SIMILAR PATTERNS OF AMINO ACIDS FOR 1P91_A_SAMA1401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  29
GLY A  61
ILE A  78
TYR A  79
LEU A  88
 None
None
None
FBP  A 354 (-4.0A)
None
 1.08A 1p91A-1a5zA:
2.9		 1p91A-1a5zA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 134
GLY A 129
ILE A 270
TYR A 436
HIS A 434
 None
FAD  A 600 (-3.0A)
None
None
None
 1.15A 1p91A-1bhyA:
undetectable		 1p91A-1bhyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 LEU A 104
GLY A 244
GLY A  99
ILE A 205
LEU A 200
 None
LLP  A 234 ( 4.9A)
LLP  A 234 ( 3.5A)
LLP  A 234 ( 4.0A)
None
 1.21A 1p91A-1bjwA:
3.1		 1p91A-1bjwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		5 GLY A 104
GLY A 106
ILE A 109
PRO A 167
LEU A 204
 None
 1.21A 1p91A-1h3gA:
undetectable		 1p91A-1h3gA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II

(Bacteroides
fragilis) 		no annotation 5 LEU A  68
GLY A 179
GLY A 180
ILE A 167
TYR A 156
 None
 1.07A 1p91A-1hlkA:
undetectable		 1p91A-1hlkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		5 GLY A 204
GLY A 206
ILE A 120
TYR A 121
LEU A 151
 None
 1.23A 1p91A-1o20A:
3.8		 1p91A-1o20A:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p91 RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		11 LEU A  62
TYR A  67
GLY A  95
GLU A  96
GLY A  97
TYR A  99
ILE A 155
TYR A 156
PRO A 179
HIS A 183
LEU A 184
 None
None
SAM  A1401 (-3.4A)
SAM  A1401 (-3.5A)
SAM  A1401 (-3.3A)
SAM  A1401 (-4.4A)
SAM  A1401 (-4.2A)
SAM  A1401 (-3.4A)
SAM  A1401 (-4.0A)
SAM  A1401 (-4.2A)
SAM  A1401 (-4.6A)
 0.00A 1p91A-1p91A:
45.6		 1p91A-1p91A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 GLY A  92
GLY A  88
TYR A  89
TYR A 177
PRO A 184
 None
 1.17A 1p91A-1qozA:
undetectable		 1p91A-1qozA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		5 LEU A 124
TYR A 185
GLY A  63
ILE A 169
HIS A 150
 None
 1.22A 1p91A-1r44A:
undetectable		 1p91A-1r44A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 GLY A 132
GLU A  46
GLY A 133
ILE A 247
LEU A 119
 SO4  A 373 (-3.2A)
None
SO4  A 373 (-4.0A)
None
None
 1.16A 1p91A-1to6A:
undetectable		 1p91A-1to6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B 340
GLY B  17
GLY B  15
TYR B  21
LEU B 400
 None
 1.23A 1p91A-1tqyB:
undetectable		 1p91A-1tqyB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 LEU A 115
GLY A 258
ILE A 234
TYR A 233
PRO A  82
 None
 1.21A 1p91A-1u60A:
undetectable		 1p91A-1u60A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 162
GLY A  35
ILE A  17
TYR A  18
LEU A 158
 None
PO4  A 495 (-2.8A)
None
None
None
 1.19A 1p91A-1wp9A:
4.1		 1p91A-1wp9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 GLY A  75
GLY A  74
PRO A 249
HIS A 267
LEU A 254
 None
 1.21A 1p91A-1x2gA:
undetectable		 1p91A-1x2gA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		5 LEU A 232
GLY A 239
TYR A 236
ILE A 180
LEU A  22
 None
 1.19A 1p91A-1xs5A:
undetectable		 1p91A-1xs5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF14681
(UPRTase) 		5 GLY A  40
GLY A  36
ILE A   6
TYR A   4
LEU A 180
 None
 1.16A 1p91A-1xttA:
2.7		 1p91A-1xttA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  15
GLY A  10
ILE A 140
TYR A 305
HIS A 303
 None
FAD  A 480 (-3.2A)
None
None
None
 1.14A 1p91A-2a8xA:
2.2		 1p91A-2a8xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apn PROTEIN HI1723

