SIMILAR PATTERNS OF AMINO ACIDS FOR 1OXR_A_AINA141_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2p COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05738
(Cna_B) 		4 LEU A 840
GLY A 865
ASP A 867
TYR A 877
 None
 1.13A 1oxrA-1d2pA:
0.0		 1oxrA-1d2pA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 432
GLY A 435
ASP A 361
TYR A 387
 None
 1.39A 1oxrA-1e6zA:
0.0		 1oxrA-1e6zA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A 148
GLY A 141
ASP A 379
TYR A 105
 None
 1.13A 1oxrA-1fcpA:
0.0		 1oxrA-1fcpA:
10.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
GLY A  30
ASP A  49
TYR A  69
 None
 0.44A 1oxrA-1p7oA:
20.9		 1oxrA-1p7oA:
58.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
GLY A  30
ASP A  49
TYR A  69
 None
 0.73A 1oxrA-1pwoA:
20.3		 1oxrA-1pwoA:
58.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (GH-LOOP
FROM VIRUS CAPSID
PROTEIN VP1)
PROTEIN (VIRUS
CAPSID PROTEIN VP1)
PROTEIN (VIRUS
CAPSID PROTEIN VP2)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv)
no annotation 		4 LEU 5 155
GLY 2 164
ASP 2 169
TYR 1 130
 None
 1.43A 1oxrA-1qgc5:
undetectable		 1oxrA-1qgc5:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 505
GLY A  17
ASP A  37
TYR A 496
 None
 1.13A 1oxrA-1tmoA:
undetectable		 1oxrA-1tmoA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 LEU A 159
GLY A 167
ASP A 182
TYR A 160
 None
 1.43A 1oxrA-1v1pA:
undetectable		 1oxrA-1v1pA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		4 LEU A 190
GLY A 233
ASP A 165
TYR A 189
 None
None
PO4  A 277 (-3.4A)
None
 1.50A 1oxrA-1ywfA:
undetectable		 1oxrA-1ywfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 LEU A 489
GLY A 493
ASP A 547
TYR A 502
 None
 1.26A 1oxrA-2dkhA:
undetectable		 1oxrA-2dkhA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkv HYPOTHETICAL PROTEIN

(Exiguobacterium
sibiricum) 		PF05163
(DinB) 		4 LEU A  53
GLY A  13
ASP A   9
TYR A  92
 None
 1.42A 1oxrA-2hkvA:
2.5		 1oxrA-2hkvA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4x MITOGEN

(Streptococcus
dysgalactiae) 		PF02876
(Stap_Strp_tox_C) 		4 LEU A 155
GLY A 165
ASP A 180
TYR A 156
 None
GOL  A1213 (-4.4A)
GOL  A1213 (-2.5A)
None
 1.45A 1oxrA-2j4xA:
undetectable		 1oxrA-2j4xA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		4 LEU A 245
GLY A 241
ASP A 300
TYR A 247
 None
 1.46A 1oxrA-2jbwA:
1.7		 1oxrA-2jbwA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnl C-X-C CHEMOKINE
RECEPTOR TYPE 1

(Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A 262
GLY A 284
ASP A 288
TYR A 258
 None
 1.41A 1oxrA-2lnlA:
undetectable		 1oxrA-2lnlA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa) 		PF00089
(Trypsin) 		4 LEU B 199
GLY B 184
ASP B 189
TYR B 228
 None
None
BEN  B   1 (-3.0A)
None
 1.24A 1oxrA-2pkaB:
undetectable		 1oxrA-2pkaB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qej SUPERANTIGEN-LIKE
MOLECULE 7

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 LEU C 149
GLY C 157
ASP C 172
TYR C 150
 None
 1.45A 1oxrA-2qejC:
undetectable		 1oxrA-2qejC:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 199
GLY A 184
ASP A 189
TYR A 228
 None
 1.32A 1oxrA-2r0lA:
undetectable		 1oxrA-2r0lA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 LEU A 385
GLY A 319
ASP A 306
TYR A 357
 None
FAD  A1395 (-3.3A)
FAD  A1395 (-2.9A)
ACT  A1397 (-4.5A)
 1.16A 1oxrA-2vouA:
0.6		 1oxrA-2vouA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 LEU A 123
GLY A 259
ASP A 538
TYR A 512
 None
 1.47A 1oxrA-2xn1A:
undetectable		 1oxrA-2xn1A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 LEU A 120
GLY A 255
ASP A 526
TYR A 500
 None
 1.33A 1oxrA-2yfnA:
undetectable		 1oxrA-2yfnA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv5 YJEQ PROTEIN

(Aquifex
aeolicus) 		PF03193
(RsgA_GTPase) 		4 LEU A  10
GLY A 165
ASP A  81
TYR A  49
 None
 1.19A 1oxrA-2yv5A:
undetectable		 1oxrA-2yv5A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl0 ADENYLATE KINASE

