SIMILAR PATTERNS OF AMINO ACIDS FOR 1PB9_A_4AXA901_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4jwx	GLUN2A (Rattus norvegicus)	PF10613 (Lig_chan-Glu_bd)	5	LEU A 115 THR A 116 ARG A 121 SER A 173 ASP A 215	1N4 A 301 ( 4.9A) 1N4 A 301 (-3.5A) 1N4 A 301 (-2.9A) 1N4 A 301 (-2.3A) 1N4 A 301 ( 4.1A)	0.75A	1pb9A-4jwxA: 32.8	1pb9A-4jwxA: 36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4jwy	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D (Rattus norvegicus)	PF10613 (Lig_chan-Glu_bd)	5	LEU A 115 THR A 116 ARG A 121 SER A 173 ASP A 215	1N4 A 301 ( 4.9A) 1N4 A 301 (-3.6A) 1N4 A 301 (-2.9A) 1N4 A 301 (-2.1A) 1N4 A 301 ( 4.5A)	0.75A	1pb9A-4jwyA: 33.5	1pb9A-4jwyA: 33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4nf8	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1 (Rattus norvegicus)	PF10613 (Lig_chan-Glu_bd)	9	PHE A 92 LEU A 125 THR A 126 ARG A 131 SER A 179 SER A 180 VAL A 181 TRP A 223 ASP A 224	GLY A1001 (-3.7A) GLY A1001 (-4.5A) GLY A1001 (-3.9A) GLY A1001 (-2.8A) GLY A1001 (-4.7A) GLY A1001 (-3.2A) None None GLY A1001 (-3.1A)	0.31A	1pb9A-4nf8A: 44.6	1pb9A-4nf8A: 99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pe5	GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B (Rattus norvegicus)	PF00060 (Lig_chan) PF01094 (ANF_receptor) PF10613 (Lig_chan-Glu_bd)	5	LEU B 513 THR B 514 ARG B 519 SER B 690 ASP B 732	GLU B 921 (-4.5A) GLU B 921 (-3.7A) GLU B 921 (-2.4A) GLU B 921 (-3.2A) GLU B 921 (-4.2A)	0.74A	1pb9A-4pe5B: 29.3	1pb9A-4pe5B: 18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5aa4	MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F (Pseudomonas aeruginosa)	PF00497 (SBP_bac_3) PF01464 (SLT)	5	LEU B 110 THR B 111 SER B 159 SER B 160 ASP B 203	None	0.77A	1pb9A-5aa4B: 21.6	1pb9A-5aa4B: 21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5un1	N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT NR1-3A (Xenopus laevis)	no annotation	9	PHE G 482 LEU G 515 THR G 516 ARG G 521 SER G 677 SER G 678 VAL G 679 TRP G 721 ASP G 722	GLY G1001 (-3.6A) GLY G1001 (-4.4A) GLY G1001 (-2.9A) GLY G1001 (-2.7A) None GLY G1001 (-3.4A) None None GLY G1001 (-3.0A)	0.63A	1pb9A-5un1G: 39.1	1pb9A-5un1G: 80.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5uow	N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT NR1-8A (Xenopus laevis)	PF00060 (Lig_chan) PF01094 (ANF_receptor) PF10613 (Lig_chan-Glu_bd)	5	PHE A 482 LEU A 515 ARG A 521 SER A 685 SER A 686	None	1.16A	1pb9A-5uowA: 35.6	1pb9A-5uowA: 34.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5uow	N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT NR1-8A (Xenopus laevis)	PF00060 (Lig_chan) PF01094 (ANF_receptor) PF10613 (Lig_chan-Glu_bd)	6	PHE A 482 LEU A 515 THR A 516 ARG A 521 SER A 685 ASP A 730	None	1.20A	1pb9A-5uowA: 35.6	1pb9A-5uowA: 34.76