(Haemophilus
influenzae) 		PF01521
(Fe-S_biosyn) 		5 GLY A  40
GLY A  41
ILE A  37
TYR A  36
LEU A  69
 None
 1.15A 1p91A-2apnA:
undetectable		 1p91A-2apnA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		5 LEU A 181
GLY A  92
GLY A  93
ILE A 125
TYR A 124
 None
 1.13A 1p91A-2bszA:
undetectable		 1p91A-2bszA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF03497
(Anthrax_toxA) 		5 GLY A  61
GLY A  59
ILE A 177
PRO A  80
LEU A  85
 None
 1.22A 1p91A-2colA:
undetectable		 1p91A-2colA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT
3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi;
Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 123
GLY A 137
GLY A 116
ILE A 168
LEU C 142
 None
 0.85A 1p91A-2d3tA:
4.5		 1p91A-2d3tA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 5 LEU A 458
GLY A 323
GLY A 315
ILE A 433
LEU A 139
 None
 1.14A 1p91A-2d4yA:
undetectable		 1p91A-2d4yA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dd7 GREEN FLUORESCENT
PROTEIN

(Chiridius
poppei) 		PF01353
(GFP) 		5 LEU A  95
GLY A 118
GLY A  93
ILE A 125
LEU A  21
 None
 1.17A 1p91A-2dd7A:
undetectable		 1p91A-2dd7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb1 ENDORIBONUCLEASE
DICER

(Homo sapiens) 		PF00636
(Ribonuclease_3) 		5 LEU A  54
GLY A 151
GLU A 155
ILE A  86
PRO A 182
 None
None
MG  A 502 (-2.6A)
None
None
 1.09A 1p91A-2eb1A:
undetectable		 1p91A-2eb1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A  34
TYR A 480
GLY A 540
GLY A 538
TYR A 547
 None
 0.99A 1p91A-2ecfA:
undetectable		 1p91A-2ecfA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6y GREEN FLUORESCENT
PROTEIN 2

(Pontellina
plumata) 		PF01353
(GFP) 		5 LEU A  97
GLY A 120
GLY A  95
ILE A 127
LEU A  21
 None
 1.11A 1p91A-2g6yA:
undetectable		 1p91A-2g6yA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		5 TYR A 154
GLY A 133
ILE A 110
TYR A 130
PRO A 128
 None
None
None
ACY  A 402 (-3.9A)
None
 1.07A 1p91A-2ojhA:
undetectable		 1p91A-2ojhA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 213
TYR A 216
GLY A 173
GLY A 171
ILE A 180
 None
 1.10A 1p91A-2pgwA:
undetectable		 1p91A-2pgwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF

(Bacillus
subtilis) 		PF00448
(SRP54) 		5 GLY A 340
TYR A 314
ILE A 337
PRO A 310
LEU A 274
 None
 1.23A 1p91A-2px0A:
undetectable		 1p91A-2px0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		5 GLY A  81
GLU A  82
GLY A 305
ILE A 302
LEU A  62
 None
 1.15A 1p91A-2radA:
2.0		 1p91A-2radA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 GLY A 219
GLY A 271
ILE A 216
TYR A 196
PRO A 192
 None
 1.17A 1p91A-2uvfA:
undetectable		 1p91A-2uvfA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H

(Homo sapiens) 		PF00179
(UQ_con) 		5 GLY A  68
GLY A  59
TYR A  65
ILE A 160
TYR A 163
 None
 0.89A 1p91A-2z5dA:
undetectable		 1p91A-2z5dA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 LEU A 198
GLY A 246
GLY A 170
TYR A 243
LEU A 383
 None
 1.15A 1p91A-3al9A:
undetectable		 1p91A-3al9A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 GLY A  43
GLY A  45
TYR A  47
ILE A 100
LEU A 179
 EDO  A 261 ( 3.9A)
None
None
None
None
 1.20A 1p91A-3egeA:
12.8		 1p91A-3egeA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		5 GLY A  17
GLY A 220
ILE A 264
TYR A 260
PRO A 259
 None
 1.18A 1p91A-3fd2A:
undetectable		 1p91A-3fd2A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		5 GLY A 220
GLY A  17
ILE A  61
TYR A  57
PRO A  56
 None
 1.19A 1p91A-3fd2A:
undetectable		 1p91A-3fd2A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD
CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis;
Bacillus
anthracis) 		no annotation
no annotation 		5 LEU S 371
GLU L 114
GLY L  96
ILE L  93
LEU L 185
 None
 1.22A 1p91A-3g9kS:
undetectable		 1p91A-3g9kS:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 167
GLY A 340
TYR A 341
ILE A 344
LEU A 144
 None
 1.06A 1p91A-3gb0A:
undetectable		 1p91A-3gb0A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 341
GLY A 244
GLY A  15
ILE A 189
LEU A 359
 None
 1.13A 1p91A-3goaA:
undetectable		 1p91A-3goaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 GLY A  72
GLY A 131
ILE A 134
TYR A 135
LEU A 347
 None
 0.96A 1p91A-3h5tA:
2.0		 1p91A-3h5tA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 138
GLY A  62
ILE A  11
TYR A  16
PRO A  15
 GLU  A 264 (-4.6A)
None
None
None
None
 1.17A 1p91A-3h6tA:
undetectable		 1p91A-3h6tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		5 GLY A 139
GLY A 140
ILE A 143
TYR A 132
PRO A 125
 None
 1.11A 1p91A-3jtxA:
3.1		 1p91A-3jtxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg7 CURH

