SIMILAR PATTERNS OF AMINO ACIDS FOR 1P91_B_SAMB2401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB


([Bacillus]
caldotenax)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB)
5 GLY A  44
GLY A  42
ILE A 411
LEU A 401
THR A  36
ATP  A 700 (-3.0A)
ATP  A 700 (-3.4A)
None
None
None
1.07A 1p91B-1d9zA:
2.3
1p91B-1d9zA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE


(Triticum
aestivum)
PF00709
(Adenylsucc_synt)
5 TYR A 429
GLY A 435
GLY A 433
LEU A  17
PRO A  42
None
None
GDP  A 500 (-3.2A)
None
None
0.91A 1p91B-1dj3A:
undetectable
1p91B-1dj3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nff PUTATIVE
OXIDOREDUCTASE
RV2002


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
5 ARG A 177
GLY A 175
GLY A 172
ILE A 135
LEU A 215
None
0.98A 1p91B-1nffA:
5.0
1p91B-1nffA:
23.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A


(Escherichia
coli)
PF13847
(Methyltransf_31)
8 TYR A  67
GLY A  95
GLY A  97
TYR A  98
TYR A  99
LEU A 184
THR A 234
PRO A 235
None
SAM  A1401 (-3.4A)
SAM  A1401 (-3.3A)
None
SAM  A1401 (-4.4A)
SAM  A1401 (-4.6A)
None
None
0.64A 1p91B-1p91A:
37.8
1p91B-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A


(Escherichia
coli)
PF13847
(Methyltransf_31)
5 TYR A  67
LEU A  70
GLY A  93
TYR A  99
LEU A 184
None
None
None
SAM  A1401 (-4.4A)
SAM  A1401 (-4.6A)
1.00A 1p91B-1p91A:
37.8
1p91B-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A


(Escherichia
coli)
PF13847
(Methyltransf_31)
8 TYR A  67
LEU A  70
GLY A  95
GLY A  97
TYR A  98
TYR A  99
ILE A 155
LEU A 184
None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-3.3A)
None
SAM  A1401 (-4.4A)
SAM  A1401 (-4.2A)
SAM  A1401 (-4.6A)
0.41A 1p91B-1p91A:
37.8
1p91B-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A


(Escherichia
coli)
PF13847
(Methyltransf_31)
8 TYR A  67
LEU A  70
GLY A  95
GLY A  97
TYR A  98
TYR A  99
LEU A 184
THR A 234
None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-3.3A)
None
SAM  A1401 (-4.4A)
SAM  A1401 (-4.6A)
None
0.61A 1p91B-1p91A:
37.8
1p91B-1p91A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A


(Escherichia
coli)
PF13847
(Methyltransf_31)
5 TYR A  67
LEU A  70
GLY A  95
TYR A  99
ILE A 155
None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-4.4A)
SAM  A1401 (-4.2A)
1.09A 1p91B-1p91A:
37.8
1p91B-1p91A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE


(Acetobacter
pasteurianus)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
5 LEU A 532
GLY A 466
GLY A 653
ILE A 650
LEU A 587
None
1.03A 1p91B-1ryyA:
undetectable
1p91B-1ryyA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3d SERINE
ACETYLTRANSFERASE


(Escherichia
coli)
PF00132
(Hexapep)
PF06426
(SATase_N)
5 LEU A 182
GLY A 217
GLY A 215
ILE A 202
LEU A 111
None
1.02A 1p91B-1t3dA:
undetectable
1p91B-1t3dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE


(Shewanella
massilia)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 LEU A 185
GLY A 357
GLY A 359
ILE A 183
LEU A 194
None
1.03A 1p91B-1tmoA:
undetectable
1p91B-1tmoA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ton TONIN

(Rattus rattus)
PF00089
(Trypsin)
5 LEU A  67
GLY A 193
GLY A 142
ILE A  34
LEU A 108
None
1.10A 1p91B-1tonA:
undetectable
1p91B-1tonA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyd TYROSYL-TRNA
SYNTHETASE


