SIMILAR PATTERNS OF AMINO ACIDS FOR 1OQ5_A_CELA701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccz PROTEIN (CD58)

(Homo sapiens) 		PF05790
(C2-set) 		5 GLU A  74
PHE A  15
VAL A  13
LEU A  67
THR A  68
 None
 1.13A 1oq5A-1cczA:
undetectable		 1oq5A-1cczA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci5 PROTEIN (LYMPHOCYTE
FUNCTION-ASSOCIATED
ANTIGEN 3(CD58))

(Homo sapiens) 		no annotation 5 GLU A  74
PHE A  15
VAL A  13
LEU A  67
THR A  68
 None
 1.15A 1oq5A-1ci5A:
undetectable		 1oq5A-1ci5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci5 PROTEIN (LYMPHOCYTE
FUNCTION-ASSOCIATED
ANTIGEN 3(CD58))

(Homo sapiens) 		no annotation 5 GLU A  76
PHE A  15
VAL A  13
LEU A  67
THR A  68
 None
 1.14A 1oq5A-1ci5A:
undetectable		 1oq5A-1ci5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 ASN A 278
HIS A 291
VAL A 255
LEU A 282
THR A 283
 None
 1.04A 1oq5A-1dcqA:
undetectable		 1oq5A-1dcqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx7 IRON-DEPENDENT
REPRESSOR IDER

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		5 VAL A 227
VAL A 163
LEU A 157
THR A 155
PRO A 158
 None
None
None
CO  A2009 ( 4.9A)
None
 1.17A 1oq5A-1fx7A:
undetectable		 1oq5A-1fx7A:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 ASN A  62
HIS A  96
LEU A 198
THR A 199
PRO A 202
 None
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
None
 0.98A 1oq5A-1jd0A:
36.6		 1oq5A-1jd0A:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
PRO A 202
TRP A 209
 AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
None
None
 0.48A 1oq5A-1jd0A:
36.6		 1oq5A-1jd0A:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 ASN A  64
GLU A  62
GLN A  69
HIS A  94
LEU A 176
THR A 177
 BME  A 303 (-4.7A)
None
None
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
 1.40A 1oq5A-1kopA:
29.7		 1oq5A-1kopA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 ASN A  64
GLU A  62
HIS A  94
LEU A 176
THR A 177
PRO A 180
 BME  A 303 (-4.7A)
None
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
None
 1.24A 1oq5A-1kopA:
29.7		 1oq5A-1kopA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		8 GLN A  90
HIS A  92
HIS A  94
VAL A 113
LEU A 176
THR A 177
PRO A 180
TRP A 187
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
None
None
 0.46A 1oq5A-1kopA:
29.7		 1oq5A-1kopA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 GLU A  62
GLN A  69
HIS A  92
HIS A  94
LEU A 176
THR A 177
 None
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
 1.29A 1oq5A-1kopA:
29.7		 1oq5A-1kopA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 GLU A  62
HIS A  92
HIS A  94
LEU A 176
THR A 177
PRO A 180
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
None
 1.12A 1oq5A-1kopA:
29.7		 1oq5A-1kopA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 ASN A  62
GLN A  67
HIS A  96
LEU A 198
THR A 199
PRO A 202
 None
None
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
None
 1.34A 1oq5A-1rj6A:
37.3		 1oq5A-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 ASN A  62
HIS A  96
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
None
None
 1.34A 1oq5A-1rj6A:
37.3		 1oq5A-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
PRO A 202
 None
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
None
 1.13A 1oq5A-1rj6A:
37.3		 1oq5A-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
PRO A 202
TRP A 209
 AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
None
None
 0.48A 1oq5A-1rj6A:
37.3		 1oq5A-1rj6A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
None
 0.43A 1oq5A-1urtA:
36.9		 1oq5A-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 GLU A  69
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
None
 0.72A 1oq5A-1urtA:
36.9		 1oq5A-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  94
HIS A  96
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
None
 1.38A 1oq5A-1urtA:
36.9		 1oq5A-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
 0.92A 1oq5A-1urtA:
36.9		 1oq5A-1urtA:
51.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		7 GLN A 113
HIS A 115
HIS A 117
VAL A 137
LEU A 216
THR A 217
TRP A 227
 None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ACY  A 279 ( 4.7A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
None
 0.17A 1oq5A-1y7wA:
26.3		 1oq5A-1y7wA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0o UPLC1

