SIMILAR PATTERNS OF AMINO ACIDS FOR 1ONI_I_BEZI518

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 ILE A  97
GLY A 131
PHE A 126
ASN A 125
 None
 0.88A 1oniG-1b0kA:
0.0
1oniI-1b0kA:
0.0		 1oniG-1b0kA:
13.12
1oniI-1b0kA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bl5 ISOCITRATE
DEHYDROGENASE

(Escherichia
coli) 		PF00180
(Iso_dh) 		4 ILE A 320
GLY A 321
PHE A 393
ASN A 352
 None
NAP  A   2 ( 3.9A)
None
None
 1.01A 1oniG-1bl5A:
0.1
1oniI-1bl5A:
0.6		 1oniG-1bl5A:
17.75
1oniI-1bl5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 216
GLY A 323
PHE A 295
ASN A 292
 None
 0.98A 1oniG-1cg2A:
0.3
1oniI-1cg2A:
0.3		 1oniG-1cg2A:
17.57
1oniI-1cg2A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA

(Pariacoto virus) 		PF01829
(Peptidase_A6) 		4 GLY A 149
PRO A 112
ASN A 155
ASN A 154
 None
 0.94A 1oniG-1f8vA:
0.0
1oniI-1f8vA:
0.0		 1oniG-1f8vA:
18.46
1oniI-1f8vA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ILE A  54
GLY A  53
PHE A  49
ASN A  50
 None
 0.87A 1oniG-1gpmA:
0.7
1oniI-1gpmA:
0.0		 1oniG-1gpmA:
13.70
1oniI-1gpmA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		4 ILE A 444
GLY A 441
PHE A 423
ASN A 324
 None
SAF  A1998 ( 4.6A)
None
None
 0.98A 1oniG-1gqrA:
0.0
1oniI-1gqrA:
1.9		 1oniG-1gqrA:
14.53
1oniI-1gqrA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		4 GLY A 315
PHE A 317
ASN A 318
ARG A 147
 None
 0.97A 1oniG-1kplA:
0.0
1oniI-1kplA:
0.0		 1oniG-1kplA:
13.71
1oniI-1kplA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ILE A 798
GLY A 807
PRO A 790
ASN A 801
 None
 0.92A 1oniG-1kqfA:
undetectable
1oniI-1kqfA:
undetectable		 1oniG-1kqfA:
9.32
1oniI-1kqfA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ILE A  17
GLY A  19
PRO A 348
ARG A 343
 ATP  A 450 (-4.2A)
None
None
None
 0.97A 1oniG-1kyiA:
0.1
1oniI-1kyiA:
0.2		 1oniG-1kyiA:
15.09
1oniI-1kyiA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 GLY A  20
PRO A   5
PHE A 243
ASN A 242
 None
 0.87A 1oniG-1mzrA:
undetectable
1oniI-1mzrA:
undetectable		 1oniG-1mzrA:
17.28
1oniI-1mzrA:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oni 14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN

(Homo sapiens) 		PF01042
(Ribonuc_L-PSP) 		4 PHE A  89
ASN A  90
ASN A  93
ARG A 107
 BEZ  A 502 ( 3.6A)
None
BEZ  A 502 (-3.1A)
BEZ  A 501 ( 3.6A)
 0.44A 1oniG-1oniA:
26.3
1oniI-1oniA:
27.3		 1oniG-1oniA:
100.00
1oniI-1oniA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		4 ILE X 149
GLY X 150
ASN X 198
ARG X 287
 None
 0.89A 1oniG-1pp1X:
undetectable
1oniI-1pp1X:
undetectable		 1oniG-1pp1X:
16.98
1oniI-1pp1X:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		4 ILE A  70
GLY A  67
PRO A 188
PHE A 192
 None
 0.77A 1oniG-1qf6A:
1.4
1oniI-1qf6A:
3.1		 1oniG-1qf6A:
12.52
1oniI-1qf6A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		4 ILE A 257
GLY A 258
ASN A 303
ASN A 289
 None
 0.99A 1oniG-1r53A:
undetectable
1oniI-1r53A:
undetectable		 1oniG-1r53A:
19.28
1oniI-1r53A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B

