SIMILAR PATTERNS OF AMINO ACIDS FOR 1P9G_A_ACTA42_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byw PROTEIN (HUMAN ERG
POTASSIUM CHANNEL)

(Homo sapiens) 		PF13426
(PAS_9) 		3 CYH A  44
ARG A  56
CYH A  49
 None
 1.45A 1p9gA-1bywA:
0.0		 1p9gA-1bywA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 CYH L  73
ARG L 425
CYH L  70
 FCO  L 499 ( 2.2A)
FCO  L 499 (-4.1A)
NI  L 500 ( 2.2A)
 1.47A 1p9gA-1cc1L:
undetectable		 1p9gA-1cc1L:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		3 CYH B  74
ARG B 469
CYH B  71
 FNE  B 543 (-2.2A)
FNE  B 543 (-3.5A)
FNE  B 543 (-2.1A)
 1.40A 1p9gA-1e3dB:
undetectable		 1p9gA-1e3dB:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 CYH A 277
ARG A 338
CYH A 285
 None
 1.41A 1p9gA-1fpqA:
undetectable		 1p9gA-1fpqA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2o FUSION OF
RHOMBOTIN-2 AND LIM
DOMAIN-BINDING
PROTEIN 1

(Mus musculus) 		PF00412
(LIM) 		3 CYH A  33
ARG A  95
CYH A  36
 ZN  A 116 (-2.2A)
None
ZN  A 116 (-2.2A)
 1.46A 1p9gA-1j2oA:
undetectable		 1p9gA-1j2oA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1joc EARLY ENDOSOMAL
AUTOANTIGEN 1

(Homo sapiens) 		PF01363
(FYVE) 		3 CYH A1377
ARG A1347
CYH A1405
 ZN  A 300 (-2.2A)
None
ZN  A 300 (-2.2A)
 1.20A 1p9gA-1jocA:
undetectable		 1p9gA-1jocA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 CYH A 268
ARG A 330
CYH A 276
 None
 1.41A 1p9gA-1kywA:
0.0		 1p9gA-1kywA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyi PROTEIN (PYRIMIDINE
PATHWAY REGULATOR 1)

(Saccharomyces
cerevisiae) 		PF00172
(Zn_clus) 		3 CYH A  34
ARG A  74
CYH A  44
 ZN  A  21 ( 2.2A)
None
ZN  A  22 (-2.1A)
 1.27A 1p9gA-1pyiA:
undetectable		 1p9gA-1pyiA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 CYH A  38
ARG A 331
CYH A 148
 ZN  A 402 (-2.2A)
None
ZN  A 402 (-2.4A)
 1.50A 1p9gA-1rjwA:
undetectable		 1p9gA-1rjwA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tev UMP-CMP KINASE

(Homo sapiens) 		PF00406
(ADK) 		3 CYH A 127
ARG A 130
CYH A 122
 None
 1.32A 1p9gA-1tevA:
undetectable		 1p9gA-1tevA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		3 CYH A 237
ARG A 241
CYH A 235
 ZN  A1291 (-2.2A)
None
ZN  A1291 (-2.2A)
 1.17A 1p9gA-1vzyA:
undetectable		 1p9gA-1vzyA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5l NONSTRUCTURAL
PROTEIN V

(Mammalian
rubulavirus 5) 		PF13008
(zf-Paramyx-P)
PF14313
(Soyouz_module) 		3 CYH C 190
ARG C 173
CYH C 215
 ZN  C3002 (-2.2A)
None
ZN  C3002 (-2.2A)
 1.43A 1p9gA-2b5lC:
undetectable		 1p9gA-2b5lC:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckl POLYCOMB GROUP RING
FINGER PROTEIN 4
UBIQUITIN LIGASE
PROTEIN RING2

(Mus musculus;
Mus musculus) 		PF13923
(zf-C3HC4_2)
PF13923
(zf-C3HC4_2) 		3 CYH A  42
ARG B  26
CYH A  21
 ZN  A1104 (-2.3A)
ZN  A1104 ( 4.5A)
ZN  A1104 (-2.3A)
 1.48A 1p9gA-2cklA:
undetectable		 1p9gA-2cklA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnf PUTATIVE RAS
EFFECTOR NORE1

