SIMILAR PATTERNS OF AMINO ACIDS FOR 1P93_A_DEXA1999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 5 LEU A 287
ASN A 286
GLY A 284
GLN A 301
THR A 334
 None
 1.41A 1p93A-1bwdA:
undetectable		 1p93A-1bwdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		5 LEU A 242
LEU A  94
GLY A  95
GLN A  98
THR A 234
 None
None
PLP  A 400 (-3.2A)
None
None
 1.43A 1p93A-1djuA:
undetectable		 1p93A-1djuA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 ASN A 226
LEU A 218
GLY A 219
THR C 558
ILE C 562
 None
 1.43A 1p93A-1ef1A:
undetectable		 1p93A-1ef1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiq XANTHINE OXIDASE

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 LEU A  30
LEU A  36
GLY A  35
THR A  24
ILE A  77
 None
 1.44A 1p93A-1fiqA:
undetectable		 1p93A-1fiqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A  30
LEU A  36
GLY A  35
THR A  24
ILE A  77
 None
 1.43A 1p93A-1n5xA:
undetectable		 1p93A-1n5xA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		5 ASN A 188
LEU A 190
GLY A 493
MET A 159
ILE A 184
 None
 1.37A 1p93A-1ohfA:
undetectable		 1p93A-1ohfA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		5 ASN A 188
LEU A 190
GLY A 493
THR A 478
ILE A 184
 None
 1.40A 1p93A-1ohfA:
undetectable		 1p93A-1ohfA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		5 MET A 683
ASN A 529
LEU A 362
GLY A 363
MET A 357
 None
 1.46A 1p93A-1qafA:
undetectable		 1p93A-1qafA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8i TRAC

(Escherichia
coli) 		PF07996
(T4SS) 		5 MET A 131
LEU A 135
ASN A 132
MET A  65
ILE A 128
 None
 1.19A 1p93A-1r8iA:
undetectable		 1p93A-1r8iA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 719
LEU A 716
GLY A 715
GLN A 703
THR A 681
 None
 1.07A 1p93A-1r8wA:
undetectable		 1p93A-1r8wA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz6 CYTOCHROME C
PEROXIDASE

(Marinobacter
hydrocarbonoclasticus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 LEU A 206
ASN A 205
GLY A 207
THR A 165
ILE A  14
 None
 1.30A 1p93A-1rz6A:
undetectable		 1p93A-1rz6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz6 CYTOCHROME C
PEROXIDASE

(Marinobacter
hydrocarbonoclasticus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 LEU A 206
ASN A 205
GLY A 208
THR A 165
ILE A  14
 None
 1.25A 1p93A-1rz6A:
undetectable		 1p93A-1rz6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu2 APOCYTOCHROME F

(Nostoc sp. PCC
7119) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 ASN B 154
GLY B 241
GLN B 242
ARG B  19
GLN B 159
 HEC  B 255 (-3.9A)
None
None
None
None
 1.36A 1p93A-1tu2B:
undetectable		 1p93A-1tu2B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 321
LEU A 326
GLY A 325
THR A 292
ILE A 288
 None
 1.46A 1p93A-1um8A:
undetectable		 1p93A-1um8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASN A 138
GLY A  47
MET A 130
ARG A  52
ILE A 141
 None
 1.47A 1p93A-1yfmA:
undetectable		 1p93A-1yfmA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 704
ASN A 705
LEU A 707
GLY A 708
GLN A 711
MET A 742
ARG A 752
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
 0.91A 1p93A-2ax9A:
31.8		 1p93A-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 704
LEU A 707
GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 1.03A 1p93A-2ax9A:
31.8		 1p93A-2ax9A:
46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 336
ASN A 339
LEU A 337
GLN A 334
ILE A 131
 None
 1.27A 1p93A-2de2A:
undetectable		 1p93A-2de2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjg GTP-BINDING PROTEIN
ENGA

(Bacillus
subtilis) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 ASN A 119
LEU A 121
GLY A  92
THR A  18
ILE A  19
 GDP  A 800 (-3.3A)
None
None
GDP  A 800 (-3.5A)
None
 1.27A 1p93A-2hjgA:
undetectable		 1p93A-2hjgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 ASN A 226
LEU A 218
GLY A 219
THR A 556
ILE A 560
 None
 1.42A 1p93A-2i1jA:
3.1		 1p93A-2i1jA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1

