SIMILAR PATTERNS OF AMINO ACIDS FOR 1P5Z_B_AR3B304_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		5 ILE A  10
VAL A 228
TRP A 233
LEU A 234
PHE A 211
 None
 1.33A 1p5zB-1k1xA:
undetectable		 1p5zB-1k1xA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 578
GLN A 596
ASP A 592
PHE A 595
GLU A 575
 None
 1.41A 1p5zB-1kcwA:
undetectable		 1p5zB-1kcwA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 150
GLU A 143
LEU A 102
ARG A 146
GLU A 100
 None
 1.37A 1p5zB-1ofeA:
undetectable		 1p5zB-1ofeA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz6 CYTOCHROME C
PEROXIDASE

(Marinobacter
hydrocarbonoclasticus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 VAL A 122
LEU A 126
MET A 129
TYR A 132
GLU A  37
 None
 1.20A 1p5zB-1rz6A:
undetectable		 1p5zB-1rz6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vtk THYMIDINE KINASE

(Human
alphaherpesvirus
1) 		PF00693
(Herpes_TK) 		5 GLU A  83
TRP A  88
TYR A 101
GLN A 125
GLU A 225
 TMP  A 500 (-2.7A)
None
TMP  A 500 (-4.5A)
TMP  A 500 (-3.0A)
TMP  A 500 (-3.5A)
 1.14A 1p5zB-1vtkA:
16.5		 1p5zB-1vtkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		5 ILE A 126
VAL A  58
LEU A  48
MET A 274
TYR A 281
 None
 1.44A 1p5zB-1xqwA:
2.2		 1p5zB-1xqwA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		11 ILE A  30
GLU A  53
TRP A  58
LEU A  82
MET A  85
TYR A  86
GLN A  97
ARG A 128
ASP A 133
PHE A 137
GLU A 197
 DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
DCZ  A 302 (-3.5A)
 0.43A 1p5zB-2a30A:
36.5		 1p5zB-2a30A:
94.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		11 ILE A  30
GLU A  53
VAL A  55
TRP A  58
LEU A  82
MET A  85
TYR A  86
GLN A  97
ARG A 128
ASP A 133
PHE A 137
 DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
 0.55A 1p5zB-2a30A:
36.5		 1p5zB-2a30A:
94.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ah6 BH1595, UNKNOWN
CONSERVED PROTEIN