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 LEU A1198
GLY A1206
ILE A1195
PRO A1143
LEU A1075
 None
 1.08A 1p91A-3kg7A:
undetectable		 1p91A-3kg7A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		5 GLY A 318
GLU A 315
GLY A 320
ILE A 235
LEU A 257
 None
 1.15A 1p91A-3l0zA:
undetectable		 1p91A-3l0zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 182
GLY A 179
ILE A 347
TYR A 348
HIS A 315
 None
 1.22A 1p91A-3l8kA:
undetectable		 1p91A-3l8kA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcm PUTATIVE
OXIDOREDUCTASE

(Streptococcus
mutans) 		PF02525
(Flavodoxin_2) 		5 LEU A  92
GLY A 142
GLY A  87
ILE A 149
LEU A   4
 None
 1.14A 1p91A-3lcmA:
undetectable		 1p91A-3lcmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 GLY A  12
GLY A  15
ILE A 284
PRO A 287
LEU A 304
 FAD  A 500 (-3.4A)
None
FAD  A 500 (-3.7A)
None
None
 0.92A 1p91A-3lovA:
undetectable		 1p91A-3lovA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 LEU A 219
TYR A 270
GLY A 191
GLY A 196
TYR A 231
 None
 1.16A 1p91A-3lv4A:
undetectable		 1p91A-3lv4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o44 HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		5 LEU A 626
GLY A 632
GLY A 631
ILE A 616
LEU A 639
 None
 1.14A 1p91A-3o44A:
undetectable		 1p91A-3o44A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 LEU A 198
GLY A 246
GLY A 170
TYR A 243
LEU A 383
 None
 1.14A 1p91A-3okyA:
undetectable		 1p91A-3okyA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 156
GLY A 188
GLY A 154
ILE A 219
TYR A 218
 None
 1.05A 1p91A-3r3jA:
3.8		 1p91A-3r3jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s35 6.64 FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU H  11
GLY H   8
GLU H  10
PRO H 204
HIS H 203
 None
 1.15A 1p91A-3s35H:
undetectable		 1p91A-3s35H:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 LEU A 427
TYR A 455
GLY A 332
GLY A 388
TYR A 394
 None
None
None
None
GOL  A 558 (-4.4A)
 1.08A 1p91A-3sggA:
undetectable		 1p91A-3sggA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Sphingomonas
sp. SKA58) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 188
GLY A 222
GLY A 225
ILE A 212
LEU A 395
 None
 1.16A 1p91A-3thuA:
undetectable		 1p91A-3thuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8i DOPAMINE N
ACETYLTRANSFERASE,
ISOFORM A

(Drosophila
melanogaster) 		PF00583
(Acetyltransf_1) 		5 GLY A 159
GLY A 156
ILE A  24
TYR A  75
LEU A  69
 None
EPE  A 301 ( 4.1A)
None
None
None
 1.13A 1p91A-3v8iA:
undetectable		 1p91A-3v8iA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 5 LEU B 485
GLY B 333
GLY B 338
TYR B 330
LEU B 323
 None
 1.23A 1p91A-3w0lB:
undetectable		 1p91A-3w0lB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkq NITRITE REDUCTASE

(Geobacillus
thermodenitrificans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 TYR A 133
GLY A 276
GLY A 275
ILE A 173
LEU A  31
 None
 1.21A 1p91A-3wkqA:
undetectable		 1p91A-3wkqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avo BETA-1,4-EXOCELLULAS
E

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		5 LEU A 276
GLY A 306
GLY A 304
ILE A 271
LEU A 407
 None
 1.01A 1p91A-4avoA:
undetectable		 1p91A-4avoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		5 LEU A  90
GLY A 129
ILE A 125
PRO A  74
LEU A 227
 None
 1.21A 1p91A-4b43A:
undetectable		 1p91A-4b43A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b61 ALGINATE PRODUCTION
PROTEIN ALGE

(Pseudomonas
aeruginosa) 		PF13372
(Alginate_exp) 		5 GLY A 372
GLU A 373
GLY A 411
ILE A 415
LEU A  66
 None
 1.09A 1p91A-4b61A:
undetectable		 1p91A-4b61A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b61 ALGINATE PRODUCTION
PROTEIN ALGE

