SIMILAR PATTERNS OF AMINO ACIDS FOR 1P2Y_A_NCTA440_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens) 		PF14580
(LRR_9) 		4 PHE A  60
LEU A  93
VAL A  71
ILE A  34
 None
 0.82A 1p2yA-1a9nA:
0.0		 1p2yA-1a9nA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		4 VAL A 100
GLY A  99
ASP A 253
ILE A 252
 None
 0.77A 1p2yA-1es6A:
undetectable		 1p2yA-1es6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 VAL A 375
GLY A 376
ASP A 360
VAL A 358
 None
 0.52A 1p2yA-1gg4A:
0.0		 1p2yA-1gg4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 LEU P 276
VAL P 310
GLY P 311
ASP P 290
 None
 0.75A 1p2yA-1h71P:
0.0		 1p2yA-1h71P:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh2 N UTILIZATION
SUBSTANCE PROTEIN A

(Thermotoga
maritima) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		4 GLY P 248
ASP P 241
ILE P 219
VAL P 220
 None
 0.74A 1p2yA-1hh2P:
0.0		 1p2yA-1hh2P:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 4 LEU T  94
VAL T  97
GLY T  98
VAL T 133
 None
 0.61A 1p2yA-1lthT:
undetectable		 1p2yA-1lthT:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 VAL A 294
GLY A 278
ILE A 153
VAL A 130
 None
FAD  A3000 (-3.8A)
None
None
 0.82A 1p2yA-1m64A:
undetectable		 1p2yA-1m64A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 831
LEU A 847
VAL A 850
ILE A 875
 None
 0.69A 1p2yA-1nd7A:
0.0		 1p2yA-1nd7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		4 VAL C 177
GLY C 176
ASP C 195
VAL C 259
 None
 0.81A 1p2yA-1odtC:
0.0		 1p2yA-1odtC:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A  13
GLY A  14
ASP A  97
VAL A 362
 NAP  A1372 (-3.7A)
None
None
None
 0.79A 1p2yA-1pquA:
undetectable		 1p2yA-1pquA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		4 LEU A 350
GLY A 420
ILE A 362
VAL A 361
 None
 0.81A 1p2yA-1qguA:
undetectable		 1p2yA-1qguA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		4 LEU A 354
VAL A 306
GLY A 307
ILE A 296
 None
 0.69A 1p2yA-1u2xA:
undetectable		 1p2yA-1u2xA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		4 LEU A  23
VAL A  48
GLY A  47
ILE A  39
 None
 0.77A 1p2yA-1v2xA:
undetectable		 1p2yA-1v2xA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrb DJVLGB

(Dugesia
japonica) 		PF00270
(DEAD) 		4 PHE A 238
ASP A 342
ILE A 266
VAL A 316
 None
 0.77A 1p2yA-1wrbA:
undetectable		 1p2yA-1wrbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 PHE Y1093
LEU X  47
GLY X  52
ILE X 135
 None
 0.82A 1p2yA-1xewY:
undetectable		 1p2yA-1xewY:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk5 F17G ADHESIN SUBUNIT

(Escherichia
coli) 		PF09222
(Fim-adh_lectin) 		4 LEU A  62
VAL A  60
GLY A 145
VAL A 122
 None
 0.78A 1p2yA-1zk5A:
undetectable		 1p2yA-1zk5A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		4 VAL C 120
GLY C 119
ILE C 138
VAL C 139
 None
 0.56A 1p2yA-2af4C:
undetectable		 1p2yA-2af4C:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arf WILSON DISEASE
ATPASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 LEU A1057
VAL A1060
GLY A1061
ILE A1192
 None
 0.82A 1p2yA-2arfA:
undetectable		 1p2yA-2arfA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdr CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF13419
(HAD_2) 		4 LEU A 118
VAL A 121
GLY A 122
ILE A  89
 None
 0.78A 1p2yA-2fdrA:
undetectable		 1p2yA-2fdrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 LEU A 212
VAL A 215
GLY A 216
VAL A 177
 None
 0.67A 1p2yA-2fuqA:
undetectable		 1p2yA-2fuqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 VAL B 308
GLY B 386
ILE B 341
VAL B 360
 None
 0.78A 1p2yA-2hdnB:
undetectable		 1p2yA-2hdnB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kqy PARVALBUMIN, THYMIC

