SIMILAR PATTERNS OF AMINO ACIDS FOR 1P93_C_DEXC3999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		5 MET A  90
GLY A  85
GLN A 179
MET A 183
LEU A  77
 None
 1.13A 1p93C-1i5pA:
0.3		 1p93C-1i5pA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN

(Mus musculus) 		no annotation 5 MET H 101
GLY H 104
GLN H   6
GLN L  89
LEU H  45
 None
 1.43A 1p93C-1j05H:
undetectable		 1p93C-1j05H:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CDC4 PROTEIN

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12937
(F-box-like) 		5 ASN B 332
GLY B 330
LEU B 320
GLN B 347
LEU B 338
 None
 1.29A 1p93C-1nexB:
0.0		 1p93C-1nexB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 GLY A 404
GLN A 407
LEU A 358
LEU A 417
THR A 346
 None
 1.26A 1p93C-1s4fA:
0.0		 1p93C-1s4fA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
LEU A 873
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
 0.81A 1p93C-2ax9A:
31.6		 1p93C-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 1.06A 1p93C-2ax9A:
31.6		 1p93C-2ax9A:
46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 GLY A 404
GLN A 407
LEU A 358
LEU A 417
THR A 346
 None
 1.15A 1p93C-2cjqA:
0.0		 1p93C-2cjqA:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
LEU A 201
CYH A 205
THR A 208
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 0.82A 1p93C-2q3yA:
34.8		 1p93C-2q3yA:
58.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
 1CA  A 247 (-2.9A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 1.20A 1p93C-2q3yA:
34.8		 1p93C-2q3yA:
58.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00392
(GntR)
PF07702
(UTRA) 		5 GLY A 226
LEU A 169
ARG A 136
MET A 173
LEU A 180
 None
SRT  A 247 (-4.0A)
SRT  A 247 (-2.9A)
None
None
 0.97A 1p93C-2ra5A:
undetectable		 1p93C-2ra5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boq TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Ruegeria
pomeroyi) 		PF12802
(MarR_2) 		5 GLY A  74
LEU A  79
ARG A  82
GLN A  52
LEU A  65
 None
 1.50A 1p93C-3boqA:
undetectable		 1p93C-3boqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE

(Enterococcus
faecalis) 		PF02110
(HK) 		5 ASN A 230
GLY A 233
LEU A 254
LEU A 203
THR A 172
 ADP  A 500 (-2.8A)
None
None
None
ADP  A 500 (-3.5A)
 1.38A 1p93C-3dzvA:
undetectable		 1p93C-3dzvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		5 MET A 126
LEU A 134
MET A 165
LEU A 169
THR A 199
 None
None
OXE  A 243 ( 4.6A)
None
None
 1.19A 1p93C-3e0xA:
undetectable		 1p93C-3e0xA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 719
GLY A 722
MET A 756
LEU A 763
ARG A 766
MET A 801
LEU A 887
CYH A 891
THR A 894
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.82A 1p93C-3kbaA:
34.1		 1p93C-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
LEU A 887
CYH A 891
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.90A 1p93C-3kbaA:
34.1		 1p93C-3kbaA:
49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		5 GLY A 308
LEU A 137
LEU A 328
CYH A 327
THR A 323
 None
 1.46A 1p93C-3kv4A:
undetectable		 1p93C-3kv4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp7 FLAVOPROTEIN
MONOOXYGENASE

(Klebsiella
pneumoniae) 		PF01494
(FAD_binding_3) 		5 GLY A 295
ARG A 204
MET A  71
LEU A  87
THR A  94
 URC  A7579 ( 3.5A)
URC  A7579 (-2.9A)
None
None
None
 1.48A 1p93C-3rp7A:
undetectable		 1p93C-3rp7A:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
LEU A 201
CYH A 205
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.78A 1p93C-3ry9A:
35.1		 1p93C-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 1.09A 1p93C-3ry9A:
35.1		 1p93C-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		5 GLY A 149
ARG A 207
MET A 381
LEU A 375
THR A 352
 None
 1.49A 1p93C-4c1tA:
undetectable		 1p93C-4c1tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 MET A 134
GLY A 141
LEU A 151
LEU A 116
THR A  90
 None
 1.34A 1p93C-4ehcA:
undetectable		 1p93C-4ehcA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eu2 PROTEASOME COMPONENT
C7-ALPHA

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ASN A  84
LEU A 214
MET A 210
LEU A  43
THR A 142
 None
 1.46A 1p93C-4eu2A:
undetectable		 1p93C-4eu2A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdr AP-4 COMPLEX SUBUNIT
MU-1

