SIMILAR PATTERNS OF AMINO ACIDS FOR 1P7R_A_NCTA440

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		4 PHE A 213
TYR A 189
ASP A 215
ILE B 300
 None
 0.91A 1p7rA-1b5fA:
0.0		 1p7rA-1b5fA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		4 PHE A 214
VAL A 144
ASP A 216
ILE A 182
 None
None
LLP  A 253 ( 2.8A)
None
 0.99A 1p7rA-1bw0A:
0.0		 1p7rA-1bw0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		4 PHE A 129
TYR A 122
THR A  67
VAL A  72
 None
 0.98A 1p7rA-1fokA:
0.0		 1p7rA-1fokA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 PHE A 260
VAL A 284
VAL A 272
ILE A 274
 PHE  A 260 ( 1.3A)
VAL  A 284 ( 0.6A)
VAL  A 272 ( 0.6A)
ILE  A 274 ( 0.7A)
 0.96A 1p7rA-1fxjA:
0.0		 1p7rA-1fxjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE O   8
VAL O  66
VAL O  73
ILE O  30
 None
 0.91A 1p7rA-1gaeO:
0.0		 1p7rA-1gaeO:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 TYR A 373
VAL A 142
VAL A 180
ASP A 181
 None
 0.93A 1p7rA-1gjuA:
0.0		 1p7rA-1gjuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 PHE A 663
VAL A 518
VAL A 604
ILE A 608
 None
 0.69A 1p7rA-1mqqA:
0.0		 1p7rA-1mqqA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607

(Haemophilus
influenzae) 		PF08501
(Shikimate_dh_N) 		4 VAL A 182
VAL A 238
ASP A 103
ILE A 107
 None
 0.96A 1p7rA-1npyA:
0.0		 1p7rA-1npyA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 THR A 458
VAL A 439
ASP A 461
ILE A 459
 None
None
CA  A 914 (-2.6A)
None
 0.72A 1p7rA-1q5aA:
undetectable		 1p7rA-1q5aA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcq PROTEIN (UBIQUITIN
CONJUGATING ENZYME)

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 PHE A  57
TYR A  61
VAL A 103
ILE A  55
 None
 1.01A 1p7rA-1qcqA:
undetectable		 1p7rA-1qcqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 PHE A 148
VAL A 205
VAL A 155
ILE A 152
 None
 0.83A 1p7rA-1t8qA:
undetectable		 1p7rA-1t8qA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		4 VAL A 265
VAL A 250
ASP A 256
ILE A 255
 None
 1.00A 1p7rA-1w6fA:
undetectable		 1p7rA-1w6fA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 PHE A 203
VAL A 247
VAL A 218
ILE A 215
 None
 1.01A 1p7rA-1xpgA:
undetectable		 1p7rA-1xpgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxr MANNOSE-BINDING
LECTIN

(Morus nigra) 		PF01419
(Jacalin) 		4 THR A  16
VAL A 142
VAL A  19
ILE A  17
 None
 0.84A 1p7rA-1xxrA:
undetectable		 1p7rA-1xxrA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c06 KID TOXIN PROTEIN

(Escherichia
coli) 		PF02452
(PemK_toxin) 		4 THR A  68
VAL A  45
VAL A  93
ILE A  66
 None
C  C   4 ( 4.9A)
None
None
 0.80A 1p7rA-2c06A:
undetectable		 1p7rA-2c06A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		4 PHE A 324
THR A 319
VAL A 307
ILE A 320
 None
 0.92A 1p7rA-2f1zA:
undetectable		 1p7rA-2f1zA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 PHE A 307
VAL A 247
VAL A 274
ILE A 272
 None
 0.98A 1p7rA-2fmtA:
undetectable		 1p7rA-2fmtA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A

(Homo sapiens) 		PF00025
(Arf) 		4 PHE A  16
VAL A  93
VAL A  37
ILE A  40
 None
 0.92A 1p7rA-2h18A:
undetectable		 1p7rA-2h18A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Chlorobaculum
tepidum) 		PF13419
(HAD_2) 		4 PHE A   8
VAL A 223
VAL A 173
ILE A 175
 None
 0.84A 1p7rA-2hcfA:
undetectable		 1p7rA-2hcfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		4 PHE A  66
THR A 100
VAL A  21
VAL A  31
 None
 0.90A 1p7rA-2he3A:
undetectable		 1p7rA-2he3A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i32 ANTI-SILENCING
FACTOR 1 PARALOG A