(Pseudomonas
aeruginosa) 		PF13372
(Alginate_exp) 		5 LEU A 419
GLY A 427
GLY A 468
TYR A 471
ILE A 415
 None
 1.21A 1p91A-4b61A:
undetectable		 1p91A-4b61A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 LEU A 215
TYR A 266
GLY A 187
GLY A 192
TYR A 227
 None
 1.15A 1p91A-4cotA:
undetectable		 1p91A-4cotA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU A 464
TYR A 468
GLY A 439
ILE A 374
TYR A 373
 None
 1.14A 1p91A-4cyjA:
undetectable		 1p91A-4cyjA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN

(Vibrio cholerae) 		PF16458
(Beta-prism_lec) 		5 LEU A 626
GLY A 632
GLY A 631
ILE A 616
LEU A 639
 None
MMA  A 801 (-3.3A)
MMA  A 801 ( 3.7A)
None
None
 1.19A 1p91A-4gx7A:
undetectable		 1p91A-4gx7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 LEU A 328
GLY A 284
GLU A 287
GLY A 283
PRO A 333
 None
 1.12A 1p91A-4i3hA:
undetectable		 1p91A-4i3hA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 LEU A 438
GLY A 222
GLY A 113
ILE A 220
LEU A 286
 None
K  A 504 ( 4.5A)
K  A 504 ( 4.6A)
None
None
 1.03A 1p91A-4j9uA:
undetectable		 1p91A-4j9uA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juo DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		5 LEU C 328
GLY C 284
GLU C 287
GLY C 283
PRO C 333
 None
 1.13A 1p91A-4juoC:
undetectable		 1p91A-4juoC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 LEU A 214
TYR A 265
GLY A 186
GLY A 191
TYR A 226
 None
 1.10A 1p91A-4kc8A:
undetectable		 1p91A-4kc8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 LEU A 167
GLU A 182
GLY A 169
ILE A 209
LEU A 326
 None
 1.00A 1p91A-4kpnA:
2.7		 1p91A-4kpnA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 LEU A 241
GLY A 247
GLY A 246
ILE A 278
TYR A 279
 None
 1.23A 1p91A-4kpuA:
undetectable		 1p91A-4kpuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 5 LEU A 183
TYR A 174
GLY A 228
HIS A 126
LEU A 122
 None
 1.04A 1p91A-4mfzA:
undetectable		 1p91A-4mfzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsp ENDONUCLEASE V

(Homo sapiens) 		PF04493
(Endonuclease_5) 		5 GLY A 129
GLY A 212
ILE A 209
TYR A 208
PRO A 206
 None
 1.11A 1p91A-4nspA:
undetectable		 1p91A-4nspA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv7 ARYLAMINE
N-ACETYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF00797
(Acetyltransf_2) 		5 LEU A 181
GLY A  92
GLY A  93
ILE A 125
TYR A 124
 None
 1.11A 1p91A-4nv7A:
undetectable		 1p91A-4nv7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 LEU A 537
TYR A 530
GLY A 619
PRO A 522
LEU A 548
 None
 1.18A 1p91A-4o9xA:
undetectable		 1p91A-4o9xA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Bacteroides
fragilis) 		PF01368
(DHH) 		5 LEU A  66
GLY A 173
GLY A  38
ILE A 207
TYR A 208
 None
 0.99A 1p91A-4py9A:
undetectable		 1p91A-4py9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  33
GLY A  12
GLY A  10
TYR A  20
LEU A  52
 None
CL  A 402 ( 4.1A)
CL  A 402 ( 4.1A)
None
None
 1.02A 1p91A-4q3nA:
2.3		 1p91A-4q3nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 GLU A 639
GLY A 585
ILE A 605
TYR A 604
LEU A 634
 None
 0.93A 1p91A-4u1rA:
undetectable		 1p91A-4u1rA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9l HEAT SHOCK PROTEIN

(Oryza sativa) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 GLY A 125
GLY A 123
ILE A  21
TYR A 130
LEU A 179
 ACP  A 301 (-2.8A)
None
None
None
None
 1.23A 1p91A-4x9lA:
undetectable		 1p91A-4x9lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		5 LEU A 105
GLU A 129
GLY A  98
ILE A 121
LEU A 154
 None
 1.12A 1p91A-4yxcA:
undetectable		 1p91A-4yxcA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 LEU A  16
GLY A  37
GLY A  35
ILE A  40
PRO A  24
 None
 1.08A 1p91A-5demA:
undetectable		 1p91A-5demA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia) 		PF00144
(Beta-lactamase) 		5 LEU A 156
GLY A  97
GLY A  85
ILE A 127
TYR A 129
 None
 1.18A 1p91A-5e2gA:
undetectable		 1p91A-5e2gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A 527
TYR A 557
GLY A 463
TYR A 510
LEU A 644
 None
 1.23A 1p91A-5f7sA:
undetectable		 1p91A-5f7sA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 LEU A 187
GLY A 202
ILE A 162
TYR A 178
LEU A 253
 None
 1.21A 1p91A-5f7uA:
undetectable		 1p91A-5f7uA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj3 PERIPLASMIC BINDING
PROTEIN