(Homo sapiens) 		PF00928
(Adap_comp_sub) 		5 GLY A 277
GLN A 276
LEU A 220
MET A 226
LEU A 272
 None
 1.42A 1p93C-4mdrA:
undetectable		 1p93C-4mdrA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 ASN A 564
GLY A 567
GLN A 570
MET A 601
LEU A 608
ARG A 611
MET A 646
LEU A 732
CYH A 736
THR A 739
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 0.45A 1p93C-4p6wA:
37.4		 1p93C-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 564
GLY A 568
MET A 601
CYH A 736
THR A 739
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 1.16A 1p93C-4p6wA:
37.4		 1p93C-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 560
ASN A 564
GLY A 567
MET A 601
LEU A 732
CYH A 736
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 0.83A 1p93C-4p6wA:
37.4		 1p93C-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 601
LEU A 608
GLN A 642
MET A 646
LEU A 732
CYH A 736
 MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
 1.04A 1p93C-4p6wA:
37.4		 1p93C-4p6wA:
96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		5 ASN A 134
GLY A 161
LEU A  86
CYH A  89
THR A  93
 PYC  A 402 (-4.2A)
None
None
None
None
 1.50A 1p93C-4q60A:
undetectable		 1p93C-4q60A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 ASN A 309
GLY A 307
GLN A 385
MET A 389
LEU B 220
 None
 1.21A 1p93C-4r1dA:
undetectable		 1p93C-4r1dA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 MET A1756
GLY A3756
LEU A3762
GLN A3752
LEU A3779
 None
 1.42A 1p93C-4rh7A:
undetectable		 1p93C-4rh7A:
6.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
LEU A 938
CYH A 942
THR A 945
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
 0.79A 1p93C-4udbA:
33.4		 1p93C-4udbA:
51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 MET A 603
ASN A 604
GLY A 628
LEU A 631
LEU A 655
 None
 1.08A 1p93C-5gmhA:
undetectable		 1p93C-5gmhA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		6 ASN A 127
GLY A 182
MET A 140
LEU A 174
LEU A 162
THR A 155
 None
None
None
None
None
SRM  A 702 (-3.2A)
 1.42A 1p93C-5h8yA:
undetectable		 1p93C-5h8yA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		5 ASN A  81
GLY A 159
GLN A 163
LEU A 208
THR A 217
 None
 1.46A 1p93C-5icqA:
undetectable		 1p93C-5icqA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		5 MET A 402
ASN A 392
GLY A 393
GLN A 408
THR A  56
 None
 1.49A 1p93C-5k1rA:
undetectable		 1p93C-5k1rA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 5 ASN A  94
GLY A 218
LEU A   8
LEU A 121
THR A  85
 None
 1.38A 1p93C-5lf9A:
undetectable		 1p93C-5lf9A:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
LEU A 938
CYH A 942
THR A 945
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.54A 1p93C-5mwpA:
33.8		 1p93C-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
MET A 807
CYH A 942
THR A 945
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 1.21A 1p93C-5mwpA:
33.8		 1p93C-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
LEU A 938
 ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 1.40A 1p93C-5mwpA:
33.8		 1p93C-5mwpA:
41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 GLY A 219
LEU A 214
MET A 213
LEU A 158
THR A 136
 None
 1.25A 1p93C-5opjA:
undetectable		 1p93C-5opjA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thx FERREDOXIN--NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 GLY A  35
LEU A 112
GLN A 134
LEU A 104
CYH A 102
 None
 0.94A 1p93C-5thxA:
undetectable		 1p93C-5thxA:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
GLY A 563
GLN A 566
MET A 597
ARG A 607
GLN A 638
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 (-4.6A)
 1.00A 1p93C-5uc1A:
25.2		 1p93C-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 ASN A 560
GLY A 563
GLN A 566
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.79A 1p93C-5uc1A:
25.2		 1p93C-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
LEU A 201
CYH A 205
THR A 208
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
 0.62A 1p93C-5ufsA:
36.7		 1p93C-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
 1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
 1.11A 1p93C-5ufsA:
36.7		 1p93C-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 GLN A  39
MET A  70
LEU A  77
ARG A  80
GLN A 111
MET A 115
CYH A 205
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
 1.42A 1p93C-5ufsA:
36.7		 1p93C-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 MET A  29
ASN A  33
GLY A  36
MET A  70
LEU A 201
CYH A 205
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
 0.88A 1p93C-5ufsA:
36.7		 1p93C-5ufsA:
71.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 GLY A 404
GLN A 407
LEU A 358
LEU A 417
THR A 346
 None
 1.18A 1p93C-5y6rA:
undetectable		 1p93C-5y6rA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 5 MET A  92
ASN A 189
GLY A 191
GLN A 141
LEU A 145
 HEZ  A 703 (-4.1A)
None
None
None
None
 1.50A 1p93C-5ya1A:
undetectable		 1p93C-5ya1A:
16.13