(Mus musculus) 		PF00130
(C1_1) 		3 CYH X 135
ARG X 137
CYH X 157
 ZN  X   1 (-2.1A)
None
ZN  X   1 (-2.1A)
 1.35A 1p9gA-2fnfX:
undetectable		 1p9gA-2fnfX:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0d B LYMPHOMA MO-MLV
INSERTION REGION
UBIQUITIN LIGASE
PROTEIN RING2

(Homo sapiens;
Homo sapiens) 		PF13923
(zf-C3HC4_2)
PF13923
(zf-C3HC4_2) 		3 CYH A  42
ARG B  26
CYH A  21
 ZN  A 201 (-2.3A)
ZN  A 201 ( 4.5A)
ZN  A 201 (-2.3A)
 1.49A 1p9gA-2h0dA:
undetectable		 1p9gA-2h0dA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrv 2A CYSTEINE
PROTEINASE

(Rhinovirus A) 		PF00947
(Pico_P2A) 		3 CYH A  54
ARG A 134
CYH A 112
 ZN  A 143 (-2.3A)
None
ZN  A 143 (-2.4A)
 1.13A 1p9gA-2hrvA:
undetectable		 1p9gA-2hrvA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i50 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 16

(Homo sapiens) 		PF02148
(zf-UBP) 		3 CYH A   7
ARG A   8
CYH A 102
 ZN  A 338 (-2.3A)
None
ZN  A 338 (-2.2A)
 1.32A 1p9gA-2i50A:
undetectable		 1p9gA-2i50A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 3 CYH B  55
ARG B  35
CYH B  99
 None
ZN  B 605 ( 4.6A)
ZN  B 605 (-2.1A)
 1.19A 1p9gA-2pvcB:
undetectable		 1p9gA-2pvcB:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 3 CYH B 121
ARG B  35
CYH B  99
 ZN  B 605 (-2.1A)
ZN  B 605 ( 4.6A)
ZN  B 605 (-2.1A)
 1.31A 1p9gA-2pvcB:
undetectable		 1p9gA-2pvcB:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE

(Homo sapiens) 		no annotation 3 CYH B 121
ARG B  35
CYH B 118
 ZN  B 605 (-2.1A)
ZN  B 605 ( 4.6A)
ZN  B 605 (-2.2A)
 1.31A 1p9gA-2pvcB:
undetectable		 1p9gA-2pvcB:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1
REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens;
Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12)
PF04050
(Upf2) 		3 CYH A 209
ARG D1128
CYH A 186
 ZN  A   3 (-2.1A)
None
ZN  A   3 (-2.3A)
 1.25A 1p9gA-2wjvA:
undetectable		 1p9gA-2wjvA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 CYH A 366
ARG A 200
CYH A 316
 None
 1.38A 1p9gA-2xymA:
undetectable		 1p9gA-2xymA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1b DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A,
HISTONE H3.1

(Homo sapiens) 		no annotation 3 CYH A 540
ARG A 476
CYH A 559
 ZN  A   2 (-2.3A)
ZN  A   2 ( 4.9A)
ZN  A   2 ( 2.3A)
 1.02A 1p9gA-3a1bA:
undetectable		 1p9gA-3a1bA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF00628
(PHD)
PF12148
(TTD) 		3 CYH A 313
ARG A 324
CYH A 305
 ZN  A 501 (-2.3A)
ZN  A 501 (-4.4A)
ZN  A 501 (-2.3A)
 1.41A 1p9gA-3askA:
undetectable		 1p9gA-3askA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 CYH A 656
ARG A 654
CYH A 694
 ZN  A2002 (-2.4A)
None
ZN  A2002 (-2.5A)
 1.42A 1p9gA-3av6A:
undetectable		 1p9gA-3av6A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		3 CYH A  79
ARG A 523
CYH A  76
 O  A 609 (-1.8A)
O  A 606 (-3.6A)
O  A 609 (-1.5A)
 1.41A 1p9gA-3ayxA:
undetectable		 1p9gA-3ayxA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US14