(Bacillus
subtilis) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 LEU A 157
GLY A 134
ASP A 153
TYR A 137
 None
None
ZN  A 219 (-2.4A)
None
 1.45A 1oxrA-3dl0A:
undetectable		 1oxrA-3dl0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdo PUTATIVE
PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Parabacteroides
distasonis) 		PF02769
(AIRS_C) 		4 LEU A 220
GLY A 241
ASP A 246
TYR A 219
 None
None
None
PEG  A 400 ( 4.2A)
 1.40A 1oxrA-3mdoA:
undetectable		 1oxrA-3mdoA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meb ASPARTATE
AMINOTRANSFERASE

(Giardia
intestinalis) 		PF00155
(Aminotran_1_2) 		4 LEU A 158
GLY A 195
ASP A 197
TYR A 157
 None
None
EDO  A 506 (-3.8A)
EDO  A 506 (-4.3A)
 1.12A 1oxrA-3mebA:
undetectable		 1oxrA-3mebA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 LEU A 120
GLY A 256
ASP A 535
TYR A 509
 None
 1.37A 1oxrA-3mi6A:
undetectable		 1oxrA-3mi6A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtq PUTATIVE
PHOSPHOENOLPYRUVATE-
DEPENDENT SUGAR
PHOSPHOTRANSFERASE
SYSTEM (PTS)
PERMEASE

(Klebsiella
pneumoniae) 		PF03610
(EIIA-man) 		4 LEU A  44
GLY A  70
ASP A  66
TYR A  37
 None
 1.27A 1oxrA-3mtqA:
undetectable		 1oxrA-3mtqA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
GLY A  30
ASP A  49
TYR A  69
 None
CA  A 125 (-4.3A)
CA  A 125 (-2.1A)
None
 0.58A 1oxrA-3p2pA:
21.9		 1oxrA-3p2pA:
57.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2t PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 LEU A 182
GLY A 190
ASP A 205
TYR A 183
 None
 1.44A 1oxrA-3r2tA:
undetectable		 1oxrA-3r2tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr2 CYSTEINE SYNTHASE

(Mycobacterium
marinum) 		PF00291
(PALP) 		4 LEU A 105
GLY A  41
ASP A  45
TYR A 109
 None
 1.12A 1oxrA-3rr2A:
undetectable		 1oxrA-3rr2A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		4 LEU A  23
GLY A  69
ASP A  48
TYR A  19
 None
 1.18A 1oxrA-3tglA:
undetectable		 1oxrA-3tglA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		4 LEU A 349
GLY A 340
ASP A 186
TYR A 319
 None
None
ZN  A 500 (-2.3A)
None
 1.10A 1oxrA-4bz7A:
undetectable		 1oxrA-4bz7A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 LEU A 119
GLY A 255
ASP A 534
TYR A 508
 None
 1.44A 1oxrA-4fnqA:
undetectable		 1oxrA-4fnqA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1p NHEA

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 LEU A 289
GLY A 185
ASP A 281
TYR A  38
 None
 1.01A 1oxrA-4k1pA:
undetectable		 1oxrA-4k1pA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc6 BIFUNCTIONAL AAC/APH

(Staphylococcus
warneri) 		PF13523
(Acetyltransf_8) 		4 LEU A 174
GLY A  97
ASP A  99
TYR A  86
 None
None
KAN  A 201 ( 3.9A)
None
 1.29A 1oxrA-4qc6A:
undetectable		 1oxrA-4qc6A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU E 199
GLY E 184
ASP E 189
TYR E 228
 None
 1.29A 1oxrA-5brrE:
undetectable		 1oxrA-5brrE:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 LEU F  59
GLY F 713
ASP F 711
TYR F  63
 None
 1.40A 1oxrA-5gjwF:
undetectable		 1oxrA-5gjwF:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 4 LEU A 199
GLY A 184
ASP A 189
TYR A 228
 None
 1.37A 1oxrA-5gvtA:
undetectable		 1oxrA-5gvtA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 LEU A 269
GLY A 224
ASP A 221
TYR A 240
 None
 1.20A 1oxrA-5kf7A:
0.8		 1oxrA-5kf7A:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 LEU A1007
GLY A 937
ASP A 944
TYR A 998
 None
 1.03A 1oxrA-5mqsA:
undetectable		 1oxrA-5mqsA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 4 LEU A 247
GLY A  85
ASP A  49
TYR A   9
 None
 1.17A 1oxrA-6f9mA:
undetectable		 1oxrA-6f9mA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 LEU A 826
GLY A 335
ASP A 340
TYR A 811
 None
 1.27A 1oxrA-6gh2A:
1.5		 1oxrA-6gh2A:
18.40