(Streptomyces
griseus) 		PF00089
(Trypsin) 		4 ILE E 124
GLY E 117
PRO E 198
ASN E  47
 None
 0.97A 1oniG-1sgqE:
undetectable
1oniI-1sgqE:
undetectable		 1oniG-1sgqE:
20.94
1oniI-1sgqE:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 571
GLY A 574
PRO A 527
ASN A 592
 None
 0.92A 1oniG-1snxA:
undetectable
1oniI-1snxA:
undetectable		 1oniG-1snxA:
19.92
1oniI-1snxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tke THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF02824
(TGS)
PF07973
(tRNA_SAD) 		4 ILE A  70
GLY A  67
PRO A 188
PHE A 192
 None
 0.86A 1oniG-1tkeA:
undetectable
1oniI-1tkeA:
undetectable		 1oniG-1tkeA:
21.76
1oniI-1tkeA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhw PLECKSTRIN

(Mus musculus) 		PF00610
(DEP) 		4 ILE A  62
GLY A  59
PHE A  91
ASN A  89
 None
 0.83A 1oniG-1uhwA:
undetectable
1oniI-1uhwA:
undetectable		 1oniG-1uhwA:
22.15
1oniI-1uhwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		5 GLY A 714
PRO A 311
PHE A 709
ASN A 600
ASN A 601
 None
None
None
ACT  A1107 (-4.1A)
None
 1.27A 1oniG-1xf1A:
undetectable
1oniI-1xf1A:
undetectable		 1oniG-1xf1A:
8.78
1oniI-1xf1A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4h CYSTEINE PROTEASE
INHIBITOR

(Staphylococcus
aureus) 		PF09023
(Staphostatin_B) 		4 ILE C  42
GLY C  29
ASN C  25
ARG C 107
 None
None
SO4  C 462 (-4.0A)
None
 0.63A 1oniG-1y4hC:
undetectable
1oniI-1y4hC:
undetectable		 1oniG-1y4hC:
18.88
1oniI-1y4hC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 ILE A 332
GLY A 462
PRO A 326
ASN A 329
 None
 1.01A 1oniG-2bmfA:
undetectable
1oniI-2bmfA:
undetectable		 1oniG-2bmfA:
14.48
1oniI-2bmfA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu9 HISTONE CHAPERONE
CIA1

(Schizosaccharomyces
pombe) 		PF04729
(ASF1_hist_chap) 		4 ILE A  69
GLY A  68
PHE A  28
ASN A   5
 None
 0.86A 1oniG-2cu9A:
undetectable
1oniI-2cu9A:
undetectable		 1oniG-2cu9A:
20.86
1oniI-2cu9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl2 PROTEIN (MHC CLASS I
NK CELL RECEPTOR
PRECURSOR (P58
NATURAL KILLER CELL
RECEPTOR CLONE
CL-43))

(Homo sapiens) 		PF00047
(ig) 		4 ILE A  52
GLY A  53
PHE A  64
ASN A  63
 None
 0.93A 1oniG-2dl2A:
undetectable
1oniI-2dl2A:
undetectable		 1oniG-2dl2A:
19.12
1oniI-2dl2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 ILE A 239
PRO A 178
ASN A 236
ARG A 575
 None
 1.00A 1oniG-2eidA:
undetectable
1oniI-2eidA:
undetectable		 1oniG-2eidA:
13.83
1oniI-2eidA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7c TOXIN A

(Clostridioides
difficile) 		PF01473
(CW_binding_1) 		4 ILE A 165
GLY A 189
ASN A 181
ASN A 186
 None
 0.89A 1oniG-2g7cA:
undetectable
1oniI-2g7cA:
undetectable		 1oniG-2g7cA:
19.44
1oniI-2g7cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		4 GLY A 392
PHE A 164
ASN A 207
ARG A 169
 None
None
SO4  A 600 (-3.9A)
None
 0.91A 1oniG-2horA:
undetectable
1oniI-2horA:
undetectable		 1oniG-2horA:
15.33
1oniI-2horA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
HISTONE REGULATORY
HOMOLOG A