(Homo sapiens) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 ASN E 455
HIS E 468
VAL E 432
LEU E 459
THR E 460
 None
 1.09A 1oq5A-2b0oE:
undetectable		 1oq5A-2b0oE:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.55A 1oq5A-2it4A:
41.0		 1oq5A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  96
PHE A  91
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.24A 1oq5A-2it4A:
41.0		 1oq5A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.85A 1oq5A-2it4A:
41.0		 1oq5A-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mp4 ACTIN-DEPOLYMERIZING
FACTOR 1, ISOFORMS
A/B

(Caenorhabditis
elegans) 		PF00241
(Cofilin_ADF) 		5 VAL A  84
PHE A  30
VAL A  11
LEU A 133
THR A 135
 None
 0.83A 1oq5A-2mp4A:
undetectable		 1oq5A-2mp4A:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 118
VAL A 157
LEU A 222
THR A 223
PRO A 226
TRP A 233
 CL  A 401 (-4.2A)
None
None
CL  A 401 ( 4.8A)
None
None
 0.39A 1oq5A-2w2jA:
37.5		 1oq5A-2w2jA:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
TRP A 209
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
 0.35A 1oq5A-2zncA:
32.0		 1oq5A-2zncA:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 ASN A 110
HIS A 165
LEU A 259
THR A 260
PRO A 263
 None
ZN  A 378 (-3.3A)
None
ZN  A 378 ( 4.5A)
None
 0.89A 1oq5A-3b1bA:
25.4		 1oq5A-3b1bA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		8 GLN A 161
HIS A 163
HIS A 165
VAL A 184
LEU A 259
THR A 260
PRO A 263
TRP A 270
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
None
None
 0.37A 1oq5A-3b1bA:
25.4		 1oq5A-3b1bA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 165
VAL A 201
LEU A 259
THR A 260
PRO A 263
 ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
None
 1.15A 1oq5A-3b1bA:
25.4		 1oq5A-3b1bA:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  68
GLN A  93
HIS A  95
PHE A 132
LEU A 199
PRO A 203
 None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 ( 4.9A)
 0.93A 1oq5A-3da2A:
42.5		 1oq5A-3da2A:
59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 ASN A  68
HIS A  95
HIS A  97
VAL A 122
PHE A 132
LEU A 199
THR A 200
PRO A 203
TRP A 210
 None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 0.49A 1oq5A-3da2A:
42.5		 1oq5A-3da2A:
59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A 109
HIS A 111
HIS A 113
VAL A 140
LEU A 219
THR A 220
TRP A 230
 None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
 0.68A 1oq5A-3fe4A:
31.1		 1oq5A-3fe4A:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 VAL A 140
LEU A 219
THR A 220
PRO A 223
TRP A 230
 None
 0.58A 1oq5A-3fe4A:
31.1		 1oq5A-3fe4A:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 129
PHE A 166
VAL A 170
LEU A 235
THR A 236
PRO A 239
 None
 1.15A 1oq5A-3jxfA:
33.6		 1oq5A-3jxfA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 129
VAL A 170
LEU A 235
THR A 236
PRO A 239
TRP A 246
 None
 0.72A 1oq5A-3jxfA:
33.6		 1oq5A-3jxfA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6g BETAINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN

(Lactococcus
lactis) 		PF04069
(OpuAC) 		5 VAL A 568
PHE A 572
VAL A 529
LEU A 340
TRP A 535
 None
 0.94A 1oq5A-3l6gA:
undetectable		 1oq5A-3l6gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		5 ASN E 455
HIS E 468
VAL E 432
LEU E 459
THR E 460
 None
 1.13A 1oq5A-3lvrE:
undetectable		 1oq5A-3lvrE:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 ASN A  62
HIS A  96
LEU A 198
THR A 199
PRO A 202
 None
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
 0.99A 1oq5A-3ml5A:
43.3		 1oq5A-3ml5A:
55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
PRO A 202
TRP A 209
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
None
 0.31A 1oq5A-3ml5A:
43.3		 1oq5A-3ml5A:
55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 200
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
 1.48A 1oq5A-3ml5A:
43.3		 1oq5A-3ml5A:
55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 263 ( 3.1A)
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
 1.47A 1oq5A-3ml5A:
43.3		 1oq5A-3ml5A:
55.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		5 GLU A 118
GLN A 122
VAL A 109
LEU A 101
PRO A  90
 None
 1.15A 1oq5A-3pshA:
undetectable		 1oq5A-3pshA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		8 GLN A 121
HIS A 123
HIS A 125
VAL A 144
LEU A 214
THR A 215
PRO A 218
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
None
MLT  A   3 (-4.9A)
 0.46A 1oq5A-3q31A:
24.8		 1oq5A-3q31A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 GLU A  95
HIS A 123
HIS A 125
LEU A 214
THR A 215
 None
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
 1.18A 1oq5A-3q31A:
24.8		 1oq5A-3q31A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		5 HIS A 125
VAL A 154
LEU A 214
THR A 215
PRO A 218
 ZN  A   1 (-3.3A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
None
 1.14A 1oq5A-3q31A:
24.8		 1oq5A-3q31A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 198
PRO A 201
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
None
 0.47A 1oq5A-3uyqA:
41.0		 1oq5A-3uyqA:
58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 198
TRP A 208
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
None
 0.38A 1oq5A-3uyqA:
41.0		 1oq5A-3uyqA:
58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 199
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
None
 1.29A 1oq5A-3uyqA:
41.0		 1oq5A-3uyqA:
58.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ASN P 278
PHE P 264
VAL P 365
LEU P 471
THR P 470
 None
 1.08A 1oq5A-4crnP:
undetectable		 1oq5A-4crnP:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 ASN A  62
HIS A  91
LEU A 173
THR A 174
PRO A 177
 None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 1.02A 1oq5A-4g7aA:
30.1		 1oq5A-4g7aA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		8 GLN A  87
HIS A  89
HIS A  91
VAL A 110
LEU A 173
THR A 174
PRO A 177
TRP A 184
 AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
None
 0.38A 1oq5A-4g7aA:
30.1		 1oq5A-4g7aA:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		5 HIS A  91
VAL A 120
LEU A 173
THR A 174
PRO A 177
 ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 1.03A 1oq5A-4g7aA:
30.1		 1oq5A-4g7aA:
34.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF06283
(ThuA) 		5 HIS A 120
HIS A  48
PHE A 216
VAL A 211
TRP A 148
 None
 1.00A 1oq5A-4jqsA:
undetectable		 1oq5A-4jqsA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 ASN A  62
HIS A  96
PHE A 131
VAL A 135
LEU A 198
THR A 199
PRO A 202
 None
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
 1.15A 1oq5A-4qk3A:
44.7		 1oq5A-4qk3A:
95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		12 ASN A  67
GLU A  69
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
VAL A 135
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
ZN  A 301 ( 4.4A)
None
None
 0.37A 1oq5A-4qk3A:
44.7		 1oq5A-4qk3A:
95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 135
LEU A 198
THR A 200
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
 1.44A 1oq5A-4qk3A:
44.7		 1oq5A-4qk3A:
95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
VAL A 143
VAL A 135
LEU A 198
THR A 199
PRO A 202
 ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
 1.13A 1oq5A-4qk3A:
44.7		 1oq5A-4qk3A:
95.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		5 HIS A  97
VAL A 116
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 1oq5A-4twlA:
28.8		 1oq5A-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 ASN A  85
HIS A 114
LEU A 197
THR A 198
PRO A 201
 None
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.00A 1oq5A-4uovA:
31.3		 1oq5A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		8 GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
PRO A 201
TRP A 208
 CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
None
 0.49A 1oq5A-4uovA:
31.3		 1oq5A-4uovA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		5 ASN A  62
HIS A  91
LEU A 173
THR A 174
PRO A 177
 None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 0.98A 1oq5A-4x5sA:
30.2		 1oq5A-4x5sA:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		8 GLN A  87
HIS A  89
HIS A  91
VAL A 110
LEU A 173
THR A 174
PRO A 177
TRP A 184
 AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
None
 0.38A 1oq5A-4x5sA:
30.2		 1oq5A-4x5sA:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 174
PRO A 177
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 1.15A 1oq5A-4x5sA:
