SIMILAR PATTERNS OF AMINO ACIDS FOR 1P6K_A_ACTA860_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		4 GLY A 247
GLN A  34
VAL A   5
ALA A 245
 None
 1.03A 1p6kA-1cg4A:
0.0		 1p6kA-1cg4A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY B 273
VAL B 241
ALA B 238
SER B 236
 None
 0.95A 1p6kA-1ffvB:
undetectable		 1p6kA-1ffvB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 GLY A 191
GLN A 187
ALA A 211
SER A 210
 None
 0.98A 1p6kA-1ibqA:
undetectable		 1p6kA-1ibqA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		4 GLY H 142
GLN H 156
VAL H 138
ALA H 190
 None
 0.85A 1p6kA-1id5H:
undetectable		 1p6kA-1id5H:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kny KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		PF07827
(KNTase_C) 		4 GLY A 114
VAL A  56
ALA A  33
SER A 112
 None
 1.02A 1p6kA-1knyA:
0.3		 1p6kA-1knyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		4 GLY A1013
GLN A1012
VAL A1138
ALA A1009
 None
 1.03A 1p6kA-1lurA:
undetectable		 1p6kA-1lurA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		6 GLY A 417
GLN A 420
TRP A 587
VAL A 649
ALA A 654
SER A 657
 ACT  A 860 ( 3.9A)
None
HEM  A 750 (-3.4A)
ACT  A 860 (-4.3A)
ACT  A 860 ( 4.7A)
ACT  A 860 ( 3.9A)
 0.11A 1p6kA-1lzxA:
64.2		 1p6kA-1lzxA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLN A 189
TRP A 356
VAL A 418
ALA A 423
SER A 426
 None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 ( 4.0A)
MPD  A 604 (-3.1A)
 0.69A 1p6kA-1m9qA:
59.7		 1p6kA-1m9qA:
64.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 GLY A 186
GLN A 189
TRP A 356
VAL A 418
ALA A 423
 MPD  A 604 (-3.8A)
None
HEM  A 901 (-3.6A)
MPD  A 604 (-4.2A)
MPD  A 604 ( 4.0A)
 0.15A 1p6kA-1m9qA:
59.7		 1p6kA-1m9qA:
64.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG

(Staphylococcus
aureus) 		PF02898
(NO_synthase) 		4 GLY A  64
TRP A 225
VAL A 287
ALA A 292
 HEM  A 500 ( 4.0A)
HEM  A 500 ( 3.4A)
None
None
 0.14A 1p6kA-1mjtA:
45.4		 1p6kA-1mjtA:
36.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY H 142
GLN H 156
VAL H 138
ALA H 190
 None
None
None
CR9  H 256 (-2.9A)
 0.93A 1p6kA-1o5fH:
undetectable		 1p6kA-1o5fH:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A   4
VAL A  58
ALA A  64
SER A  66
 None
 0.79A 1p6kA-1pjbA:
undetectable		 1p6kA-1pjbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqw POLYKETIDE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N) 		4 GLY A 123
GLN A 125
VAL A  93
ALA A 119
 None
 0.95A 1p6kA-1pqwA:
undetectable		 1p6kA-1pqwA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 GLN A 199
TRP A 366
ALA A 433
SER A 436
 None
HEM  A 900 ( 3.5A)
None
None
 0.73A 1p6kA-1qw5A:
58.1		 1p6kA-1qw5A:
63.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 GLY A 196
GLN A 199
TRP A 366
ALA A 433
 HEM  A 900 ( 4.1A)
None
HEM  A 900 ( 3.5A)
None
 0.32A 1p6kA-1qw5A:
58.1		 1p6kA-1qw5A:
63.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 GLY B 122
GLN B 124
VAL B  89
ALA B 126
 None
 0.87A 1p6kA-1sxjB:
undetectable		 1p6kA-1sxjB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLY A   6
GLN A   8
VAL A  31
ALA A  10
 None
 1.03A 1p6kA-1uaaA:
undetectable		 1p6kA-1uaaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 GLY A 372
GLN A 634
ALA A 402
SER A 370
 None
 1.01A 1p6kA-1uf2A:
undetectable		 1p6kA-1uf2A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp8 HYPOTHETICAL PROTEIN
AF0103