(Geobacillus
stearothermophilus)
PF00579
(tRNA-synt_1b)
5 LEU E  44
GLY E  71
GLY E  74
ILE E 101
LEU E 109
None
1.09A 1p91B-1tydE:
2.4
1p91B-1tydE:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE


(Thermus
thermophilus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 LEU A 265
GLY A 232
GLY A  90
LEU A 187
PRO A 182
None
1.04A 1p91B-1uekA:
undetectable
1p91B-1uekA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE


(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 187
GLY A 151
GLY A 148
ILE A 145
THR A 141
None
None
NAD  A1001 (-3.2A)
None
None
1.08A 1p91B-1wwkA:
6.2
1p91B-1wwkA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii)
PF00128
(Alpha-amylase)
5 TYR A  62
LEU A  63
GLY A  51
ILE A  37
LEU A 418
None
None
CA  A 601 ( 4.9A)
None
None
1.09A 1p91B-1wzaA:
undetectable
1p91B-1wzaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE


(Bacillus sp.
NS-129)
PF01266
(DAO)
5 LEU A  71
GLY A  15
GLY A  19
TYR A  20
TYR A  21
None
1.08A 1p91B-1zovA:
undetectable
1p91B-1zovA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zud ADENYLYLTRANSFERASE
THIF


(Escherichia
coli)
PF00899
(ThiF)
5 LEU 1 107
GLY 1  40
GLY 1  37
ILE 1  34
THR 1  54
None
1.10A 1p91B-1zud1:
3.8
1p91B-1zud1:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT


(Streptococcus
pyogenes)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 LEU A 292
GLY A 322
ILE A 299
LEU A 338
THR A 268
None
1.10A 1p91B-2avtA:
undetectable
1p91B-2avtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14


(Homo sapiens)
PF00443
(UCH)
5 LEU A 285
GLY A 480
TYR A 479
ILE A 325
THR A 424
None
1.09A 1p91B-2aynA:
undetectable
1p91B-2aynA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bqp PROTEIN (PEA LECTIN)

(Pisum sativum)
PF00139
(Lectin_legB)
5 GLY A 102
GLY A  97
TYR A 100
ILE A 144
THR A 112
None
1.12A 1p91B-2bqpA:
undetectable
1p91B-2bqpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbr GLYOXYLATE REDUCTASE

(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 198
GLY A 162
GLY A 159
ILE A 156
THR A 152
None
None
NAP  A 401 (-3.5A)
None
None
1.09A 1p91B-2dbrA:
5.9
1p91B-2dbrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN


(Homo sapiens)
PF00128
(Alpha-amylase)
5 TYR A 149
LEU A 150
GLY A 138
ILE A 126
LEU A 419
None
1.04A 1p91B-2dh3A:
undetectable
1p91B-2dh3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 LEU A 556
GLY A 583
ILE A 600
LEU A 533
THR A 571
None
1.10A 1p91B-2g3nA:
undetectable
1p91B-2g3nA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024


(Pseudomonas
aeruginosa)
PF03060
(NMO)
5 LEU A 187
GLY A  21
GLY A 201
ILE A  18
PRO A 174
None
FMN  A1904 (-4.0A)
FMN  A1904 (-3.3A)
None
None
0.97A 1p91B-2gjnA:
undetectable
1p91B-2gjnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0b NEUREXIN-1-ALPHA

(Bos taurus)
PF02210
(Laminin_G_2)
5 GLY A 349
GLY A 347
ILE A 344
LEU A 320
PRO A 436
None
CA  A1000 ( 4.4A)
None
None
None
1.02A 1p91B-2h0bA:
undetectable
1p91B-2h0bA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis)
PF03309
(Pan_kinase)
5 LEU X 223
GLY X 191
GLY X 195
TYR X 196
ILE X 173
None
1.09A 1p91B-2h3gX:
undetectable
1p91B-2h3gX:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H