(Gallus gallus) 		PF13499
(EF-hand_7) 		4 PHE A  66
VAL A  33
GLY A  34
VAL A  46
 None
 0.77A 1p2yA-2kqyA:
undetectable		 1p2yA-2kqyA:
12.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		7 PHE A  87
LEU A 244
VAL A 247
GLY A 248
ASP A 297
ILE A 395
VAL A 396
 CAM  A 502 (-4.6A)
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.9A)
HEM  A 501 (-2.8A)
None
None
 0.49A 1p2yA-2m56A:
68.0		 1p2yA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		4 PHE A 512
VAL A 496
GLY A 495
VAL A 572
 None
 0.72A 1p2yA-2o1tA:
undetectable		 1p2yA-2o1tA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 PHE A 512
VAL A 496
GLY A 495
VAL A 572
 None
 0.77A 1p2yA-2o1vA:
undetectable		 1p2yA-2o1vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvs CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT

(Mus musculus) 		PF00027
(cNMP_binding) 		4 LEU B 225
VAL B 156
GLY B 223
ILE B 218
 LEU  B 225 ( 0.6A)
VAL  B 156 ( 0.6A)
GLY  B 223 ( 0.0A)
ILE  B 218 ( 0.7A)
 0.81A 1p2yA-2qvsB:
undetectable		 1p2yA-2qvsB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 VAL G 184
GLY G 185
ILE G 244
VAL G 243
 None
 0.74A 1p2yA-2uv8G:
undetectable		 1p2yA-2uv8G:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Sphingomonas
elodea) 		PF00483
(NTP_transferase) 		4 PHE A  57
LEU A  95
GLY A  92
ILE A  40
 None
 0.75A 1p2yA-2ux8A:
undetectable		 1p2yA-2ux8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 516
GLY A 514
ILE A 353
VAL A 447
 None
 0.81A 1p2yA-2x40A:
undetectable		 1p2yA-2x40A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 GLY A 194
ASP A 217
ILE A 216
VAL A 215
 None
 0.70A 1p2yA-2x4gA:
undetectable		 1p2yA-2x4gA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjt ATP-DEPENDENT RNA
HELICASE SRMB

(Escherichia
coli) 		PF00271
(Helicase_C) 		4 LEU D 360
VAL D 363
GLY D 364
ILE D 336
 None
 0.80A 1p2yA-2yjtD:
undetectable		 1p2yA-2yjtD:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 552
GLY A 560
ILE A 469
VAL A 466
 None
 0.75A 1p2yA-3b9pA:
undetectable		 1p2yA-3b9pA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi8 CHOLINE KINASE

(Plasmodium
falciparum) 		PF01633
(Choline_kinase) 		4 PHE A 120
GLY A 179
ASP A  83
ILE A  87
 None
 0.79A 1p2yA-3fi8A:
undetectable		 1p2yA-3fi8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r CAMP-DEPENDENT
PROTEIN KINASE TYPE
II-ALPHA REGULATORY
SUBUNIT

(Mus musculus) 		PF00027
(cNMP_binding)
PF02197
(RIIa) 		4 LEU B 227
VAL B 158
GLY B 225
ILE B 220
 None
 0.81A 1p2yA-3j4rB:
undetectable		 1p2yA-3j4rB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Nostoc
punctiforme) 		PF00903
(Glyoxalase) 		4 PHE A 138
GLY A  42
ILE A 116
VAL A 115
 None
 0.55A 1p2yA-3kolA:
undetectable		 1p2yA-3kolA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 LEU A  40
VAL A 146
GLY A  38
ILE A 113
 None
 0.78A 1p2yA-3lmkA:
undetectable		 1p2yA-3lmkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln7 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Pasteurella
multocida) 		PF02655
(ATP-grasp_3)
PF04262
(Glu_cys_ligase) 		4 VAL A 470
ASP A 441
ILE A 749
VAL A 748
 None
 0.82A 1p2yA-3ln7A:
undetectable		 1p2yA-3ln7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxt GLUTATHIONE S
TRANSFERASE