(Homo sapiens;
Homo sapiens) 		PF04729
(ASF1_hist_chap)
PF09453
(HIRA_B) 		4 GLY A  68
PRO E 463
PHE A  28
ASN A   7
 None
 0.95A 1oniG-2i32A:
undetectable
1oniI-2i32A:
undetectable		 1oniG-2i32A:
22.63
1oniI-2i32A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqn CRK-LIKE PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07653
(SH3_2) 		4 GLY A 136
PRO A 174
PHE A 144
ASN A 165
 None
 0.98A 1oniG-2lqnA:
undetectable
1oniI-2lqnA:
undetectable		 1oniG-2lqnA:
17.32
1oniI-2lqnA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		4 ILE A 298
GLY A 294
PRO A 413
ASN A  62
 None
 0.99A 1oniG-2pefA:
undetectable
1oniI-2pefA:
undetectable		 1oniG-2pefA:
16.67
1oniI-2pefA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		4 ILE A 200
GLY A 199
ASN A 168
ARG A 206
 None
 0.88A 1oniG-2ppvA:
undetectable
1oniI-2ppvA:
undetectable		 1oniG-2ppvA:
18.24
1oniI-2ppvA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7n LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Mus musculus) 		PF00041
(fn3) 		4 ILE A 310
PRO A 307
ASN A 366
ASN A 318
 None
 0.91A 1oniG-2q7nA:
undetectable
1oniI-2q7nA:
undetectable		 1oniG-2q7nA:
15.30
1oniI-2q7nA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 ILE A 548
GLY A 546
ASN A 183
ASN A 149
 None
 0.95A 1oniG-2wk2A:
undetectable
1oniI-2wk2A:
undetectable		 1oniG-2wk2A:
15.30
1oniI-2wk2A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 ILE A 260
GLY A 354
PHE A 107
ASN A 105
 None
 0.91A 1oniG-2wknA:
1.5
1oniI-2wknA:
undetectable		 1oniG-2wknA:
15.93
1oniI-2wknA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 245
PRO A 254
PHE A 125
ASN A 126
 None
 0.86A 1oniG-2yp2A:
undetectable
1oniI-2yp2A:
undetectable		 1oniG-2yp2A:
14.32
1oniI-2yp2A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 ILE A 579
GLY A 577
ASN A 184
ASN A 150
 None
 0.98A 1oniG-3b9eA:
undetectable
1oniI-3b9eA:
undetectable		 1oniG-3b9eA:
15.25
1oniI-3b9eA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 ILE A 390
GLY A 388
PRO A 409
PHE A 410
 None
 0.99A 1oniG-3c9fA:
undetectable
1oniI-3c9fA:
undetectable		 1oniG-3c9fA:
14.03
1oniI-3c9fA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ILE A 434
GLY A 433
PHE A 302
ASN A 304
 None
 0.67A 1oniG-3gdnA:
undetectable
1oniI-3gdnA:
undetectable		 1oniG-3gdnA:
16.91
1oniI-3gdnA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjc HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90) 		4 GLY A  91
PRO A  52
PHE A 149
ASN A 152
 None
 0.95A 1oniG-3hjcA:
undetectable
1oniI-3hjcA:
undetectable		 1oniG-3hjcA:
14.45
1oniI-3hjcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ILE A 366
GLY A 362
PHE A 216
ASN A 217
 None
 0.91A 1oniG-3l01A:
undetectable
1oniI-3l01A:
undetectable		 1oniG-3l01A:
15.50
1oniI-3l01A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		4 ILE A 150
GLY A 149
PHE A 144
ASN A 143
 None
 0.85A 1oniG-3n9xA:
undetectable
1oniI-3n9xA:
undetectable		 1oniG-3n9xA:
13.86
1oniI-3n9xA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		4 ILE B 237
GLY B 236
PRO B 327
ARG B 301
 SF4  B 386 ( 4.3A)
None
SF4  B 386 ( 4.5A)
None
 0.97A 1oniG-3o3mB:
undetectable
1oniI-3o3mB:
undetectable		 1oniG-3o3mB:
18.72
1oniI-3o3mB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 ILE A 222
GLY A 223
PHE A 360
ASN A 331
 None
 0.65A 1oniG-3ouhA:
undetectable
1oniI-3ouhA:
undetectable		 1oniG-3ouhA:
20.00
1oniI-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oui EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 ILE A 222
GLY A 223
PHE A 360
ASN A 331
 None
 0.70A 1oniG-3ouiA:
undetectable
1oniI-3ouiA:
undetectable		 1oniG-3ouiA:
21.23
1oniI-3ouiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pry HEAT SHOCK PROTEIN
HSP 90-BETA