(Human
immunodeficiency
virus 1)
PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb)
5 LEU A 368
GLY A 352
TYR A 354
ILE A 329
THR A 386
None
0.84A 1p91B-2hnzA:
undetectable
1p91B-2hnzA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa)
PF01580
(FtsK_SpoIIIE)
5 LEU A 462
GLY A 676
GLY A 471
ILE A 650
TYR A 680
None
AGS  A1723 (-3.6A)
AGS  A1723 (-3.1A)
None
None
1.04A 1p91B-2iutA:
2.5
1p91B-2iutA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbf ATP-DEPENDENT RNA
HELICASE DBP5


(Saccharomyces
cerevisiae)
PF00271
(Helicase_C)
5 TYR A 325
LEU A 324
GLY A 434
ILE A 437
LEU A 350
None
1.11A 1p91B-2kbfA:
undetectable
1p91B-2kbfA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhf UNCHARACTERIZED
PROTEIN


(Danio rerio)
PF00027
(cNMP_binding)
5 GLY A  70
GLY A  68
ILE A  73
TYR A  48
THR A  28
None
1.02A 1p91B-2mhfA:
undetectable
1p91B-2mhfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vii PSP OPERON
TRANSCRIPTIONAL
ACTIVATOR


(Escherichia
coli)
PF00158
(Sigma54_activat)
5 LEU A 229
TYR A 220
ILE A 186
LEU A 247
THR A 210
None
1.01A 1p91B-2viiA:
undetectable
1p91B-2viiA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE


(Staphylococcus
aureus)
PF00155
(Aminotran_1_2)
5 GLY A 146
TYR A 148
ILE A 192
THR A 203
PRO A 204
None
0.96A 1p91B-2x5fA:
2.9
1p91B-2x5fA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yet GH61 ISOZYME A

(Thermoascus
aurantiacus)
PF03443
(Glyco_hydro_61)
5 LEU A 181
GLY A 187
GLY A 185
ILE A 145
LEU A 109
None
1.09A 1p91B-2yetA:
undetectable
1p91B-2yetA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK


([Ruminococcus]
gnavus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
5 TYR A 150
LEU A  14
GLY A 113
ILE A   3
LEU A  31
None
1.11A 1p91B-2yfnA:
undetectable
1p91B-2yfnA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A


(Escherichia
coli)
PF03737
(RraA-like)
5 LEU A  51
GLY A  34
GLY A  58
ILE A  37
LEU A  73
None
1.07A 1p91B-2yjvA:
undetectable
1p91B-2yjvA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE


(Thermus
thermophilus)
PF13561
(adh_short_C2)
5 ARG A 184
GLY A 182
GLY A 179
ILE A 142
LEU A 229
None
0.98A 1p91B-2yw9A:
4.5
1p91B-2yw9A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze5 ISOPENTENYL
TRANSFERASE


(Agrobacterium
tumefaciens)
PF01745
(IPT)
5 TYR A 211
GLY A  97
GLY A   8
LEU A 152
THR A  43
None
0.89A 1p91B-2ze5A:
undetectable
1p91B-2ze5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aih PROTEIN OS-9

(Homo sapiens)
PF07915
(PRKCSH)
5 GLY A 178
GLY A 176
TYR A 175
LEU A 112
THR A 119
None
1.12A 1p91B-3aihA:
undetectable
1p91B-3aihA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b74 UNCHARACTERIZED
PROTEIN YKL091C


(Saccharomyces
cerevisiae)
PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N)
5 TYR A 195
TYR A 137
ILE A 131
TYR A 109
LEU A 149
PEE  A 311 (-4.0A)
PEE  A 311 (-3.8A)
PEE  A 311 ( 4.4A)
PEE  A 311 ( 4.8A)
None
1.13A 1p91B-3b74A:
undetectable
1p91B-3b74A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bop BETA-NEUREXIN 2D4

