SIMILAR PATTERNS OF AMINO ACIDS FOR 1OPJ_B_STIB4_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
ALA A 143
 None
 0.81A 1opjB-1h4lA:
16.6		 1opjB-1h4lA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
GLY A 272
 None
 0.49A 1opjB-1k9aA:
30.7		 1opjB-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
 None
 0.53A 1opjB-1k9aA:
30.7		 1opjB-1k9aA:
30.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 588
ALA A 606
VAL A 638
GLY A 660
ALA A 741
ASP A 742
 None
 0.74A 1opjB-1lufA:
34.1		 1opjB-1lufA:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 TYR A 272
VAL A 275
ALA A 288
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
 P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
 0.77A 1opjB-1opkA:
37.1		 1opjB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
THR A 334
PHE A 336
GLY A 340
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
 0.70A 1opjB-1opkA:
37.1		 1opjB-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
ASP A 829
 None
 0.83A 1opjB-1rjbA:
32.4		 1opjB-1rjbA:
35.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
GLY A 676
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
 0.55A 1opjB-1t46A:
34.0		 1opjB-1t46A:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
 0.53A 1opjB-1u59A:
29.9		 1opjB-1u59A:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
GLU A  65
PHE A 100
GLY A 104
ASP A 166
 STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
 0.75A 1opjB-2bujA:
22.9		 1opjB-2bujA:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL X  25
ALA X  37
GLU X  54
MET X  58
VAL X  67
THR X  82
GLY X  88
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 ( 4.1A)
 0.62A 1opjB-2dq7X:
31.6		 1opjB-2dq7X:
44.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 170
ALA A 184
GLU A 201
ILE A 208
VAL A 220
GLY A 240
ALA A 319
 None
 0.85A 1opjB-2eu9A:
21.3		 1opjB-2eu9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 463
ALA A 476
MET A 498
VAL A 507
PHE A 525
ASP A 586
 None
None
None
None
None
TRS  A 802 (-2.6A)
 0.74A 1opjB-2f57A:
21.5		 1opjB-2f57A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  67
ALA A  80
MET A 104
VAL A 113
GLY A 135
ALA A 192
 None
 0.86A 1opjB-2hakA:
8.8		 1opjB-2hakA:
26.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 293
VAL A 323
THR A 338
PHE A 340
GLY A 344
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.83A 1opjB-2hckA:
29.2		 1opjB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
GLU A 678
MET A 682
THR A 707
PHE A 709
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 0.88A 1opjB-2henA:
31.3		 1opjB-2henA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
MET A 292
VAL A 301
THR A 316
PHE A 318
GLY A 322
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.79A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
PHE A 318
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.96A 1opjB-2hk5A:
26.3		 1opjB-2hk5A:
46.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
GLU A 286
MET A 290
ILE A 293
VAL A 299
THR A 315
PHE A 317
GLY A 321
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.72A 1opjB-2hz0A:
34.1		 1opjB-2hz0A:
97.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 256
ALA A 269
GLU A 286
MET A 290
ILE A 293
VAL A 299
THR A 315
PHE A 317
GLY A 321
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
GIN  A 600 (-3.1A)
 0.63A 1opjB-2hz0A:
34.1		 1opjB-2hz0A:
97.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.7A)
 0.78A 1opjB-2j0jA:
31.7		 1opjB-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
 0.60A 1opjB-2j0jA:
31.7		 1opjB-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
GLU A  51
VAL A  64
PHE A  82
ALA A 144
 None
 0.66A 1opjB-2jgzA:
16.3		 1opjB-2jgzA:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
ASP A 564
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
None
None
BII  A1687 (-3.6A)
None
 0.86A 1opjB-2jkmA:
31.5		 1opjB-2jkmA:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
THR A 316
GLY A 322
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.52A 1opjB-2og8A:
31.9		 1opjB-2og8A:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
GLY A 669
ASP A 796
 None
 0.91A 1opjB-2ogvA:
21.9		 1opjB-2ogvA:
38.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.66A 1opjB-2psqA:
