SIMILAR PATTERNS OF AMINO ACIDS FOR 1OPJ_A_STIA3_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		4 TYR A  33
VAL A  51
ILE A  55
MET A 219
 None
 1.29A 1opjA-1cg4A:
0.0		 1opjA-1cg4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		4 TYR A 414
VAL A 345
ILE A 341
MET A 287
 None
 1.45A 1opjA-1gkpA:
0.0		 1opjA-1gkpA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 290
VAL A 308
ILE A 332
MET A 337
 P16  A   2 (-4.5A)
None
P16  A   2 (-4.1A)
None
 0.55A 1opjA-1opkA:
37.3		 1opjA-1opkA:
58.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 TYR A 272
VAL A 308
ILE A 332
MET A 337
 P16  A   2 (-3.6A)
None
P16  A   2 (-4.1A)
None
 0.75A 1opjA-1opkA:
37.3		 1opjA-1opkA:
58.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 TYR A 142
LYS A 302
VAL A 100
ILE A 300
 None
 1.49A 1opjA-1pgsA:
0.0		 1opjA-1pgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 TYR A 387
LYS A 385
VAL A 559
ILE A 380
 None
 1.35A 1opjA-1qhgA:
0.0		 1opjA-1qhgA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 TYR B 387
LYS B 385
VAL D 559
ILE B 380
 None
 1.31A 1opjA-1qhhB:
0.0		 1opjA-1qhhB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 TYR A 235
VAL A 137
ILE A 159
MET A 238
 None
 1.46A 1opjA-1qwjA:
0.0		 1opjA-1qwjA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
VAL A 291
ILE A 314
MET A 319
 1BM  A 499 (-3.8A)
None
1BM  A 499 (-3.9A)
None
 0.67A 1opjA-2hk5A:
26.4		 1opjA-2hk5A:
46.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 TYR A 217
VAL A 343
ILE A 268
MET A 210
 None
 1.31A 1opjA-2qneA:
undetectable		 1opjA-2qneA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		4 TYR A 109
VAL A 288
ILE A 419
MET A 359
 None
 1.37A 1opjA-2rfzA:
undetectable		 1opjA-2rfzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		4 TYR A 254
VAL A 135
ILE A 227
MET A  24
 None
None
PEG  A 303 ( 4.7A)
None
 1.50A 1opjA-3c6cA:
undetectable		 1opjA-3c6cA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn5 SORTASE A

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		4 TYR A 178
LYS A 220
VAL A 191
ILE A 218
 None
 1.34A 1opjA-3fn5A:
undetectable		 1opjA-3fn5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		4 TYR A 240
VAL A 246
ILE A  91
MET A 174
 None
EDO  A   3 ( 4.0A)
None
None
 1.37A 1opjA-3ib5A:
undetectable		 1opjA-3ib5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtw DIHYDROFOLATE
REDUCTASE

(Pediococcus
pentosaceus) 		PF01872
(RibD_C) 		4 TYR A 171
VAL A 158
ILE A 161
MET A  43
 None
 1.42A 1opjA-3jtwA:
undetectable		 1opjA-3jtwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vba ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
SMALL SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00694
(Aconitase_C) 		4 TYR A  94
VAL A   9
ILE A  81
MET A 148
 None
 1.17A 1opjA-3vbaA:
undetectable		 1opjA-3vbaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 TYR A 357
VAL A 450
ILE A 478
MET A 398
 GOL  A1888 (-3.9A)
None
None
None
 1.31A 1opjA-4aioA:
undetectable		 1opjA-4aioA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 TYR A 135
LYS A 150
VAL A  82
ILE A 153
 None
 1.37A 1opjA-4avyA:
undetectable		 1opjA-4avyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 TYR A  67
VAL A 211
ILE A  72
MET A  28
 None
 1.43A 1opjA-4c23A:
undetectable		 1opjA-4c23A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqx PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		4 TYR A 161
LYS A 177
VAL A 106
ILE A 180
 None
 1.44A 1opjA-4dqxA:
0.5		 1opjA-4dqxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 TYR A 109
VAL A 288
ILE A 428
MET A 367
 None
 1.29A 1opjA-4v20A:
undetectable		 1opjA-4v20A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 4 TYR A 356
VAL A 345
ILE A 310
MET A 359
 None
 1.40A 1opjA-4xn3A:
undetectable		 1opjA-4xn3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Helicobacter
pylori) 		PF00793
(DAHP_synth_1) 		4 TYR A 142
LYS A 146
ILE A 117
MET A 192
 None
 1.19A 1opjA-4z1aA:
undetectable		 1opjA-4z1aA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 LYS M 331
VAL A 443
ILE M 325
MET M 277
 None
 1.15A 1opjA-5a5tM:
undetectable		 1opjA-5a5tM:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d76 PUTATIVE PHAGE LYSIN

(Streptococcus
phage phi7917) 		PF05257
(CHAP)
PF08460
(SH3_5) 		4 TYR A 237
VAL A 214
ILE A 206
MET A  36
 None
 1.25A 1opjA-5d76A:
undetectable		 1opjA-5d76A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 TYR A1547
VAL A1844
ILE A1614
MET A1609
 None
 1.40A 1opjA-5i6gA:
undetectable		 1opjA-5i6gA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 TYR L 323
VAL L 260
ILE L 367
MET L 372
 None
 1.38A 1opjA-5jfcL:
undetectable		 1opjA-5jfcL:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t53 N-ACETYLTRANSFERASE
ESCO1

(Homo sapiens) 		PF13878
(zf-C2H2_3)
PF13880
(Acetyltransf_13) 		4 TYR A 677
LYS A 681
VAL A 719
ILE A 685
 None
 0.89A 1opjA-5t53A:
undetectable		 1opjA-5t53A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tou PHYCOCYANIN BETA-1
SUBUNIT

(Pseudanabaena
sp. lw0831) 		no annotation 4 TYR D 163
VAL D  52
ILE D 131
MET D 157
 None
 1.27A 1opjA-5touD:
undetectable		 1opjA-5touD:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tru CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4

(Homo sapiens) 		PF07686
(V-set) 		4 TYR c  25
VAL c  46
ILE c 108
MET c  99
 None
 1.44A 1opjA-5truc:
undetectable		 1opjA-5truc:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 TYR A  26
VAL A  33
ILE A 119
MET A  59
 None
 1.17A 1opjA-5tulA:
undetectable		 1opjA-5tulA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Trypanosoma
brucei) 		PF01536
(SAM_decarbox) 		4 TYR B  81
VAL A 232
ILE A 237
MET A  91
 None
 1.40A 1opjA-5tvoB:
undetectable		 1opjA-5tvoB:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yak -

(-) 		no annotation 4 TYR A 184
VAL A 115
ILE A 190
MET A 261
 None
 1.32A 1opjA-5yakA:
1.0		 1opjA-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck9 35O22 SCFV LIGHT
CHAIN PORTION

(Homo sapiens) 		no annotation 4 TYR E  68
LYS E  66
VAL E  97
ILE E  33
 None
 1.13A 1opjA-6ck9E:
undetectable		 1opjA-6ck9E:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE

(Proteus
mirabilis) 		no annotation 4 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 0.98A 1opjA-6cn0A:
1.0		 1opjA-6cn0A:
14.95