(Anopheles
gambiae) 		PF00481
(PP2C) 		5 LEU A  86
LEU A  87
GLY A  88
GLN A  89
ILE A  54
 None
 1.21A 1p93A-2irmA:
undetectable		 1p93A-2irmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY X 334
GLN X 335
GLN X 463
THR X  36
ILE X 161
 MGD  X 802 ( 3.3A)
2MD  X 801 (-3.2A)
None
None
None
 1.34A 1p93A-2iv2X:
undetectable		 1p93A-2iv2X:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 302
GLN A 306
MET A 191
THR A 315
ILE A 290
 None
 1.35A 1p93A-2nmpA:
undetectable		 1p93A-2nmpA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		5 LEU A 231
LEU A 265
GLY A 266
THR A 179
ILE A 194
 None
 1.48A 1p93A-2ntbA:
undetectable		 1p93A-2ntbA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 307
LEU A 330
GLY A 304
MET A 281
MET A 294
 LEU  A 307 ( 0.6A)
LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
PHE  A 279 ( 3.6A)
ILE  A 328 ( 3.9A)
 1.48A 1p93A-2nvvA:
undetectable		 1p93A-2nvvA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 LEU A  31
LEU A  39
GLY A  33
MET A  65
ILE A  83
 None
None
SO4  A 254 (-3.4A)
None
None
 1.47A 1p93A-2nwqA:
undetectable		 1p93A-2nwqA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 115
THR A 208
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-3.4A)
 0.86A 1p93A-2q3yA:
34.9		 1p93A-2q3yA:
58.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A 177
ASN A 178
LEU A 180
GLY A 181
GLN A 118
 None
 1.13A 1p93A-2q80A:
2.6		 1p93A-2q80A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhd CYTOCHROME C551
PEROXIDASE

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 LEU A 206
ASN A 205
GLY A 207
THR A 165
ILE A  14
 None
 1.27A 1p93A-2vhdA:
undetectable		 1p93A-2vhdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		5 LEU A 436
ASN A 437
GLY A 439
ARG A 194
THR A 460
 None
 1.41A 1p93A-2yk0A:
undetectable		 1p93A-2yk0A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 LEU A 116
LEU A 113
GLY A  47
MET A  73
GLN A 220
 None
 1.44A 1p93A-2yr0A:
undetectable		 1p93A-2yr0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akz GLUTAMYL-TRNA
SYNTHETASE 2

(Thermotoga
maritima) 		no annotation 5 MET B 278
LEU B 281
LEU B 284
GLY B 285
ILE B 296
 None
None
C  F  12 ( 4.7A)
U  F  13 ( 4.6A)
None
 0.85A 1p93A-3akzB:
undetectable		 1p93A-3akzB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A 230
LEU A 242
GLY A  64
THR A 175
ILE A  60
 None
 1.42A 1p93A-3da2A:
undetectable		 1p93A-3da2A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv8 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

([Eubacterium]
rectale) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 155
LEU A 156
GLN A 217
THR A 173
ILE A 169
 None
 1.50A 1p93A-3dv8A:
undetectable		 1p93A-3dv8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		5 MET A 261
LEU A 264
ASN A 265
LEU A 267
GLY A 268
 None
 1.17A 1p93A-3egcA:
undetectable		 1p93A-3egcA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		5 MET A 261
LEU A 264
ASN A 265
LEU A 269
GLY A 268
 None
 1.28A 1p93A-3egcA:
undetectable		 1p93A-3egcA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 135
LEU A 132
GLY A 131
GLN A 144
ILE A 110
 None
 1.02A 1p93A-3fi9A:
undetectable		 1p93A-3fi9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A 235
LEU A 238
LEU A 241
GLN A 225
ILE A 266
 None
 1.24A 1p93A-3i6eA:
undetectable		 1p93A-3i6eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A 235
LEU A 238
LEU A 241
GLY A 240
GLN A 225
 None
None
None
NA  A 387 ( 4.4A)
None
 1.48A 1p93A-3i6eA:
undetectable		 1p93A-3i6eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iox AGI/II