31.3		 1opjB-2psqA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
GLU A 230
THR A 265
PHE A 267
GLY A 271
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
 0.77A 1opjB-2qluA:
24.0		 1opjB-2qluA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  85
GLU B 118
VAL B 131
THR B 147
PHE B 149
GLY B 153
 ANP  B 432 (-4.6A)
None
None
ANP  B 432 (-4.3A)
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.2A)
 0.85A 1opjB-2wtkB:
22.0		 1opjB-2wtkB:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 273
MET A 294
VAL A 303
THR A 319
PHE A 321
GLY A 325
ALA A 384
 None
 0.96A 1opjB-2zv7A:
25.3		 1opjB-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 261
ALA A 273
GLU A 290
MET A 294
VAL A 303
THR A 319
PHE A 321
ASP A 385
 None
 1.03A 1opjB-2zv7A:
25.3		 1opjB-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 261
ALA A 273
MET A 294
VAL A 303
THR A 319
PHE A 321
ALA A 384
ASP A 385
 None
 1.06A 1opjB-2zv7A:
25.3		 1opjB-2zv7A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.8A)
None
 0.75A 1opjB-3b2tA:
30.3		 1opjB-3b2tA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.71A 1opjB-3c4fA:
24.6		 1opjB-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
GLY A 272
 None
 0.49A 1opjB-3d7uA:
26.7		 1opjB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
THR A 266
 None
 0.53A 1opjB-3d7uA:
26.7		 1opjB-3d7uA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
ALA A 663
GLU A 682
MET A 686
VAL A 695
PHE A 713
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.8A)
 0.82A 1opjB-3dkoA:
30.6		 1opjB-3dkoA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
ALA A  83
MET A 107
VAL A 116
GLY A 138
ALA A 195
 None
 0.70A 1opjB-3fe3A:
21.7		 1opjB-3fe3A:
28.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
GLY A 915
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.75A 1opjB-3hngA:
32.9		 1opjB-3hngA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
MET A 104
VAL A 113
GLY A 135
ALA A 192
ASP A 193
 None
 0.84A 1opjB-3iecA:
22.4		 1opjB-3iecA:
25.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
GLU A 684
MET A 688
THR A 713
GLY A 719
 None
None
None
None
None
GOL  A 403 (-3.4A)
 0.71A 1opjB-3kulA:
31.5		 1opjB-3kulA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  33
ALA A  46
GLU A  66
VAL A  79
PHE A 105
ALA A 166
 None
 0.70A 1opjB-3mi9A:
22.3		 1opjB-3mi9A:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  37
ALA A  49
GLU A  69
VAL A  82
PHE A 100
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
ADP  A 314 ( 4.3A)
None
MG  A 312 ( 3.3A)
 1.04A 1opjB-3nizA:
22.5		 1opjB-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  96
ALA A 109
GLU A 130
MET A 134
GLY A 165
ASP A 223
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
SO4  A   5 ( 4.5A)
 0.85A 1opjB-3nuuA:
22.5		 1opjB-3nuuA:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
GLU A 596
MET A 600
VAL A 609
THR A 625
GLY A 631
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 0.57A 1opjB-3ppzA:
28.4		 1opjB-3ppzA:
35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 VAL A 565
ALA A 576
MET A 600
VAL A 609
THR A 625
GLY A 631
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 0.77A 1opjB-3ppzA:
28.4		 1opjB-3ppzA:
35.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
GLU A 232
THR A 267
PHE A 269
GLY A 273
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
TAK  A   2 ( 4.2A)
 0.78A 1opjB-3q4tA:
23.7		 1opjB-3q4tA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  71
ALA A  84
GLU A 115
THR A 144
PHE A 146
GLY A 150
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
 0.87A 1opjB-3q5iA:
20.0		 1opjB-3q5iA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 (-3.7A)
07J  A   1 (-3.2A)
 0.66A 1opjB-3tt0A:
30.5		 1opjB-3tt0A:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
 0.78A 1opjB-3vidA:
29.9		 1opjB-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.79A 1opjB-3wzdA:
30.8		 1opjB-3wzdA:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
GLU A 668
MET A 672
THR A 697
PHE A 699
 None
 0.81A 1opjB-3zfxA:
31.7		 1opjB-3zfxA:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
ASP A1046
 B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
 0.72A 1opjB-4agdA:
32.5		 1opjB-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.4A)