(Plasmodium
falciparum) 		PF00253
(Ribosomal_S14) 		3 CYH T  40
ARG T  44
CYH T  22
 ZN  T 100 (-2.5A)
G  A1679 ( 4.4A)
ZN  T 100 (-2.7A)
 1.21A 1p9gA-3j7aT:
undetectable		 1p9gA-3j7aT:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Thermus
thermophilus;
Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02686
(Glu-tRNAGln) 		3 CYH F  22
ARG G  63
CYH F  38
 ZN  F 673 (-2.1A)
None
ZN  F 673 (-2.1A)
 1.35A 1p9gA-3kfuF:
undetectable		 1p9gA-3kfuF:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Thermus
thermophilus;
Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02686
(Glu-tRNAGln) 		3 CYH F  24
ARG G  63
CYH F  38
 ZN  F 673 (-2.1A)
None
ZN  F 673 (-2.1A)
 1.47A 1p9gA-3kfuF:
undetectable		 1p9gA-3kfuF:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases) 		3 CYH B1064
ARG B1487
CYH B1061
 NFV  B2005 (-2.3A)
NFV  B2005 (-3.8A)
NFV  B2005 (-2.2A)
 1.42A 1p9gA-3myrB:
undetectable		 1p9gA-3myrB:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 CYH L  78
ARG L 530
CYH L  75
 NFU  L1004 (-2.2A)
NFU  L1004 (-4.2A)
NFU  L1004 (-2.2A)
 1.40A 1p9gA-3rgwL:
undetectable		 1p9gA-3rgwL:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6r E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A 313
ARG A 324
CYH A 305
 ZN  A   1 (-2.3A)
ZN  A   1 ( 4.3A)
ZN  A   1 (-2.3A)
 1.36A 1p9gA-3t6rA:
undetectable		 1p9gA-3t6rA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6r E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A 313
ARG A 324
CYH A 316
 ZN  A   1 (-2.3A)
ZN  A   1 ( 4.3A)
ZN  A   1 (-2.3A)
 1.48A 1p9gA-3t6rA:
undetectable		 1p9gA-3t6rA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		3 CYH L  79
ARG L 509
CYH L  76
 FCO  L 601 ( 2.3A)
FCO  L 601 (-4.2A)
3NI  L 602 (-2.2A)
 1.39A 1p9gA-3uscL:
undetectable		 1p9gA-3uscL:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v43 HISTONE
ACETYLTRANSFERASE
KAT6A

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A 212
ARG A 220
CYH A 209
 ZN  A   2 (-2.3A)
None
ZN  A   2 (-2.3A)
 1.36A 1p9gA-3v43A:
undetectable		 1p9gA-3v43A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve5 RECOMBINATION
PROTEIN RECR

(Caldanaerobacter
subterraneus) 		no annotation 3 CYH D  58
ARG D 128
CYH D  70
 ZN  D 201 (-2.4A)
None
ZN  D 201 (-2.5A)
 1.33A 1p9gA-3ve5D:
undetectable		 1p9gA-3ve5D:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 CYH A 186
ARG A 128
CYH A 167
 ZN  A 802 (-2.3A)
None
ZN  A 802 (-2.3A)
 1.50A 1p9gA-3vthA:
undetectable		 1p9gA-3vthA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w95 GENOME POLYPROTEIN

(Enterovirus A) 		PF00947
(Pico_P2A) 		3 CYH A  58
ARG A 138
CYH A 116
 ZN  A 201 (-2.3A)
None
ZN  A 201 (-2.3A)
 1.18A 1p9gA-3w95A:
undetectable		 1p9gA-3w95A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6d RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1) 		3 CYH A 303
ARG A 330
CYH A 300
 ZN  A1340 (-2.2A)
None
ZN  A1340 (-2.3A)
 1.28A 1p9gA-4b6dA:
undetectable		 1p9gA-4b6dA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6d RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1) 		3 CYH A 327
ARG A 330
CYH A 300
 ZN  A1340 (-2.3A)
None
ZN  A1340 (-2.3A)
 1.47A 1p9gA-4b6dA:
undetectable		 1p9gA-4b6dA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		3 CYH A  38
ARG A  35
CYH A  40
 ZN  A 403 (-2.2A)
ZN  A 403 ( 4.2A)
ZN  A 403 (-2.3A)
 1.45A 1p9gA-4bhiA:
undetectable		 1p9gA-4bhiA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE

(Homo sapiens) 		PF02668
(TauD)
PF06155
(DUF971) 		3 CYH A  38
ARG A  35
CYH A  43
 ZN  A 403 (-2.2A)
ZN  A 403 ( 4.2A)
ZN  A 403 (-2.3A)
 1.49A 1p9gA-4bhiA:
undetectable		 1p9gA-4bhiA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4w METHYL-CPG-BINDING
DOMAIN PROTEIN 1

(Homo sapiens) 		PF02008
(zf-CXXC) 		3 CYH A  18
ARG A  56
CYH A  15
 None
 1.37A 1p9gA-4d4wA:
undetectable		 1p9gA-4d4wA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo sapiens;
Homo sapiens) 		PF12678
(zf-rbx1)
PF08568
(Kinetochor_Ybp2) 		3 CYH B  45
ARG E 479
CYH B  53
 ZN  B 201 (-2.2A)
None
ZN  B 203 (-2.5A)
 1.09A 1p9gA-4f52B:
undetectable		 1p9gA-4f52B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo sapiens;
Homo sapiens) 		PF12678
(zf-rbx1)
PF08568
(Kinetochor_Ybp2) 		3 CYH B  45
ARG E 479
CYH B  83
 ZN  B 201 (-2.2A)
None
ZN  B 201 (-2.4A)
 1.34A 1p9gA-4f52B:
undetectable		 1p9gA-4f52B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 CYH A 112
ARG A 172
CYH A 109
 ZN  A1001 (-2.6A)
None
ZN  A1001 (-2.7A)
 1.43A 1p9gA-4g9iA:
undetectable		 1p9gA-4g9iA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 CYH A 181
ARG A 123
CYH A 162
 ZN  A1002 (-2.8A)
None
ZN  A1002 (-2.6A)
 1.40A 1p9gA-4g9iA:
undetectable		 1p9gA-4g9iA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		3 CYH A 348
ARG A 402
CYH A 372
 ZN  A 901 (-2.3A)
None
ZN  A 901 (-2.3A)
 1.36A 1p9gA-4h3sA:
undetectable		 1p9gA-4h3sA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hp1 LOC100036628 PROTEIN

(Xenopus
tropicalis) 		PF02008
(zf-CXXC) 		3 CYH C  77
ARG C  73
CYH C  93
 ZN  C 202 (-2.3A)
None
ZN  C 202 (-2.3A)
 1.41A 1p9gA-4hp1C:
undetectable		 1p9gA-4hp1C:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s NON-STRUCTURAL
PROTEIN V

(Mammalian
rubulavirus 5) 		PF13008
(zf-Paramyx-P) 		3 CYH B 190
ARG B 203
CYH B 218
 ZN  B 302 (-2.4A)
None
ZN  B 302 (-2.2A)
 1.34A 1p9gA-4i1sB:
undetectable		 1p9gA-4i1sB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s NON-STRUCTURAL
PROTEIN V

(Mammalian
rubulavirus 5) 		PF13008
(zf-Paramyx-P) 		3 CYH B 218
ARG B 173
CYH B 215
 ZN  B 302 (-2.2A)
None
ZN  B 302 (-2.2A)
 1.34A 1p9gA-4i1sB:
undetectable		 1p9gA-4i1sB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE

(Thermotoga
maritima) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		3 CYH A 311
ARG A 300
CYH A 319
 FES  A 409 ( 2.2A)
None
H2S  A 410 ( 2.0A)
 1.31A 1p9gA-4jxcA:
undetectable		 1p9gA-4jxcA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lik DNA PRIMASE SMALL
SUBUNIT

(Homo sapiens) 		PF01896
(DNA_primase_S) 		3 CYH A 122
ARG A 119
CYH A 128
 ZN  A 501 (-2.2A)
None
ZN  A 501 (-2.0A)
 1.38A 1p9gA-4likA:
undetectable		 1p9gA-4likA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mg3 PROTEASE 2A

(Enterovirus A) 		PF00947
(Pico_P2A) 		3 CYH A  58
ARG A 138
CYH A 116
 ZN  A 201 (-2.4A)
None
ZN  A 201 (-2.3A)
 1.18A 1p9gA-4mg3A:
undetectable		 1p9gA-4mg3A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0n REPLICASE
POLYPROTEIN 1AB