30.2		 1oq5A-4x5sA:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		5 ASN A 108
HIS A 112
VAL A 141
THR A 191
PRO A 194
 None
ZN  A 301 (-3.4A)
None
ZN  A 301 (-4.3A)
None
 0.87A 1oq5A-4xfwA:
26.8		 1oq5A-4xfwA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		7 HIS A 110
HIS A 112
VAL A 131
LEU A 190
THR A 191
PRO A 194
TRP A 201
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
None
ZN  A 301 (-4.3A)
None
None
 0.46A 1oq5A-4xfwA:
26.8		 1oq5A-4xfwA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		5 HIS A 112
VAL A 141
LEU A 190
THR A 191
PRO A 194
 ZN  A 301 (-3.4A)
None
None
ZN  A 301 (-4.3A)
None
 0.88A 1oq5A-4xfwA:
26.8		 1oq5A-4xfwA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		8 GLN A 158
HIS A 160
HIS A 162
VAL A 181
LEU A 253
THR A 254
PRO A 257
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
None
None
 0.44A 1oq5A-4xixA:
26.2		 1oq5A-4xixA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 GLN A 158
HIS A 160
HIS A 162
VAL A 181
LEU A 253
THR A 255
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-3.6A)
 1.48A 1oq5A-4xixA:
26.2		 1oq5A-4xixA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 162
VAL A 192
LEU A 253
THR A 254
PRO A 257
 ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
None
 1.16A 1oq5A-4xixA:
26.2		 1oq5A-4xixA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 ASN A 138
HIS A 167
LEU A 251
THR A 252
PRO A 255
 None
ZN  A 401 ( 3.3A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
None
 0.96A 1oq5A-4xz5A:
29.7		 1oq5A-4xz5A:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		8 GLN A 163
HIS A 165
HIS A 167
VAL A 186
LEU A 251
THR A 252
PRO A 255
TRP A 262
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
None
None
 0.38A 1oq5A-4xz5A:
29.7		 1oq5A-4xz5A:
32.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 HIS A 167
VAL A 196
LEU A 251
THR A 252
PRO A 255
 ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
None
 1.04A 1oq5A-4xz5A:
29.7		 1oq5A-4xz5A:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 GLN A 697
HIS A 666
VAL A 266
LEU A 237
PRO A 236
 None
 1.16A 1oq5A-5aw4A:
undetectable		 1oq5A-5aw4A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		5 ASN A  98
HIS A  72
VAL A 203
LEU A 176
THR A 177
 NA  A 303 (-3.6A)
ZN  A 301 (-3.2A)
None
None
HIW  A 321 ( 2.8A)
 1.17A 1oq5A-5b1uA:
undetectable		 1oq5A-5b1uA:
25.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 ASN A  62
HIS A  96
LEU A 198
THR A 199
PRO A 202
 GOL  A 303 (-3.9A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
 0.96A 1oq5A-5cjfA:
36.9		 1oq5A-5cjfA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
PRO A 202
TRP A 209
 GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
None
 0.39A 1oq5A-5cjfA:
36.9		 1oq5A-5cjfA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
 GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
 1.50A 1oq5A-5cjfA:
36.9		 1oq5A-5cjfA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 151
LEU A 256
THR A 257
PRO A 260
TRP A 267
 None
 0.44A 1oq5A-5e5uA:
34.4		 1oq5A-5e5uA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 151
PHE A 187
LEU A 256
THR A 257
TRP A 267
 None
 0.64A 1oq5A-5e5uA:
34.4		 1oq5A-5e5uA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 GLU A1437
HIS A1594
VAL A1469
LEU A1549
THR A1548
 None
 1.03A 1oq5A-5e6pA:
undetectable		 1oq5A-5e6pA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 ASN X  61
HIS X  95
LEU X 196
THR X 197
PRO X 200
 None
ZN  X 301 (-3.2A)
None
ZN  X 301 ( 4.4A)
None
 1.12A 1oq5A-5eztX:
44.3		 1oq5A-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		11 ASN X  66
GLU X  68
GLN X  91
HIS X  93
HIS X  95
VAL X 120
PHE X 129
LEU X 196
THR X 197
PRO X 200
TRP X 207
 None
None
None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
None
ZN  X 301 ( 4.4A)
None
None
 0.46A 1oq5A-5eztX:
44.3		 1oq5A-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		7 GLN X  91
HIS X  93
HIS X  95
VAL X 120
PHE X 129
LEU X 196
THR X 198
 None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
None
None
 1.44A 1oq5A-5eztX:
44.3		 1oq5A-5eztX:
80.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 HIS X  95
VAL X 141
LEU X 196
THR X 197
PRO X 200
 ZN  X 301 (-3.2A)
None
None
ZN  X 301 ( 4.4A)
None
 0.98A 1oq5A-5eztX:
44.3		 1oq5A-5eztX:
80.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		5 GLN A 287
HIS A 290
HIS A 294
PHE A 347
LEU A 336
 None
MN  A1000 (-3.5A)
MN  A1000 (-3.3A)
None
None
 1.16A 1oq5A-5fx8A:
undetectable		 1oq5A-5fx8A:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 ASN A  69
HIS A  98
LEU A 181
THR A 182
PRO A 185
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
 1.08A 1oq5A-5hpjA:
29.7		 1oq5A-5hpjA:
35.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		8 GLN A  94
HIS A  96
HIS A  98
VAL A 117
LEU A 181
THR A 182
PRO A 185
TRP A 192
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
None
 0.40A 1oq5A-5hpjA:
29.7		 1oq5A-5hpjA:
35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 GLU A 140
VAL A 144
PHE A 195
VAL A 194
LEU A 179
 None
 1.18A 1oq5A-5hzgA:
undetectable		 1oq5A-5hzgA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
TRP A 209
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
None
 0.33A 1oq5A-5jn9A:
33.5		 1oq5A-5jn9A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
 1.13A 1oq5A-5jn9A:
33.5		 1oq5A-5jn9A:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuv AUTOPHAGY-RELATED
PROTEIN 16-1

