SIMILAR PATTERNS OF AMINO ACIDS FOR 1OPJ_B_STIB4_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 LEU A 477
VAL A 457
ILE A 471
ARG A 371
 None
 1.05A 1opjB-1bf5A:
undetectable		 1opjB-1bf5A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)

(Escherichia
coli) 		PF02075
(RuvC) 		4 LEU A 143
VAL A  86
ILE A  65
ARG A  43
 None
 1.10A 1opjB-1hjrA:
undetectable		 1opjB-1hjrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.96A 1opjB-1iovA:
undetectable		 1opjB-1iovA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
LYS A 290
VAL A 308
ILE A 332
MET A 337
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
None
 0.53A 1opjB-1opkA:
37.1		 1opjB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
LYS A 623
VAL A 643
ARG A 791
 STI  A   3 ( 3.8A)
STI  A   3 (-3.7A)
None
None
 0.79A 1opjB-1t46A:
34.0		 1opjB-1t46A:
36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		4 LEU A 189
VAL A 266
ILE A 272
MET A 217
 None
 1.00A 1opjB-1un9A:
undetectable		 1opjB-1un9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		4 LEU A 246
LYS A 243
ILE A 224
ARG A 169
 None
 1.08A 1opjB-1vfwA:
undetectable		 1opjB-1vfwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 176
VAL A  79
MET A 181
ARG A 139
 None
 1.12A 1opjB-1wpqA:
undetectable		 1opjB-1wpqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx3 TONB PROTEIN

(Escherichia
coli) 		PF03544
(TonB_C)
PF16031
(TonB_N) 		4 LEU A 156
VAL A 176
ILE A 238
ARG A 204
 None
 1.00A 1opjB-1xx3A:
undetectable		 1opjB-1xx3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.02A 1opjB-1ycnA:
undetectable		 1opjB-1ycnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		4 LEU A 477
VAL A 457
ILE A 471
ARG A 371
 None
 0.99A 1opjB-1yvlA:
undetectable		 1opjB-1yvlA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d89 EHBP1 PROTEIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  54
VAL A 101
ILE A 108
ARG A  38
 None
 0.98A 1opjB-2d89A:
undetectable		 1opjB-2d89A:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
ILE X  80
MET X  85
ARG X 129
 STU  X 902 (-3.8A)
None
None
PTR  X 160 ( 3.4A)
 0.95A 1opjB-2dq7X:
31.6		 1opjB-2dq7X:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
LYS X  39
ILE X  80
MET X  85
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
None
 0.68A 1opjB-2dq7X:
31.6		 1opjB-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 162
LYS A 186
VAL A 204
ILE A 234
 None
 0.61A 1opjB-2eu9A:
21.3		 1opjB-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A  19
ILE A  91
MET A  96
ARG A 136
 ADP  A 500 (-4.3A)
None
None
None
 1.00A 1opjB-2f9gA:
13.9		 1opjB-2f9gA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A  19
LYS A  42
ILE A  91
ARG A 136
 ADP  A 500 (-4.3A)
ADP  A 500 (-2.9A)
None
None
 0.96A 1opjB-2f9gA:
13.9		 1opjB-2f9gA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		4 LEU A1820
VAL A1761
ILE A1769
ARG A1902
 None
 1.10A 1opjB-2fr1A:
undetectable		 1opjB-2fr1A:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.85A 1opjB-2hckA:
29.2		 1opjB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LYS A 273
VAL A 291
ILE A 314
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
 0.56A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-3.9A)
None
 0.69A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
VAL A 291
ILE A 314
ARG A 363
 1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
None
 1.02A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 291
ILE A 314
MET A 319
ARG A 363
 None
1BM  A 499 (-3.9A)
None
None
 0.98A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
LYS A 271
VAL A 289
ILE A 313
ARG A 362
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
None
 1.28A 1opjB-2hz0A:
34.1		 1opjB-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 289
ILE A 313
MET A 318
ARG A 362
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-3.8A)
None
None
 1.05A 1opjB-2hz0A:
34.1		 1opjB-2hz0A:
97.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 348
LYS A 371
VAL A 393
ARG A 465
 PDS  A 901 (-3.9A)
PDS  A 901 ( 4.5A)
None
TPO  A 500 ( 2.9A)
 0.87A 1opjB-2i0eA:
12.9		 1opjB-2i0eA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsa TRIGGER FACTOR