(Equine
arteritis virus) 		PF01443
(Viral_helicase1) 		3 CYH A  53
ARG A  49
CYH A  56
 ZN  A 502 (-2.2A)
None
ZN  A 502 (-2.4A)
 1.50A 1p9gA-4n0nA:
undetectable		 1p9gA-4n0nA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqa LIVER X NUCLEAR
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 CYH B 107
ARG B 138
CYH B 104
 ZN  B 502 (-2.3A)
None
ZN  B 502 (-2.3A)
 1.48A 1p9gA-4nqaB:
undetectable		 1p9gA-4nqaB:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqa LIVER X NUCLEAR
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 CYH B 144
ARG B 147
CYH B 125
 ZN  B 503 (-2.3A)
None
ZN  B 503 (-2.2A)
 1.48A 1p9gA-4nqaB:
undetectable		 1p9gA-4nqaB:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o64 LYSINE-SPECIFIC
DEMETHYLASE 2B

(Homo sapiens) 		PF02008
(zf-CXXC)
PF16866
(PHD_4) 		3 CYH A 624
ARG A 621
CYH A 646
 ZN  A2002 (-2.2A)
None
ZN  A2002 (-2.3A)
 1.44A 1p9gA-4o64A:
undetectable		 1p9gA-4o64A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 CYH A 319
ARG A 337
CYH A 246
 None
 1.09A 1p9gA-4o9xA:
undetectable		 1p9gA-4o9xA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaq R-SPECIFIC CARBONYL
REDUCTASE

(Candida
parapsilosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 CYH A 102
ARG A 129
CYH A 116
 ZN  A 403 (-2.3A)
None
ZN  A 403 (-2.3A)
 1.30A 1p9gA-4oaqA:
undetectable		 1p9gA-4oaqA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		no annotation 3 CYH A 540
ARG A 476
CYH A 559
 ZN  A 702 (-2.4A)
ZN  A 702 ( 4.8A)
ZN  A 702 (-2.2A)
 1.11A 1p9gA-4qbrA:
undetectable		 1p9gA-4qbrA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		3 CYH A 372
ARG A 128
CYH A 375
 None
CL  A 503 (-3.0A)
None
 1.36A 1p9gA-4rtbA:
undetectable		 1p9gA-4rtbA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
POLYCOMB GROUP RING
FINGER PROTEIN 5

(Homo sapiens;
Homo sapiens) 		PF13923
(zf-C3HC4_2)
PF13923
(zf-C3HC4_2) 		3 CYH C  42
ARG B  26
CYH C  21
 ZN  C 201 (-2.2A)
ZN  C 201 ( 4.7A)
ZN  C 201 (-2.2A)
 1.40A 1p9gA-4s3oC:
undetectable		 1p9gA-4s3oC:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyk NUCLEAR RNA EXPORT
FACTOR 1
NTF2-RELATED EXPORT
PROTEIN 1

(Homo sapiens;
Homo sapiens) 		PF02136
(NTF2)
PF02136
(NTF2) 		3 CYH B  77
ARG A 440
CYH B  14
 None
 1.01A 1p9gA-4wykB:
undetectable		 1p9gA-4wykB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b76 HISTONE
ACETYLTRANSFERASE
KAT6A

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A 212
ARG A 220
CYH A 209
 ZN  A 403 (-2.3A)
None
ZN  A 403 (-2.3A)
 1.44A 1p9gA-5b76A:
undetectable		 1p9gA-5b76A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elh RING FINGER PROTEIN
UNKEMPT HOMOLOG

(Mus musculus) 		no annotation 3 CYH A 106
ARG A  72
CYH A  90
 ZN  A 202 (-2.3A)
None
ZN  A 202 (-2.2A)
 1.15A 1p9gA-5elhA:
undetectable		 1p9gA-5elhA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB10

(Homo sapiens) 		PF01194
(RNA_pol_N) 		3 CYH J  44
ARG J  47
CYH J   7
 None
 1.29A 1p9gA-5iy7J:
undetectable		 1p9gA-5iy7J:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2l NAB2P