(Homo sapiens) 		PF00400
(WD40) 		5 HIS A 576
VAL A 328
PHE A 330
VAL A 351
LEU A 603
 None
 1.13A 1oq5A-5nuvA:
undetectable		 1oq5A-5nuvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7k LIPASE B

(Serratia
marcescens) 		no annotation 5 GLU A 333
VAL A 351
PHE A 353
LEU A 374
THR A 373
 None
 1.17A 1oq5A-5x7kA:
undetectable		 1oq5A-5x7kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 5 ASN A  90
HIS A 119
LEU A 201
THR A 202
PRO A 205
 None
ZN  A 301 (-3.3A)
None
ZN  A 301 (-4.4A)
None
 1.02A 1oq5A-6ekiA:
30.2		 1oq5A-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 8 GLN A 115
HIS A 117
HIS A 119
VAL A 138
LEU A 201
THR A 202
PRO A 205
TRP A 212
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
ZN  A 301 (-4.4A)
None
None
 0.30A 1oq5A-6ekiA:
30.2		 1oq5A-6ekiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 ASN A  62
HIS A  96
LEU A 198
THR A 199
PRO A 202
 V14  A 302 (-3.4A)
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
 1.09A 1oq5A-6fe1A:
33.9		 1oq5A-6fe1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 8 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
PRO A 202
TRP A 209
 V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
None
 0.47A 1oq5A-6fe1A:
33.9		 1oq5A-6fe1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 131
 V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 ( 4.6A)
 1.17A 1oq5A-6fe1A:
33.9		 1oq5A-6fe1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
 0.85A 1oq5A-6fe1A:
33.9		 1oq5A-6fe1A:
14.90