SIMILAR PATTERNS OF AMINO ACIDS FOR 1OSV_B_CHCB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhq PROTEIN KINASE SPK1

(Saccharomyces
cerevisiae)
PF00498
(FHA)
5 LEU A 618
PHE A 601
ILE A 678
PHE A 692
ILE A 613
None
1.39A 1osvB-1fhqA:
undetectable
1osvB-1fhqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 LEU A 258
MET A 124
ILE A 322
PHE A 201
ILE A 260
None
1.48A 1osvB-1h7kA:
0.0
1osvB-1h7kA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi)
PF03291
(Pox_MCEL)
5 LEU A  71
PHE A 147
ILE A 155
ILE A 160
MET A 233
None
1.38A 1osvB-1ri3A:
0.0
1osvB-1ri3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1e KV CHANNEL
INTERACTING PROTEIN
1


(Homo sapiens)
PF13499
(EF-hand_7)
PF13833
(EF-hand_8)
5 LEU A 192
MET A 182
PHE A 178
TYR A 134
MET A 147
None
1.45A 1osvB-1s1eA:
undetectable
1osvB-1s1eA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis)
PF01381
(HTH_3)
5 LEU A 163
ILE A 155
PHE A 110
ILE A 134
TYR A 113
None
1.43A 1osvB-2grmA:
undetectable
1osvB-2grmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT


(Thermus
thermophilus)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
5 PHE A 375
ILE A  96
PHE A 395
ILE A 216
TYR A 399
None
1.23A 1osvB-2ipcA:
0.1
1osvB-2ipcA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf8 TRANSCRIPTION FACTOR
ETV6


(Mus musculus)
PF00178
(Ets)
5 LEU A 394
MET A 390
ILE A 354
PHE A 364
ILE A 403
None
1.46A 1osvB-2lf8A:
0.0
1osvB-2lf8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn2 CHROMOSOME
REPLICATION
INITIATION PROTEIN


(Geobacillus
kaustophilus)
no annotation 5 LEU A  76
MET A  41
PHE A  45
PHE A  51
ILE A  83
None
1.40A 1osvB-2vn2A:
undetectable
1osvB-2vn2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E


(Bacteroides
thetaiotaomicron)
PF07971
(Glyco_hydro_92)
5 LEU A 311
SER A 649
MET A  30
TYR A 639
TRP A 282
None
1.47A 1osvB-2wzsA:
0.0
1osvB-2wzsA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA


(Homo sapiens)
PF01602
(Adaptin_N)
5 LEU B 396
ILE B 417
PHE B 418
ILE B 428
MET B 448
None
1.37A 1osvB-2xa7B:
0.0
1osvB-2xa7B:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE


(Pyrococcus
horikoshii)
PF01177
(Asp_Glu_race)
5 LEU A  38
PHE A  34
SER A  26
ILE A  25
ILE A   4
None
1.47A 1osvB-2zskA:
0.0
1osvB-2zskA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis)
PF13460
(NAD_binding_10)
5 LEU A  16
ILE A 148
ILE A  68
TYR A  25
MET A 186
None
1.46A 1osvB-3dqpA:
undetectable
1osvB-3dqpA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edi TOLLOID-LIKE PROTEIN
1


(Homo sapiens)
PF01400
(Astacin)
5 LEU A  94
MET A  34
MET A  29
ILE A  19
ILE A  77
None
DMS  A 215 ( 3.9A)
None
None
None
1.29A 1osvB-3ediA:
undetectable
1osvB-3ediA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1e LIN2157 PROTEIN

(Listeria
innocua)
PF13180
(PDZ_2)
5 LEU A  19
ILE A  28
PHE A  39
ILE A  82
TYR A   5
None
1.39A 1osvB-3i1eA:
undetectable
1osvB-3i1eA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg4 UNCHARACTERIZED
PROTEIN


([Mannheimia]
succiniciproducens)
PF09704
(Cas_Cas5d)
5 LEU A 186
PHE A  16
SER A  27
PHE A  64
TYR A 114
None
1.38A 1osvB-3kg4A:
undetectable
1osvB-3kg4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg4 UNCHARACTERIZED
PROTEIN


