SIMILAR PATTERNS OF AMINO ACIDS FOR 1P93_D_DEXD4999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		5 GLY A 421
MET A 497
THR A 275
ILE A 276
PHE A 417
 None
HC1  A 580 (-3.3A)
None
None
HC1  A 580 (-4.3A)
 1.29A 1p93D-1fehA:
undetectable		 1p93D-1fehA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		5 GLY L 300
MET L 376
THR L 152
ILE L 153
PHE L 296
 None
PDT  L 425 (-3.6A)
None
None
CMO  L 431 ( 4.5A)
 1.34A 1p93D-1hfeL:
undetectable		 1p93D-1hfeL:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ASN A 213
GLN A 188
THR A  35
ILE A 109
PHE A 192
 None
 1.11A 1p93D-1rj6A:
undetectable		 1p93D-1rj6A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 GLY A 596
GLN A 659
ARG A 662
THR A 551
ILE A 555
 None
 1.30A 1p93D-1ulvA:
undetectable		 1p93D-1ulvA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 891
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 0.91A 1p93D-2ax9A:
31.7		 1p93D-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 764
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
 0.97A 1p93D-2ax9A:
31.7		 1p93D-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 764
PHE A 891
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
None
 0.89A 1p93D-2ax9A:
31.7		 1p93D-2ax9A:
46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		5 GLY A 289
ARG A 183
THR A 108
ILE A 119
PHE A 292
 None
 1.27A 1p93D-2hi1A:
undetectable		 1p93D-2hi1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 GLY A 484
MET A 502
ARG A 478
ILE A 395
PHE A 343
 None
 1.29A 1p93D-2ifyA:
undetectable		 1p93D-2ifyA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.80A 1p93D-2q3yA:
34.8		 1p93D-2q3yA:
58.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.94A 1p93D-2q3yA:
34.8		 1p93D-2q3yA:
58.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 5 GLN A  39
PHE A 143
THR A  67
ILE A  16
PHE A  33
 None
 1.47A 1p93D-3ba3A:
undetectable		 1p93D-3ba3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 GLY A 451
CYH A 279
THR A 280
ILE A 428
PHE A 444
 None
NAD  A 501 ( 2.5A)
SIN  A 504 (-3.0A)
None
NAD  A 501 (-4.3A)
 1.41A 1p93D-3ju8A:
undetectable		 1p93D-3ju8A:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 719
GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.87A 1p93D-3kbaA:
34.1		 1p93D-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 GLY A 722
GLN A 725
MET A 756
ARG A 766
PHE A 778
MET A 801
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.87A 1p93D-3kbaA:
34.1		 1p93D-3kbaA:
49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 GLY A 115
GLN A 169
PHE A  26
MET A  49
ILE A 402
 None
SO4  A1502 (-3.8A)
GOL  A1509 (-3.8A)
None
None
 1.35A 1p93D-3kehA:
undetectable		 1p93D-3kehA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		5 GLY A 109
GLN A 102
PHE A 100
ILE A 131
PHE A 127
 None
 1.44A 1p93D-3ldfA:
undetectable		 1p93D-3ldfA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.76A 1p93D-3ry9A:
35.2		 1p93D-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.06A 1p93D-3ry9A:
35.2		 1p93D-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 MET A 472
ASN A 473
PHE A 521
ILE A 469
PHE A 139
 None
 1.47A 1p93D-3s29A:
undetectable		 1p93D-3s29A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		5 GLY A 292
GLN A 260
PHE A 107
ILE A 335
PHE A 308
 None
 1.38A 1p93D-3vupA:
undetectable		 1p93D-3vupA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 GLY A 128
ARG A 448
PHE A 130
ILE A 263
PHE A 264
 None
HEM  A 601 (-3.8A)
0T3  A 602 (-4.0A)
None
None
 1.28A 1p93D-4fdhA:
undetectable		 1p93D-4fdhA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nul FLAVODOXIN