(Homo sapiens) 		PF00183
(HSP90) 		4 ILE A 377
PRO A 336
PHE A 433
ASN A 436
 None
 0.77A 1oniG-3pryA:
undetectable
1oniI-3pryA:
undetectable		 1oniG-3pryA:
20.33
1oniI-3pryA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90) 		4 ILE A 385
PRO A 344
PHE A 441
ASN A 444
 None
 0.84A 1oniG-3q6mA:
undetectable
1oniI-3q6mA:
undetectable		 1oniG-3q6mA:
15.55
1oniI-3q6mA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ILE A 435
GLY A 434
PHE A 303
ASN A 305
 None
 0.68A 1oniG-3redA:
undetectable
1oniI-3redA:
undetectable		 1oniG-3redA:
14.68
1oniI-3redA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN

([Eubacterium]
rectale) 		PF16472
(DUF5050) 		4 ILE A  88
GLY A  47
PHE A  49
ASN A 298
 None
 1.01A 1oniG-3s25A:
undetectable
1oniI-3s25A:
undetectable		 1oniG-3s25A:
19.27
1oniI-3s25A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum) 		PF00491
(Arginase) 		4 ILE A  66
GLY A  67
ASN A 188
ARG A  48
 None
 0.98A 1oniG-3sl1A:
undetectable
1oniI-3sl1A:
undetectable		 1oniG-3sl1A:
14.32
1oniI-3sl1A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl2 SENSOR HISTIDINE
KINASE YYCG

(Bacillus
subtilis) 		PF02518
(HATPase_c) 		4 ILE A 536
GLY A 537
PRO A 509
ASN A 503
 None
ATP  A 703 (-4.3A)
None
MG  A 701 ( 2.5A)
 0.88A 1oniG-3sl2A:
undetectable
1oniI-3sl2A:
undetectable		 1oniG-3sl2A:
20.88
1oniI-3sl2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 ILE A 607
PRO A  61
PHE A 314
ASN A 587
 None
 0.95A 1oniG-3thcA:
undetectable
1oniI-3thcA:
undetectable		 1oniG-3thcA:
11.97
1oniI-3thcA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ILE A  54
GLY A  53
PHE A  49
ASN A  50
 None
 0.82A 1oniG-3tqiA:
undetectable
1oniI-3tqiA:
undetectable		 1oniG-3tqiA:
14.90
1oniI-3tqiA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfj 2-DEHYDROPANTOATE
2-REDUCTASE