(Saccharomyces
cerevisiae) 		PF14608
(zf-CCCH_2) 		3 CYH A 464
ARG A 477
CYH A 469
 ZN  A 503 (-2.3A)
ZN  A 503 ( 4.7A)
ZN  A 503 (-2.3A)
 1.41A 1p9gA-5l2lA:
undetectable		 1p9gA-5l2lA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		3 CYH A1258
ARG A1645
CYH A1164
 ZN  A1703 (-2.3A)
None
ZN  A1703 (-2.3A)
 1.47A 1p9gA-5lkzA:
undetectable		 1p9gA-5lkzA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		3 CYH F  64
ARG F 375
CYH F  61
 NFU  F 501 (-2.2A)
NFU  F 501 (-4.2A)
NFU  F 501 (-2.2A)
 1.47A 1p9gA-5odrF:
undetectable		 1p9gA-5odrF:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2

(Homo sapiens) 		PF00397
(WW)
PF00632
(HECT) 		3 CYH A 750
ARG A 389
CYH A 802
 None
 1.48A 1p9gA-5tj7A:
undetectable		 1p9gA-5tj7A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trb E3 UBIQUITIN-PROTEIN
LIGASE BRE1A

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		3 CYH A 945
ARG A 949
CYH A 924
 ZN  A1001 (-2.3A)
None
None
 1.49A 1p9gA-5trbA:
undetectable		 1p9gA-5trbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2j HISTONE
ACETYLTRANSFERASE
KAT6B

(Homo sapiens) 		PF00628
(PHD) 		3 CYH A 212
ARG A 220
CYH A 209
 ZN  A 403 (-2.3A)
None
ZN  A 403 (-2.3A)
 1.39A 1p9gA-5u2jA:
undetectable		 1p9gA-5u2jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x45 PROTEASE 2A

(Rhinovirus C) 		no annotation 3 CYH A  53
ARG A 133
CYH A 111
 ZN  A 201 (-2.6A)
None
ZN  A 201 (-2.5A)
 0.96A 1p9gA-5x45A:
undetectable		 1p9gA-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xht PHD FINGER PROTEIN
24

(Homo sapiens) 		no annotation 3 CYH A  28
ARG A  31
CYH A   6
 ZN  A 201 (-2.3A)
None
ZN  A 201 (-2.3A)
 1.49A 1p9gA-5xhtA:
undetectable		 1p9gA-5xhtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		3 CYH A 744
ARG A 378
CYH A 796
 None
 1.48A 1p9gA-5xmcA:
undetectable		 1p9gA-5xmcA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon RNA POLYMERASE
SUBUNIT ABC10-BETA,
COMMON TO RNA
POLYMERASES I, II,
AND III

(Komagataella
phaffii) 		PF01194
(RNA_pol_N) 		3 CYH J  44
ARG J  47
CYH J   7
 ZN  J 101 (-2.3A)
None
ZN  J 101 (-2.4A)
 1.28A 1p9gA-5xonJ:
undetectable		 1p9gA-5xonJ:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S29,
PUTATIVE

(Trichomonas
vaginalis) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		3 CYH d  43
ARG d  47
CYH d  22
 G  21242 ( 3.9A)
G  21242 ( 4.7A)
None
 1.32A 1p9gA-5xyid:
undetectable		 1p9gA-5xyid:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6asb F-BOX/LRR-REPEAT
PROTEIN 19

(Homo sapiens) 		no annotation 3 CYH C  50
ARG C  47
CYH C  72
 ZN  C2002 (-2.2A)
None
ZN  C2002 (-2.3A)
 1.44A 1p9gA-6asbC:
undetectable		 1p9gA-6asbC:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 3 CYH A 171
ARG A 154
CYH A 160
 ZN  A 701 (-2.3A)
None
ZN  A 701 (-2.3A)
 0.97A 1p9gA-6cddA:
undetectable		 1p9gA-6cddA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ces RAS-RELATED
GTP-BINDING PROTEIN
A

(Homo sapiens) 		no annotation 3 CYH A 157
ARG A 149
CYH A 159
 None
 1.43A 1p9gA-6cesA:
undetectable		 1p9gA-6cesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs NPL4

(Chaetomium
thermophilum) 		no annotation 3 CYH A 171
ARG A 154
CYH A 168
 ZN  A 701 (-2.3A)
None
ZN  A 701 (-2.3A)
 1.13A 1p9gA-6chsA:
undetectable		 1p9gA-6chsA:
undetectable