(Roseiflexus sp.
RS-1) 		PF01497
(Peripla_BP_2) 		5 LEU A 240
GLY A 304
GLY A 307
ILE A 325
LEU A 334
 None
None
None
None
HEM  A 401 ( 4.7A)
 1.02A 1p91A-5gj3A:
undetectable		 1p91A-5gj3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdb MONOCLONAL ANTIBODY
10E5 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU E  11
GLY E   8
GLU E  10
PRO E 206
HIS E 205
 None
 1.11A 1p91A-5hdbE:
undetectable		 1p91A-5hdbE:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		5 LEU A 454
GLY A 433
GLY A 432
ILE A 398
LEU A  92
 None
 1.14A 1p91A-5hucA:
undetectable		 1p91A-5hucA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		5 LEU A 477
GLY A 415
GLY A 473
TYR A 465
PRO A 462
 None
 1.05A 1p91A-5hy5A:
undetectable		 1p91A-5hy5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		5 LEU A 496
GLY A 527
GLY A 491
TYR A 492
ILE A 232
 None
 1.02A 1p91A-5i6cA:
undetectable		 1p91A-5i6cA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ieb SENSORY TRANSDUCTION
REGULATORY PROTEIN

(Sphingomonas
melonis) 		PF00072
(Response_reg) 		5 LEU A   8
GLY A  48
GLY A  49
PRO A  67
LEU A  59
 None
 1.16A 1p91A-5iebA:
undetectable		 1p91A-5iebA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 LEU L   4
GLY L 114
GLY L 117
ILE L 120
PRO L  63
 None
None
None
SF4  L 502 ( 4.2A)
SF4  L 502 ( 4.4A)
 1.13A 1p91A-5jfcL:
undetectable		 1p91A-5jfcL:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 LEU A 198
GLY A 246
GLY A 170
TYR A 243
LEU A 383
 None
 1.16A 1p91A-5l5gA:
undetectable		 1p91A-5l5gA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE

(Giardia
intestinalis) 		PF07992
(Pyr_redox_2) 		5 LEU A  79
GLY A  18
GLY A  22
ILE A  68
PRO A  62
 None
 1.23A 1p91A-5m5jA:
2.3		 1p91A-5m5jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 141
GLY B 148
GLY B 146
ILE B 154
LEU B 428
 None
None
G2P  B 501 (-3.5A)
None
None
 1.01A 1p91A-5n5nB:
2.3		 1p91A-5n5nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN
CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1;
Rosellinia
necatrix
quadrivirus 1) 		no annotation
no annotation 		5 GLY B 188
GLY A 513
TYR A 441
HIS A 455
LEU A 611
 None
 1.13A 1p91A-5nd1B:
undetectable		 1p91A-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 129
GLY A 124
ILE A 265
TYR A 431
HIS A 429
 None
FAD  A 601 (-3.3A)
None
None
None
 1.15A 1p91A-5u25A:
undetectable		 1p91A-5u25A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU B 139
GLY B 146
GLY B 144
ILE B 152
LEU B 418
 None
None
GDP  B 501 (-4.6A)
None
None
 1.09A 1p91A-5w3jB:
undetectable		 1p91A-5w3jB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		5 LEU A 594
GLY A 547
TYR A 541
PRO A 511
LEU A 599
 None
 1.22A 1p91A-5wzrA:
undetectable		 1p91A-5wzrA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A

(Aspergillus
awamori) 		PF10503
(Esterase_phd) 		5 LEU A   4
TYR A  22
GLY A  46
GLY A  44
TYR A  66
 None
 1.02A 1p91A-5x6sA:
undetectable		 1p91A-5x6sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 5 GLY A 509
GLY A 484
ILE A 505
TYR A 504
HIS A 489
 None
 1.20A 1p91A-5znnA:
undetectable		 1p91A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 5 LEU A 356
TYR A 273
GLY A 204
GLY A 209
ILE A 346
 None
 1.09A 1p91A-6eslA:
undetectable		 1p91A-6eslA:
undetectable