(Pseudomonas
protegens) 		PF13417
(GST_N_3) 		4 LEU A  94
VAL A  97
GLY A  98
ILE A  69
 None
 0.77A 1p2yA-3lxtA:
undetectable		 1p2yA-3lxtA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 VAL A1308
GLY A1386
ILE A1341
VAL A1360
 None
 0.79A 1p2yA-3mmpA:
undetectable		 1p2yA-3mmpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o59 DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
horikoshii) 		PF03833
(PolC_DP2) 		4 LEU X 263
VAL X 256
GLY X 255
ILE X 219
 None
 0.75A 1p2yA-3o59X:
undetectable		 1p2yA-3o59X:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LEU A 118
VAL A 114
ILE A 101
VAL A 100
 None
 0.77A 1p2yA-3oz6A:
undetectable		 1p2yA-3oz6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1x 2-OXO-3-DEOXYGALACTO
NATE KINASE

(Klebsiella
pneumoniae) 		PF05035
(DGOK) 		4 VAL A  67
GLY A  68
ILE A  99
VAL A  95
 None
 0.74A 1p2yA-3r1xA:
undetectable		 1p2yA-3r1xA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 LEU A  67
VAL A  70
GLY A  71
ILE A  15
 None
 0.80A 1p2yA-3s6kA:
undetectable		 1p2yA-3s6kA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE A 388
GLY A 560
ILE A 529
VAL A 530
 None
 0.79A 1p2yA-3sqwA:
undetectable		 1p2yA-3sqwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		4 LEU A 164
VAL A 171
GLY A 172
ASP A 302
 None
 0.61A 1p2yA-3tsnA:
undetectable		 1p2yA-3tsnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis) 		PF00303
(Thymidylat_synt) 		4 LEU A 233
VAL A 236
GLY A 237
ILE A 174
 None
 0.75A 1p2yA-3v8hA:
undetectable		 1p2yA-3v8hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		4 LEU A 279
VAL A 313
GLY A 314
ASP A 293
 None
 0.77A 1p2yA-3vi1A:
undetectable		 1p2yA-3vi1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 PHE A 905
LEU A 954
VAL A 957
GLY A 937
 None
 0.82A 1p2yA-3vuoA:
undetectable		 1p2yA-3vuoA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 299
VAL A 349
ILE A 341
VAL A 337
 None
 0.82A 1p2yA-4a2pA:
undetectable		 1p2yA-4a2pA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 PHE A 581
VAL A 557
GLY A 556
ILE A 548
 None
 0.72A 1p2yA-4bc7A:
undetectable		 1p2yA-4bc7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		4 PHE A 196
LEU A 211
VAL A  35
ILE A  65
 None
 0.82A 1p2yA-4c0rA:
undetectable		 1p2yA-4c0rA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 LEU A 252
GLY A 256
ASP A 305
ILE A 403
VAL A 404
 HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
HEM  A1418 (-2.7A)
None
GOL  A1419 (-3.5A)
 0.65A 1p2yA-4c9mA:
57.9		 1p2yA-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 PHE A 388
GLY A 560
ILE A 529
VAL A 530
 None
 0.77A 1p2yA-4db4A:
undetectable		 1p2yA-4db4A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 PHE A  87
GLY A 254
ILE A 401
VAL A 402
 None
PEG  A 502 (-3.8A)
None
None
 0.78A 1p2yA-4dxyA:
51.5		 1p2yA-4dxyA:
46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		4 PHE A 109
LEU A  52
GLY A  27
ILE A 115
 None
 0.74A 1p2yA-4ei8A:
undetectable		 1p2yA-4ei8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 VAL A 593
GLY A 671
ILE A 626
VAL A 645
 None
 0.71A 1p2yA-4fwtA:
undetectable		 1p2yA-4fwtA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI

(Caulobacter
vibrioides) 		PF06230
(DUF1009) 		4 PHE A 115
LEU A  33
VAL A  49
GLY A  50
 None
 0.77A 1p2yA-4j6eA:
undetectable		 1p2yA-4j6eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC

(Mycobacterium
marinum) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A  87
ASP A 212
ILE A 213
VAL A 214
 None
 0.69A 1p2yA-4kamA:
undetectable		 1p2yA-4kamA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjr CATION EXCHANGER
YFKE