(Streptococcus
mutans) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		5 LEU A 599
LEU A 600
GLY A 525
GLN A 604
GLN A 563
 None
 1.50A 1p93A-3ioxA:
undetectable		 1p93A-3ioxA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		5 LEU A 347
LEU A 348
GLY A 349
THR A 379
ILE A 375
 None
 1.22A 1p93A-3j0aA:
undetectable		 1p93A-3j0aA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtl PROTEASOME SUBUNIT
BETA

(Thermoplasma
acidophilum) 		PF00227
(Proteasome) 		5 MET H  59
LEU H  65
GLN H  69
THR H  41
ILE H  37
 None
 0.97A 1p93A-3jtlH:
undetectable		 1p93A-3jtlH:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 718
ASN A 719
LEU A 721
GLY A 722
MET A 756
ARG A 766
MET A 801
THR A 894
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
 0.88A 1p93A-3kbaA:
34.0		 1p93A-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 718
LEU A 721
GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
THR A 894
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
 0.94A 1p93A-3kbaA:
34.0		 1p93A-3kbaA:
49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 272
ASN A 273
LEU A 275
GLY A 276
THR A 283
 None
 1.42A 1p93A-3mjoA:
3.3		 1p93A-3mjoA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		5 LEU A 485
ASN A 484
GLY A 240
ARG A 335
THR A 248
 None
 1.42A 1p93A-3nm1A:
undetectable		 1p93A-3nm1A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 LEU A  30
LEU A  36
GLY A  35
THR A  24
ILE A  77
 None
 1.41A 1p93A-3nvyA:
undetectable		 1p93A-3nvyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Campylobacter
jejuni) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 LEU A 248
ASN A 249
LEU A 251
GLY A 252
ARG A 222
 None
 0.95A 1p93A-3pfiA:
undetectable		 1p93A-3pfiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		5 LEU A 130
GLY A 126
GLN A 127
THR A 188
ILE A 212
 None
None
None
T3Q  A 301 ( 4.2A)
None
 1.45A 1p93A-3px2A:
undetectable		 1p93A-3px2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 197
LEU A 198
GLY A 149
THR A 144
ILE A 128
 ANP  A1634 (-4.4A)
None
None
ANP  A1634 (-4.6A)
None
 1.37A 1p93A-3q5iA:
undetectable		 1p93A-3q5iA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
THR A 208
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
 0.85A 1p93A-3ry9A:
35.2		 1p93A-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vp8 GENERAL
TRANSCRIPTIONAL
COREPRESSOR TUP1

(Saccharomyces
cerevisiae) 		PF08581
(Tup_N) 		5 MET A  45
LEU A  49
ASN A  46
GLN A  53
ARG A  56
 None
 1.24A 1p93A-3vp8A:
undetectable		 1p93A-3vp8A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila') 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 213
ASN A 214
LEU A 160
GLY A 161
THR A 115
 None
 1.30A 1p93A-3wnvA:
undetectable		 1p93A-3wnvA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 LEU A 185
ASN A 186
LEU A 188
GLN A 192
THR A 160
 None
 1.12A 1p93A-3wxbA:
undetectable		 1p93A-3wxbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 5 LEU A 221
LEU A 220
GLY A 219
MET A 599
ARG A 227
 None
 1.37A 1p93A-4b2nA:
undetectable		 1p93A-4b2nA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 147
LEU A 188
GLY A 189
GLN A 168
THR A 194
 None
 1.23A 1p93A-4b6lA:
undetectable		 1p93A-4b6lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6

(Homo sapiens) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		5 LEU F 150
LEU F 152
MET F  84
GLN F  76
ILE F 146
 None
 1.28A 1p93A-4d10F:
undetectable		 1p93A-4d10F:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 178
ASN A 177
LEU A 175
GLY A 174
ILE A 207
 None
 1.04A 1p93A-4eexA:
undetectable		 1p93A-4eexA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		5 MET A 257
LEU A  93
ASN A  92
LEU A  74
ILE A 180
 None
 1.24A 1p93A-4i0nA:
undetectable		 1p93A-4i0nA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		5 LEU A 763
ASN A 760
LEU A 762
GLY A 761
MET A 791
 None
FM9  A1901 (-3.9A)
None
None
None
 1.30A 1p93A-4or2A:
undetectable		 1p93A-4or2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4osp OXYGENASE-REDUCTASE