(Clostridium
beijerinckii) 		PF00258
(Flavodoxin_1) 		5 GLY A  52
MET A  96
MET A 103
ILE A 135
PHE A 131
 None
 1.34A 1p93D-4nulA:
undetectable		 1p93D-4nulA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 MET A  96
GLY A  99
THR A 250
ILE A 104
PHE A 102
 None
 1.36A 1p93D-4om9A:
undetectable		 1p93D-4om9A:
15.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ASN A 564
GLY A 567
GLN A 570
MET A 601
ARG A 611
PHE A 623
MET A 646
CYH A 736
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.51A 1p93D-4p6wA:
37.6		 1p93D-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
GLY A 568
MET A 601
CYH A 736
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 1.03A 1p93D-4p6wA:
37.6		 1p93D-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 560
ASN A 564
GLY A 567
GLN A 570
MET A 601
MET A 646
CYH A 736
ILE A 747
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.67A 1p93D-4p6wA:
37.6		 1p93D-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 770
GLN A 776
MET A 807
ARG A 817
PHE A 829
MET A 852
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.76A 1p93D-4udbA:
33.3		 1p93D-4udbA:
51.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 770
GLY A 774
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
None
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.05A 1p93D-4udbA:
33.3		 1p93D-4udbA:
51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLY X 326
GLN X 327
ARG X 363
ILE X  63
PHE X 112
 None
 1.40A 1p93D-5evyX:
undetectable		 1p93D-5evyX:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw5 RNA REPLICASE
POLYPROTEIN

(Turnip yellow
mosaic virus) 		no annotation 5 GLY A 850
GLN A 837
PHE A 836
ILE A 806
PHE A 749
 None
 1.42A 1p93D-5lw5A:
undetectable		 1p93D-5lw5A:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 ASN A 770
GLN A 776
MET A 807
ARG A 817
PHE A 829
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.67A 1p93D-5mwpA:
33.9		 1p93D-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.98A 1p93D-5mwpA:
33.9		 1p93D-5mwpA:
41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 GLY A 453
CYH A 282
THR A 283
ILE A 430
PHE A 446
 None
EDO  A 509 (-3.3A)
EDO  A 509 (-3.1A)
None
8YP  A 507 ( 3.5A)
 1.45A 1p93D-5u0lA:
undetectable		 1p93D-5u0lA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 ASN A 560
GLY A 563
GLN A 566
MET A 597
ARG A 607
PHE A 619
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 (-4.7A)
486  A 801 ( 3.8A)
 0.78A 1p93D-5uc1A:
25.0		 1p93D-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 115
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 (-4.4A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.56A 1p93D-5ufsA:
36.8		 1p93D-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.05A 1p93D-5ufsA:
36.8		 1p93D-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 MET A  29
ASN A  33
GLY A  36
GLN A  39
MET A  70
CYH A 205
PHE A 218
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.6A)
1TA  A 301 (-4.0A)
 0.72A 1p93D-5ufsA:
36.8		 1p93D-5ufsA:
71.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 MET A 474
GLY A 396
GLN A 392
MET A 451
ILE A 477
 None
 1.15A 1p93D-5yj6A:
undetectable		 1p93D-5yj6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 MET A  78
GLY A  64
GLN A 255
THR A  20
ILE A  24
 ACP  A 500 (-4.6A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 3.9A)
None
 0.92A 1p93D-6ci7A:
undetectable		 1p93D-6ci7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dus TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN

(Salmonella
enterica) 		no annotation 5 ASN A 259
ARG A 184
MET A 279
CYH A 293
ILE A 262
 NAG  A 502 (-3.2A)
None
None
None
None
 1.37A 1p93D-6dusA:
undetectable		 1p93D-6dusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.09A 1p93D-6e85A:
undetectable		 1p93D-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 5 ARG A 191
PHE A 187
THR A 207
ILE A 216
PHE A 256
 None
 1.39A 1p93D-6fhfA:
undetectable		 1p93D-6fhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE

(Escherichia
coli) 		PF01025
(GrpE) 		4 LEU A  96
MET A 130
LEU A 131
GLN A 175
 None
 1.28A 1p93D-1dkgA:
undetectable		 1p93D-1dkgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF

(Homo sapiens) 		PF09128
(RGS-like) 		4 LEU A  76
MET A  60
LEU A  59
GLN A 153
 None
 1.45A 1p93D-1iapA:
undetectable		 1p93D-1iapA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 LEU A 100
TRP A  83
LEU A  58
GLN A  98
 None
 1.47A 1p93D-1kugA:
0.0		 1p93D-1kugA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 LEU A 195
TRP A 210
LEU A  83
GLN A 139
 None
 1.45A 1p93D-1pjaA:
0.0		 1p93D-1pjaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF09128
(RGS-like) 		4 LEU C  76
MET C  60
LEU C  59
GLN C 153
 None
 1.48A 1p93D-1shzC:
undetectable		 1p93D-1shzC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzn ANTHRAX TOXIN
RECEPTOR 2

(Homo sapiens) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 LEU a1069
MET a1078
LEU a1080
GLN a1067
 None
 1.47A 1p93D-1tzna:
undetectable		 1p93D-1tzna:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 LEU A1376
TRP A1397
MET A1356
LEU A1359
 None
 1.22A 1p93D-1ug3A:
0.5		 1p93D-1ug3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 TRP A 399
MET A 411
LEU A 412
GLN A 487
 None
 1.28A 1p93D-1yfoA:
undetectable		 1p93D-1yfoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus musculus) 		PF00104
(Hormone_recep) 		4 LEU A 375
TRP A 280
LEU A 227
GLN A 395
 None
 1.41A 1p93D-1yp0A:
21.5		 1p93D-1yp0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus) 		PF01122
(Cobalamin_bind) 		4 LEU A 281
MET A 239
LEU A 235
GLN A 260
 None
 1.20A 1p93D-2bb6A:
undetectable		 1p93D-2bb6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw2 SUPEROXIDE DISMUTASE
1

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A 102
TRP A 189
MET A 159
LEU A 158
 None
 1.49A 1p93D-2cw2A:
undetectable		 1p93D-2cw2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw1 CATROCOLLASTATIN

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 LEU A 290
TRP A 273
LEU A 248
GLN A 288
 None
 1.37A 1p93D-2dw1A:
undetectable		 1p93D-2dw1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkv HYPOTHETICAL PROTEIN

(Exiguobacterium
sibiricum) 		PF05163
(DinB) 		4 LEU A  49
TRP A  31
LEU A  22
GLN A 130
 None
None
None
CL  A 150 (-3.8A)
 0.90A 1p93D-2hkvA:
undetectable		 1p93D-2hkvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 211
MET A 145
LEU A 149
GLN A 177
 None
 1.27A 1p93D-2jiiA:
undetectable		 1p93D-2jiiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 LEU A 403
TRP A 345
MET A 331
LEU A 329
 None
I3P  A 800 (-4.1A)
None
None
 1.35A 1p93D-2p0dA:
undetectable		 1p93D-2p0dA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LEU A  70
TRP A  89
MET A  54
GLN A  72
 None
PEG  A 201 (-3.7A)
None
None
 1.50A 1p93D-2pbcA:
undetectable		 1p93D-2pbcA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkh HISTIDINE
UTILIZATION
REPRESSOR

(Pseudomonas
syringae group
genomosp. 3) 		PF07702
(UTRA) 		4 LEU A 207
MET A 115
LEU A 142
GLN A 153
 None
EDO  A1009 ( 4.6A)
None
EDO  A1001 ( 3.6A)
 1.47A 1p93D-2pkhA:
undetectable		 1p93D-2pkhA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 LEU A  32
TRP A  69
MET A  73
LEU A  77
 1CA  A 247 (-4.0A)
None
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
 0.77A 1p93D-2q3yA:
34.8		 1p93D-2q3yA:
58.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn7 OUTER SURFACE
PROTEIN