(Homo sapiens) 		PF04729
(ASF1_hist_chap) 		4 PHE A  74
VAL A  56
ASP A  58
ILE A  42
 None
 0.93A 1p7rA-2i32A:
undetectable		 1p7rA-2i32A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kki INTERLEUKIN-1 ALPHA

(Homo sapiens) 		PF00340
(IL1) 		4 PHE A 152
VAL A  90
ASP A  26
ILE A  32
 None
 1.00A 1p7rA-2kkiA:
undetectable		 1p7rA-2kkiA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l08 REGULATOR OF
NONSENSE TRANSCRIPTS
3A

(Homo sapiens) 		PF03467
(Smg4_UPF3) 		4 PHE A  60
VAL A  90
ASP A  65
ILE A  66
 None
 0.94A 1p7rA-2l08A:
undetectable		 1p7rA-2l08A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 PHE A 196
VAL A 333
VAL A 158
ILE A 132
 None
 0.99A 1p7rA-2lbpA:
undetectable		 1p7rA-2lbpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 PHE A 196
VAL A 331
VAL A 158
ILE A 132
 None
 0.99A 1p7rA-2livA:
undetectable		 1p7rA-2livA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		7 PHE A  87
TYR A  96
THR A 185
VAL A 247
VAL A 295
ASP A 297
ILE A 395
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
None
None
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
 0.53A 1p7rA-2m56A:
68.1		 1p7rA-2m56A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 PHE A  87
TYR A  96
VAL A 247
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
None
None
 0.78A 1p7rA-2m56A:
68.1		 1p7rA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyk M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 PHE A  75
THR A 150
VAL A 114
ILE A 153
 None
 0.91A 1p7rA-2nykA:
undetectable		 1p7rA-2nykA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 PHE A 260
VAL A 284
VAL A 272
ILE A 274
 None
 0.98A 1p7rA-2oi6A:
undetectable		 1p7rA-2oi6A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 PHE A 260
VAL A 284
VAL A 272
ILE A 274
 None
 0.95A 1p7rA-2v0jA:
undetectable		 1p7rA-2v0jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 THR A  66
VAL A 217
VAL A 247
ASP A 276
 None
None
None
ZN  A 401 (-2.9A)
 0.93A 1p7rA-2vunA:
undetectable		 1p7rA-2vunA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 THR A 923
VAL A 931
VAL A 884
ILE A 924
 None
 0.99A 1p7rA-2vz9A:
undetectable		 1p7rA-2vz9A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xiv HYPOTHETICAL
INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 THR A 434
VAL A 457
VAL A 466
ASP A 421
 None
 1.01A 1p7rA-2xivA:
undetectable		 1p7rA-2xivA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE A 144
VAL A 158
VAL A 235
ILE A 227
 None
 0.97A 1p7rA-2zvwA:
undetectable		 1p7rA-2zvwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE
SLIDING CLAMP

(Pyrococcus
furiosus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE B 157
VAL B 208
VAL B 136
ILE B 219
 None
 0.97A 1p7rA-3a2fB:
undetectable		 1p7rA-3a2fB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 PHE A 144
VAL A  99
ASP A 100
ILE A 110
 None
 1.01A 1p7rA-3acpA:
undetectable		 1p7rA-3acpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 THR F  15
VAL F  53
VAL G 145
ILE G 142
 None
 0.93A 1p7rA-3dwlF:
undetectable		 1p7rA-3dwlF:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE

(Lactobacillus
delbrueckii) 		PF00155
(Aminotran_1_2) 		4 PHE A 337
VAL A 309
VAL A 325
ILE A 327
 None
 0.79A 1p7rA-3dzzA:
undetectable		 1p7rA-3dzzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 TYR A 290
VAL A 143
VAL A 235
ILE A 233
 None
 1.00A 1p7rA-3ei8A:
undetectable		 1p7rA-3ei8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE A 163
VAL A 223
VAL A 213
ILE A 131
 None
 0.90A 1p7rA-3hi8A:
undetectable		 1p7rA-3hi8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjj MALTOSE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		4 PHE A  82
VAL A 108
VAL A  96
ILE A  98
 None
 0.90A 1p7rA-3hjjA:
undetectable		 1p7rA-3hjjA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb5 MAJOR CAPSID PROTEIN

