SIMILAR PATTERNS OF AMINO ACIDS FOR 1P93_B_DEXB2999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 MET A  25
LEU A 196
CYH A  51
ILE A  83
PHE A  84
 None
 1.39A 1p93B-1crkA:
undetectable		 1p93B-1crkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f89 32.5 KDA PROTEIN
YLR351C

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 GLY A 236
GLN A  17
LEU A  15
CYH A 169
PHE A 195
 None
 1.39A 1p93B-1f89A:
undetectable		 1p93B-1f89A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ASN 1 292
GLY 1 296
LEU 1 356
THR 1 157
ILE 1 124
 None
 1.15A 1p93B-1gt91:
undetectable		 1p93B-1gt91:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 MET A 446
GLY A 470
GLN A 474
LEU A 439
ILE A 455
 None
 1.05A 1p93B-1iq0A:
undetectable		 1p93B-1iq0A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 MET A 331
GLY A  62
GLN A  63
LEU A 119
ARG A 184
 None
 1.45A 1p93B-1nntA:
undetectable		 1p93B-1nntA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		5 ASN A 121
GLY A 298
MET A 360
LEU A 353
ILE A 430
 None
None
None
None
NAG  A 440 ( 4.8A)
 1.39A 1p93B-1q9hA:
undetectable		 1p93B-1q9hA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ASN A 213
GLN A 188
THR A  35
ILE A 109
PHE A 192
 None
 1.18A 1p93B-1rj6A:
undetectable		 1p93B-1rj6A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		5 ASN A 481
GLY A 485
LEU A 545
THR A 346
ILE A 313
 None
 1.16A 1p93B-1t1eA:
undetectable		 1p93B-1t1eA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 GLY A 596
GLN A 659
ARG A 662
THR A 551
ILE A 555
 None
 1.20A 1p93B-1ulvA:
undetectable		 1p93B-1ulvA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		5 GLY A  28
GLN A  92
LEU A  99
THR A  38
PHE A  40
 None
 1.39A 1p93B-1uwvA:
undetectable		 1p93B-1uwvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		5 MET 3 165
GLY 3 211
LEU 3  94
CYH 3 191
ILE 3 153
 None
 1.23A 1p93B-1z7z3:
undetectable		 1p93B-1z7z3:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 891
 BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 0.85A 1p93B-2ax9A:
32.2		 1p93B-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 0.93A 1p93B-2ax9A:
32.2		 1p93B-2ax9A:
46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 MET A 331
GLY A  62
GLN A  63
LEU A 119
ARG A 184
 None
 1.43A 1p93B-2d3iA:
undetectable		 1p93B-2d3iA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 GLY A 306
LEU A 253
MET A 261
THR A  36
ILE A 326
 None
 1.14A 1p93B-2og2A:
undetectable		 1p93B-2og2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 GLY A 344
LEU A 349
ARG A 348
CYH A 269
PHE A 213
 None
 1.34A 1p93B-2p50A:
undetectable		 1p93B-2p50A:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.68A 1p93B-2q3yA:
35.1		 1p93B-2q3yA:
58.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.93A 1p93B-2q3yA:
35.1		 1p93B-2q3yA:
58.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY 1 100
MET 1 140
LEU 1 147
ILE 1 165
PHE 1 132
 GDP  1 339 (-3.3A)
None
None
None
None
 1.46A 1p93B-2r6r1:
undetectable		 1p93B-2r6r1:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		5 GLY A 258
GLN A  48
LEU A  46
CYH A 191
PHE A 217
 None
 1.30A 1p93B-2w1vA:
undetectable		 1p93B-2w1vA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 MET A 467
LEU A 455
MET A 395
THR A 502
ILE A 503
 None
 1.30A 1p93B-2x0qA:
undetectable		 1p93B-2x0qA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agf GLUTAMINASE 1

(Bacillus
subtilis) 		PF04960
(Glutaminase) 		5 LEU A 324
MET A 318
CYH A  52
THR A 211
ILE A 214
 None
 1.45A 1p93B-3agfA:
undetectable		 1p93B-3agfA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 ASN A 112
GLY A  69
LEU A   7
MET A  19
ILE A 108
 None
 1.37A 1p93B-3b9gA:
undetectable		 1p93B-3b9gA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmo CYTIDINE DEAMINASE

(Burkholderia
pseudomallei) 		PF00383
(dCMP_cyt_deam_1) 		5 GLY A  40
LEU A  59
MET A  95
THR A 108
ILE A   7
 None
 1.30A 1p93B-3dmoA:
undetectable		 1p93B-3dmoA:
17.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 719
GLY A 722
MET A 756
LEU A 763
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.71A 1p93B-3kbaA:
34.1		 1p93B-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 GLY A 722
GLN A 725
MET A 756
LEU A 763
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.87A 1p93B-3kbaA:
34.1		 1p93B-3kbaA:
49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		5 ASN A 216
GLY A 333
LEU A 307
MET A 316
ILE A 185
 None
 1.40A 1p93B-3khzA:
undetectable		 1p93B-3khzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ASN A 113
GLY A 115
LEU A 118
THR A 260
ILE A 264
 None
 1.38A 1p93B-3pwzA:
undetectable		 1p93B-3pwzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qax PROBABLE ABC
TRANSPORTER
ARGININE-BINDING
PROTEIN ARTJ

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		5 GLY A 196
LEU A 193
THR A 227
ILE A 223
PHE A  35
 None
 1.40A 1p93B-3qaxA:
undetectable		 1p93B-3qaxA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.67A 1p93B-3ry9A:
35.4		 1p93B-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.04A 1p93B-3ry9A:
35.4		 1p93B-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH
AOPB