(Mus musculus)
PF02210
(Laminin_G_2)
5 LEU A 241
GLY A  95
GLY A  92
ILE A  98
LEU A 115
None
1.12A 1p91B-3bopA:
undetectable
1p91B-3bopA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME


(Escherichia
coli)
PF04055
(Radical_SAM)
PF13353
(Fer4_12)
5 LEU A 183
GLY A 240
TYR A 239
ILE A 196
THR A 228
None
1.04A 1p91B-3c8fA:
undetectable
1p91B-3c8fA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens)
PF05147
(LANC_like)
5 ARG A 155
LEU A 228
GLY A 154
GLY A 157
ILE A 224
None
1.09A 1p91B-3e73A:
undetectable
1p91B-3e73A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum)
PF00082
(Peptidase_S8)
5 GLY A 235
GLY A 237
TYR A 239
ILE A  15
THR A  84
None
1.12A 1p91B-3f7oA:
undetectable
1p91B-3f7oA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3few COLICIN S4

(Escherichia
coli)
PF01024
(Colicin)
5 GLY X 104
GLY X  92
TYR X  91
ILE X 107
LEU X 228
None
1.10A 1p91B-3fewX:
undetectable
1p91B-3fewX:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 LEU A 315
GLY A 343
GLY A 363
ILE A 320
LEU A 350
None
1.04A 1p91B-3fxiA:
undetectable
1p91B-3fxiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 GLY A 167
GLY A 340
TYR A 341
ILE A 344
LEU A 144
None
1.10A 1p91B-3gb0A:
undetectable
1p91B-3gb0A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvd SERINE
ACETYLTRANSFERASE


(Yersinia pestis)
PF00132
(Hexapep)
PF06426
(SATase_N)
5 LEU A 182
GLY A 217
GLY A 215
ILE A 202
LEU A 111
None
0.98A 1p91B-3gvdA:
undetectable
1p91B-3gvdA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE


(Haemophilus
influenzae)
PF02395
(Peptidase_S6)
PF03212
(Pertactin)
5 TYR A 520
GLY A 546
GLY A 660
ILE A 543
THR A 175
None
1.04A 1p91B-3h09A:
undetectable
1p91B-3h09A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2d CHEC-LIKE
SUPERFAMILY PROTEIN


(Shewanella
oneidensis)
PF13690
(CheX)
5 GLY A 123
GLY A 121
ILE A 126
LEU A  13
PRO A 138
None
1.10A 1p91B-3h2dA:
undetectable
1p91B-3h2dA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Vibrio cholerae)
PF00698
(Acyl_transf_1)
5 TYR A 101
GLY A 108
ILE A 248
LEU A 217
THR A 220
None
1.02A 1p91B-3hjvA:
undetectable
1p91B-3hjvA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Mus musculus)
PF00155
(Aminotran_1_2)
5 LEU A 358
GLY A 218
GLY A 379
ILE A 374
LEU A 394
None
1.04A 1p91B-3hlmA:
3.2
1p91B-3hlmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN


(Bacteroides
thetaiotaomicron)
PF01833
(TIG)
5 LEU A 254
GLY A 235
ILE A 209
THR A 229
PRO A 228
None
1.06A 1p91B-3hrpA:
undetectable
1p91B-3hrpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE


(Aquifex
aeolicus)
PF07992
(Pyr_redox_2)
5 GLY A  13
GLY A  11
ILE A 398
LEU A 407
PRO A 415
FAD  A 441 (-3.4A)
FAD  A 441 (-3.3A)
None
LMT  A 600 ( 4.9A)
None
0.99A 1p91B-3hyvA:
3.0
1p91B-3hyvA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibx PUTATIVE THIAMINASE
II


(Helicobacter
pylori)
PF03070
(TENA_THI-4)
5 TYR A 165
GLY A  26
GLY A  28
ILE A 142
LEU A  48
None
1.11A 1p91B-3ibxA:
undetectable
1p91B-3ibxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR


(Homo sapiens)
PF13621
(Cupin_8)
5 LEU A 187
GLY A 266
GLY A 268
ILE A 291
THR A 196
None
None
None
None
CQL  A   1 (-3.8A)
1.05A 1p91B-3kcxA:
undetectable
1p91B-3kcxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 GLY A  54
GLY A  52
TYR A  51
TYR A 232
ILE A  26
None
None
LLP  A  47 ( 4.6A)
None
None
0.91A 1p91B-3kw3A:
undetectable
1p91B-3kw3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE


(Streptomyces
coelicolor)
no annotation 6 LEU A 206
GLY A  75
TYR A  76
TYR A  77
ILE A  88
TYR A  91
None
1.11A 1p91B-3lg5A:
undetectable
1p91B-3lg5A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
5 GLY A 365
GLY A 363
ILE A 360
LEU A 336
PRO A 452
None
1.12A 1p91B-3poyA:
undetectable
1p91B-3poyA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgq PROTEIN-TYROSINE
PHOSPHATASE
MITOCHONDRIAL 1


(Mus musculus)
PF00782
(DSPc)
5 LEU A 215
GLY A 116
GLY A 203
ILE A 109
LEU A 187
None
None
5P5  A 300 (-3.8A)
None
None
1.11A 1p91B-3rgqA:
undetectable
1p91B-3rgqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcr MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN


(Mycobacteroides
abscessus)
PF00994
(MoCF_biosynth)
5 ARG A 119
LEU A 162
GLY A 131
GLY A 122
ILE A 148
None
1.11A 1p91B-3tcrA:
undetectable
1p91B-3tcrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzq SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
marinum)
no annotation 5 ARG B 179
GLY B 177
GLY B 174
ILE B 137
LEU B 223
None
1.09A 1p91B-3tzqB:
4.9
1p91B-3tzqB:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE


(Sporosarcina
psychrophila)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 LEU A 106
GLY A  77
GLY A  37
ILE A  31
THR A  43
None
0.96A 1p91B-3vpxA:
4.9
1p91B-3vpxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB


(Aspergillus
oryzae)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 LEU A 372
GLY A 154
GLY A 376
ILE A 349
LEU A 222
None
0.95A 1p91B-3wxyA:
undetectable
1p91B-3wxyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC


(Homo sapiens)
PF00155
(Aminotran_1_2)
5 LEU A 337
GLY A 197
GLY A 358
ILE A 353
LEU A 373
None
1.07A 1p91B-3wzfA:
3.2
1p91B-3wzfA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 LEU A 119
GLY A 241
GLY A 186
LEU A 546
PRO A  25
None
1.10A 1p91B-3zuqA:
undetectable
1p91B-3zuqA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
5 GLY A 128
GLY A 391
ILE A 394
LEU A 536
PRO A 223
None
1.04A 1p91B-4ainA:
undetectable
1p91B-4ainA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX


(Legionella
pneumophila)
PF02661
(Fic)
PF12796
(Ank_2)
5 LEU A  76
GLY A 236
TYR A 225
ILE A  80
LEU A   8
None
C5P  A1000 (-3.3A)
None
None
None
1.09A 1p91B-4berA:
undetectable
1p91B-4berA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT


(Pseudonaja
textilis)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3)
5 LEU V1329
GLY V1282
GLY V1278
ILE V1289
THR V1315
None
1.08A 1p91B-4bxsV:
undetectable
1p91B-4bxsV:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7u ENDOGLUCANASE II

(Neurospora
crassa)
PF03443
(Glyco_hydro_61)
5 GLY A 213
GLY A 205
TYR A 204
ILE A 201
LEU A 151
None
1.08A 1p91B-4d7uA:
undetectable
1p91B-4d7uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35


(Streptococcus
pneumoniae)
PF01301
(Glyco_hydro_35)
5 LEU A 364
GLY A 537
ILE A 495
LEU A 446
THR A 571
None
1.01A 1p91B-4e8dA:
undetectable
1p91B-4e8dA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE


(Burkholderia
pseudomallei)
PF00155
(Aminotran_1_2)
5 LEU A 327
GLY A 188
GLY A 348
ILE A 343
LEU A 363
None
1.02A 1p91B-4effA:
undetectable
1p91B-4effA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora)
PF02171
(Piwi)
5 LEU A 398
GLY A 480
GLY A 249
TYR A 402
ILE A 401
None
1.07A 1p91B-4f1nA:
undetectable
1p91B-4f1nA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7o SERINE
ACETYLTRANSFERASE


(Vibrio cholerae)
PF00132
(Hexapep)
PF06426
(SATase_N)
5 LEU A 182
GLY A 217
GLY A 215
ILE A 202
LEU A 111
None
1.01A 1p91B-4h7oA:
undetectable
1p91B-4h7oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT


(Lactobacillus
brevis;
Lactobacillus
brevis)
PF07155
(ECF-ribofla_trS)
PF02361
(CbiQ)
5 LEU T 171
GLY S  60
GLY S  64
LEU T 219
THR S  10
None
1.03A 1p91B-4hzuT:
undetectable
1p91B-4hzuT:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jge RED FLUORESCENT
PROTEIN BLFP-R5


(Branchiostoma
lanceolatum)
PF01353
(GFP)
5 TYR A  75
GLY A 179
GLY A  82
ILE A 182
THR A 174
None
1.05A 1p91B-4jgeA:
undetectable
1p91B-4jgeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN


(Homo sapiens)
PF01403
(Sema)
PF01437
(PSI)
5 ARG B 521
LEU B 481
GLY B 517
GLY B 519
ILE B 513
None
1.03A 1p91B-4k3jB:
undetectable
1p91B-4k3jB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4


(Homo sapiens)
PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 LEU A  62
GLY A  47
GLY A  45
LEU A 101
PRO A  73
None
NAG  A 601 (-4.2A)
None
None
None
0.97A 1p91B-4kt1A:
undetectable
1p91B-4kt1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozx ALGINATE LYASE

(Klebsiella
pneumoniae)
PF08787
(Alginate_lyase2)
5 GLY A 156
TYR A 174
ILE A 159
TYR A 280
THR A  90
None
1.04A 1p91B-4ozxA:
undetectable
1p91B-4ozxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER


(Neisseria
gonorrhoeae)
PF03806
(ABG_transport)
5 TYR A 234
LEU A 231
GLY A 139
GLY A 178
PRO A 127
None
1.08A 1p91B-4r1iA:
undetectable
1p91B-4r1iA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE


(Staphylococcus
aureus)
PF00388
(PI-PLC-X)
5 LEU A 100
GLY A  60
ILE A 108
THR A 153
PRO A 152
None
1.07A 1p91B-4rv3A:
undetectable
1p91B-4rv3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE


(Methylovorus
sp. MP688)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 LEU A 269
GLY A 463
TYR A  89
ILE A  73
THR A 376
None
1.12A 1p91B-4udrA:
undetectable
1p91B-4udrA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Trypanosoma
brucei)
PF00155
(Aminotran_1_2)
5 LEU A 316
GLY A 176
GLY A 337
ILE A 332
LEU A 352
None
1.11A 1p91B-4w5kA:
2.5
1p91B-4w5kA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
5 GLY A 654
GLY A 656
TYR A 659
LEU A  69
PRO A 563
None
1.10A 1p91B-4zr5A:
undetectable
1p91B-4zr5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS


(Vibrio
vulnificus)
PF09818
(ABC_ATPase)
5 LEU A 366
GLY A 387
GLY A 389
TYR A 391
ILE A 383
None
1.08A 1p91B-5d6aA:
undetectable
1p91B-5d6aA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e25 BRANCHED-CHAIN
AMINOTRANSFERASE


(Geoglobus
acetivorans)
PF01063
(Aminotran_4)
5 TYR A 238
LEU A 237
GLY A 266
GLY A 264
ILE A 243
None
1.04A 1p91B-5e25A:
undetectable
1p91B-5e25A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo7 PREDICTED PROTEIN