(Propionibacterium
virus PA6) 		no annotation 4 PHE A 125
VAL A 249
VAL A 120
ASP A 121
 None
 0.94A 1p7rA-3jb5A:
undetectable		 1p7rA-3jb5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 PHE A  81
VAL A 111
VAL A  98
ILE A  95
 None
 0.88A 1p7rA-3l06A:
undetectable		 1p7rA-3l06A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 THR A 203
VAL A 226
VAL A 235
ASP A 190
 None
 1.01A 1p7rA-3pbiA:
undetectable		 1p7rA-3pbiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0i METHIONYL-TRNA
FORMYLTRANSFERASE

(Vibrio cholerae) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 PHE A 308
VAL A 248
VAL A 275
ILE A 273
 None
 0.95A 1p7rA-3q0iA:
undetectable		 1p7rA-3q0iA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8x METHIONYL-TRNA
FORMYLTRANSFERASE

(Yersinia pestis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 PHE A 308
VAL A 248
VAL A 275
ILE A 273
 None
 0.93A 1p7rA-3r8xA:
undetectable		 1p7rA-3r8xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy6 FIMBRIAL PROTEIN
BF1861

(Bacteroides
fragilis) 		PF13149
(Mfa_like_1) 		4 PHE A 184
TYR A 233
VAL A 249
ILE A 247
 None
 0.99A 1p7rA-3sy6A:
undetectable		 1p7rA-3sy6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		4 PHE A 107
VAL A  16
VAL A  64
ILE A  67
 None
 0.97A 1p7rA-3tvaA:
undetectable		 1p7rA-3tvaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv1 PROTEIN LEC-6

(Caenorhabditis
elegans) 		PF00337
(Gal-bind_lectin) 		4 PHE A 100
VAL A  70
VAL A 111
ILE A 109
 None
 0.98A 1p7rA-3vv1A:
undetectable		 1p7rA-3vv1A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1o DNA MIMIC PROTEIN
DMP12

(Neisseria
meningitidis) 		PF16779
(DMP12) 		4 TYR A  47
THR A  40
VAL A  37
ILE A  39
 None
 0.97A 1p7rA-3w1oA:
undetectable		 1p7rA-3w1oA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whc FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Bacillus
subtilis) 		PF00440
(TetR_N)
PF08359
(TetR_C_4) 		4 PHE A  47
TYR A   8
ASP A  52
ILE A  53
 None
 0.99A 1p7rA-3whcA:
undetectable		 1p7rA-3whcA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 VAL A 567
VAL A 554
ASP A 551
ILE A 555
 None
 0.90A 1p7rA-3wmeA:
undetectable		 1p7rA-3wmeA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akd MANNOSE-SPECIFIC
LECTIN KM+

(Artocarpus
integer) 		PF01419
(Jacalin) 		4 THR A   5
VAL A 131
VAL A   8
ILE A   6
 None
 0.92A 1p7rA-4akdA:
undetectable		 1p7rA-4akdA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 PHE A 178
VAL A 194
VAL A 187
ASP A 185
 None
 0.95A 1p7rA-4bp8A:
undetectable		 1p7rA-4bp8A:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 TYR A  98
THR A 187
VAL A 303
ASP A 305
ILE A 403
 None
None
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
None
 0.68A 1p7rA-4c9mA:
58.2		 1p7rA-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d63 FIBER KNOB DOMAIN

(Turkey
siadenovirus A) 		no annotation 4 PHE A 449
THR A 395
VAL A 398
ILE A 396
 None
 0.72A 1p7rA-4d63A:
undetectable		 1p7rA-4d63A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 TYR A 407
THR A 333
VAL A 343
ILE A 338
 None
 0.98A 1p7rA-4e2zA:
undetectable		 1p7rA-4e2zA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exj UNCHARACTERIZED
PROTEIN

(Lodderomyces
elongisporus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 THR A  64
VAL A  56
ASP A  57
ILE A  63
 None
 0.95A 1p7rA-4exjA:
undetectable		 1p7rA-4exjA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4z DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		no annotation 4 VAL B 183
VAL B 171
ASP B 231
ILE B 175
 None
 0.96A 1p7rA-4f4zB:
undetectable		 1p7rA-4f4zB:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		4 PHE A 270
VAL A 180
VAL A 226
ILE A 229
 None
 0.97A 1p7rA-4g3hA:
undetectable		 1p7rA-4g3hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 PHE A  89
VAL A 102
VAL A  77
ILE A 380
 None
 0.85A 1p7rA-4g3jA:
29.2		 1p7rA-4g3jA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt6 CELL SURFACE PROTEIN