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 LEU A 368
MET A 302
LEU A 301
GLN A 364
 None
 1.40A 1p93D-2yn7A:
undetectable		 1p93D-2yn7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzj GLUCURONAN LYASE A

(Trichoderma
reesei) 		PF14099
(Polysacc_lyase) 		4 LEU A  76
MET A  40
LEU A 199
GLN A 214
 None
 1.08A 1p93D-2zzjA:
undetectable		 1p93D-2zzjA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		4 LEU A 221
MET A 166
LEU A 165
GLN A 193
 None
 1.32A 1p93D-3dniA:
undetectable		 1p93D-3dniA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb2 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		4 LEU A 233
TRP A 205
MET A 198
LEU A 199
 None
 1.46A 1p93D-3eb2A:
undetectable		 1p93D-3eb2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5c NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 1

(Mus musculus) 		PF00104
(Hormone_recep) 		4 LEU B 288
MET B 464
LEU B 468
GLN B 284
 None
 1.12A 1p93D-3f5cB:
12.7		 1p93D-3f5cB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4r EXODEOXYRIBONUCLEASE
8

(Escherichia
coli) 		PF12684
(DUF3799) 		4 LEU A 715
TRP A 756
LEU A 802
GLN A 719
 None
 1.13A 1p93D-3h4rA:
undetectable		 1p93D-3h4rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 4 LEU A  64
TRP A  26
MET A 193
GLN A  91
 None
 1.14A 1p93D-3iusA:
undetectable		 1p93D-3iusA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		4 LEU A 270
TRP A 288
LEU A 297
GLN A 283
 None
 1.29A 1p93D-3opsA:
undetectable		 1p93D-3opsA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  32
TRP A  69
MET A  73
LEU A  77
 1CA  A 249 (-3.9A)
None
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
 0.68A 1p93D-3ry9A:
35.2		 1p93D-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		4 LEU A 127
TRP A  79
LEU A 115
GLN A  98
 None
 1.49A 1p93D-4d1iA:
undetectable		 1p93D-4d1iA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 190
TRP A 269
LEU A 345
GLN A 144
 None
 1.46A 1p93D-4i3gA:
undetectable		 1p93D-4i3gA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A 204
MET A 222
LEU A 219
GLN A 194
 None
 1.49A 1p93D-4jwyA:
undetectable		 1p93D-4jwyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 LEU A 154
MET A 140
LEU A 141
GLN A 158
 None
 1.05A 1p93D-4krfA:
undetectable		 1p93D-4krfA:
15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 563
TRP A 600
MET A 604
LEU A 608
 MOF  A 801 (-3.9A)
None
None
MOF  A 801 ( 4.6A)
 0.43A 1p93D-4p6wA:
37.6		 1p93D-4p6wA:
96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		4 LEU A  98
TRP A  81
LEU A  56
GLN A  96
 None
 1.44A 1p93D-4q1lA:
undetectable		 1p93D-4q1lA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		4 LEU A   6
MET A  12
LEU A  13
GLN A  80
 None
 0.90A 1p93D-4r2wA:
undetectable		 1p93D-4r2wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		4 LEU A   7
MET A  13
LEU A  14
GLN A  81
 None
 0.88A 1p93D-4r31A:
undetectable		 1p93D-4r31A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		4 LEU A 535
MET A 529
LEU A 528
GLN A 516
 None
 1.21A 1p93D-4r3uA:
undetectable		 1p93D-4r3uA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		4 LEU B 518
TRP B 596
LEU B 616
GLN B 452
 None
None
CLA  A9012 (-4.1A)
None
 1.32A 1p93D-4rkuB:
undetectable		 1p93D-4rkuB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 286
MET A 304
LEU A 305
GLN A 269
 None
 1.01A 1p93D-4uhiA:
undetectable		 1p93D-4uhiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 4 LEU A  67
TRP A  36
LEU A 118
GLN A  29
 None
 1.46A 1p93D-4v30A:
undetectable		 1p93D-4v30A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 LEU A 575
TRP A 584
LEU A 565
GLN A 548
 None
 1.48A 1p93D-4wjlA:
undetectable		 1p93D-4wjlA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 LEU A 624
TRP A 581
LEU A 636
GLN A 596
 None
 1.17A 1p93D-4yw5A:
undetectable		 1p93D-4yw5A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 420
TRP A 458
MET A 431
LEU A 406
 None
 0.94A 1p93D-4z64A:
undetectable		 1p93D-4z64A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		4 LEU A 640
TRP A 549
LEU A 580
GLN A 620
 None
 1.49A 1p93D-4zcfA:
undetectable		 1p93D-4zcfA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 4 LEU A 253
TRP A 297
LEU A  33
GLN A 284
 None
 1.41A 1p93D-5ah1A:
undetectable		 1p93D-5ah1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 LEU A 427
MET A 490
LEU A 491
GLN A 448
 None
 1.39A 1p93D-5dxfA:
undetectable		 1p93D-5dxfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		PF00348
(polyprenyl_synt) 		4 LEU A 210
TRP A  62
MET A 324
LEU A 328
 None
 1.04A 1p93D-5ernA:
3.2		 1p93D-5ernA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0t PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale) 		PF01794
(Ferric_reduct) 		4 LEU A 264
TRP A 378
MET A 306
LEU A 309
 None
HEM  A 504 ( 3.3A)
HEM  A 504 ( 4.6A)
LFA  A 507 ( 4.8A)
 1.49A 1p93D-5o0tA:
undetectable		 1p93D-5o0tA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojj UBIQUITIN-CONJUGATIN
G ENZYME E2 T