(Streptomyces
fradiae) 		PF13561
(adh_short_C2) 		5 LEU A  26
LEU A   4
GLY A  30
THR A  47
ILE A  24
 None
 1.45A 1p93A-4ospA:
undetectable		 1p93A-4ospA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 564
GLY A 568
MET A 601
THR A 739
ILE A 747
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
 0.96A 1p93A-4p6wA:
38.0		 1p93A-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 563
ASN A 564
LEU A 566
GLY A 567
GLN A 570
MET A 601
ARG A 611
MET A 646
THR A 739
ILE A 747
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
 0.50A 1p93A-4p6wA:
38.0		 1p93A-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 MET A 560
ASN A 564
GLY A 567
GLN A 570
MET A 601
ILE A 747
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
 0.74A 1p93A-4p6wA:
38.0		 1p93A-4p6wA:
96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		5 LEU A 142
LEU A 311
GLY A 310
THR A 134
ILE A 130
 None
 1.49A 1p93A-4rk2A:
undetectable		 1p93A-4rk2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 ASN A 226
LEU A 218
GLY A 219
THR A 567
ILE A 571
 None
 1.43A 1p93A-4rm9A:
undetectable		 1p93A-4rm9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rth MEMBRANE-EXTRINSIC
PROTEIN OF
PHOTOSYSTEM II PSBP

(Zea mays) 		PF01789
(PsbP) 		5 LEU A  87
LEU A  88
GLY A  89
GLN A  91
GLN A  64
 None
 1.23A 1p93A-4rthA:
undetectable		 1p93A-4rthA:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 852
THR A 945
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
 0.82A 1p93A-4udbA:
33.4		 1p93A-4udbA:
51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 LEU A  98
ASN A  99
LEU A  97
GLN A 119
ILE A  77
 None
 1.47A 1p93A-4wlpA:
undetectable		 1p93A-4wlpA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A  30
LEU A  36
GLY A  35
THR A  24
ILE A  77
 None
 1.46A 1p93A-4yswA:
undetectable		 1p93A-4yswA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 LEU A 224
LEU A 223
GLY A 222
GLN A 227
ILE A 215
 None
FAD  A 601 (-3.7A)
None
None
None
 1.39A 1p93A-4z43A:
undetectable		 1p93A-4z43A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE

(Pectobacterium
carotovorum) 		PF13561
(adh_short_C2) 		5 LEU A  30
LEU A   8
GLY A  34
THR A  48
ILE A  28
 None
 1.39A 1p93A-4za2A:
undetectable		 1p93A-4za2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqq TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Arabidopsis
thaliana) 		PF00520
(Ion_trans) 		5 ASN A 665
LEU A 663
MET A 629
THR A 297
ILE A 300
 None
 1.15A 1p93A-5dqqA:
undetectable		 1p93A-5dqqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 5 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.46A 1p93A-5ex6C:
2.4		 1p93A-5ex6C:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 LEU A 664
LEU A 665
GLY A 616
THR A 611
ILE A 595
 4ZS  A 901 (-3.6A)
None
None
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.3A)
 1.44A 1p93A-5ezrA:
undetectable		 1p93A-5ezrA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9p ANTHRONE
OXIDASE-LIKE PROTEIN

(Streptomyces
ambofaciens) 		PF03992
(ABM) 		5 LEU A 143
GLY A 144
GLN A 147
GLN A 180
ILE A   4
 None
None
GOL  A 301 (-2.7A)
None
None
 1.30A 1p93A-5f9pA:
undetectable		 1p93A-5f9pA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjp O-SUCCINYLBENZOATE
SYNTHASE