(Enterococcus
faecium) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 GLY A 143
PHE A  48
ASN A  47
ARG A  14
 None
 0.92A 1oniG-3wfjA:
undetectable
1oniI-3wfjA:
undetectable		 1oniG-3wfjA:
21.00
1oniI-3wfjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvj BETA-GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00722
(Glyco_hydro_16) 		4 ILE A 218
GLY A 217
PRO A  89
ASN A  56
 None
None
None
B3P  A 302 (-3.1A)
 0.97A 1oniG-3wvjA:
undetectable
1oniI-3wvjA:
undetectable		 1oniG-3wvjA:
20.95
1oniI-3wvjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ILE B1061
GLY B1102
ASN B1087
ASN B1099
 None
 0.84A 1oniG-3zefB:
undetectable
1oniI-3zefB:
undetectable		 1oniG-3zefB:
6.79
1oniI-3zefB:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ILE A 358
GLY A 359
PRO A 395
ASN A 414
 None
 1.00A 1oniG-3zz1A:
undetectable
1oniI-3zz1A:
undetectable		 1oniG-3zz1A:
11.67
1oniI-3zz1A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ILE A 652
GLY A 651
PHE A 631
ASN A 632
 None
 0.81A 1oniG-4a2lA:
undetectable
1oniI-4a2lA:
undetectable		 1oniG-4a2lA:
10.50
1oniI-4a2lA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		5 ILE A 549
GLY A 548
PRO A 561
ASN A  67
ASN A  68
 None
 1.28A 1oniG-4amfA:
undetectable
1oniI-4amfA:
undetectable		 1oniG-4amfA:
14.38
1oniI-4amfA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		4 ILE A 196
GLY A 226
PRO A 148
ASN A 259
 None
 0.95A 1oniG-4cczA:
2.7
1oniI-4cczA:
0.9		 1oniG-4cczA:
13.56
1oniI-4cczA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 GLY A 112
PRO A  33
ASN A 363
ASN A 124
 None
 0.90A 1oniG-4djiA:
undetectable
1oniI-4djiA:
0.1		 1oniG-4djiA:
14.17
1oniI-4djiA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		4 GLY A 184
PRO A 177
PHE A 187
ASN A 201
 None
 0.93A 1oniG-4ix3A:
undetectable
1oniI-4ix3A:
undetectable		 1oniG-4ix3A:
20.68
1oniI-4ix3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		4 ILE A 272
GLY A 271
ASN A 442
ASN A 230
 None
None
EDO  A 506 (-3.5A)
None
 0.90A 1oniG-4jqtA:
undetectable
1oniI-4jqtA:
undetectable		 1oniG-4jqtA:
14.49
1oniI-4jqtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		4 GLY A  95
PRO A  89
ASN A 135
ASN A 136
 None
 0.89A 1oniG-4kbmA:
undetectable
1oniI-4kbmA:
undetectable		 1oniG-4kbmA:
16.22
1oniI-4kbmA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLY A 325
PHE A 328
ASN A 351
ASN A 350
 None
 0.99A 1oniG-4m7eA:
1.7
1oniI-4m7eA:
undetectable		 1oniG-4m7eA:
10.62
1oniI-4m7eA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 GLY A 165
PHE A 176
ASN A 191
ARG A 142
 None
 0.94A 1oniG-4mh1A:
undetectable
1oniI-4mh1A:
undetectable		 1oniG-4mh1A:
14.34
1oniI-4mh1A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 ILE A 381
GLY A 364
ASN A 359
ASN A 360
 None
 0.98A 1oniG-4ozyA:
undetectable
1oniI-4ozyA:
undetectable		 1oniG-4ozyA:
15.60
1oniI-4ozyA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN

(Streptococcus
pyogenes) 		PF16569
(GramPos_pilinBB) 		4 GLY A 337
PRO A 332
ASN A 323
ASN A 220
 None
 0.78A 1oniG-4p0dA:
undetectable
1oniI-4p0dA:
undetectable		 1oniG-4p0dA:
15.98
1oniI-4p0dA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN

(Entamoeba
histolytica) 		PF13499
(EF-hand_7) 		4 ILE A  82
GLY A  80
PHE A 123
ASN A 121
 None
 1.00A 1oniG-4q04A:
undetectable
1oniI-4q04A:
undetectable		 1oniG-4q04A:
19.46
1oniI-4q04A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 GLY A 647
PRO A 754
PHE A 651
ASN A 676
 None
 0.95A 1oniG-4q73A:
undetectable
1oniI-4q73A:
undetectable		 1oniG-4q73A:
10.72
1oniI-4q73A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00571
(CBS) 		4 ILE G 312
GLY G 311
PRO G 229
ASN G 203
 AMP  G 403 (-3.6A)
None
None
None
 0.88A 1oniG-4rerG:
undetectable
1oniI-4rerG:
undetectable		 1oniG-4rerG:
18.09
1oniI-4rerG:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		4 ILE A 491
GLY A 492
ASN A 548
ARG A 168
 None
 0.95A 1oniG-4rulA:
undetectable
1oniI-4rulA:
undetectable		 1oniG-4rulA:
10.45
1oniI-4rulA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 ILE A 271
GLY A 272
PRO A 280
ASN A 276
 None
None
None
SO4  A 501 (-3.9A)
 0.98A 1oniG-4s3kA:
undetectable
1oniI-4s3kA:
1.1		 1oniG-4s3kA:
17.32
1oniI-4s3kA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4we6 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 205
PRO A 214
PHE A  85
ASN A  86
 None
None
None
NAG  A 301 (-1.8A)
 0.86A 1oniG-4we6A:
undetectable
1oniI-4we6A:
undetectable		 1oniG-4we6A:
18.35
1oniI-4we6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 ILE A 287
GLY A 288
PHE A 499
ASN A 498
 None
None
XE  A 604 (-3.8A)
None
 0.98A 1oniG-4wn9A:
undetectable
1oniI-4wn9A:
undetectable		 1oniG-4wn9A:
13.89
1oniI-4wn9A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Thermotoga
maritima) 		PF01867
(Cas_Cas1) 		4 ILE A 210
GLY A 211
ASN A 217
ARG A  99
 None
 1.01A 1oniG-4xtkA:
undetectable
1oniI-4xtkA:
undetectable		 1oniG-4xtkA:
17.50
1oniI-4xtkA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjz SCFV H2526