([Mannheimia]
succiniciproducens)
PF09704
(Cas_Cas5d)
5 PHE A  16
SER A  27
PHE A  64
ILE A  62
TYR A 114
None
1.30A 1osvB-3kg4A:
undetectable
1osvB-3kg4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa)
PF00211
(Guanylate_cyc)
5 MET A 330
ILE A 304
ILE A 264
TYR A 257
MET A 310
None
1.16A 1osvB-3r5gA:
undetectable
1osvB-3r5gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sg1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Bacillus
anthracis)
PF00275
(EPSP_synthase)
5 MET A 271
SER A 263
ILE A 264
ILE A 295
MET A 298
None
1.45A 1osvB-3sg1A:
undetectable
1osvB-3sg1A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
5 LEU A 196
MET A 193
SER A 163
ILE A 185
PHE A 180
GOL  A   3 (-3.6A)
None
None
None
None
1.49A 1osvB-3t6qA:
undetectable
1osvB-3t6qA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjz COATOMER SUBUNIT
GAMMA


(Bos taurus)
PF01602
(Adaptin_N)
5 LEU B 109
MET B  73
ILE B 104
ILE B 131
MET B  95
None
1.40A 1osvB-3tjzB:
undetectable
1osvB-3tjzB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
5 LEU A 318
SER A 326
ILE A 325
ILE A 290
TYR A 295
None
1.16A 1osvB-3u4jA:
undetectable
1osvB-3u4jA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE


(Xanthomonas
oryzae)
PF09704
(Cas_Cas5d)
5 PHE A  16
SER A  27
PHE A  64
ILE A  62
TYR A 114
None
1.31A 1osvB-3vziA:
undetectable
1osvB-3vziA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus)
PF00141
(peroxidase)
5 LEU A 151
MET A  89
ILE A 158
ILE A 138
TRP A 148
None
1.47A 1osvB-3wxoA:
undetectable
1osvB-3wxoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB


(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 LEU A 559
PHE A 509
SER A 512
ILE A 515
ILE A 563
None
1.07A 1osvB-4b3iA:
undetectable
1osvB-4b3iA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM


(Mus musculus)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
5 LEU A 927
PHE A 952
SER A 906
ILE A 911
ILE A 919
None
1.36A 1osvB-4bfrA:
undetectable
1osvB-4bfrA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF03464
(eRF1_2)
PF03465
(eRF1_3)
5 LEU X 284
MET X 407
PHE X 298
ILE X 404
TYR X 300
None
1.47A 1osvB-4crmX:
undetectable
1osvB-4crmX:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cua BETA-GALACTOSIDASE

(Streptococcus
pneumoniae)
no annotation 5 LEU A1541
SER A1471
ILE A1470
PHE A1527
ILE A1620
None
None
EDO  A2650 ( 4.8A)
None
None
1.40A 1osvB-4cuaA:
undetectable
1osvB-4cuaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2a PUTATIVE
ACETYLTRANSFERASE


(Streptococcus
mutans)
PF13673
(Acetyltransf_10)
5 LEU A  51
PHE A  25
ILE A  20
PHE A  74
TYR A  98
None
1.42A 1osvB-4e2aA:
undetectable
1osvB-4e2aA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE


(Bacteroides
thetaiotaomicron)
PF16411
(SusF_SusE)
5 MET A 181
PHE A 208
ILE A 183
PHE A 263
ILE A 278
None
1.28A 1osvB-4fchA:
undetectable
1osvB-4fchA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE


(Plasmodium
falciparum)
PF00156
(Pribosyltran)
5 LEU A 116
MET A 140
PHE A  19
ILE A 270
MET A  67
None
1.03A 1osvB-4fymA:
undetectable
1osvB-4fymA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsn GLUTATHIONE
S-TRANSFERASE E2


(Anopheles
gambiae)
PF00043
(GST_C)
PF13417
(GST_N_3)
5 LEU A 175
MET A 170
PHE A 102
ILE A 163
ILE A 183
None
1.16A 1osvB-4gsnA:
undetectable
1osvB-4gsnA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 PHE A 220
ILE A  85
TYR A 185
MET A 189
TYR A  23
None
1.40A 1osvB-4jr7A:
undetectable
1osvB-4jr7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE


(Homo sapiens)
PF00067
(p450)
5 LEU A 195
SER A 180
ILE A 179
PHE A 300
ILE A 198
None
1.29A 1osvB-4nkyA:
1.4
1osvB-4nkyA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 291
ILE A 339
ILE A 356
MET A 369
TYR A 373
XX9  A 501 (-4.1A)
None
XX9  A 501 ( 4.6A)
XX9  A 501 (-4.5A)
None
1.03A 1osvB-4oivA:
24.8
1osvB-4oivA:
93.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 291
MET A 294
ILE A 356
MET A 369
TYR A 373
XX9  A 501 (-4.1A)
XX9  A 501 ( 4.3A)
XX9  A 501 ( 4.6A)
XX9  A 501 (-4.5A)
None
0.83A 1osvB-4oivA:
24.8
1osvB-4oivA:
93.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 291
MET A 294
PHE A 333
ILE A 356
MET A 369
XX9  A 501 (-4.1A)
XX9  A 501 ( 4.3A)
XX9  A 501 (-4.7A)
XX9  A 501 ( 4.6A)
XX9  A 501 (-4.5A)
0.81A 1osvB-4oivA:
24.8
1osvB-4oivA:
93.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 291
MET A 294
PHE A 333
SER A 336
ILE A 356
XX9  A 501 (-4.1A)
XX9  A 501 ( 4.3A)
XX9  A 501 (-4.7A)
XX9  A 501 (-4.2A)
XX9  A 501 ( 4.6A)
0.66A 1osvB-4oivA:
24.8
1osvB-4oivA:
93.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 291
MET A 294
SER A 336
ILE A 356
TYR A 373
XX9  A 501 (-4.1A)
XX9  A 501 ( 4.3A)
XX9  A 501 (-4.2A)
XX9  A 501 ( 4.6A)
None
0.94A 1osvB-4oivA:
24.8
1osvB-4oivA:
93.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 291
PHE A 333
ILE A 339
ILE A 356
MET A 369
XX9  A 501 (-4.1A)
XX9  A 501 (-4.7A)
None
XX9  A 501 ( 4.6A)
XX9  A 501 (-4.5A)
0.80A 1osvB-4oivA:
24.8
1osvB-4oivA:
93.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 291
PHE A 333
SER A 336
ILE A 339
ILE A 356
XX9  A 501 (-4.1A)
XX9  A 501 (-4.7A)
XX9  A 501 (-4.2A)
None
XX9  A 501 ( 4.6A)
0.79A 1osvB-4oivA:
24.8
1osvB-4oivA:
93.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oiv BILE ACID RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 291
SER A 336
ILE A 339
ILE A 356
TYR A 373
XX9  A 501 (-4.1A)
XX9  A 501 (-4.2A)
None
XX9  A 501 ( 4.6A)
None
0.93A 1osvB-4oivA:
24.8
1osvB-4oivA:
93.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1


(Homo sapiens)
PF00282
(Pyridoxal_deC)
5 LEU A 453
MET A 467
SER A 507
ILE A 511
ILE A 440
None
None
None
GOL  A 902 ( 4.7A)
None
1.44A 1osvB-4q6rA:
undetectable
1osvB-4q6rA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvu UNCHARACTERIZED
PROTEIN


(Bacillus cereus)
PF16285
(DUF4931)
5 LEU A 205
SER A  88
ILE A  89
ILE A 185
TYR A  76
None
1.15A 1osvB-4qvuA:
undetectable
1osvB-4qvuA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR


(Bacillus
anthracis)
PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11)
5 PHE A 338
SER A 374
ILE A 373
ILE A 319
TYR A 371
None
1.32A 1osvB-4r6iA:
undetectable
1osvB-4r6iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1


(Pisum sativum)
PF00223
(PsaA_PsaB)
5 LEU A 346
PHE A 417
ILE A 349
TYR A 428
TYR A 422
CLA  A1122 ( 4.7A)
BCR  A6007 ( 4.3A)
None
None
None
1.46A 1osvB-4rkuA:
undetectable
1osvB-4rkuA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE


(Bacillus
licheniformis)
PF01019
(G_glu_transpept)
5 LEU A 435
ILE A  87
PHE A 236
ILE A 245
TYR A 237
None
1.04A 1osvB-4y23A:
undetectable
1osvB-4y23A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
5 LEU A1083
MET A 937
PHE A1094
ILE A 930
ILE A 977
None
1.40A 1osvB-5amqA:
2.9
1osvB-5amqA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 454
SER A 413
ILE A 417
PHE A 412
ILE A 462
None
1.36A 1osvB-5c4tA:
19.8
1osvB-5c4tA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus)
no annotation 5 LEU B 164
ILE B 137
PHE B 138
ILE B 198
TRP B 236
None
1.31A 1osvB-5dlqB:
2.0
1osvB-5dlqB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P


(Lachancea
thermotolerans)
no annotation 5 LEU A 737
SER A 707
ILE A 706
PHE A 714
TYR A 783
None
1.29A 1osvB-5f0oA:
undetectable
1osvB-5f0oA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2


(Homo sapiens)
PF03372
(Exo_endo_phos)
5 LEU A 337
ILE A 117
MET A 183
TYR A 168
TRP A 119
None
1.48A 1osvB-5j3pA:
undetectable
1osvB-5j3pA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA


(Escherichia
coli)
PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD)
5 PHE A 381
ILE A  99
PHE A 401
ILE A 216
TYR A 405
None
1.38A 1osvB-5k9tA:
undetectable
1osvB-5k9tA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B


(Pseudomonas
aeruginosa)
no annotation 5 SER A 101
ILE A 304
ILE A  66
TYR A  61
TRP A  58
None
1.35A 1osvB-5o8xA:
undetectable
1osvB-5o8xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oge GDP-MANNOSE
TRANSPORTER 1


(Saccharomyces
cerevisiae)
no annotation 5 LEU A 200
MET A  98
ILE A 193
ILE A 125
TYR A 281
None
1.50A 1osvB-5ogeA:
undetectable
1osvB-5ogeA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY


(Staphylococcus
aureus)
no annotation 5 LEU A 149
MET A 152
ILE A 124
ILE A  88
TYR A  98
None
None
PLM  A 301 ( 4.9A)
None
None
1.13A 1osvB-5utoA:
undetectable
1osvB-5utoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD


(Helicobacter
pylori)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
5 LEU A 275
MET A  66
ILE A  58
ILE A 271
TYR A  16
None
1.45A 1osvB-6apeA:
undetectable
1osvB-6apeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
4 MET A 355
HIS A 385
ILE A 329
HIS A 309
None
ZN  A   1 ( 3.3A)
None
None
1.11A 1osvB-1evlA:
0.0
1osvB-1evlA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08519
(RFC1)
4 HIS A 659
ARG A 600
ILE A 592
HIS A 556
None
1.43A 1osvB-1sxjA:
0.0
1osvB-1sxjA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
4 HIS A 311
ARG A 312
ILE A 285
HIS A  44
None
None
None
GLA  A 393 (-3.6A)
1.48A 1osvB-1wuuA:
0.0
1osvB-1wuuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE


(Entamoeba
histolytica)
PF05770
(Ins134_P3_kin)
4 MET X  65
HIS X  60
ILE X  97
HIS X 147
None
None
None
ADP  X 871 ( 3.6A)
1.21A 1osvB-1z2oX:
0.0
1osvB-1z2oX:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785


(Thermus
thermophilus)
PF01139
(RtcB)
4 HIS A 204
ARG A 239
ILE A 170
HIS A 328
None
0.96A 1osvB-2epgA:
0.0
1osvB-2epgA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB


(Pseudomonas
aeruginosa)
PF02668
(TauD)
4 MET X 114
HIS X 287
ARG X 194
ILE X 217
None
1.32A 1osvB-3eatX:
0.0
1osvB-3eatX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 MET A 535
ARG A 391
ILE A 136
HIS A 112
None
1.46A 1osvB-3gg4A:
0.0
1osvB-3gg4A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Saccharomyces
cerevisiae)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo)
4 HIS W 911
ARG W 596
ILE W 549
HIS W 584
None
1.44A 1osvB-3mwyW:
0.0
1osvB-3mwyW:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Homo sapiens)
PF00443
(UCH)
4 HIS A1086
ARG A 780
ILE A 791
HIS A1067
None
1.23A 1osvB-3n3kA:
0.0
1osvB-3n3kA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15


