SIMILAR PATTERNS OF AMINO ACIDS FOR 1OT7_B_IU5B1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7s GDP-FUCOSE
SYNTHETASE

(Escherichia
coli) 		PF01370
(Epimerase) 		5 LEU A  41
HIS A  48
ILE A  91
ILE A  86
TYR A  81
 NAP  A1317 (-3.8A)
None
None
None
None
 1.47A 1ot7B-1e7sA:
0.0		 1ot7B-1e7sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		5 LEU F 242
HIS F 210
ILE F 233
PHE F 228
ILE F   7
 None
 1.45A 1ot7B-1ka9F:
0.0		 1ot7B-1ka9F:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 LEU A  16
ARG A  72
SER A  73
ILE A 367
ILE A  24
 None
 1.39A 1ot7B-1oseA:
0.0		 1ot7B-1oseA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		5 LEU A  51
MET A  44
HIS A  47
ARG A  42
ILE A  59
 None
None
HEM  A 991 (-3.9A)
HEM  A 992 ( 2.7A)
HEM  A 991 ( 4.6A)
 1.45A 1ot7B-1pbyA:
undetectable		 1ot7B-1pbyA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 375
HIS A 153
ILE A 264
PHE A 199
TYR A 165
 None
 1.35A 1ot7B-1rblA:
0.0		 1ot7B-1rblA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uky URIDYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00406
(ADK) 		5 LEU A  45
ARG A  86
ILE A 119
PHE A 115
ILE A 102
 None
 1.24A 1ot7B-1ukyA:
0.1		 1ot7B-1ukyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		5 LEU A 212
ARG A 270
SER A 289
ILE A 222
TYR A 296
 None
 1.31A 1ot7B-1w8oA:
undetectable		 1ot7B-1w8oA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		5 LEU A 118
ILE A 106
PHE A 165
ILE A 178
TYR A 161
 None
None
None
None
SNN  A 112 ( 4.4A)
 1.46A 1ot7B-1wl8A:
0.0		 1ot7B-1wl8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2diw PUTATIVE RNA-BINDING
PROTEIN 16

(Homo sapiens) 		PF04818
(CTD_bind) 		5 LEU A 140
MET A 143
ARG A 110
ILE A 101
TRP A 126
 None
 1.41A 1ot7B-2diwA:
0.0		 1ot7B-2diwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 LEU A 528
HIS A 680
SER A 682
ILE A 685
PHE A 518
 None
 1.25A 1ot7B-2f8tA:
0.0		 1ot7B-2f8tA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 LEU A  94
ARG A  42
ILE A  38
ILE A  96
TYR A 202
 None
 1.48A 1ot7B-2ggqA:
undetectable		 1ot7B-2ggqA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		5 LEU A 163
ILE A 155
PHE A 110
ILE A 134
TYR A 113
 None
 1.39A 1ot7B-2grmA:
undetectable		 1ot7B-2grmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		5 LEU A  57
HIS A  82
ILE A  50
PHE A  38
ILE A 213
 None
 1.44A 1ot7B-2hf8A:
undetectable		 1ot7B-2hf8A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 371
MET A 365
HIS A 363
ILE A 358
ILE A 340
 None
 1.47A 1ot7B-2o3jA:
undetectable		 1ot7B-2o3jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 LEU A 325
HIS A 331
ILE A 333
PHE A 364
ILE A 417
 None
GOL  A 501 (-3.7A)
None
None
None
 1.14A 1ot7B-2okcA:
undetectable		 1ot7B-2okcA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LEU A  72
ARG A  68
ILE A  61
PHE A  60
ILE A   8
 None
 1.47A 1ot7B-2p4qA:
undetectable		 1ot7B-2p4qA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q04 ACETOIN UTILIZATION
PROTEIN

(Exiguobacterium
sibiricum) 		PF00583
(Acetyltransf_1) 		5 LEU A 164
MET A 159
SER A 119
PHE A  77
ILE A 130
 None
 1.40A 1ot7B-2q04A:
undetectable		 1ot7B-2q04A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1l HYPOTHETICAL PROTEIN

(Vibrio cholerae) 		PF10980
(DUF2787) 		5 LEU A  21
HIS A  28
ILE A 142
PHE A  45
ILE A  62
 None
 1.41A 1ot7B-2v1lA:
undetectable		 1ot7B-2v1lA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vec PIRIN-LIKE PROTEIN
YHAK