(Aspergillus
oryzae)
PF07938
(Fungal_lectin)
5 TYR A 139
GLY A 162
TYR A 128
ILE A 112
THR A 132
None
1.12A 1p91B-5eo7A:
undetectable
1p91B-5eo7A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h68 CHROMOSOME PARTITION
PROTEIN SMC


(Geobacillus
stearothermophilus)
PF02463
(SMC_N)
5 TYR A1131
LEU A1123
GLY A1049
GLY A1053
LEU A1116
None
0.99A 1p91B-5h68A:
undetectable
1p91B-5h68A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN


(Stenotrophomonas
maltophilia)
PF12849
(PBP_like_2)
5 GLY A 325
GLY A 315
TYR A 314
ILE A  23
LEU A  11
None
None
None
None
PO4  A 401 (-4.1A)
1.07A 1p91B-5j1dA:
undetectable
1p91B-5j1dA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct)
PF04587
(ADP_PFK_GK)
5 LEU A 106
GLY A  96
ILE A 102
LEU A 382
THR A 369
None
1.11A 1p91B-5kkgA:
3.1
1p91B-5kkgA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii)
no annotation 5 LEU A 316
GLY A  70
TYR A  71
ILE A 493
TYR A 492
None
1.12A 1p91B-5oc1A:
undetectable
1p91B-5oc1A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE


(Providencia
stuartii)
PF13673
(Acetyltransf_10)
5 GLY A 111
GLY A 155
TYR A 123
LEU A  25
THR A  41
None
1.11A 1p91B-5us1A:
undetectable
1p91B-5us1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0s PREPHENATE
DEHYDROGENASE


(Bacillus
anthracis)
PF01842
(ACT)
5 LEU A 320
GLY A 345
ILE A 339
LEU A 367
THR A 374
None
0.99A 1p91B-5v0sA:
undetectable
1p91B-5v0sA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE


(Mycolicibacterium
hassiacum)
PF00561
(Abhydrolase_1)
5 GLY A 216
GLY A 214
TYR A 213
TYR A 212
LEU A 273
None
1.04A 1p91B-5w8oA:
undetectable
1p91B-5w8oA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION


(Mycobacterium
tuberculosis)
no annotation 5 LEU A 290
GLY A 177
GLY A  82
ILE A 270
THR A 244
1PE  A 401 (-4.4A)
None
None
1PE  A 401 (-4.3A)
None
1.06A 1p91B-5w95A:
undetectable
1p91B-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkt UREASE ACCESSORY
PROTEIN UREG


(Klebsiella
pneumoniae)
no annotation 5 LEU A 110
GLY A  19
GLY A  17
ILE A 126
THR A 122
None
GNP  A 301 (-3.3A)
GNP  A 301 (-3.3A)
None
None
1.13A 1p91B-5xktA:
undetectable
1p91B-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3, PUTATIVE


(Trichomonas
vaginalis)
PF00189
(Ribosomal_S3_C)
PF07650
(KH_2)
5 LEU D  67
GLY D  36
GLY D  34
ILE D  89
LEU D  85
None
0.94A 1p91B-5xyiD:
undetectable
1p91B-5xyiD:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE


(Bacillus
alcalophilus)
no annotation 5 LEU A 211
GLY A  63
TYR A  62
ILE A 302
THR A 292
None
1.06A 1p91B-5yo8A:
undetectable
1p91B-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum)
no annotation 5 LEU A 133
GLY A 156
GLY A 137
ILE A 110
LEU A 122
None
1.05A 1p91B-5zh5A:
undetectable
1p91B-5zh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans)
no annotation 5 TYR A 281
GLY A 285
GLY A 146
ILE A 101
THR A 113
83Y  A 404 ( 4.0A)
None
None
None
None
1.02A 1p91B-6d3uA:
undetectable
1p91B-6d3uA:
undetectable