(Mycobacterium
marinum)
PF00378
(ECH_1)
4 MET A  37
HIS A  38
ILE A 136
HIS A 140
None
UNL  A 291 ( 4.0A)
None
UNL  A 291 ( 3.9A)
1.36A 1osvB-3qk8A:
undetectable
1osvB-3qk8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy2 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT


(Saccharomyces
cerevisiae)
PF01111
(CKS)
4 HIS A  43
ARG A  42
ILE A  54
HIS A  96
None
1.37A 1osvB-3qy2A:
undetectable
1osvB-3qy2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica)
PF00069
(Pkinase)
PF09632
(Rac1)
4 HIS B 179
ARG B 292
ILE B 268
HIS B 257
None
1.21A 1osvB-4ci6B:
undetectable
1osvB-4ci6B:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE


(Thermotoga
maritima)
PF09861
(DUF2088)
4 MET A 320
HIS A 352
ILE A 202
HIS A 154
None
None
None
SO4  A 502 (-4.0A)
1.48A 1osvB-4narA:
undetectable
1osvB-4narA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome)
PF00144
(Beta-lactamase)
4 HIS A 261
ARG A 258
ILE A 109
HIS A 117
None
1.47A 1osvB-4p6bA:
undetectable
1osvB-4p6bA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6


(Ruminiclostridium
thermocellum)
PF17189
(Glyco_hydro_30C)
4 MET A  18
HIS A  51
ILE A 162
HIS A 113
None
1.35A 1osvB-4uq9A:
undetectable
1osvB-4uq9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE


(Neurospora
crassa)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
4 HIS A 705
ARG A 742
ILE A 733
HIS A 652
None
None
None
ZN  A1000 (-3.2A)
1.40A 1osvB-4ztxA:
undetectable
1osvB-4ztxA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm2 TRNA
METHYLTRANSFERASE
TRNA
METHYLTRANSFERASE
ACTIVATOR SUBUNIT


(Yarrowia
lipolytica)
PF03966
(Trm112p)
PF08241
(Methyltransf_11)
4 MET M  47
ARG M  50
ILE Z 120
HIS Z 111
None
1.27A 1osvB-5cm2M:
undetectable
1osvB-5cm2M:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22)
PF16510
(P22_portal)
4 MET A 102
ARG A 145
ILE A 293
HIS A 177
None
1.27A 1osvB-5gaiA:
undetectable
1osvB-5gaiA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B


(Homo sapiens)
no annotation 4 HIS A  71
ARG A  77
ILE A  87
HIS A  62
None
1.46A 1osvB-5hdtA:
undetectable
1osvB-5hdtA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Saccharomyces
cerevisiae)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 HIS A1367
ARG A1366
ILE A 511
HIS A 451
None
1.29A 1osvB-5ip9A:
undetectable
1osvB-5ip9A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR


(Mus musculus)
no annotation 4 HIS B 233
ARG B 230
ILE B 242
HIS B  91
NI  B 303 (-3.9A)
None
None
None
1.47A 1osvB-5lhsB:
undetectable
1osvB-5lhsB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Mycolicibacterium
smegmatis)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
4 HIS A 138
ARG A 104
ILE A 301
HIS A 152
None
1.30A 1osvB-5mp7A:
undetectable
1osvB-5mp7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus)
no annotation 4 HIS A  79
ARG A 160
ILE A  90
HIS A  39
None
1.47A 1osvB-5nuxA:
undetectable
1osvB-5nuxA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT


(Komagataella
phaffii)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 HIS A1370
ARG A1369
ILE A 512
HIS A 452
None
1.28A 1osvB-5xogA:
undetectable
1osvB-5xogA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE


(Klebsiella
pneumoniae)
no annotation 4 HIS A 440
ARG A 400
ILE A 409
HIS A 403
None
1.42A 1osvB-6duxA:
undetectable
1osvB-6duxA:
18.87