(Escherichia
coli) 		PF02678
(Pirin) 		5 LEU A  69
MET A 137
ILE A 143
ILE A 186
TRP A  17
 None
 1.19A 1ot7B-2vecA:
undetectable		 1ot7B-2vecA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wng TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU A 111
HIS A  24
SER A  77
ILE A  76
ILE A  81
 None
 1.42A 1ot7B-2wngA:
undetectable		 1ot7B-2wngA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3)
PF12041
(DELLA) 		5 LEU A 323
HIS A 113
ILE A  24
TYR B  36
TYR A  31
 None
None
GA4  A 345 ( 4.3A)
None
None
 1.45A 1ot7B-2zsiA:
undetectable		 1ot7B-2zsiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		5 LEU A 337
SER A 306
PHE A 309
ILE A 329
TRP A 334
 None
 1.40A 1ot7B-3aarA:
undetectable		 1ot7B-3aarA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 365
HIS A 166
ILE A 353
PHE A 337
ILE A 404
 None
 1.25A 1ot7B-3aatA:
undetectable		 1ot7B-3aatA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		5 LEU A 184
ILE A 138
PHE A 110
ILE A  71
TRP A  74
 None
 1.15A 1ot7B-3c3jA:
undetectable		 1ot7B-3c3jA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 LEU A 339
ARG A 192
ILE A 217
PHE A 214
ILE A 342
 None
 1.48A 1ot7B-3ejnA:
undetectable		 1ot7B-3ejnA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		5 LEU A 146
HIS A 228
ARG A 202
ILE A 170
TYR A  54
 None
 1.27A 1ot7B-3flbA:
undetectable		 1ot7B-3flbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Methylobacillus
flagellatus) 		PF13460
(NAD_binding_10) 		5 LEU A  16
ARG A 160
PHE A 152
ILE A 192
TYR A 257
 None
 1.10A 1ot7B-3gpiA:
undetectable		 1ot7B-3gpiA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 LEU A 358
SER A 342
ILE A 181
TYR A 424
TYR A 495
 None
 1.11A 1ot7B-3hq2A:
undetectable		 1ot7B-3hq2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7m XAA-PRO DIPEPTIDASE

(Lactobacillus
brevis) 		PF01321
(Creatinase_N) 		5 LEU A 115
PHE A  53
ILE A  86
TYR A  76
TRP A  83
 None
 1.32A 1ot7B-3i7mA:
undetectable		 1ot7B-3i7mA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		5 LEU T 889
MET T 893
ILE T 970
PHE T 966
TYR T 950
 None
 1.32A 1ot7B-3icqT:
undetectable		 1ot7B-3icqT:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)

(Sulfolobus
solfataricus) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		5 LEU A  78
HIS A  70
ILE A  62
PHE A   7
ILE A  51
 None
 1.32A 1ot7B-3kxiA:
undetectable		 1ot7B-3kxiA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyr TRANSCRIPTION FACTOR
COE1

(Homo sapiens) 		PF16422
(COE1_DBD) 		5 LEU A 192
HIS A 157
ARG A 173
PHE A  89
ILE A 108
 None
ZN  A   1 (-3.3A)
SO4  A 251 (-4.0A)
None
None
 1.45A 1ot7B-3lyrA:
undetectable		 1ot7B-3lyrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 LEU A  90
HIS A 182
SER A 130
ILE A 131
TYR A 126
 None
 1.03A 1ot7B-3s48A:
undetectable		 1ot7B-3s48A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER

(Homo sapiens) 		PF00069
(Pkinase)
PF08332
(CaMKII_AD) 		5 LEU A  57
ARG A   8
SER A  80
ILE A  79
ILE A  44
 None
 1.50A 1ot7B-3soaA:
undetectable		 1ot7B-3soaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 388
HIS A 452
ILE A 465
PHE A 467
ILE A 386
 None
CU  A 503 ( 3.3A)
None
None
None
 1.28A 1ot7B-3t6wA:
undetectable		 1ot7B-3t6wA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tze TRYPTOPHANYL-TRNA
SYNTHETASE

(Encephalitozoon
cuniculi) 		PF00579
(tRNA-synt_1b) 		5 HIS A  98
MET A  94
ILE A  96
PHE A 360
TYR A 364
 None
 1.32A 1ot7B-3tzeA:
undetectable		 1ot7B-3tzeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 280
HIS A 200
SER A 203
ILE A 205
ILE A 243
 None
LLP  A  61 ( 3.6A)
LLP  A  61 ( 2.5A)
None
None
 1.25A 1ot7B-3vabA:
undetectable		 1ot7B-3vabA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		5 LEU A 272
MET A 289
ARG A 333
SER A 282
TYR A 250
 None
 1.49A 1ot7B-3zgqA:
undetectable		 1ot7B-3zgqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis) 		PF01263
(Aldose_epim) 		5 MET A 147
HIS A 159
SER A 316
ILE A  66
TYR A 259
 None
 1.43A 1ot7B-4bzgA:
undetectable		 1ot7B-4bzgA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmw DITERPENE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 100
SER A  59
ILE A  60
TYR A  51
TYR A 233
 None
 1.46A 1ot7B-4cmwA:
undetectable		 1ot7B-4cmwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cua BETA-GALACTOSIDASE

