 124
LEU B 120
ALA B 141
 None
 1.41A 1pbcA-4xsrB:
3.1		 1pbcA-4xsrB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		5 GLY K1035
VAL K 665
LEU K1052
TYR K 985
LEU K1028
 None
 1.35A 1pbcA-5anbK:
undetectable		 1pbcA-5anbK:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 827
VAL A 826
LEU A 452
LEU A 455
ARG A 828
 None
 1.29A 1pbcA-5b7iA:
undetectable		 1pbcA-5b7iA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		5 GLY E  84
VAL E 107
LEU E  81
LEU E 150
ALA E 134
 SAH  E 301 (-3.8A)
None
None
None
SAH  E 301 (-3.6A)
 1.27A 1pbcA-5ginE:
3.7		 1pbcA-5ginE:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		5 GLY A  36
VAL A  35
LEU A  11
SER A   6
ALA A 237
 None
 0.86A 1pbcA-5ht0A:
undetectable		 1pbcA-5ht0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 VAL A 116
LEU A 151
LEU A 142
TYR A  98
ALA A 118
 None
 1.29A 1pbcA-5m11A:
undetectable		 1pbcA-5m11A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 5 VAL A 460
LEU A 450
LEU A 447
SER A 474
ALA A 462
 None
 1.37A 1pbcA-5oglA:
undetectable		 1pbcA-5oglA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
DENSITY-REGULATED
PROTEIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 VAL A  97
LEU A 143
LEU A 106
TYR B  46
ALA A 101
 None
 1.35A 1pbcA-5onsA:
undetectable		 1pbcA-5onsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9q PUTATIVE
CYTIDYLYLTRANSFERASE

(Burkholderia
pseudomallei) 		no annotation 5 GLY A  31
VAL A  58
LEU A  85
LEU A  44
TYR A  43
 None
 1.04A 1pbcA-5x9qA:
undetectable		 1pbcA-5x9qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhi PROTEIN YIIM

(Escherichia
coli) 		no annotation 5 VAL A 154
LEU A  39
LEU A  57
TYR A 146
ALA A 109
 None
 1.18A 1pbcA-5yhiA:
undetectable		 1pbcA-5yhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 VAL C 936
LEU C 974
LEU C 978
TYR C 981
ALA C 951
 None
 1.26A 1pbcA-5zyaC:
undetectable		 1pbcA-5zyaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A  68
VAL A  73
LEU A  38
LEU A  51
TYR A  77
 None
 1.13A 1pbcA-6b5eA:
undetectable		 1pbcA-6b5eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq9 DNA TOPOISOMERASE 4
SUBUNIT A

(Pseudomonas
putida) 		no annotation 5 GLY A  44
LEU A 139
TYR A 135
LEU A 106
TYR A 102
 None
 1.41A 1pbcA-6bq9A:
undetectable		 1pbcA-6bq9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 GLY A 203
TYR A  58
SER A 246
ARG A 253
ALA A 197
 LLP  A 199 ( 3.2A)
None
None
None
None
 1.27A 1pbcA-6cjbA:
undetectable		 1pbcA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 GLY A  12
VAL A  34
LEU A   9
LEU A 142
ALA A 118
 FAD  A 502 (-3.2A)
FAD  A 502 (-4.9A)
None
None
FAD  A 502 (-3.4A)
 1.27A 1pbcA-6cmzA:
1.1		 1pbcA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 9 GLY A  46
VAL A  47
TRP A 185
LEU A 199
TYR A 201
LEU A 210
SER A 212
TYR A 222
ALA A 296
 None
None
None
None
None
None
None
FAD  A 401 (-4.3A)
FAD  A 401 ( 4.7A)
 0.36A 1pbcA-6dllA:
63.9		 1pbcA-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-) 		no annotation 5 GLY A 450
VAL A 448
TRP A 657
LEU A 659
TYR A 675
 None
 1.29A 1pbcA-6fg9A:
undetectable		 1pbcA-6fg9A:
undetectable