(Faecalibacterium
prausnitzii) 		PF13306
(LRR_5) 		4 VAL A 279
VAL A 249
ASP A 247
ILE A 246
 None
 0.98A 1p7rA-4gt6A:
undetectable		 1p7rA-4gt6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE A 998
VAL A 954
VAL A1023
ILE A1024
 None
 0.86A 1p7rA-4h6yA:
undetectable		 1p7rA-4h6yA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfv GOLGI
REASSEMBLY-STACKING
PROTEIN 1

(Rattus
norvegicus) 		PF04495
(GRASP55_65) 		4 PHE A 148
VAL A 177
VAL A 114
ILE A 135
 None
 0.90A 1p7rA-4kfvA:
undetectable		 1p7rA-4kfvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llo POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Mus musculus) 		PF13426
(PAS_9) 		4 PHE B  87
VAL B  31
VAL B 111
ILE B 113
 None
 1.01A 1p7rA-4lloB:
undetectable		 1p7rA-4lloB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
cruzi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A  16
VAL A  73
VAL A  80
ILE A  38
 None
 0.87A 1p7rA-4lsmA:
undetectable		 1p7rA-4lsmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION

(Danio rerio) 		PF08337
(Plexin_cytopl) 		4 PHE A1002
VAL A 737
VAL A1013
ILE A1006
 None
 0.98A 1p7rA-4m8nA:
undetectable		 1p7rA-4m8nA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 PHE A 121
VAL A 169
ASP A 123
ILE A 124
 None
 0.92A 1p7rA-4o5pA:
undetectable		 1p7rA-4o5pA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2b GLUTAMINE
AMINOACYL-TRNA
SYNTHETASE

(Toxoplasma
gondii) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 THR A 367
VAL A 433
VAL A 364
ILE A 366
 None
 0.98A 1p7rA-4p2bA:
undetectable		 1p7rA-4p2bA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A  10
VAL A  67
VAL A  74
ILE A  32
 None
 0.90A 1p7rA-4p8rA:
undetectable		 1p7rA-4p8rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		4 TYR A 149
THR A 111
VAL A 108
ILE A 110
 None
 0.98A 1p7rA-4pagA:
undetectable		 1p7rA-4pagA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq1 PUTATIVE ELECTRON
TRANSPORT RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00578
(AhpC-TSA) 		4 VAL A 148
VAL A 112
ASP A 136
ILE A 110
 None
 1.01A 1p7rA-4pq1A:
undetectable		 1p7rA-4pq1A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 THR X1172
VAL X1195
VAL X1204
ASP X1159
 None
 0.99A 1p7rA-4q4gX:
undetectable		 1p7rA-4q4gX:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		4 PHE A  63
VAL A 204
ASP A  65
ILE A 279
 None
 0.92A 1p7rA-4rv3A:
undetectable		 1p7rA-4rv3A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyp CELLULOSOMAL
SCAFFOLDIN ANCHORING
PROTEIN C

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 PHE A  36
THR A  22
VAL A  19
ILE A  21
 None
 0.83A 1p7rA-4uypA:
undetectable		 1p7rA-4uypA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		4 VAL A 495
VAL A 438
ASP A 436
ILE A 488
 None
 0.97A 1p7rA-4wviA:
undetectable		 1p7rA-4wviA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8

(Arabidopsis
thaliana) 		PF00179
(UQ_con) 		4 PHE A  56
TYR A  60
VAL A 102
ILE A  54
 None
 0.99A 1p7rA-4x57A:
undetectable		 1p7rA-4x57A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		4 PHE A 284
VAL A 273
ASP A 283
ILE A 269
 None
 0.94A 1p7rA-4xscA:
undetectable		 1p7rA-4xscA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		4 PHE A 163
TYR A 202
VAL A 151
VAL A 117
 None
 0.99A 1p7rA-4y96A:
undetectable		 1p7rA-4y96A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 PHE A 331
THR A 322
VAL A 267
ILE A 321
 None
 0.89A 1p7rA-4y9tA:
undetectable		 1p7rA-4y9tA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 PHE A  12
TYR A  15
VAL A 115
ASP A  84
ILE A  80
 None
 1.40A 1p7rA-4zjsA:
undetectable		 1p7rA-4zjsA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 PHE A 372
VAL A 568
VAL A 609
ASP A 610
 None
 0.98A 1p7rA-5a3fA:
undetectable		 1p7rA-5a3fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 295
VAL A 288
ASP A 321
ILE A 322
 None
 1.01A 1p7rA-5a7mA:
undetectable		 1p7rA-5a7mA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B

