SIMILAR PATTERNS OF AMINO ACIDS FOR 1OSV_B_CHCB201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 MET A 355
HIS A 385
ILE A 329
HIS A 309
 None
ZN  A   1 ( 3.3A)
None
None
 1.11A 1osvB-1evlA:
0.0		 1osvB-1evlA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		4 HIS A 659
ARG A 600
ILE A 592
HIS A 556
 None
 1.43A 1osvB-1sxjA:
0.0		 1osvB-1sxjA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 HIS A 311
ARG A 312
ILE A 285
HIS A  44
 None
None
None
GLA  A 393 (-3.6A)
 1.48A 1osvB-1wuuA:
0.0		 1osvB-1wuuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		4 MET X  65
HIS X  60
ILE X  97
HIS X 147
 None
None
None
ADP  X 871 ( 3.6A)
 1.21A 1osvB-1z2oX:
0.0		 1osvB-1z2oX:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		4 HIS A 204
ARG A 239
ILE A 170
HIS A 328
 None
 0.96A 1osvB-2epgA:
0.0		 1osvB-2epgA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB

(Pseudomonas
aeruginosa) 		PF02668
(TauD) 		4 MET X 114
HIS X 287
ARG X 194
ILE X 217
 None
 1.32A 1osvB-3eatX:
0.0		 1osvB-3eatX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 MET A 535
ARG A 391
ILE A 136
HIS A 112
 None
 1.46A 1osvB-3gg4A:
0.0		 1osvB-3gg4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		4 HIS W 911
ARG W 596
ILE W 549
HIS W 584
 None
 1.44A 1osvB-3mwyW:
0.0		 1osvB-3mwyW:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		4 HIS A1086
ARG A 780
ILE A 791
HIS A1067
 None
 1.23A 1osvB-3n3kA:
0.0		 1osvB-3n3kA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 MET A  37
HIS A  38
ILE A 136
HIS A 140
 None
UNL  A 291 ( 4.0A)
None
UNL  A 291 ( 3.9A)
 1.36A 1osvB-3qk8A:
undetectable		 1osvB-3qk8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy2 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01111
(CKS) 		4 HIS A  43
ARG A  42
ILE A  54
HIS A  96
 None
 1.37A 1osvB-3qy2A:
undetectable		 1osvB-3qy2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		4 HIS B 179
ARG B 292
ILE B 268
HIS B 257
 None
 1.21A 1osvB-4ci6B:
undetectable		 1osvB-4ci6B:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		4 MET A 320
HIS A 352
ILE A 202
HIS A 154
 None
None
None
SO4  A 502 (-4.0A)
 1.48A 1osvB-4narA:
undetectable		 1osvB-4narA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		4 HIS A 261
ARG A 258
ILE A 109
HIS A 117
 None
 1.47A 1osvB-4p6bA:
undetectable		 1osvB-4p6bA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF17189
(Glyco_hydro_30C) 		4 MET A  18
HIS A  51
ILE A 162
HIS A 113
 None
 1.35A 1osvB-4uq9A:
undetectable		 1osvB-4uq9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 HIS A 705
ARG A 742
ILE A 733
HIS A 652
 None
None
None
ZN  A1000 (-3.2A)
 1.40A 1osvB-4ztxA:
undetectable		 1osvB-4ztxA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm2 TRNA
METHYLTRANSFERASE
TRNA
METHYLTRANSFERASE
ACTIVATOR SUBUNIT

(Yarrowia
lipolytica) 		PF03966
(Trm112p)
PF08241
(Methyltransf_11) 		4 MET M  47
ARG M  50
ILE Z 120
HIS Z 111
 None
 1.27A 1osvB-5cm2M:
undetectable		 1osvB-5cm2M:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22) 		PF16510
(P22_portal) 		4 MET A 102
ARG A 145
ILE A 293
HIS A 177
 None
 1.27A 1osvB-5gaiA:
undetectable		 1osvB-5gaiA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 4 HIS A  71
ARG A  77
ILE A  87
HIS A  62
 None
 1.46A 1osvB-5hdtA:
undetectable		 1osvB-5hdtA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 HIS A1367
ARG A1366
ILE A 511
HIS A 451
 None
 1.29A 1osvB-5ip9A:
undetectable		 1osvB-5ip9A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 4 HIS B 233
ARG B 230
ILE B 242
HIS B  91
 NI  B 303 (-3.9A)
None
None
None
 1.47A 1osvB-5lhsB:
undetectable		 1osvB-5lhsB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 HIS A 138
ARG A 104
ILE A 301
HIS A 152
 None
 1.30A 1osvB-5mp7A:
undetectable		 1osvB-5mp7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 4 HIS A  79
ARG A 160
ILE A  90
HIS A  39
 None
 1.47A 1osvB-5nuxA:
undetectable		 1osvB-5nuxA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 HIS A1370
ARG A1369
ILE A 512
HIS A 452
 None
 1.28A 1osvB-5xogA:
undetectable		 1osvB-5xogA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 4 HIS A 440
ARG A 400
ILE A 409
HIS A 403
 None
 1.42A 1osvB-6duxA:
undetectable		 1osvB-6duxA:
18.87