(Thermotoga
maritima) 		PF05698
(Trigger_C) 		4 LEU A 384
VAL A 397
ILE A 392
ARG A 338
 None
None
SO4  A 415 (-4.7A)
None
 1.12A 1opjB-2nsaA:
undetectable		 1opjB-2nsaA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
ILE A 314
MET A 319
ARG A 363
 None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
None
 0.56A 1opjB-2og8A:
31.9		 1opjB-2og8A:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LYS A 273
ILE A 314
ARG A 363
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
None
 1.00A 1opjB-2og8A:
31.9		 1opjB-2og8A:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 LEU A  25
LYS A  48
MET A 106
ARG A 148
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.2A)
None
None
 1.09A 1opjB-2phkA:
21.7		 1opjB-2phkA:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LEU X  34
ILE X 115
MET X 120
ARG X 171
 HMD  X 400 ( 4.3A)
None
None
None
 1.05A 1opjB-2pmoX:
20.4		 1opjB-2pmoX:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LEU X  34
LYS X  55
ILE X 115
ARG X 171
 HMD  X 400 ( 4.3A)
HMD  X 400 (-4.2A)
None
None
 0.94A 1opjB-2pmoX:
20.4		 1opjB-2pmoX:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtp GTPASE IMAP FAMILY
MEMBER 2

(Homo sapiens) 		PF04548
(AIG1) 		4 LEU A 144
VAL A  95
ILE A  26
ARG A 251
 None
 0.97A 1opjB-2xtpA:
undetectable		 1opjB-2xtpA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 653
ILE A 697
MET A 702
ARG A 745
 Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
None
None
 0.72A 1opjB-2xyuA:
32.4		 1opjB-2xyuA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 VAL O 385
ILE O 299
MET O 485
ARG O 470
 None
 1.01A 1opjB-2zf5O:
undetectable		 1opjB-2zf5O:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 LEU A 373
VAL A 155
MET A 273
ARG A 139
 None
 1.12A 1opjB-3b1bA:
undetectable		 1opjB-3b1bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN-TYPE

