SIMILAR PATTERNS OF AMINO ACIDS FOR 1OSV_A_CHCA202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		5 MET A6035
ARG A6213
SER A6134
PHE A6163
ILE A6174
 None
 1.50A 1osvA-1koaA:
0.0		 1osvA-1koaA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7i UPF0339 PROTEIN
ATU0232

(Agrobacterium
fabrum) 		PF07411
(DUF1508) 		5 ALA A  38
ARG A  15
SER A  29
PHE A  27
ILE A  45
 None
 1.49A 1osvA-2k7iA:
undetectable		 1osvA-2k7iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN

(Aeropyrum
pernix) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 ALA A 233
SER A  56
PHE A  57
ILE A 154
TYR A 143
 None
 1.48A 1osvA-3a5wA:
undetectable		 1osvA-3a5wA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 MET A 600
ALA A 740
PHE A 685
ILE A 691
TYR A 695
 None
 1.10A 1osvA-3actA:
0.0		 1osvA-3actA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3s GCN5-RELATED
N-ACETYLTRANSFERASE

(Streptococcus
suis) 		PF12746
(GNAT_acetyltran) 		5 MET A 125
ALA A 204
PHE A 107
ILE A 184
TYR A 217
 None
 1.44A 1osvA-3g3sA:
0.0		 1osvA-3g3sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg4 UNCHARACTERIZED
PROTEIN

([Mannheimia]
succiniciproducens) 		PF09704
(Cas_Cas5d) 		5 PHE A  16
SER A  27
PHE A  64
ILE A  62
TYR A 114
 None
 1.38A 1osvA-3kg4A:
undetectable		 1osvA-3kg4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5

(Saccharomyces
cerevisiae) 		PF00397
(WW)
PF00632
(HECT) 		5 ALA A 468
PHE A 504
SER A 508
PHE A 512
ILE A 548
 None
 1.50A 1osvA-3olmA:
0.0		 1osvA-3olmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 MET A  60
SER A 419
ILE A 360
TYR A 384
TYR A 376
 None
 1.47A 1osvA-3sggA:
0.0		 1osvA-3sggA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE

(Xanthomonas
oryzae) 		PF09704
(Cas_Cas5d) 		5 PHE A  16
SER A  27
PHE A  64
ILE A  62
TYR A 114
 None
 1.38A 1osvA-3vziA:
0.0		 1osvA-3vziA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 5 ALA A 554
SER A 564
PHE A 601
ILE A 573
TRP A 561
 None
 1.18A 1osvA-4lgnA:
undetectable		 1osvA-4lgnA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2g BETA-LACTAMASE

(Burkholderia
cenocepacia) 		PF00144
(Beta-lactamase) 		5 MET A 191
MET A 207
ARG A 206
ILE A  57
TRP A 213
 None
 1.35A 1osvA-5e2gA:
0.0		 1osvA-5e2gA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 ALA A 244
ILE A 239
TYR A 292
TRP A 227
TRP A 279
 None
 1.40A 1osvA-5opqA:
0.1		 1osvA-5opqA:
19.23