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A   7
MET A  13
LEU A  14
GLN A  26
 None
 1.00A 1p93D-5ojjA:
undetectable		 1p93D-5ojjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 4 LEU b 515
TRP b 593
LEU b 613
GLN b 450
 None
None
CLA  b1806 (-4.7A)
None
 1.29A 1p93D-5oy0b:
undetectable		 1p93D-5oy0b:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 4 TRP A 596
MET A 600
LEU A 604
GLN A 641
 None
None
486  A 801 ( 3.8A)
CPS  A 803 (-3.5A)
 1.17A 1p93D-5uc1A:
25.0		 1p93D-5uc1A:
75.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufk EFFECTOR PROTEIN
SIDK

(Legionella
pneumophila) 		no annotation 4 LEU A 183
MET A 155
LEU A 159
GLN A 135
 MLY  A 180 ( 4.8A)
None
None
None
 1.32A 1p93D-5ufkA:
undetectable		 1p93D-5ufkA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		4 LEU A  32
TRP A  69
MET A  73
LEU A  77
 1TA  A 301 (-3.5A)
None
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.4A)
 0.43A 1p93D-5ufsA:
36.8		 1p93D-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		4 TRP A  69
MET A  73
LEU A  77
GLN A 111
 None
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.4A)
None
 1.17A 1p93D-5ufsA:
36.8		 1p93D-5ufsA:
71.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 4 LEU C  43
TRP C 248
MET C 337
LEU C 340
 None
EXA  C 247 ( 3.9A)
None
None
 1.28A 1p93D-5v12C:
undetectable		 1p93D-5v12C:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 LEU A 469
MET A 545
LEU A 544
GLN A 399
 None
 1.26A 1p93D-5vqdA:
undetectable		 1p93D-5vqdA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A 464
MET A 484
LEU A 487
GLN A 470
 None
 1.36A 1p93D-5wu7A:
undetectable		 1p93D-5wu7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 LEU C 862
TRP C 776
LEU C 793
GLN C 786
 None
 1.44A 1p93D-5y3rC:
undetectable		 1p93D-5y3rC:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 LEU A1060
MET A1098
LEU A1108
GLN A1084
 None
 1.46A 1p93D-6egtA:
undetectable		 1p93D-6egtA:
20.19