None
 0.81A 1opjB-4agdA:
32.5		 1opjB-4agdA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
 0.81A 1opjB-4aw5A:
26.5		 1opjB-4aw5A:
39.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
GLU A  81
VAL A  94
PHE A 112
GLY A 116
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
XZN  A1317 ( 4.3A)
 0.77A 1opjB-4bc6A:
21.3		 1opjB-4bc6A:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 653
GLU A 672
MET A 676
THR A 701
GLY A 707
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.62A 1opjB-4ckrA:
32.3		 1opjB-4ckrA:
37.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 671
ALA A 684
GLU A 705
VAL A 721
GLY A 743
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 ( 4.5A)
 0.67A 1opjB-4crsA:
20.4		 1opjB-4crsA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
GLU A  55
VAL A  68
PHE A  88
GLY A  92
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.72A 1opjB-4eutA:
11.8		 1opjB-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
GLU A  55
VAL A  68
PHE A  88
GLY A  92
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.71A 1opjB-4euuA:
15.4		 1opjB-4euuA:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		7 ALA A1053
GLU A1078
MET A1082
VAL A1091
PHE A1107
GLY A1111
ALA A1176
 None
 1.04A 1opjB-4f0gA:
26.1		 1opjB-4f0gA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		7 VAL A1040
ALA A1053
GLU A1078
VAL A1091
PHE A1107
GLY A1111
ALA A1176
 None
 0.80A 1opjB-4f0gA:
26.1		 1opjB-4f0gA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
 ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.6A)
None
ANP  A1001 ( 4.6A)
None
 0.86A 1opjB-4fieA:
21.5		 1opjB-4fieA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 836
ALA A 853
GLU A 871
VAL A 884
GLY A 908
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 ( 4.1A)
 0.71A 1opjB-4hviA:
24.1		 1opjB-4hviA:
35.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
GLU A 525
MET A 529
ILE A 532
GLY A 561
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
None
 0.81A 1opjB-4k33A:
25.2		 1opjB-4k33A:
37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
GLU A 525
MET A 529
ILE A 532
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
None
 0.68A 1opjB-4k33A:
25.2		 1opjB-4k33A:
37.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
GLU A  70
MET A  74
VAL A  83
GLY A 105
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 3.0A)
 1.06A 1opjB-4lg4A:
17.2		 1opjB-4lg4A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
GLU B  70
GLY B 105
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
 0.87A 1opjB-4o27B:
17.8		 1opjB-4o27B:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
None
 0.96A 1opjB-4o38A:
19.0		 1opjB-4o38A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
 0.79A 1opjB-4o38A:
19.0		 1opjB-4o38A:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
None
 0.71A 1opjB-4rt7A:
27.9		 1opjB-4rt7A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
None
 1.03A 1opjB-4ueuA:
32.3		 1opjB-4ueuA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
MET A  56
VAL A  65
THR A  81
GLY A  87
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
 0.99A 1opjB-4ueuA:
32.3		 1opjB-4ueuA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  72
GLU A  90
MET A  94
VAL A 104
PHE A 128
GLY A 132
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
ZN  A 403 ( 2.6A)
 0.97A 1opjB-4wsqA:
22.0		 1opjB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  60
ALA A  72
GLU A  90
MET A  94
VAL A 104
PHE A 128
GLY A 132
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
 0.88A 1opjB-4wsqA:
22.0		 1opjB-4wsqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  60
ALA A  72
MET A  94
VAL A 104
PHE A 128
GLY A 131
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.8A)
None
 0.77A 1opjB-4wsqA:
22.0		 1opjB-4wsqA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
 0.67A 1opjB-4xcuA:
31.0		 1opjB-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 VAL B 275
ALA B 288
MET B 309
ILE B 312
VAL B 318
THR B 334
PHE B 336
GLY B 340
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.5A)
 0.87A 1opjB-4xeyB:
27.9		 1opjB-4xeyB:
71.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
VAL A 675
GLY A 697
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