(Homo sapiens) 		PF07686
(V-set) 		4 ILE L 300
GLY L 314
PRO L  56
ASN L  52
 None
 0.84A 1oniG-4yjzL:
undetectable
1oniI-4yjzL:
undetectable		 1oniG-4yjzL:
23.43
1oniI-4yjzL:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ILE A 731
GLY A 723
PRO A 702
ASN A 696
 None
 0.98A 1oniG-5a55A:
undetectable
1oniI-5a55A:
undetectable		 1oniG-5a55A:
8.87
1oniI-5a55A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay7 XYLANASE

(Aegilops
speltoides) 		PF00331
(Glyco_hydro_10) 		4 ILE A  87
GLY A  88
PRO A 150
ASN A 108
 None
 0.97A 1oniG-5ay7A:
0.9
1oniI-5ay7A:
1.0		 1oniG-5ay7A:
16.62
1oniI-5ay7A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96

(Vicugna pacos;
Xenopus
tropicalis) 		PF07686
(V-set)
PF04096
(Nucleoporin2) 		5 ILE B 721
GLY B 719
ASN A  33
ASN B 771
ARG A 114
 None
 1.29A 1oniG-5e0qB:
undetectable
1oniI-5e0qB:
undetectable		 1oniG-5e0qB:
21.25
1oniI-5e0qB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 ILE E 177
GLY E 178
PRO E 145
ASN E 231
 None
 0.74A 1oniG-5e24E:
undetectable
1oniI-5e24E:
undetectable		 1oniG-5e24E:
14.95
1oniI-5e24E:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egw CYSTEINE PROTEASE

(Ambrosia
artemisiifolia) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 ILE A 101
GLY A 196
ASN A 190
ARG A 108
 None
 0.99A 1oniG-5egwA:
undetectable
1oniI-5egwA:
undetectable		 1oniG-5egwA:
16.53
1oniI-5egwA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 ILE A 216
GLY A 170
PRO A 242
ASN A 167
 None
None
COI  A 601 ( 4.4A)
None
 0.76A 1oniG-5ereA:
undetectable
1oniI-5ereA:
undetectable		 1oniG-5ereA:
14.47
1oniI-5ereA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 ILE A 453
GLY A 450
PHE A 430
ASN A 333
 None
 1.00A 1oniG-5fv4A:
1.3
1oniI-5fv4A:
undetectable		 1oniG-5fv4A:
14.88
1oniI-5fv4A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 377
PRO A 336
PHE A 433
ASN A 436
 None
 0.99A 1oniG-5fwmA:
undetectable
1oniI-5fwmA:
undetectable		 1oniG-5fwmA:
11.77
1oniI-5fwmA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 ILE A 541
GLY A 539
ASN A 176
ASN A 142
 ILE  A 541 ( 0.7A)
GLY  A 539 ( 0.0A)
ASN  A 176 ( 0.6A)
ASN  A 142 ( 0.6A)
 1.01A 1oniG-5gprA:
undetectable
1oniI-5gprA:
0.8		 1oniG-5gprA:
14.23
1oniI-5gprA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY A 377
PHE A 495
ASN A 497
ASN A 374
 None
 0.94A 1oniG-5h3kA:
undetectable
1oniI-5h3kA:
undetectable		 1oniG-5h3kA:
14.59
1oniI-5h3kA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 GLY A 351
PRO A 340
PHE A 354
ARG A 423
 None
 0.99A 1oniG-5h4eA:
undetectable
1oniI-5h4eA:
undetectable		 1oniG-5h4eA:
17.03
1oniI-5h4eA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 PRO B 233
PHE B 246
ASN B 245
ASN B 242
 None
 0.96A 1oniG-5hccB:
undetectable
1oniI-5hccB:
undetectable		 1oniG-5hccB:
12.16
1oniI-5hccB:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		4 ILE A 188
GLY A 189
ASN A 147
ARG A 158
 None
 0.98A 1oniG-5hj5A:
undetectable
1oniI-5hj5A:
undetectable		 1oniG-5hj5A:
22.92
1oniI-5hj5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES1