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		4 LEU A  64
VAL A 145
ILE A  57
ARG A  10
 SO4  A 205 (-4.3A)
None
None
None
 0.89A 1opjB-3bo7A:
undetectable		 1opjB-3bo7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 STU  A   1 (-3.8A)
STU  A   1 ( 4.2A)
None
None
 0.52A 1opjB-3fmeA:
17.0		 1opjB-3fmeA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 982
VAL A 907
ILE A 952
ARG A 675
 None
 1.10A 1opjB-3ho8A:
undetectable		 1opjB-3ho8A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		4 LEU A 226
ILE A 299
MET A 304
ARG A 346
 None
 1.05A 1opjB-3i6uA:
20.9		 1opjB-3i6uA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 LEU A 397
VAL A 734
ILE A 651
ARG A 811
 None
 1.01A 1opjB-3ihyA:
5.4		 1opjB-3ihyA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 LEU A 246
VAL A 182
ILE A 252
ARG A  58
 None
 0.92A 1opjB-3l6cA:
undetectable		 1opjB-3l6cA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 246
VAL A 182
ILE A 252
ARG A  58
 None
 0.92A 1opjB-3l6rA:
undetectable		 1opjB-3l6rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 LEU A 680
LYS A 702
ILE A 743
ARG A 796
 ADP  A2101 ( 4.1A)
ADP  A2101 (-2.7A)
None
TPO  A 844 ( 3.0A)
 0.94A 1opjB-3lj0A:
21.0		 1opjB-3lj0A:
24.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1005
LYS A1033
VAL A1053
MET A1082
 None
CCX  A   1 ( 3.7A)
None
None
 0.88A 1opjB-3lw0A:
31.7		 1opjB-3lw0A:
44.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 LEU A 375
LYS A 368
ILE A 245
MET A 254
 None
 1.11A 1opjB-3maxA:
undetectable		 1opjB-3maxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 LEU A  42
VAL A 189
ILE A  26
ARG A 175
 GOL  A 277 ( 4.4A)
None
None
None
 1.07A 1opjB-3nibA:
undetectable		 1opjB-3nibA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		4 LEU A 348
LYS A 371
VAL A 393
ARG A 465
 ANP  A 800 ( 4.4A)
ANP  A 800 (-3.3A)
None
TPO  A 500 ( 2.9A)
 1.09A 1opjB-3pfqA:
19.0		 1opjB-3pfqA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus) 		no annotation 4 LEU A 102
VAL A 183
ILE A 226
ARG A 219
 FMT  A 279 ( 4.5A)
None
None
None
 1.11A 1opjB-3rxyA:
undetectable		 1opjB-3rxyA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 345
LYS A 368
VAL A 387
ARG A 459
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
None
None
 1.00A 1opjB-3s95A:
23.6		 1opjB-3s95A:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  50
LYS A  73
ILE A 116
ARG A 165
 I85  A 350 (-3.7A)
I85  A 350 (-2.8A)
None
None
 1.05A 1opjB-3sheA:
18.2		 1opjB-3sheA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 LEU A 675
VAL A 290
ILE A 293
ARG A 221
 None
 1.11A 1opjB-3slkA:
undetectable		 1opjB-3slkA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		4 LEU A 182
VAL A 116
ILE A 138
ARG A 160
 None
 1.10A 1opjB-3tr5A:
undetectable		 1opjB-3tr5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
LYS A  82
ILE A 127
MET A 132
 None
ANK  A 401 (-2.4A)
None
None
 0.82A 1opjB-3vn9A:
21.1		 1opjB-3vn9A:
26.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1951
LYS A1980
ILE A2024
MET A2029
 VGH  A3000 ( 4.4A)
VGH  A3000 ( 4.7A)
None
None
 0.87A 1opjB-3zbfA:
24.6		 1opjB-3zbfA:
38.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 802
ILE A 892
MET A 883
ARG A 863
 None
 0.94A 1opjB-4agdA:
32.6		 1opjB-4agdA:
35.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  68
LYS A  91
ILE A 137
ARG A 184
 9ZP  A1333 (-3.9A)
None
None
None
 1.07A 1opjB-4b6lA:
22.6		 1opjB-4b6lA:
26.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
LYS A 655
MET A 704
ARG A 765
 None
DI1  A1000 (-3.9A)
None
None
 0.75A 1opjB-4ckrA:
32.3		 1opjB-4ckrA:
37.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 VAL A  47
ILE A  80
MET A  33
ARG A  58
 None
 1.10A 1opjB-4cw4A:
undetectable		 1opjB-4cw4A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
LYS A  38
VAL A  58
ARG A 134
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
 0.97A 1opjB-4eutA:
11.8		 1opjB-4eutA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 515
LYS A 543
MET A 591
ARG A 648
 None
 1.01A 1opjB-4f0iA:
26.5		 1opjB-4f0iA:
36.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 156
LYS A 179
VAL A 201
ARG A 273
 0XZ  A 501 ( 4.1A)
GOL  A 503 ( 2.8A)
None
TPO  A 308 ( 2.9A)
 1.07A 1opjB-4gv1A:
20.7		 1opjB-4gv1A:
26.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
ILE A 336
MET A 341
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 (-4.2A)
None
None
 0.89A 1opjB-4lggA:
29.5		 1opjB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
ILE A 336
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
VGG  A 601 (-4.2A)
None
 1.00A 1opjB-4lggA:
29.5		 1opjB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
LYS A 295
VAL A 313
ILE A 336
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.2A)
 0.76A 1opjB-4lggA:
29.5		 1opjB-4lggA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 313
ILE A 336
MET A 341
 VGG  A 601 (-3.2A)
None
VGG  A 601 (-4.2A)
None
 0.84A 1opjB-4lggA:
29.5		 1opjB-4lggA:
45.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 LEU A 143
VAL A  73
ILE A  61
ARG A 166
 None
 0.93A 1opjB-4ovkA:
undetectable		 1opjB-4ovkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p17 RABGAP/TBC PROTEIN

(Chlamydomonas
reinhardtii) 		PF00566
(RabGAP-TBC) 		4 LEU A 121
VAL A 139
ILE A 107
MET A 157
 None
 1.07A 1opjB-4p17A:
undetectable		 1opjB-4p17A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu6 L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Phaseolus
vulgaris) 		PF01112
(Asparaginase_2) 		4 VAL B 197
ILE B 292
MET B 320
ARG A  56
 None
 1.00A 1opjB-4pu6B:
undetectable		 1opjB-4pu6B:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		4 LEU A 197
ILE A 284
MET A 229
ARG A  20
 None
None
CSO  A 255 ( 4.0A)
None
 1.09A 1opjB-4q2hA:
undetectable		 1opjB-4q2hA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
ILE A  79
MET A  84
ARG A 128
 ACP  A1264 ( 4.5A)
None
None
None
 0.62A 1opjB-4ueuA:
32.2		 1opjB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
LYS A  37
ILE A  79
ARG A 128
 ACP  A1264 ( 4.5A)
None
None
None
 0.90A 1opjB-4ueuA:
32.2		 1opjB-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU A 332
VAL A 188
ILE A  73
MET A 139
 None
 1.10A 1opjB-4wa8A:
undetectable		 1opjB-4wa8A:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
LYS B 290
VAL B 308
ILE B 332
 1N1  B 601 (-3.7A)
1N1  B 601 (-4.6A)
None
1N1  B 601 (-4.1A)
 0.91A 1opjB-4xeyB:
27.9		 1opjB-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
VAL B 308
ILE B 332
MET B 337
 1N1  B 601 (-3.7A)
None
1N1  B 601 (-4.1A)
None
 0.64A 1opjB-4xeyB:
27.9		 1opjB-4xeyB:
71.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		no annotation 4 LEU E 293
VAL E 335
ILE E 331
MET E 259
 None
 1.13A 1opjB-4xmmE:
undetectable		 1opjB-4xmmE:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A  33
VAL A 540
ILE A 273
ARG A 559
 None
 1.13A 1opjB-4ynuA:
undetectable		 1opjB-4ynuA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 LEU I 377
VAL I 389
ILE I 197
ARG I 411
 None
 1.03A 1opjB-4zoqI:
undetectable		 1opjB-4zoqI:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 VAL A 259
ILE A 312
MET A 103
ARG A 248
 None
 0.91A 1opjB-5e3cA:
undetectable		 1opjB-5e3cA:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 730
LYS A 758
VAL A 778
ARG A 873
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.1A)
None
SEP  A 909 ( 3.0A)
 1.11A 1opjB-5fm2A:
30.8		 1opjB-5fm2A:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 LEU A 599
VAL A 667
ILE A 647
ARG A 555
 None
 0.91A 1opjB-5fmqA:
undetectable		 1opjB-5fmqA:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
LYS A 627
ILE A 672
ARG A 817
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
None
 0.69A 1opjB-5grnA:
28.1		 1opjB-5grnA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcf CALRETICULIN,
PUTATIVE,CALRETICULI
N, PUTATIVE

