SIMILAR PATTERNS OF AMINO ACIDS FOR 1OT7_A_CHCA1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF12252
(SidE) 		4 MET A 409
MET A 500
ALA A 501
HIS A 504
 None
 1.09A 1ot7A-5bq9A:
2.1		 1ot7A-5bq9A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		4 MET A 409
MET A 500
ALA A 501
HIS A 504
 None
 1.04A 1ot7A-5bu1A:
0.0		 1ot7A-5bu1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu2 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		4 MET A 409
MET A 500
ALA A 501
HIS A 504
 None
None
None
ADP  A 702 (-3.5A)
 1.15A 1ot7A-5bu2A:
2.3		 1ot7A-5bu2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 MET A 259
MET A 137
ALA A 136
HIS A 133
 None
None
None
EDO  A 607 ( 4.7A)
 1.09A 1ot7A-5vpuA:
0.0		 1ot7A-5vpuA:
19.63