(Archaeoglobus
fulgidus) 		PF02887
(PK_C) 		4 GLY A 158
VAL A 130
ALA A  38
SER A  40
 FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-2.7A)
 0.99A 1p6kA-1vp8A:
undetectable		 1p6kA-1vp8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		4 GLY A 185
GLN A 182
VAL A 150
ALA A 188
 None
 0.95A 1p6kA-1xqsA:
undetectable		 1p6kA-1xqsA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y11 HYPOTHETICAL PROTEIN
RV1264/MT1302

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc)
PF16701
(Ad_Cy_reg) 		4 GLY A 304
VAL A 320
ALA A 302
SER A 338
 None
 0.96A 1p6kA-1y11A:
undetectable		 1p6kA-1y11A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		4 GLY B  26
GLN B  24
ALA B   9
SER B   8
 None
 0.89A 1p6kA-1y43B:
undetectable		 1p6kA-1y43B:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		4 GLY A 351
VAL A  72
ALA A 237
SER A 353
 None
 1.01A 1p6kA-1zkdA:
undetectable		 1p6kA-1zkdA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A 142
GLN A 156
VAL A 138
ALA A 190
 None
None
None
368  A 901 (-3.7A)
 0.80A 1p6kA-1zlrA:
undetectable		 1p6kA-1zlrA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		4 GLY A  64
TRP A 234
VAL A 296
ALA A 301
 HEM  A 901 ( 3.9A)
HEM  A 901 ( 3.6A)
None
None
 0.25A 1p6kA-2an2A:
48.8		 1p6kA-2an2A:
40.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 GLN A  28
VAL A  32
ALA A  22
SER A  21
 None
 1.01A 1p6kA-2detA:
undetectable		 1p6kA-2detA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ed8 NETRIN RECEPTOR DCC

(Homo sapiens) 		PF00041
(fn3) 		4 GLY A  40
TRP A  28
VAL A  11
ALA A  80
 None
 0.84A 1p6kA-2ed8A:
undetectable		 1p6kA-2ed8A:
15.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2flq NITRIC OXIDE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF02898
(NO_synthase) 		4 GLY A  78
TRP A 243
VAL A 305
ALA A 310
 HEM  A 901 ( 4.3A)
HEM  A 901 ( 3.5A)
None
None
 0.39A 1p6kA-2flqA:
48.2		 1p6kA-2flqA:
42.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus;
Lupinus luteus) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		4 GLY B 315
VAL A  39
ALA B 311
SER B 317
 None
 0.99A 1p6kA-2gezB:
undetectable		 1p6kA-2gezB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		4 GLY A 358
GLN A 292
VAL A 101
ALA A 345
 None
 0.93A 1p6kA-2hmaA:
undetectable		 1p6kA-2hmaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 GLN A  21
VAL A  51
ALA A  14
SER A  15
 None
 1.00A 1p6kA-2ozgA:
undetectable		 1p6kA-2ozgA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus) 		PF12796
(Ank_2) 		4 GLY A 344
VAL A 292
ALA A 340
SER A 342
 GLY  A 344 ( 0.0A)
VAL  A 292 ( 0.6A)
ALA  A 340 ( 0.0A)
SER  A 342 ( 0.0A)
 1.02A 1p6kA-2pnnA:
undetectable		 1p6kA-2pnnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		4 GLY A 144
GLN A 146
VAL A 110
ALA A 108
 None
 0.95A 1p6kA-2vdjA:
undetectable		 1p6kA-2vdjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1n O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00041
(fn3)
PF00963
(Cohesin) 		4 GLY A 945
TRP A 934
VAL A 917
ALA A 982
 None
 0.96A 1p6kA-2w1nA:
undetectable		 1p6kA-2w1nA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
PROTEIN TRANSPORT
PROTEIN SSS1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon)
PF00584
(SecE) 		4 GLY B  32
GLN B  34
VAL A 268
ALA A 426
 None
 1.03A 1p6kA-2ww9B:
undetectable		 1p6kA-2ww9B:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A

(Mycobacterium
tuberculosis) 		PF00977
(His_biosynth) 		4 GLY A  15
VAL A  70
ALA A  34
SER A  33
 None
None
None
SO4  A1248 ( 4.4A)
 0.93A 1p6kA-2y89A:
undetectable		 1p6kA-2y89A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 394
VAL A 210
ALA A 137
SER A 139
 None
 1.03A 1p6kA-2y8nA:
1.1		 1p6kA-2y8nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 GLY A  88
GLN A  90
VAL A 143
ALA A 129
 None
 1.02A 1p6kA-3b1bA:
undetectable		 1p6kA-3b1bA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 208
GLN A 183
ALA A 204
SER A 206
 None
 0.88A 1p6kA-3b70A:
undetectable		 1p6kA-3b70A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf4 ETHYL TERT-BUTYL
ETHER DEGRADATION
ETHD PROTEIN