(Streptococcus
pneumoniae) 		no annotation 5 LEU A1541
SER A1471
ILE A1470
PHE A1527
ILE A1620
 None
None
EDO  A2650 ( 4.8A)
None
None
 1.48A 1ot7B-4cuaA:
undetectable		 1ot7B-4cuaA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		5 LEU A 212
ARG A 270
SER A 289
ILE A 222
TYR A 296
 None
 1.31A 1ot7B-4j9tA:
undetectable		 1ot7B-4j9tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjy HIGH-AFFINITY SIRPA
VARIANT FD6

(Homo sapiens) 		PF07686
(V-set) 		5 LEU B 111
HIS B  24
SER B  77
ILE B  76
ILE B  81
 None
 1.29A 1ot7B-4kjyB:
undetectable		 1ot7B-4kjyB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 195
SER A 180
ILE A 179
PHE A 300
ILE A 198
 None
 1.27A 1ot7B-4nkyA:
1.6		 1ot7B-4nkyA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 291
ARG A 335
SER A 336
ILE A 339
ILE A 356
TYR A 373
 XX9  A 501 (-4.1A)
None
XX9  A 501 (-4.2A)
None
XX9  A 501 ( 4.6A)
None
 0.91A 1ot7B-4oivA:
24.6		 1ot7B-4oivA:
93.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 291
MET A 294
ARG A 335
SER A 336
ILE A 356
TYR A 373
 XX9  A 501 (-4.1A)
XX9  A 501 ( 4.3A)
None
XX9  A 501 (-4.2A)
XX9  A 501 ( 4.6A)
None
 1.01A 1ot7B-4oivA:
24.6		 1ot7B-4oivA:
93.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvu UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF16285
(DUF4931) 		5 LEU A 205
SER A  88
ILE A  89
ILE A 185
TYR A  76
 None
 1.18A 1ot7B-4qvuA:
undetectable		 1ot7B-4qvuA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 LEU A 346
PHE A 417
ILE A 349
TYR A 428
TYR A 422
 CLA  A1122 ( 4.7A)
BCR  A6007 ( 4.3A)
None
None
None
 1.50A 1ot7B-4rkuA:
undetectable		 1ot7B-4rkuA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		5 LEU A 435
ILE A  87
PHE A 236
ILE A 245
TYR A 237
 None
 1.03A 1ot7B-4y23A:
undetectable		 1ot7B-4y23A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aim TRANSCRIPTION FACTOR
TAU 138 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 608
ARG A 573
PHE A 576
ILE A 559
TYR A 577
 None
 1.44A 1ot7B-5aimA:
undetectable		 1ot7B-5aimA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 HIS A 479
MET A 480
ARG A 482
ILE A 542
ILE A 512
 None
 1.47A 1ot7B-5bn4A:
undetectable		 1ot7B-5bn4A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 LEU B 164
ILE B 137
PHE B 138
ILE B 198
TRP B 236
 None
 1.30A 1ot7B-5dlqB:
undetectable		 1ot7B-5dlqB:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		5 LEU A 337
ARG A 519
ILE A 327
PHE A 423
ILE A 428
 None
 1.43A 1ot7B-5mtzA:
undetectable		 1ot7B-5mtzA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B

(Pseudomonas
aeruginosa) 		no annotation 5 SER A 101
ILE A 304
ILE A  66
TYR A  61
TRP A  58
 None
 1.34A 1ot7B-5o8xA:
undetectable		 1ot7B-5o8xA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oge GDP-MANNOSE
TRANSPORTER 1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 200
MET A  98
ILE A 193
ILE A 125
TYR A 281
 None
 1.50A 1ot7B-5ogeA:
undetectable		 1ot7B-5ogeA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szq PROTOCADHERIN
GAMMA-A4

(Mus musculus) 		PF00028
(Cadherin) 		5 LEU A 463
ARG A 507
ILE A 460
ILE A 479
TYR A 429
 None
 1.47A 1ot7B-5szqA:
undetectable		 1ot7B-5szqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY

(Staphylococcus
aureus) 		no annotation 5 LEU A 149
MET A 152
ILE A 124
ILE A  88
TYR A  98
 None
None
PLM  A 301 ( 4.9A)
None
None
 1.09A 1ot7B-5utoA:
undetectable		 1ot7B-5utoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-) 		no annotation 5 LEU A 241
HIS A 209
ILE A 232
PHE A 227
ILE A   6
 None
 1.44A 1ot7B-6c7vA:
undetectable		 1ot7B-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 5 LEU A 376
ARG A 331
ILE A 335
PHE A 324
TYR A 112
 None
 1.24A 1ot7B-6c87A:
undetectable		 1ot7B-6c87A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 5 LEU M 232
MET M 235
ARG M 244
ILE M 186
TYR M 279
 None
A  O  23 ( 4.5A)
None
None
None
 1.36A 1ot7B-6d6qM:
undetectable		 1ot7B-6d6qM:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 LEU M 216
HIS M 293
SER M 323
ILE M 286
PHE M 327
 None
 1.23A 1ot7B-6g2jM:
undetectable		 1ot7B-6g2jM:
15.28