(Aeromonas
hydrophila) 		PF04888
(SseC)
no annotation 		5 GLY B 197
LEU A  74
ARG A  78
THR B 242
ILE B 239
 None
 1.49A 1p93B-3wxxB:
undetectable		 1p93B-3wxxB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		5 GLY A  73
GLN A  77
LEU A 279
ARG A 269
ILE A 201
 None
 1.48A 1p93B-4g1uA:
undetectable		 1p93B-4g1uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Drosophila
melanogaster) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 MET A  90
GLY A   7
LEU A 244
ILE A 101
PHE A 103
 None
 0.92A 1p93B-4hk1A:
undetectable		 1p93B-4hk1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 GLY A 156
GLN A 217
LEU A 213
MET A 169
THR A 148
 None
 1.48A 1p93B-4j2uA:
undetectable		 1p93B-4j2uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwp GCN5-RELATED
N-ACETYLTRANSFERASE

(Brucella
abortus) 		PF13420
(Acetyltransf_4) 		5 GLY A 137
LEU A 164
ARG A 111
CYH A 141
ILE A 122
 None
None
None
None
ACO  A 201 (-4.0A)
 1.44A 1p93B-4jwpA:
undetectable		 1p93B-4jwpA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ASN A 564
GLY A 567
GLN A 570
MET A 601
LEU A 608
ARG A 611
MET A 646
CYH A 736
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.41A 1p93B-4p6wA:
37.8		 1p93B-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
GLY A 568
MET A 601
CYH A 736
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.99A 1p93B-4p6wA:
37.8		 1p93B-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 MET A 560
ASN A 564
GLY A 567
MET A 601
CYH A 736
ILE A 747
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.77A 1p93B-4p6wA:
37.8		 1p93B-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 560
ASN A 564
LEU A 621
CYH A 736
ILE A 747
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 1.25A 1p93B-4p6wA:
37.8		 1p93B-4p6wA:
96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 GLY A1032
MET A1029
LEU A1023
ILE A1055
PHE A1064
 None
 1.42A 1p93B-4s0vA:
undetectable		 1p93B-4s0vA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.61A 1p93B-4udbA:
33.6		 1p93B-4udbA:
51.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 770
GLY A 774
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
None
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.05A 1p93B-4udbA:
33.6		 1p93B-4udbA:
51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmh HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
 None
 1.45A 1p93B-4wmhA:
undetectable		 1p93B-4wmhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkb YCF53-LIKE PROTEIN

(Synechocystis
sp. PCC 6803) 		PF05419
(GUN4)
PF16416
(GUN4_N) 		5 GLY A 205
LEU A 200
THR A 112
ILE A 146
PHE A 160
 None
 1.48A 1p93B-4xkbA:
undetectable		 1p93B-4xkbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 MET A 313
ASN A 315
GLY A 317
LEU A 947
THR A 360
 None
NI  A1601 (-3.3A)
None
None
None
 1.47A 1p93B-5dotA:
undetectable		 1p93B-5dotA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 ASN A  93
GLY A  94
GLN A  98
LEU A 102
ILE A 118
 NDP  A1000 (-3.5A)
None
None
None
NDP  A1000 (-4.3A)
 1.47A 1p93B-5g6rA:
undetectable		 1p93B-5g6rA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 ASN A  99
LEU A 393
ARG A 390
THR A 460
ILE A 450
 None
 1.41A 1p93B-5m6gA:
undetectable		 1p93B-5m6gA:
17.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.50A 1p93B-5mwpA:
34.3		 1p93B-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.97A 1p93B-5mwpA:
34.3		 1p93B-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
 ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.27A 1p93B-5mwpA:
34.3		 1p93B-5mwpA:
41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojl IMINE REDUCTASE

(Aspergillus
terreus) 		no annotation 5 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.50A 1p93B-5ojlA:
undetectable		 1p93B-5ojlA:
15.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 ASN A 560
GLY A 563
GLN A 566
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.75A 1p93B-5uc1A:
25.1		 1p93B-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		10 ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.45A 1p93B-5ufsA:
37.1		 1p93B-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.02A 1p93B-5ufsA:
37.1		 1p93B-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 MET A  29
ASN A  33
GLY A  36
MET A  70
CYH A 205
PHE A 218
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.6A)
1TA  A 301 (-4.0A)
 0.80A 1p93B-5ufsA:
37.1		 1p93B-5ufsA:
71.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli) 		no annotation 5 MET A  92
ASN A 189
GLY A 191
GLN A 141
LEU A 145
 HEZ  A 703 (-4.1A)
None
None
None
None
 1.45A 1p93B-5ya1A:
undetectable		 1p93B-5ya1A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		no annotation 5 GLN C1023
LEU A 266
THR A 220
ILE A 226
PHE A 232
 None
 1.35A 1p93B-6au8C:
undetectable		 1p93B-6au8C:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 MET A  78
GLY A  64
GLN A 255
THR A  20
ILE A  24
 ACP  A 500 (-4.6A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 3.9A)
None
 1.08A 1p93B-6ci7A:
undetectable		 1p93B-6ci7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dus TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN

(Salmonella
enterica) 		no annotation 5 ASN A 259
ARG A 184
MET A 279
CYH A 293
ILE A 262
 NAG  A 502 (-3.2A)
None
None
None
None
 1.44A 1p93B-6dusA:
undetectable		 1p93B-6dusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.10A 1p93B-6e85A:
undetectable		 1p93B-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 5 MET A 240
ASN A 244
MET A  78
LEU A  85
ILE A 210
 None
 1.27A 1p93B-6f79A:
undetectable		 1p93B-6f79A:
undetectable