(Cupriavidus
pinatubonensis) 		PF07110
(EthD) 		4 GLY A   0
GLN A  -1
ALA A  68
SER A  67
 None
 0.97A 1p6kA-3bf4A:
undetectable		 1p6kA-3bf4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv) 		4 GLY C  94
VAL C  83
ALA C  88
SER C  91
 None
 1.00A 1p6kA-3cjiC:
undetectable		 1p6kA-3cjiC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 329
VAL A 320
ALA A 317
SER A 334
 None
 0.85A 1p6kA-3dtcA:
undetectable		 1p6kA-3dtcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dz1 DIHYDRODIPICOLINATE
SYNTHASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		4 GLY A 103
VAL A  81
ALA A  93
SER A  96
 None
 0.91A 1p6kA-3dz1A:
undetectable		 1p6kA-3dz1A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris) 		PF08241
(Methyltransf_11) 		4 GLY A  55
GLN A  57
VAL A  68
ALA A  70
 None
SAM  A 221 ( 4.9A)
None
None
 0.92A 1p6kA-3e23A:
undetectable		 1p6kA-3e23A:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 GLN A 205
TRP A 372
ALA A 439
SER A 442
 None
HEM  A 901 ( 3.7A)
None
None
 0.76A 1p6kA-3e7gA:
57.0		 1p6kA-3e7gA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 GLY A 202
GLN A 205
TRP A 372
ALA A 439
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.20A 1p6kA-3e7gA:
57.0		 1p6kA-3e7gA:
65.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A 142
GLN A 156
VAL A 138
ALA A 190
 None
 0.77A 1p6kA-3gymA:
undetectable		 1p6kA-3gymA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00072
(Response_reg) 		4 GLY A  64
GLN A  66
VAL A  97
ALA A  68
 None
 1.02A 1p6kA-3h5iA:
undetectable		 1p6kA-3h5iA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibs CONSERVED
HYPOTHETICAL PROTEIN
BATB

(Bacteroides
thetaiotaomicron) 		PF00092
(VWA) 		4 GLY A 106
GLN A 135
ALA A 207
SER A 209
 None
 0.99A 1p6kA-3ibsA:
undetectable		 1p6kA-3ibsA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		5 GLY A 509
GLN A 510
TRP A 507
ALA A 244
SER A 247
 None
 1.49A 1p6kA-3iukA:
undetectable		 1p6kA-3iukA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A 202
VAL A 356
ALA A 198
SER A 197
 None
 0.95A 1p6kA-3k8zA:
0.8		 1p6kA-3k8zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 TRP A 751
VAL A 745
ALA A 742
SER A 759
 None
 0.92A 1p6kA-3lltA:
undetectable		 1p6kA-3lltA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN

(Xanthomonas
campestris) 		PF00378
(ECH_1) 		4 GLY A 154
VAL A 209
ALA A 197
SER A 196
 IOD  A 290 (-4.3A)
None
IOD  A 290 ( 3.9A)
IOD  A 290 ( 4.2A)
 0.96A 1p6kA-3m6mA:
undetectable		 1p6kA-3m6mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 309
VAL A 336
ALA A 306
SER A 305
 None
 1.03A 1p6kA-3my0A:
undetectable		 1p6kA-3my0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA

(Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A 120
GLN A 256
ALA A 117
SER A 133
 None
 1.02A 1p6kA-3myrA:
undetectable		 1p6kA-3myrA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 GLY A  83
VAL A  56
ALA A  63
SER A  66
 None
 0.95A 1p6kA-3pdiA:
undetectable		 1p6kA-3pdiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6g LIGHT CHAIN OF FAB
OF RHESUS MAB 2.5B

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY L  24
GLN L   6
VAL L  33
ALA L  71
 None
 0.77A 1p6kA-3q6gL:
undetectable		 1p6kA-3q6gL:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 GLN A 125
VAL A  37
ALA A 111
SER A 123
 None
 1.01A 1p6kA-3qzbA:
undetectable		 1p6kA-3qzbA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 GLY A 281
GLN A 122
VAL A 136
ALA A 279
 None
 0.99A 1p6kA-3se7A:
undetectable		 1p6kA-3se7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A 296
VAL A 284
ALA A 154
SER A 152
 None
 0.99A 1p6kA-3u3xA:
undetectable		 1p6kA-3u3xA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE

(Agrobacterium
fabrum) 		PF13407
(Peripla_BP_4) 		4 GLY A 112
GLN A 110
VAL A 156
ALA A 116
 None
 0.96A 1p6kA-3uugA:
undetectable		 1p6kA-3uugA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A  78
GLN A  80
VAL A 529
ALA A  82
 None
 1.03A 1p6kA-3zz1A:
undetectable		 1p6kA-3zz1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am2 BACTERIOFERRITIN

(Blastochloris
viridis) 		PF00210
(Ferritin) 		4 GLY A 112
VAL A   7
ALA A 108
SER A 110
 None
 0.98A 1p6kA-4am2A:
undetectable		 1p6kA-4am2A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cja BURRH

(Paraburkholderia
rhizoxinica) 		PF03377
(TAL_effector) 		4 GLY A 195
GLN A 197
ALA A 165
SER A 168
 None
 0.98A 1p6kA-4cjaA:
undetectable		 1p6kA-4cjaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		4 GLY A  40
VAL A  14
ALA A  35
SER A  36
 None
 1.01A 1p6kA-4g2tA:
undetectable		 1p6kA-4g2tA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 GLN A 212
VAL A 180
ALA A 206
SER A 205
 None
 0.97A 1p6kA-4gyoA:
undetectable		 1p6kA-4gyoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4f CHYMOTRYPSIN-C

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A 142
GLN A 156
VAL A 138
ALA A 190
 None
 0.70A 1p6kA-4h4fA:
undetectable		 1p6kA-4h4fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi2 ACYLPHOSPHATASE

(Vibrio cholerae) 		PF00708
(Acylphosphatase) 		4 GLY A  12
VAL A  17
ALA A  69
SER A  70
 None
 1.02A 1p6kA-4hi2A:
undetectable		 1p6kA-4hi2A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk0 UCA LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  23
GLN B   6
VAL B  32
ALA B  70
 None
 0.80A 1p6kA-4hk0B:
undetectable		 1p6kA-4hk0B:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwm UNCHARACTERIZED
PROTEIN YEDD

(Klebsiella
pneumoniae) 		PF13987
(YedD) 		4 GLY A  34
TRP A  39
VAL A  59
ALA A  31
 None
 1.02A 1p6kA-4hwmA:
undetectable		 1p6kA-4hwmA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iml CROSSED LIGHT CHAIN
(VL-CH1)

(Homo sapiens) 		no annotation 4 GLY L  23
GLN L   6
VAL L  32
ALA L  70
 None
 0.90A 1p6kA-4imlL:
undetectable		 1p6kA-4imlL:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixw HALOHYDRIN
DEHALOGENASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 GLY A 151
VAL A 101
ALA A 148
SER A 147
 None
 1.03A 1p6kA-4ixwA:
undetectable		 1p6kA-4ixwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		4 GLY D 633
GLN D 667
ALA D 635
SER D 653
 None
 1.03A 1p6kA-4j3oD:
undetectable		 1p6kA-4j3oD:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  23
GLN B   6
VAL B  32
ALA B  70
 None
 0.84A 1p6kA-4jznB:
undetectable		 1p6kA-4jznB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 GLY A 176
GLN A 183
VAL A 147
ALA A 158
 None
 0.99A 1p6kA-4kcbA:
undetectable		 1p6kA-4kcbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 GLY A 139
GLN A 140
VAL A 107
ALA A  96
 None
 0.90A 1p6kA-4l4qA:
undetectable		 1p6kA-4l4qA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 GLY A 246
GLN A  34
VAL A   5
ALA A 244
 None
 0.86A 1p6kA-4m9dA:
undetectable		 1p6kA-4m9dA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oki PHTHIOCEROL
SYNTHESIS POLYKETIDE
SYNTHASE TYPE I PPSC

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N) 		4 GLY A 779
GLN A 781
VAL A 749
ALA A 775
 None
None
None
NA  A 901 ( 4.4A)
 0.90A 1p6kA-4okiA:
undetectable		 1p6kA-4okiA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhz CRY23AA1