(Bacillus
halodurans) 		PF01923
(Cob_adeno_trans) 		5 ILE A  55
GLU A 104
TYR A 160
ARG A 171
GLU A  58
 None
 1.40A 1p5zB-2ah6A:
undetectable		 1p5zB-2ah6A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 VAL A 566
TYR A 604
ASP A 645
PHE A 644
GLU A 575
 None
 1.09A 1p5zB-2d5lA:
2.4		 1p5zB-2d5lA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		7 VAL A  33
TYR A  43
GLN A  54
ARG A  78
ASP A  83
PHE A  86
GLU A 150
 DCP  A1202 (-4.6A)
None
DCP  A1202 (-2.9A)
DCP  A1202 (-2.8A)
DCP  A1202 (-3.6A)
DCP  A1202 (-3.6A)
DCP  A1202 (-3.5A)
 0.54A 1p5zB-2jaqA:
22.4		 1p5zB-2jaqA:
27.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		6 ILE A  29
VAL A  54
TRP A  57
GLN A  81
ARG A 105
PHE A 114
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-3.0A)
TTP  A1210 (-3.7A)
TTP  A1210 (-3.5A)
 0.93A 1p5zB-2jcsA:
27.3		 1p5zB-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		8 ILE A  29
VAL A  54
TRP A  57
LEU A  66
MET A  69
TYR A  70
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.76A 1p5zB-2jcsA:
27.3		 1p5zB-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		8 ILE A  29
VAL A  54
TRP A  57
LEU A  66
TYR A  70
GLN A  81
PHE A 114
GLU A 172
 TTP  A1210 (-3.9A)
TTP  A1210 (-4.5A)
None
TTP  A1210 (-4.8A)
TTP  A1210 (-4.6A)
TTP  A1210 (-3.0A)
TTP  A1210 (-3.5A)
TTP  A1210 (-3.6A)
 0.66A 1p5zB-2jcsA:
27.3		 1p5zB-2jcsA:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 GLU A  70
VAL A  72
TRP A  75
MET A  99
ASP A 147
 None
DTP  A 301 (-4.1A)
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.1A)
 1.41A 1p5zB-2ocpA:
32.7		 1p5zB-2ocpA:
46.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 GLU A  70
VAL A  72
TRP A  75
MET A  99
GLN A 111
 None
DTP  A 301 (-4.1A)
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-2.9A)
 1.24A 1p5zB-2ocpA:
32.7		 1p5zB-2ocpA:
46.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		8 ILE A  47
VAL A  72
TRP A  75
LEU A  96
MET A  99
TYR A 100
ASP A 147
PHE A 151
 DTP  A 301 (-3.8A)
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-4.1A)
DTP  A 301 (-3.3A)
 0.85A 1p5zB-2ocpA:
32.7		 1p5zB-2ocpA:
46.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		10 ILE A  47
VAL A  72
TRP A  75
LEU A  96
MET A  99
TYR A 100
GLN A 111
ARG A 142
PHE A 151
GLU A 211
 DTP  A 301 (-3.8A)
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
DTP  A 301 (-3.5A)
 0.81A 1p5zB-2ocpA:
32.7		 1p5zB-2ocpA:
46.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		5 VAL A  72
LEU A  96
MET A  99
TYR A 100
ARG A 118
 DTP  A 301 (-4.1A)
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-3.1A)
 1.42A 1p5zB-2ocpA:
32.7		 1p5zB-2ocpA:
46.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 400
GLU A 240
VAL A 238
LEU A 425
ARG A 396
 None
 1.46A 1p5zB-2vpqA:
undetectable		 1p5zB-2vpqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 5 GLU A 150
LEU A  42
MET A  30
TYR A  32
GLN A  28
 ARS  A1176 (-4.1A)
None
None
None
None
 1.16A 1p5zB-2y0oA:
undetectable		 1p5zB-2y0oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		5 ILE A 189
MET A  77
TYR A  74
PHE A 203
GLU A 186
 None
 1.30A 1p5zB-3cmnA:
undetectable		 1p5zB-3cmnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8h PUTATIVE POLYKETIDE
CYCLASE

(Ruegeria sp.
TM1040) 		PF12680
(SnoaL_2) 		5 VAL A  28
LEU A  24
MET A  20
TYR A   8
PHE A  47
 None
None
MRD  A 135 ( 3.9A)
None
None
 1.45A 1p5zB-3f8hA:
undetectable		 1p5zB-3f8hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0y PUTATIVE POLYKETIDE
CYCLASE

(Xanthomonas
campestris) 		PF12680
(SnoaL_2) 		5 VAL A  36
LEU A  32
MET A  28
TYR A  16
PHE A  55
 None
None
None
UNL  A 143 (-4.8A)
None
 1.49A 1p5zB-3i0yA:
undetectable		 1p5zB-3i0yA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyy LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE

(Enterococcus
faecium) 		no annotation 5 ILE A  45
VAL A  64
LEU A  14
ASP A  56
PHE A  55
 None
 1.46A 1p5zB-3jyyA:
undetectable		 1p5zB-3jyyA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Bacillus cereus) 		PF01923
(Cob_adeno_trans) 		5 ILE A  55
GLU A 102
TYR A 158
ARG A 169
GLU A  58
 None
 1.35A 1p5zB-3ke5A:
undetectable		 1p5zB-3ke5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnn DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg) 		5 ILE A  18
VAL A 114
LEU A  78
ASP A 106
PHE A 105
 None
 1.33A 1p5zB-3nnnA:
undetectable		 1p5zB-3nnnA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 ILE A 172
GLU A 123
LEU A 139
ARG A 174
ASP A 179
 GOL  A2006 (-3.9A)
None
None
GOL  A2006 (-4.1A)
None
 1.42A 1p5zB-3okyA:
undetectable		 1p5zB-3okyA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ILE B 943
VAL B 903
TRP B 906
LEU B 907
MET B 913
 None
 1.19A 1p5zB-3tacB:
undetectable		 1p5zB-3tacB:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLU A 923
VAL A 931
LEU A 915
TYR A 704
ARG A 987
 None
None
None
GOL  A1904 ( 4.6A)
None
 1.42A 1p5zB-3va7A:
undetectable		 1p5zB-3va7A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		5 ILE A 122
GLU A  15
VAL A  24
LEU A  19
PHE A  49
 None
CA  A1450 (-2.4A)
None
None
None
 1.50A 1p5zB-3zm8A:
undetectable		 1p5zB-3zm8A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 VAL A 756
LEU A 714
MET A 717
TYR A 718
ASP A 767
 None
 1.41A 1p5zB-4anjA:
undetectable		 1p5zB-4anjA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Bacillus
anthracis) 		PF00483
(NTP_transferase) 		5 ILE A 105
VAL A 119
LEU A 173
ASP A 113
PHE A 111
 None
 1.46A 1p5zB-4ecmA:
undetectable		 1p5zB-4ecmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 LEU A 512
ARG A 848
ASP A 855
PHE A 578
GLU A 509
 None
 1.39A 1p5zB-5cjuA:
5.8		 1p5zB-5cjuA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLU A 299
VAL A 307
LEU A 291
TYR A  81
ARG A 373
 EDO  A 505 ( 4.2A)
None
None
None
EDO  A 505 (-4.1A)
 1.35A 1p5zB-5h80A:
undetectable		 1p5zB-5h80A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLU A 923
VAL A 931
LEU A 915
TYR A 704
ARG A 987
 None
 1.43A 1p5zB-5i8iA:
undetectable		 1p5zB-5i8iA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 5 ILE A 423
VAL A 605
LEU A 394
GLN A 374
PHE A 363
 None
 1.49A 1p5zB-5w1aA:
undetectable		 1p5zB-5w1aA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
LEU w 114
GLN w 132
ARG w 161
ASP w 166
 None
 1.06A 1p5zB-5xtdw:
18.1		 1p5zB-5xtdw:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
LEU w 114
TYR w 118
ARG w 161
ASP w 166
 None
 1.11A 1p5zB-5xtdw:
18.1		 1p5zB-5xtdw:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ILE w  66
LEU w 114
TYR w 118
ASP w 166
GLU w 226
 None
 1.17A 1p5zB-5xtdw:
18.1		 1p5zB-5xtdw:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 5 GLU A  30
LEU A  69
ARG A 167
PHE A 169
GLU A 262
 None
 1.13A 1p5zB-5y58A:
undetectable		 1p5zB-5y58A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 5 ILE A 460
VAL A 453
LEU A 514
TYR A 505
GLN A 494
 None
 0.98A 1p5zB-5zl9A:
undetectable		 1p5zB-5zl9A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Deinococcus
radiodurans;
Synechocystis
sp. PCC 6803) 		no annotation 5 ILE A 595
GLU A 676
LEU A 550
TYR A 572
GLN A 620
 None
 1.20A 1p5zB-6fhtA:
undetectable		 1p5zB-6fhtA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ILE O  31
GLU O  53
LEU O  79
GLN O  97
PHE O 134
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
None
ADP  O 401 (-3.5A)
ADP  O 401 (-3.6A)
 0.91A 1p5zB-6g2jO:
undetectable		 1p5zB-6g2jO:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
GLU O  53
LEU O  79
TYR O  83
ARG O 126
PHE O 134
 ADP  O 401 (-4.0A)
ADP  O 401 ( 4.7A)
None
ADP  O 401 (-4.9A)
ADP  O 401 ( 4.3A)
ADP  O 401 (-3.6A)
 1.03A 1p5zB-6g2jO:
undetectable		 1p5zB-6g2jO:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ILE O  31
LEU O  79
GLN O  97
PHE O 134
GLU O 191
 ADP  O 401 (-4.0A)
None
ADP  O 401 (-3.5A)
ADP  O 401 (-3.6A)
ADP  O 401 (-3.2A)
 1.00A 1p5zB-6g2jO:
undetectable		 1p5zB-6g2jO:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
LEU O  79
TYR O  83
ARG O 126
ASP O 131
PHE O 134
 ADP  O 401 (-4.0A)
None
ADP  O 401 (-4.9A)
ADP  O 401 ( 4.3A)
None
ADP  O 401 (-3.6A)
 0.97A 1p5zB-6g2jO:
undetectable		 1p5zB-6g2jO:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 6 ILE O  31
LEU O  79
TYR O  83
ARG O 126
PHE O 134
GLU O 191
 ADP  O 401 (-4.0A)
None
ADP  O 401 (-4.9A)
ADP  O 401 ( 4.3A)
ADP  O 401 (-3.6A)
ADP  O 401 (-3.2A)
 0.94A 1p5zB-6g2jO:
undetectable		 1p5zB-6g2jO:
14.62