None
 0.71A 1opjB-4xufA:
27.5		 1opjB-4xufA:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
GLU A 509
THR A 539
GLY A 545
ALA A 605
 None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 ( 3.9A)
 0.73A 1opjB-4yffA:
18.9		 1opjB-4yffA:
28.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.73A 1opjB-5a46A:
30.5		 1opjB-5a46A:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 258
ALA A 275
GLU A 290
THR A 325
PHE A 327
GLY A 331
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
 0.87A 1opjB-5e8yA:
18.1		 1opjB-5e8yA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
ALA A  83
GLU A 103
VAL A 116
GLY A 138
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
5RC  A4000 ( 3.9A)
 0.90A 1opjB-5es1A:
11.1		 1opjB-5es1A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 VAL A 107
ALA A 120
PHE A 172
GLY A 176
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
None
None
 0.85A 1opjB-5eykA:
9.8		 1opjB-5eykA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
GLY A 680
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.8A)
 0.64A 1opjB-5grnA:
28.1		 1opjB-5grnA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 VAL A  28
ALA A  41
GLU A  61
VAL A  74
GLY A  96
ALA A 156
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
None
ADP  A 301 ( 4.8A)
 0.76A 1opjB-5hu3A:
16.6		 1opjB-5hu3A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  65
ALA A  77
GLU A  95
MET A  99
VAL A 109
GLY A 136
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-3.4A)
 0.89A 1opjB-5i3oA:
21.7		 1opjB-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
GLU A  61
MET A  65
VAL A  74
PHE A  92
GLY A  96
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 ( 4.2A)
 0.82A 1opjB-5j5tA:
20.9		 1opjB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
MET A  65
VAL A  74
PHE A  92
GLY A  95
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.1A)
TPO  A 145 ( 4.7A)
 0.71A 1opjB-5j5tA:
20.9		 1opjB-5j5tA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
GLY A 350
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 ( 3.8A)
None
 1.03A 1opjB-5kbrA:
21.2		 1opjB-5kbrA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 647
ALA A 663
MET A 686
THR A 711
PHE A 713
ASP A 776
 None
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
None
 0.77A 1opjB-5l6oA:
33.3		 1opjB-5l6oA:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A 897
ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
 0.73A 1opjB-5lpyA:
22.8		 1opjB-5lpyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A 897
ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
 ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
None
None
ADP  A1200 (-4.1A)
ADP  A1200 ( 4.0A)
 0.78A 1opjB-5lpzA:
22.8		 1opjB-5lpzA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 106
ALA A 119
GLU A 140
VAL A 153
GLY A 175
ALA A 231
 None
 0.89A 1opjB-5u7qA:
18.6		 1opjB-5u7qA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 124
ALA A 137
GLU A 157
VAL A 171
THR A 187
GLY A 191
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
 0.90A 1opjB-5vcxA:
17.6		 1opjB-5vcxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 6 VAL A 335
ALA A 348
GLU A 366
VAL A 379
PHE A 397
GLY A 401
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
None
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
 0.89A 1opjB-5vefA:
21.9		 1opjB-5vefA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 VAL A 374
ALA A 388
GLU A 409
MET A 413
VAL A 422
GLY A 444
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
None
None
None
 0.86A 1opjB-6c0tA:
16.4		 1opjB-6c0tA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
ALA A  87
GLU A 107
MET A 111
VAL A 120
GLY A 142
ALA A 199
 None
 0.92A 1opjB-6c9dA:
21.1		 1opjB-6c9dA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 VAL A 179
ALA A 192
GLU A 236
VAL A 249
GLY A 273
ALA A 329
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
None
F6J  A 501 ( 3.7A)
F6J  A 501 ( 4.0A)
 0.90A 1opjB-6cmjA:
22.0		 1opjB-6cmjA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 VAL U  28
ALA U  42
VAL U  75
PHE U  93
GLY U  97
ALA U 156
ASP U 157
 DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.99A 1opjB-6fdyU:
21.6		 1opjB-6fdyU:
undetectable