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 GLY A 224
GLN A 155
VAL A 258
ALA A 255
 None
 0.84A 1p6kA-4rhzA:
undetectable		 1p6kA-4rhzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Arthrobacter
sp. FB24) 		PF13377
(Peripla_BP_3) 		4 GLY A 158
GLN A 141
VAL A 151
ALA A 137
 None
 1.00A 1p6kA-4rkrA:
undetectable		 1p6kA-4rkrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 329
VAL A 320
ALA A 317
SER A 334
 None
 0.87A 1p6kA-4uy9A:
undetectable		 1p6kA-4uy9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A 324
VAL A 315
ALA A 312
SER A 329
 None
 0.89A 1p6kA-4uyaA:
undetectable		 1p6kA-4uyaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 GLY A1147
GLN A1575
TRP A1170
ALA A1174
 SAH  A1706 (-3.2A)
None
None
None
 1.02A 1p6kA-4wxxA:
undetectable		 1p6kA-4wxxA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		4 GLY A 296
TRP A 227
ALA A 293
SER A 292
 None
 1.00A 1p6kA-4xuvA:
undetectable		 1p6kA-4xuvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esa ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  23
GLN B   6
VAL B  32
ALA B  70
 None
 0.78A 1p6kA-5esaB:
undetectable		 1p6kA-5esaB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f12 NAD(P)H
DEHYDROGENASE
(QUINONE)

(Escherichia
coli) 		PF03358
(FMN_red) 		4 GLY A 185
GLN A 184
VAL A   5
ALA A  22
 None
 0.97A 1p6kA-5f12A:
undetectable		 1p6kA-5f12A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)

(Brucella
abortus) 		PF03358
(FMN_red) 		4 GLY A 187
GLN A 186
VAL A   6
ALA A  23
 None
 0.98A 1p6kA-5f4bA:
undetectable		 1p6kA-5f4bA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 GLY A  98
GLN A  96
VAL A  57
ALA A  65
 None
 0.99A 1p6kA-5fl7A:
undetectable		 1p6kA-5fl7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvn OMPC PORIN

(Enterobacter
cloacae) 		PF00267
(Porin_1) 		4 GLY A 278
GLN A 288
VAL A 243
ALA A 249
 None
 0.99A 1p6kA-5fvnA:
undetectable		 1p6kA-5fvnA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLN A 263
VAL A 254
ALA A 259
SER A 261
 None
 0.98A 1p6kA-5i2gA:
undetectable		 1p6kA-5i2gA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  26
GLN B   9
VAL B  35
ALA B  73
 None
 0.83A 1p6kA-5j13B:
undetectable		 1p6kA-5j13B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jip CORTICAL-LYTIC
ENZYME

(Clostridium
perfringens) 		PF01183
(Glyco_hydro_25) 		4 GLY A 261
TRP A 251
VAL A 235
ALA A 302
 None
 0.96A 1p6kA-5jipA:
undetectable		 1p6kA-5jipA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 4 GLN A 338
VAL A 476
ALA A 481
SER A 484
 None
 0.97A 1p6kA-5lj6A:
undetectable		 1p6kA-5lj6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 GLY A 194
VAL A 174
ALA A 189
SER A 191
 None
 1.00A 1p6kA-5mp7A:
undetectable		 1p6kA-5mp7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udm PHAGE-ASSOCIATED
CELL WALL HYDROLASE

(Streptococcus
pyogenes) 		no annotation 4 GLY B 239
GLN B  30
TRP B 223
ALA B 241
 None
 0.90A 1p6kA-5udmB:
undetectable		 1p6kA-5udmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VL CHAIN OF 059-152

(Homo sapiens) 		no annotation 4 GLY D  24
GLN D   7
VAL D  33
ALA D  71
 None
 0.85A 1p6kA-5xwdD:
undetectable		 1p6kA-5xwdD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 4 GLY B 142
GLN B 156
VAL B 138
ALA B 190
 None
SO4  B 306 (-4.5A)
None
BEN  B 301 (-4.1A)
 0.93A 1p6kA-6b74B:
undetectable		 1p6kA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 TRP A 358
VAL A 352
ALA A 349
SER A 366
 None
 0.94A 1p6kA-6fylA:
undetectable		 1p6kA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 TRP A 356
VAL A 350
ALA A 347
SER A 364
 None
 0.90A 1p6kA-6fyoA:
undetectable		 1p6kA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 TRP A 356
VAL A 350
ALA A 347
SER A 364
 None
 0.94A 1p6kA-6fyvA:
undetectable		 1p6kA-6fyvA:
undetectable