(Bacillus
subtilis) 		PF01699
(Na_Ca_ex) 		4 VAL A 250
GLY A 251
ILE A 220
VAL A 217
 None
 0.76A 1p2yA-4kjrA:
undetectable		 1p2yA-4kjrA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		4 LEU A 167
VAL A 205
GLY A 206
VAL A 317
 None
 0.80A 1p2yA-4kpnA:
undetectable		 1p2yA-4kpnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 4 GLY H  64
ASP H 187
ILE H 188
VAL H 189
 None
 0.79A 1p2yA-4l0oH:
undetectable		 1p2yA-4l0oH:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 LEU A 155
GLY A  78
ILE A  84
VAL A  83
 None
 0.82A 1p2yA-4l39A:
undetectable		 1p2yA-4l39A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 PHE A  81
LEU A 144
GLY A 256
ILE A  83
 None
None
ACT  A 401 (-3.6A)
None
 0.77A 1p2yA-4lb0A:
undetectable		 1p2yA-4lb0A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 LEU A 401
VAL A 404
GLY A 405
ILE A 354
 None
 0.74A 1p2yA-4pfyA:
undetectable		 1p2yA-4pfyA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pt1 ODORANT-BINDING
PROTEIN 1D

(Locusta
migratoria) 		PF01395
(PBP_GOBP) 		4 PHE A  67
LEU A  73
GLY A  84
ILE A 106
 None
None
PG0  A 201 ( 4.1A)
None
 0.80A 1p2yA-4pt1A:
undetectable		 1p2yA-4pt1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		4 PHE A  81
LEU A 144
GLY A 256
ILE A  83
 None
None
CSO  A 255 (-2.4A)
None
 0.76A 1p2yA-4q2hA:
undetectable		 1p2yA-4q2hA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkf RAS-RELATED PROTEIN
RAB-3

(Drosophila
melanogaster) 		PF00071
(Ras) 		4 VAL A 158
GLY A 157
ILE A 119
VAL A 116
 None
 0.78A 1p2yA-4rkfA:
undetectable		 1p2yA-4rkfA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE A 388
GLY A 560
ILE A 529
VAL A 530
 None
 0.77A 1p2yA-4tz0A:
undetectable		 1p2yA-4tz0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u83 ACYL-COA
DEHYDROGENASE

(Brucella
abortus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A  35
GLY A  44
ILE A  84
VAL A  85
 None
 0.82A 1p2yA-4u83A:
undetectable		 1p2yA-4u83A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  89
VAL A  53
GLY A  54
ASP A  74
 None
None
None
P6G  A 705 ( 3.5A)
 0.42A 1p2yA-4uzsA:
undetectable		 1p2yA-4uzsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe7 UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		no annotation 4 VAL A 374
GLY A 373
ILE A 316
VAL A 312
 None
 0.81A 1p2yA-4xe7A:
undetectable		 1p2yA-4xe7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.76A 1p2yA-4zc0A:
undetectable		 1p2yA-4zc0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zps MCG133388, ISOFORM
CRA_M

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 VAL A  16
GLY A  17
ILE A  77
VAL A  90
 None
 0.77A 1p2yA-4zpsA:
undetectable		 1p2yA-4zpsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 VAL C 262
GLY C 263
ASP C 135
ILE C 561
 None
 0.72A 1p2yA-5aa5C:
undetectable		 1p2yA-5aa5C:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		4 PHE A 133
VAL A 194
GLY A 193
ILE A 182
 None
 0.62A 1p2yA-5bn7A:
undetectable		 1p2yA-5bn7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 LEU A  48
VAL A  51
GLY A  52
VAL A  21
 None
 0.52A 1p2yA-5c3mA:
undetectable		 1p2yA-5c3mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN

(Chaetomium
thermophilum) 		PF09439
(SRPRB) 		4 LEU B  75
VAL B  83
GLY B  84
ASP B 133
 None
 0.71A 1p2yA-5ck3B:
undetectable		 1p2yA-5ck3B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cl2 SPORULATION-CONTROL
PROTEIN SPO0M

(Bacillus
subtilis) 		PF07070
(Spo0M) 		4 PHE A 206
LEU A 202
ILE A 252
VAL A 248
 None
 0.80A 1p2yA-5cl2A:
undetectable		 1p2yA-5cl2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  87
VAL A  51
GLY A  52
ASP A  72
 None
 0.41A 1p2yA-5dfaA:
undetectable		 1p2yA-5dfaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 LEU A  85
VAL A  49
GLY A  50
ASP A  70
 None
 0.44A 1p2yA-5e9aA:
undetectable		 1p2yA-5e9aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjp O-SUCCINYLBENZOATE
SYNTHASE