(Clostridioides
difficile) 		PF04203
(Sortase) 		4 TYR A 178
THR A 186
VAL A 197
ILE A 185
 None
 0.99A 1p7rA-5gyjA:
undetectable		 1p7rA-5gyjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Homo sapiens) 		PF00009
(GTP_EFTU) 		4 PHE A 293
VAL A 228
VAL A 256
ILE A 258
 None
 0.97A 1p7rA-5izkA:
undetectable		 1p7rA-5izkA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		4 PHE A 324
THR A 319
VAL A 307
ILE A 320
 None
 0.80A 1p7rA-5j7tA:
undetectable		 1p7rA-5j7tA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqp GLUCOSIDASE 2
SUBUNIT BETA-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF12999
(PRKCSH-like) 		4 PHE B  42
VAL B  28
ASP B  69
ILE B  57
 None
None
CA  B1001 (-3.3A)
None
 0.87A 1p7rA-5jqpB:
undetectable		 1p7rA-5jqpB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		4 PHE A 158
VAL A 165
ASP A 162
ILE A 166
 None
 0.99A 1p7rA-5jufA:
undetectable		 1p7rA-5jufA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l33 DENOVO NTF2

(synthetic
construct) 		PF12680
(SnoaL_2) 		4 THR A  30
VAL A  99
VAL A  25
ILE A  26
 None
 1.01A 1p7rA-5l33A:
undetectable		 1p7rA-5l33A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		no annotation 4 PHE A 324
THR A 319
VAL A 307
ILE A 320
 None
 0.74A 1p7rA-5ngeA:
undetectable		 1p7rA-5ngeA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 TYR A 407
THR A 333
VAL A 343
ILE A 338
 None
 0.98A 1p7rA-5t67A:
undetectable		 1p7rA-5t67A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqp CUPIN

(Rhodococcus
jostii) 		PF07883
(Cupin_2) 		4 TYR A  97
VAL A  89
VAL A  54
ILE A 115
 None
 0.91A 1p7rA-5uqpA:
undetectable		 1p7rA-5uqpA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Naegleria
gruberi) 		no annotation 4 PHE A   9
VAL A  67
VAL A  74
ILE A  31
 None
 0.97A 1p7rA-5ur0A:
undetectable		 1p7rA-5ur0A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		4 PHE A 251
VAL A 263
VAL A 269
ILE A 271
 None
 1.00A 1p7rA-5vmkA:
undetectable		 1p7rA-5vmkA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlp AUTOPHAGY-RELATED
PROTEIN 32

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  33
VAL A 120
VAL A  63
ILE A  65
 None
 0.93A 1p7rA-5wlpA:
undetectable		 1p7rA-5wlpA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		4 THR A 213
VAL A 316
ASP A 313
ILE A 317
 None
 0.83A 1p7rA-5wrjA:
undetectable		 1p7rA-5wrjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x90 HYPOTHETICAL
VIRULENCE PROTEIN

(Legionella
pneumophila) 		no annotation 4 PHE D 138
VAL D 116
VAL D 159
ILE D 136
 None
 0.95A 1p7rA-5x90D:
undetectable		 1p7rA-5x90D:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 PHE A  30
VAL A 435
VAL A 410
ILE A 397
 None
 1.00A 1p7rA-5xe0A:
undetectable		 1p7rA-5xe0A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA

(Escherichia
coli) 		no annotation 5 PHE A  55
THR A  62
VAL A 107
ASP A  59
ILE A  61
 None
 1.23A 1p7rA-6bogA:
undetectable		 1p7rA-6bogA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 4 PHE A 340
VAL A 241
VAL A 273
ILE A 277
 HEM  A 401 (-4.8A)
HEM  A 401 ( 4.2A)
None
None
 0.95A 1p7rA-6fshA:
35.0		 1p7rA-6fshA:
12.47