(Amycolatopsis
sp.) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  31
LEU A  32
MET A 105
THR A 329
ILE A 328
 None
 1.26A 1p93A-5fjpA:
undetectable		 1p93A-5fjpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 MET A 410
LEU A 445
GLN A 447
THR A 346
ILE A 411
 None
 1.45A 1p93A-5fmqA:
undetectable		 1p93A-5fmqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		5 MET A 313
LEU A 316
ASN A 317
LEU A 320
GLY A 321
 None
 1.21A 1p93A-5i35A:
undetectable		 1p93A-5i35A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		5 LEU A 236
LEU A 235
GLY A 234
GLN A 239
ILE A 227
 None
 1.31A 1p93A-5lv9A:
undetectable		 1p93A-5lv9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU A 930
GLN A 936
MET A 472
THR A 921
ILE A 919
 None
 1.47A 1p93A-5m59A:
undetectable		 1p93A-5m59A:
9.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
THR A 945
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.71A 1p93A-5mwpA:
34.0		 1p93A-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 852
 ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.36A 1p93A-5mwpA:
34.0		 1p93A-5mwpA:
41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 5 LEU A 426
LEU A 411
GLY A 430
ARG A 524
ILE A 417
 None
 1.47A 1p93A-5oklA:
undetectable		 1p93A-5oklA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 295
LEU A 298
LEU A 301
MET A 336
ARG A 346
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
 1.16A 1p93A-5toaA:
24.8		 1p93A-5toaA:
27.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 8 LEU A 559
ASN A 560
LEU A 562
GLY A 563
GLN A 566
MET A 597
ARG A 607
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.81A 1p93A-5uc1A:
25.4		 1p93A-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
ASN A 560
LEU A 562
GLY A 563
GLN A 566
MET A 597
GLN A 638
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-4.6A)
 0.96A 1p93A-5uc1A:
25.4		 1p93A-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 MET A 556
ASN A 560
GLY A 563
GLN A 566
MET A 597
GLN A 638
 None
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-4.6A)
 1.05A 1p93A-5uc1A:
25.4		 1p93A-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
 0.59A 1p93A-5ufsA:
37.0		 1p93A-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 MET A  29
ASN A  33
GLY A  36
GLN A  39
MET A  70
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
 0.79A 1p93A-5ufsA:
37.0		 1p93A-5ufsA:
71.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 MET A 193
LEU A 197
LEU A 336
GLY A 337
GLN A 243
 None
 1.46A 1p93A-5vemA:
undetectable		 1p93A-5vemA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg2 INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Tetranychus
urticae) 		no annotation 5 LEU U  91
ASN U  92
LEU U  93
GLY U 151
ILE U 243
 None
 1.23A 1p93A-5vg2U:
undetectable		 1p93A-5vg2U:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A 275
LEU A 274
GLY A 273
THR A 367
ILE A 345
 None
 1.36A 1p93A-5vniA:
undetectable		 1p93A-5vniA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 LEU A 180
LEU A 169
GLY A 178
MET A 135
ILE A 145
 None
 1.26A 1p93A-5wbfA:
undetectable		 1p93A-5wbfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S29,
PUTATIVE
RIBOSOMAL PROTEIN
S10P/S20E, PUTATIVE
RIBOSOMAL PROTEIN
S3, PUTATIVE

(Trichomonas
vaginalis) 		PF00189
(Ribosomal_S3_C)
PF00338
(Ribosomal_S10)
PF07650
(KH_2) 		5 LEU d  51
GLY D  16
ARG d  23
THR U  29
ILE U  88
 None
 1.45A 1p93A-5xyid:
undetectable		 1p93A-5xyid:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C  66
LEU C  65
GLY C  64
ARG C  24
THR C 137
 None
 1.46A 1p93A-5y3rC:
undetectable		 1p93A-5y3rC:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 MET A  78
GLY A  64
GLN A 255
THR A  20
ILE A  24
 ACP  A 500 (-4.6A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
ACP  A 500 ( 3.9A)
None
 1.03A 1p93A-6ci7A:
undetectable		 1p93A-6ci7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN

(Escherichia
coli;
Homo sapiens) 		no annotation 5 MET R  44
LEU R  47
LEU R  50
GLY R  51
THR R  94
 None
 0.97A 1p93A-6cmoR:
undetectable		 1p93A-6cmoR:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2

(Saccharomyces
cerevisiae) 		no annotation 5 MET D 295
LEU D 276
GLN D 270
MET D 231
ILE D 257
 None
 1.21A 1p93A-6eojD:
undetectable		 1p93A-6eojD:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.41A 1p93A-6fshA:
undetectable		 1p93A-6fshA:
13.67