(Chaetomium
thermophilum) 		no annotation 4 ILE o 195
GLY o 196
PRO o  39
ASN o  78
 None
 0.76A 1oniG-5jpqo:
undetectable
1oniI-5jpqo:
undetectable		 1oniG-5jpqo:
20.97
1oniI-5jpqo:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 GLY A 570
PRO A 575
ASN A 350
ARG A 321
 None
 0.86A 1oniG-5l3dA:
undetectable
1oniI-5l3dA:
undetectable		 1oniG-5l3dA:
10.81
1oniI-5l3dA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 ILE A 288
GLY A  45
PHE A 174
ASN A  71
 None
 0.91A 1oniG-5lv9A:
undetectable
1oniI-5lv9A:
undetectable		 1oniG-5lv9A:
12.97
1oniI-5lv9A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 443
GLY A 440
PHE A 476
ASN A 497
 None
 0.87A 1oniG-5t98A:
undetectable
1oniI-5t98A:
undetectable		 1oniG-5t98A:
11.57
1oniI-5t98A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 GLY C  92
PRO C  86
ASN C 132
ASN C 133
 None
 0.81A 1oniG-5tw1C:
undetectable
1oniI-5tw1C:
undetectable		 1oniG-5tw1C:
8.45
1oniI-5tw1C:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ILE A  50
GLY A  49
PHE A  45
ASN A  46
 None
 0.92A 1oniG-5tw7A:
undetectable
1oniI-5tw7A:
undetectable		 1oniG-5tw7A:
16.83
1oniI-5tw7A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 ILE A 152
GLY A 151
PHE A 158
ASN A 160
 None
IOD  A1514 ( 4.4A)
None
None
 0.98A 1oniG-5wlhA:
undetectable
1oniI-5wlhA:
undetectable		 1oniG-5wlhA:
7.59
1oniI-5wlhA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ILE A 392
GLY A 393
PHE A 411
ASN A 408
 None
 0.89A 1oniG-5x49A:
undetectable
1oniI-5x49A:
undetectable		 1oniG-5x49A:
16.01
1oniI-5x49A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrt -

(-) 		no annotation 4 ILE A 245
PRO A 254
PHE A 125
ASN A 126
 None
None
None
NAG  A 525 (-1.9A)
 0.91A 1oniG-5xrtA:
undetectable
1oniI-5xrtA:
undetectable		 1oniG-5xrtA:
undetectable
1oniI-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 ILE A 550
GLY A 548
ASN A 183
ASN A 149
 None
 0.91A 1oniG-5zl9A:
undetectable
1oniI-5zl9A:
undetectable		 1oniG-5zl9A:
undetectable
1oniI-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8d ELONGATION FACTOR G

(Haemophilus
influenzae) 		no annotation 4 ILE A  40
GLY A  41
PHE A 202
ASN A 194
 None
 0.97A 1oniG-6b8dA:
1.0
1oniI-6b8dA:
undetectable		 1oniG-6b8dA:
17.39
1oniI-6b8dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 5 ILE A 259
GLY A 261
PRO A 258
ASN A 296
ARG A 325
 None
None
None
None
CIT  A 703 (-3.6A)
 1.32A 1oniG-6fcxA:
undetectable
1oniI-6fcxA:
undetectable		 1oniG-6fcxA:
undetectable
1oniI-6fcxA:
undetectable