(Amycolatopsis
sp.) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 146
VAL A 149
GLY A 150
VAL A 184
 None
 0.61A 1p2yA-5fjpA:
undetectable		 1p2yA-5fjpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu4 CYSTEINE PROTEASE

(Listeria
monocytogenes) 		PF04203
(Sortase) 		4 PHE A  65
GLY A 131
ILE A  68
VAL A  71
 None
 0.81A 1p2yA-5hu4A:
undetectable		 1p2yA-5hu4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 PHE A1213
VAL A 432
ILE A  15
VAL A1122
 None
 0.76A 1p2yA-5hy7A:
undetectable		 1p2yA-5hy7A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4q ELONGATION FACTOR TU

(Escherichia
coli) 		PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 VAL C 309
GLY C 387
ILE C 342
VAL C 361
 None
 0.76A 1p2yA-5i4qC:
undetectable		 1p2yA-5i4qC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 LEU A 462
GLY A 556
ILE A 587
VAL A 586
 None
 0.76A 1p2yA-5m2nA:
undetectable		 1p2yA-5m2nA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmx CSPYL1_ABA

(Citrus sinensis) 		no annotation 4 PHE B 100
LEU B 128
GLY B 136
ASP B  82
 None
 0.57A 1p2yA-5mmxB:
undetectable		 1p2yA-5mmxB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		no annotation 4 PHE A 166
VAL A  76
GLY A  77
VAL A  81
 None
 0.81A 1p2yA-5nfnA:
undetectable		 1p2yA-5nfnA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5a PEREGRIN

(Homo sapiens) 		no annotation 4 PHE A 675
GLY A 726
ILE A 700
VAL A 701
 None
 0.65A 1p2yA-5o5aA:
undetectable		 1p2yA-5o5aA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		4 GLY A 239
ASP C  35
ILE C  34
VAL C  33
 None
 0.81A 1p2yA-5osnA:
undetectable		 1p2yA-5osnA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szm PCDHGA8 OR
PROTOCADHERIN GAMMA
A8

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 VAL A  16
GLY A  17
ILE A  77
VAL A  90
 None
 0.75A 1p2yA-5szmA:
undetectable		 1p2yA-5szmA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU A 204
GLY A 206
ILE A 332
VAL A 331
 None
 0.73A 1p2yA-5t9jA:
undetectable		 1p2yA-5t9jA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		4 PHE A  10
VAL A 302
GLY A 301
ILE A 336
 None
 0.58A 1p2yA-5tgfA:
undetectable		 1p2yA-5tgfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE

(Sulfurisphaera
tokodaii) 		no annotation 4 LEU A 114
VAL A 117
GLY A 118
ILE A 191
 None
 0.77A 1p2yA-5uxgA:
undetectable		 1p2yA-5uxgA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PHE A 461
VAL A  17
GLY A  16
ILE A 479
 None
 0.79A 1p2yA-5vniA:
undetectable		 1p2yA-5vniA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtg TRANSLOCATION AND
ASSEMBLY MODULE
SUBUNIT TAMB

(Escherichia
coli) 		no annotation 4 LEU A1053
VAL A1034
GLY A1051
ILE A1040
 None
 0.80A 1p2yA-5vtgA:
undetectable		 1p2yA-5vtgA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
 0.68A 1p2yA-5wu3A:
undetectable		 1p2yA-5wu3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
None
None
MG  A1001 (-3.9A)
 0.70A 1p2yA-5wu6A:
undetectable		 1p2yA-5wu6A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		4 PHE A1997
LEU A1920
GLY A1922
ILE A2001
 None
 0.82A 1p2yA-5xbfA:
undetectable		 1p2yA-5xbfA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 4 VAL C  92
GLY C  93
ASP C 128
VAL C  32
 None
 0.80A 1p2yA-6eicC:
undetectable		 1p2yA-6eicC:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 PHE B 497
GLY B 620
ILE B 537
VAL B 534
 None
 0.77A 1p2yA-6reqB:
undetectable		 1p2yA-6reqB:
21.10