(Trypanosoma
cruzi) 		PF00262
(Calreticulin) 		4 LEU A 146
VAL A  97
ILE A 110
ARG A 135
 None
 1.09A 1opjB-5hcfA:
undetectable		 1opjB-5hcfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 VAL A  27
ILE A 278
MET A  40
ARG A 112
 None
 1.12A 1opjB-5hm5A:
undetectable		 1opjB-5hm5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 322
VAL A 402
ILE A 433
MET A 306
 None
 1.12A 1opjB-5jcfA:
undetectable		 1opjB-5jcfA:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 665
ILE A 709
MET A 714
ARG A 757
 None
6P6  A1001 ( 4.5A)
None
None
 0.75A 1opjB-5l6oA:
33.3		 1opjB-5l6oA:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A3011
VAL A2950
ILE A2993
ARG A2831
 None
 1.04A 1opjB-5nugA:
undetectable		 1opjB-5nugA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2j PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN PTXB

(Pseudomonas
stutzeri) 		no annotation 4 LEU A 215
VAL A  45
ILE A  61
ARG A  25
 None
 1.09A 1opjB-5o2jA:
undetectable		 1opjB-5o2jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 459
VAL A 656
ILE A 603
ARG A 647
 EDO  A 808 (-3.8A)
None
None
None
 0.97A 1opjB-5oasA:
undetectable		 1opjB-5oasA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 LEU A 229
VAL A  76
ILE A  39
MET A 213
 None
 1.07A 1opjB-5oe5A:
undetectable		 1opjB-5oe5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  17
LYS A  40
ILE A  90
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
 0.94A 1opjB-5u94A:
18.7		 1opjB-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 LEU 7 469
VAL 7 540
ILE 7 523
ARG 7 560
 None
 1.01A 1opjB-5v8f7:
undetectable		 1opjB-5v8f7:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 LEU A 114
VAL A 369
ILE A  36
MET A 153
 None
 1.04A 1opjB-5x2qA:
undetectable		 1opjB-5x2qA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 4 LEU A 438
VAL A 315
ILE A 444
ARG A 406
 None
 0.86A 1opjB-6ay4A:
undetectable		 1opjB-6ay4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE

(Proteus
mirabilis) 		no annotation 4 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 1.02A 1opjB-6cn0A:
undetectable		 1opjB-6cn0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpy GRMZM2G135359
PSEUDOKINASE

(Zea mays) 		no annotation 4 VAL A 480
ILE A 338
MET A 329
ARG A 464
 None
 1.11A 1opjB-6cpyA:
11.8		 1opjB-6cpyA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 4 LEU A 197
LYS A 219
ILE A 262
MET A 267
 FKY  A9001 (-4.1A)
None
None
None
 1.02A 1opjB-6cz4A:
21.3		 1opjB-6cz4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
LYS A 193
VAL A 211
ILE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.0A)
None
None
 0.56A 1opjB-6fylA:
21.4		 1opjB-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.63A 1opjB-6fyoA:
21.2		 1opjB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 3NG  A 501 (-3.9A)
3NG  A 501 (-2.7A)
None
None
 0.60A 1opjB-6fyvA:
21.3		 1opjB-6fyvA:
undetectable