[["1PB9_A_4AXA901_1","4jwx","Rattus norvegicus","GLUN2A","PF10613(Lig_chan-Glu_bd)",5,"LEU A 115;THR A 116;ARG A 121;SER A 173;ASP A 215","1N4 A 301 ( 4.9A);1N4 A 301 (-3.5A);1N4 A 301 (-2.9A);1N4 A 301 (-2.3A);1N4 A 301 ( 4.1A)","0.75A","1pb9A-4jwxA:32.8","1pb9A-4jwxA:36.67"],["1PB9_A_4AXA901_1","4jwy","Rattus norvegicus","GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D","PF10613(Lig_chan-Glu_bd)",5,"LEU A 115;THR A 116;ARG A 121;SER A 173;ASP A 215","1N4 A 301 ( 4.9A);1N4 A 301 (-3.6A);1N4 A 301 (-2.9A);1N4 A 301 (-2.1A);1N4 A 301 ( 4.5A)","0.75A","1pb9A-4jwyA:33.5","1pb9A-4jwyA:33.77"],["1PB9_A_4AXA901_1","4nf8","Rattus norvegicus","GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1","PF10613(Lig_chan-Glu_bd)",9,"PHE A  92;LEU A 125;THR A 126;ARG A 131;SER A 179;SER A 180;VAL A 181;TRP A 223;ASP A 224","GLY A1001 (-3.7A);GLY A1001 (-4.5A);GLY A1001 (-3.9A);GLY A1001 (-2.8A);GLY A1001 (-4.7A);GLY A1001 (-3.2A);None;None;GLY A1001 (-3.1A)","0.31A","1pb9A-4nf8A:44.6","1pb9A-4nf8A:99.66"],["1PB9_A_4AXA901_1","4pe5","Rattus norvegicus","GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B","PF00060(Lig_chan);PF01094(ANF_receptor);PF10613(Lig_chan-Glu_bd)",5,"LEU B 513;THR B 514;ARG B 519;SER B 690;ASP B 732","GLU B 921 (-4.5A);GLU B 921 (-3.7A);GLU B 921 (-2.4A);GLU B 921 (-3.2A);GLU B 921 (-4.2A)","0.74A","1pb9A-4pe5B:29.3","1pb9A-4pe5B:18.64"],["1PB9_A_4AXA901_1","5aa4","Pseudomonas aeruginosa","MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F","PF00497(SBP_bac_3);PF01464(SLT)",5,"LEU B 110;THR B 111;SER B 159;SER B 160;ASP B 203","None","0.77A","1pb9A-5aa4B:21.6","1pb9A-5aa4B:21.21"],["1PB9_A_4AXA901_1","5un1","Xenopus laevis","N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT NR1-3A","no annotation",9,"PHE G 482;LEU G 515;THR G 516;ARG G 521;SER G 677;SER G 678;VAL G 679;TRP G 721;ASP G 722","GLY G1001 (-3.6A);GLY G1001 (-4.4A);GLY G1001 (-2.9A);GLY G1001 (-2.7A);None;GLY G1001 (-3.4A);None;None;GLY G1001 (-3.0A)","0.63A","1pb9A-5un1G:39.1","1pb9A-5un1G:80.49"],["1PB9_A_4AXA901_1","5uow","Xenopus laevis","N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT NR1-8A","PF00060(Lig_chan);PF01094(ANF_receptor);PF10613(Lig_chan-Glu_bd)",5,"PHE A 482;LEU A 515;ARG A 521;SER A 685;SER A 686","None","1.16A","1pb9A-5uowA:35.6","1pb9A-5uowA:34.76"],["1PB9_A_4AXA901_1","5uow","Xenopus laevis","N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT NR1-8A","PF00060(Lig_chan);PF01094(ANF_receptor);PF10613(Lig_chan-Glu_bd)",6,"PHE A 482;LEU A 515;THR A 516;ARG A 521;SER A 685;ASP A 730","None","1.20A","1pb9A-5uowA:35.6","1pb9A-5uowA:34.76"]]